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10.07.2015 | Original Contribution

Adherence to WCRF/AICR lifestyle recommendations for cancer prevention and the risk of Barrett’s esophagus onset and evolution to esophageal adenocarcinoma: results from a pilot study in a high-risk population

verfasst von: Stefano Realdon, Alessandro Antonello, Diletta Arcidiacono, Elisa Dassie, Francesco Cavallin, Matteo Fassan, Maria Teresa Nardi, Alfredo Alberti, Massimo Rugge, Giorgio Battaglia

Erschienen in: European Journal of Nutrition | Ausgabe 4/2016

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Abstract

Purpose

While adherence to the World Cancer Research Fund (WCRF) guidelines on lifestyle and cancer was recently proven to be associated with an increased risk of esophageal cancer, no investigation has yet been carried out on its role on Barrett’s esophagus (BE) development and its progression to esophageal adenocarcinoma (EAC). The primary aim of this study was to evaluate the role of adherence to WCRF lifestyle recommendations in BE onset and progression. The secondary aim was to investigate the association between disease progression and specific aspects of diet and lifestyle.

Methods

Established risk factors for BE and EAC development and adherence to WCRF guidelines were assessed in 107 consecutive patients undergoing an upper gastrointestinal endoscopy for symptoms suggesting gastroesophageal reflux (GERD) and a suspected diagnosis of BE/dysplasia on BE. Patients were divided according to histology: those with GERD without metaplasia, with non-dysplastic BE, with low-grade dysplasia, with high-grade dysplasia or with early EAC. The four groups were expressed as an ordered categorical variable of disease progression. An ordered logit model was estimated to identify the independent predictors of disease progression.

Results

Adherence to WCRF guidelines was identified as independent protective factor (OR 0.51, 95 % CI 0.37–0.67) of disease progression. Disease progression was associated with reduced adherence to guidelines on physical activity (from 48.2 to 5.3 %, p = 0.001), sedentary habits (from 33.3 to 0 %, p = 0.03), fruit consumption (from 37.0 to 5.6 %, p = 0.02) and processed meat consumption (from 51.9 to 10.5 %, p = 0.002).

Conclusion

Adherence to WCRF guidelines has a protective factor in BE onset and its evolution to EAC.

Lepage C, Rachet B, Jooste V et al (2008) Continuing rapid increase in esophageal adenocarcinoma in England and Wales. Am J Gastroenterol 103:2694–2699CrossRef

Brown LM, Devesa SS, Chow WH (2008) Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age. J Natl Cancer Inst 100:1184–1187CrossRef

Coleman HG, Bhat S, Murray LJ et al (2011) Increasing incidence of Barrett’s oesophagus: a population-based study. Eur J Epidemiol 26:739–745CrossRef

El-Serag HB, Mason AC, Petersen N et al (2002) Epidemiological differences between adenocarcinoma of the oesophagus and adenocarcinoma of the gastric cardia in the USA. Gut 50:368–372CrossRef

Thrift AP, Whiteman DC (2012) The incidence of esophageal adenocarcinoma continues to rise: analysis of period and birth cohort effects on recent trends. Ann Oncol 23:3155–3162CrossRef

Sharma P (2009) Clinical practice. Barrett’s esophagus. N Engl J Med 361:2548–2556CrossRef

Hvid-Jensen F, Pedersen L, Drewes AM et al (2011) Incidence of adenocarcinoma among patients with Barrett’s esophagus. N Engl J Med 365:1375–1383CrossRef

Singh S, Sharma AN, Murad MH et al (2013) Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 11(11):1399–1412CrossRef

Corley DA, Kubo A (2006) Body mass index and gastroesophageal reflux disease: a systematic review and meta-analysis. Am J Gastroenterol 101:2619–2628CrossRef

10.

Cook MB, Shaheen NJ, Anderson LA et al (2012) Cigarette smoking increases the risk of Barrett’s esophagus: an analysis of the Barrett’s and Esophageal Adenocarcinoma Consortium. Gastroenterology 142:744–753CrossRef

11.

Fontana L, Adelaiye RM, Rastelli AL et al (2013) Dietary protein restriction inhibits tumor growth in human xenograft models. Oncotarget 4(12):2451–2461CrossRef

12.

Fontana L, Klein S, Holloszy JO (2006) Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk. Am J Clin Nutr 84(6):1456–1462

13.

Eslamian G, Jessri M, Hajizadeh B et al (2013) Higher glycemic index and glycemic load diet is associated with increased risk of esophageal squamous cell carcinoma: a case-control study. Nutr Res 33(9):719–725CrossRef

14.

Farvid MS, Cho E, Chen WY et al (2014) Dietary protein sources in early adulthood and breast cancer incidence: prospective cohort study. BMJ 348:g3437CrossRef

15.

