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Strahlentherapie und Onkologie

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01.08.2015 | Original Article

¹⁸F-fluorodeoxyglucose positron emission tomography for predicting tumor response to radiochemotherapy in nasopharyngeal carcinoma

verfasst von: Meng Su, Liang Zhao, Hangping Wei, Ruifang Lin, Xuebang Zhang, Changlin Zou

Erschienen in: Strahlentherapie und Onkologie | Ausgabe 8/2015

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Abstract

Purpose

The aim of this study was to evaluate the value of ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in predicting tumor response to radiochemotherapy in nasopharyngeal carcinoma (NPC).

Materials and methods

From July 2012 to March 2014, 46 NPC patients who had undergone PET scanning before receiving definitive intensity-modulated radiotherapy (IMRT) treatment in our hospital were enrolled. Factors potentially affecting tumor response to treatment were studied by multiple logistic regression analysis.

Results

After radiochemotherapy, 32 patients had a clinical complete response (CR), making the CR rate 69.6 %. Multiple logistic regression analysis demonstrated that the maximal standard uptake value (SUV_max) of the primary tumor was the only factor related to tumor response (p = 0.001), and that the logistic model had a high positive predictive value (90.6 %). The area under the receiver operating characteristic (ROC) curve was 0.809, with a best cutoff threshold at 10.05. Patients with SUV_max ≤ 10 had a higher CR rate than those with SUV_max > 10 (p < 0.001).

Conclusion

The SUV_max of the primary tumor before treatment is an independent predictor of tumor response in NPC.

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Titel: 18F-fluorodeoxyglucose positron emission tomography for predicting tumor response to radiochemotherapy in nasopharyngeal carcinoma
verfasst von: Meng Su
Liang Zhao
Hangping Wei
Ruifang Lin
Xuebang Zhang
Changlin Zou
Publikationsdatum: 01.08.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Strahlentherapie und Onkologie / Ausgabe 8/2015
Print ISSN: 0179-7158
Elektronische ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-015-0842-2

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¹⁸F-fluorodeoxyglucose positron emission tomography for predicting tumor response to radiochemotherapy in nasopharyngeal carcinoma

Abstract

Purpose

Materials and methods

Results

Conclusion

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Springer Medizin

Abstract

Purpose

Materials and methods

Results

Conclusion

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