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Breast Cancer Research and Treatment

Ausgabe 1/2024

Inhalt (20 Artikel)

Review

Neoadjuvant endocrine treatment in hormone receptor-positive breast cancer: Does it result in more breast-conserving surgery?

Merel E. van de Loo, Layla Andour, Anne E. van Heesewijk, Hendrika M. Oosterkamp, Gerrit-Jan Liefers, Marieke E. Straver

Open Access Preclinical study

The association of PD-L1 expression and CD8-positive T cell infiltration rate with the pathological complete response after neoadjuvant treatment in HER2-positive breast cancer

Kenan Çetin, Şermin Kökten, Bahar Sarıkamış, Sedat Yıldırım, Oruç Numan Gökçe, Nagehan Özdemir Barışık, Ülkan Kılıç

Clinical trial

Poziotinib treatment in patients with HER2-positive advanced breast cancer who have received prior anti-HER2 regimens

Azadeh Nasrazadani, Juan Luis Gomez Marti, Kate Lathrop, Alvaro Restrepo, Szu-Yun Leu, Gajanan Bhat, Adam Brufsky

Open Access Clinical trial

Real-world use of multigene signatures in early breast cancer: differences to clinical trials

Luca Licata, Rita De Sanctis, Andrea Vingiani, Deborah Cosentini, Monica Iorfida, Elena Rota Caremoli, Isabella Sassi, Bethania Fernandes, Andrea Gianatti, Elena Guerini-Rocco, Claudia Zambelli, Elisabetta Munzone, Edda Lucia Simoncini, Carlo Tondini, Oreste Davide Gentilini, Alberto Zambelli, Giancarlo Pruneri, Giampaolo Bianchini

Open Access Clinical trial

Effect of metformin and lifestyle intervention on adipokines and hormones in breast cancer survivors: a pooled analysis from two randomized controlled trials

Harriet Johansson, Federica Bellerba, Debora Macis, Bjørn-Erik Bertelsen, Aliana Guerrieri-Gonzaga, Valentina Aristarco, Kristin Viste, Gunnar Mellgren, Giulia Di Cola, Jemos Costantino, Augustin Scalbert, Dorothy D. Sears, Sara Gandini, Andrea DeCensi, Bernardo Bonanni

Open Access Clinical trial

Randomized placebo-controlled, double-blind clinical trial of nanoemulsion curcumin in women with aromatase inhibitor-induced arthropathy: an Alliance/NCORP pilot trial

Maryam Lustberg, Patty Fan-Havard, F. Lennie Wong, Kasey Hill, Mitch A. Phelps, Kevin W. Herrera, Ni-Chun Tsai, Timothy Synold, Ye Feng, Chidimma Kalu, Mina S. Sedrak, Lisa D. Yee

Open Access Clinical trial

Effects of physical exercise during adjuvant chemotherapy for breast cancer on long-term tested and perceived cognition: results of a pragmatic follow-up study

Willeke R. Naaktgeboren, Emmie W. Koevoets, Martijn M. Stuiver, Wim H. van Harten, Neil K. Aaronson, Elsken van der Wall, Miranda Velthuis, Gabe Sonke, Sanne B. Schagen, Wim G. Groen, Anne M. May

Open Access Clinical trial

Trastuzumab and first-line taxane chemotherapy in metastatic breast cancer patients with a HER2-negative tumor and HER2-positive circulating tumor cells: a phase II trial

Noortje Verschoor, Manouk K. Bos, Ingeborg E. de Kruijff, Mai N. Van, Jaco Kraan, Jan C. Drooger, Johanna M. Zuetenhorst, Saskia M. Wilting, Stefan Sleijfer, Agnes Jager, John W. M. Martens

Clinical trial

Deep learning-guided adjuvant chemotherapy selection for elderly patients with breast cancer

Enzhao Zhu, Linmei Zhang, Jiayi Wang, Chunyu Hu, Huiqing Pan, Weizhong Shi, Ziqin Xu, Pu Ai, Dan Shan, Zisheng Ai

Open Access Clinical trial

Investigating the role of tumour-to-skin proximity in predicting nodal metastasis in breast cancer

Thiviya Sivakanthan, J. Tanner, B. Mahata, A. Agrawal

Clinical trial

Comparison of long-term oncological outcomes after central lumpectomy versus nipple-sparing breast-conserving surgery for centrally located breast cancer: a propensity score-matched study