World Cancer Research Fund (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. World Cancer Research Fund/American Institute of Cancer Research, Washington

16.

Romaguera D, Vergnaud AC, Peeters PH et al (2012) Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study. Am J Clin Nutr 96(1):150–163CrossRef

17.

Hastert TA, Beresford SA, Patterson RE et al (2013) Adherence to WCRF/AICR cancer prevention recommendations and risk of post-menopausal breast cancer. Cancer Epidemiol Biomark Prev 22:1498–1508CrossRef

18.

Vergnaud A, Romaguera D, Peeters PH et al (2013) Adherence to the World Cancer Research Fund/American Institute for Cancer Research guidelines and risk of death in Europe: results from the European prospective investigation into nutrition and cancer cohort study. Am J Clin Nutr 97(5):1107–1120CrossRef

19.

Makarem N, Lin Y, Bandera E et al (2015) Concordance with World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines for cancer prevention and obesity-related cancer risk in the Framingham Offspring cohort (1991–2008). Cancer Causes Control 26(2):277–286CrossRef

20.

Lim YC, Fitzgerald RC (2013) Diagnosis and treatment of Barrett’s oesophagus. Br Med Bull 107:117–132CrossRef

21.

Estores D, Velanovich V (2013) Barrett esophagus: epidemiology, pathogenesis, diagnosis, and management. Curr Probl Surg 50(5):192–226CrossRef

22.

Spechler SJ (2013) Barrett esophagus and risk of esophageal cancer: a clinical review. JAMA J Am Med Assoc 310(6):627–636CrossRef

23.

Rugge M, Zaninotto G, Parente P et al (2012) Barrett’s esophagus and adenocarcinoma risk: the experience of the North-Eastern Italian Registry (EBRA). Ann Surg 256(5):788–794CrossRef

24.

Kubo A, Cook MB, Shaheen NJ et al (2013) Sex-specific associations between body mass index, waist circumference and the risk of Barrett’s oesophagus: a pooled analysis from the international BEACON consortium. Gut 62(12):1684–1691CrossRef

25.

Nelsen EM, Kirihara Y, Takahashi N et al (2012) Distribution of body fat and its influence on esophageal inflammation and dysplasia in patients with Barrett’s esophagus. Clin Gastroenterol Hepatol 10(7):728–734CrossRef

26.

Siegel R, Naishadham D, Jemal A (2013) Cancer statistics, 2013. CA Cancer J Clin 63(1):11–30CrossRef

27.

Corley Douglas A, Mehtani Kunal, Quesenberry Charles et al (2013) Impact of endoscopic surveillance on mortality from Barrett’s esophagus-associated esophageal adenocarcinomas. Gastroenterology 145(2):312–319CrossRef

28.

Murray L, Romero Y (2009) Role of obesity in Barrett’s esophagus and cancer. Surg Oncol Clin N Am 18(3):439–452CrossRef

29.

O’Doherty MG, Freedman ND, Hollenbeck AR et al (2012) A prospective cohort study of obesity and risk of oesophageal and gastric adenocarcinoma in the NIH-AARP Diet and Health Study. Gut 61(9):1261–1268CrossRef

30.

Jiao L, Kramer JR, Chen L, Rugge M et al (2013) Dietary consumption of meat, fat, animal products and advanced glycation end-products and the risk of Barrett’s oesophagus. Aliment Pharmacol Ther 38(7):817–824CrossRef

31.

O’Doherty MG, Cantwell MM, Murray LJ et al (2011) Dietary fat and meat intakes and risk of reflux esophagitis, Barrett’s esophagus and esophageal adenocarcinoma. Int J Cancer 129(6):1493–1502CrossRef

32.

Keszei AP, Schouten LJ, Driessen AL et al (2013) Meat consumption and the risk of Barrett’s esophagus in a large Dutch cohort. Cancer Epidemiol Biomarkers Prev 22(6):1162–1166CrossRef

33.

Singh PN, Batech M, Faed P et al (2014) Reliability of meat, fish, dairy, and egg intake over a 33-year interval in adventist health study 2. Nutr Cancer 8:1–7

34.

Batside NM, Pierre FH, Corpet DE (2011) Heme iron from meat and risk for colorectal cancer: a meta-analysis and a review of the mechanisms involved. Cancer Prev Res 4:177–184CrossRef

35.

Bartsh H, Montesano R (1984) Relevance of nitrosamines to human cancer. Carcinogenesis 5:1381–1393CrossRef

36.

Diggs DL, Huderson AC, Harris KL et al (2011) Polycyclic aromatic hyrdocarbons and digestive tract cancers - a perspective. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 29:324–357CrossRef

37.