Yung-Huyn Hwang, Tae-Kyung Yoo, Sae Byul Lee, Jisun Kim, Il Yong Chung, Beom Seok Ko, Hee Jeong Kim, Jong Won Lee, Byung Ho Son

Epidemiology

Omission of axillary lymph node dissection for breast cancer patients with three or more positive sentinel lymph nodes

Saranya Prathibha, McKenzie White, Madison Kolbow, Jane Yuet Ching Hui, David Brauer, Jacob Ankeny, Eric H. Jensen, Christopher J. LaRocca, Schelomo Marmor, Todd M. Tuttle

Open Access Epidemiology

Comparisons of assessment pathways after abnormal mammography screening in Denmark, Norway, and Spain

Susanne Fogh Jørgensen, Silje Sagstad, Javier Louro, Marta Román, Xavier Castells, Solveig Hofvind, Sisse Njor

Open Access Epidemiology

Information needs in breast reconstruction after mastectomy: a qualitative analysis of free-text responses from 2077 women

Kim Wuyts, Vicki Durston, Lisa Morstyn, Sam Mills, Victoria White

Epidemiology

MRI-visualized T2 hyperintense breast lesions: identifying clinical and imaging factors linked to malignant biopsy outcomes

Mary Beth Bissell, Sareh Keshavarsi, Rachel Fleming, Frederick Au, Supriya Kulkarni, Sandeep Ghai, Vivianne Freitas

Epidemiology

Socio-cultural and financial issues against breast cancer screening behaviour among eligible Indian women: evidence for action

Shibaji Gupta, Sharmistha Sinha Gupta, Abhishek De, Rudradeep Banerjee, Sonu Goel

Original Laboratory Investigation

Exploration of MELK as a downstream of Del-1 and druggable targets in triple-negative breast cancer

In Hee Lee, Soo Jung Lee, Byeongju Kang, Jeeyeon Lee, Jin Hyang Jung, Ho Yong Park, Ji-Young Park, Nora Jee-Young Park, Eun Ae Kim, Jieun Kang, Yee Soo Chae

Original Laboratory Investigation

High tumor infiltrating lymphocytes are significantly associated with pathological complete response in triple negative breast cancer treated with neoadjuvant KEYNOTE-522 chemoimmunotherapy

Sarah J. Wood, Yuan Gao, Ji-Hoon Lee, Jessica Chen, Qun Wang, Jane L. Meisel, Xiaoxian Li

Open Access Original Laboratory Investigation

Real-world treatment patterns and clinical outcomes in patients treated with eribulin after prior phosphoinositide 3-Kinase inhibitor treatment for metastatic breast cancer

Ravi K. Goyal, Jingchuan Zhang, Keith L. Davis, Martina Sluga-O’Callaghan, Peter A. Kaufman

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

29.05.2024 Larynxkarzinom Nachrichten

Fast ein Viertel der Personen mit mäßig dysplastischen Stimmlippenläsionen entwickelt einen Kehlkopftumor. Solche Personen benötigen daher eine besonders enge ärztliche Überwachung.

15% bedauern gewählte Blasenkrebs-Therapie

29.05.2024 Urothelkarzinom Nachrichten

Ob Patienten und Patientinnen mit neu diagnostiziertem Blasenkrebs ein Jahr später Bedauern über die Therapieentscheidung empfinden, wird einer Studie aus England zufolge von der Radikalität und dem Erfolg des Eingriffs beeinflusst.

Erhöhtes Risiko fürs Herz unter Checkpointhemmer-Therapie

28.05.2024 Nebenwirkungen der Krebstherapie Nachrichten

Kardiotoxische Nebenwirkungen einer Therapie mit Immuncheckpointhemmern mögen selten sein – wenn sie aber auftreten, wird es für Patienten oft lebensgefährlich. Voruntersuchung und Monitoring sind daher obligat.

Costims – das nächste heiße Ding in der Krebstherapie?

28.05.2024 Onkologische Immuntherapie Nachrichten

„Kalte“ Tumoren werden heiß – CD28-kostimulatorische Antikörper sollen dies ermöglichen. Am besten könnten diese in Kombination mit BiTEs und Checkpointhemmern wirken. Erste klinische Studien laufen bereits.

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