Mulholland HG, Cantwell MM, Anderson LA et al (2009) Glycemic index, carbohydrate and fiber intakes and risk of reflux esophagitis, Barrett’s esophagus, and esophageal adenocarcinoma. Cancer Causes Control 20(3):279–288CrossRef

38.

Hu J, La Vecchia C, Augustin LS et al (2013) Canadian Cancer Registries Epidemiology Research Group. Glycemic index, glycemic load and cancer risk. Ann Oncol 24(1):245–251CrossRef

39.

Buysschaert M, Sadikot S (2013) Diabetes and cancer: a 2013 synopsis. Diabetes Metab Syndr 7(4):247–250CrossRef

40.

Mahalle N, Kulkarni MV, Naik SS et al (2014) Association of dietary factors with insulin resistance and inflammatory markers in subjects with diabetes mellitus and coronary artery disease in Indian population. J Diabetes Complicat 28(4):536–541CrossRef

41.

Kellow NJ, Coughlan MT, Reid CM (2014) Metabolic benefits of dietary prebiotics in human subjects: a systematic review of randomised controlled trials. Br J Nutr 111(7):1147–1161CrossRef

42.

Coleman HG, Murray LJ, Hicks B et al (2013) Dietary fiber and the risk of precancerous lesions and cancer of the esophagus: a systematic review and meta-analysis. Nutr Rev 71(7):474–482CrossRef

43.

Anderson JW, Baird P, Davis RH Jr et al (2009) Health benefits of dietary fiber. Nutr Rev 67(4):188–205CrossRef

44.

Sormunen J, Bäckmand HM, Sarna S et al (2014) Lifetime physical activity and cancer incidence–a cohort study of male formerelite athletes in Finland. J Sci Med Sport 17(5):479–484CrossRef

45.

Abioye AI, Odesanya MO, Abioye AI et al (2015) Physical activity and risk of gastric cancer: a meta-analysis of observational studies. Br J Sports Med 49(4):224–229CrossRef

46.

Ling C, Rönn T (2014) Epigenetic adaptation to regular exercise in humans. Drug Discov Today 19(7):1015–1018CrossRef

47.

Milton K, Macniven R, Bauman A (2014) Review of the epidemiological evidence for physical activity and health from low- and middle-income countries. Glob Public Health 9(4):369–381CrossRef

48.

Apostolopoulos V, Borkoles E, Polman R et al (2014) Physical and immunological aspects of exercise in chronic diseases. Immunotherapy 6(10):1145–1157CrossRef

49.

Piguet AC, Saran U, Simillion C et al (2015) Regular exercise decreases liver tumors development in hepatocyte-specific PTEN-deficient mice independently of steatosis. J Hepatol 23. [Epub ahead of print]

50.

Howell A, Anderson AS, Clarke RB et al (2014) Risk determination and prevention of breast cancer. Breast Cancer Res 16(5):446CrossRef

51.

Ibiebele TI, Hughes MC, Nagle CM et al (2013) Dietary antioxidants and risk of Barrett’s esophagus and adenocarcinoma of the esophagus in an Australian population. Int J Cancer 133:214–224CrossRef

52.

Zanini S, Marzotto M, Giovinazzo F et al (2014) Effects of dietary components on cancer of the digestive system. Crit Rev Food Sci Nutr 2014:19

53.

Harasym J, Oledzki R (2014) Effect of fruit and vegetable antioxidants on total antioxidant capacity of blood plasma. Nutrition 30(5):511–517CrossRef

54.

Abdull Razis AF, Noor NM (2013) Cruciferous vegetables: dietary phytochemicals for cancer prevention. Asian Pac J Cancer Prev 14(3):1565–1570CrossRef

55.

Li B, Jiang G, Zhang G et al (2014) Intake of vegetables and fruit and risk of esophageal adenocarcinoma: a meta-analysis of observational studies. Eur J Nutr 53:1511–1521CrossRef

56.

Jeurnik SM, Büchner FL, Bueno-de-Mesquita HB et al (2012) Variety in vegetable and fruit consumption and the risk of gastric and esophageal cancer in the European Prospective Investigation into cancer and nutrition. Int J Cancer 131:E963–E973CrossRef

57.

Keszei AP, Schouten LJ, Driessen AL et al (2014) Vegetable, fruit and nitrate intake in relation to the risk of Barrett’s oesophagus in a large Dutch cohort. Br J Nutr 111(8):1452–1462CrossRef

58.

Khoury JE, Chisholm S, Jamal MM et al (2012) African Americans with Barrett’s esophagus are less likely to have dysplasia at biopsy. Dig Dis Sci 57(2):419–423CrossRef

59.

Nguyen TH, Thrift AP, Ramsey D et al (2014) Risk factors for Barrett’s esophagus compared between African Americans and non-Hispanic Whites. Am J Gastroenterol 109(12):1870–1880CrossRef

Titel: Adherence to WCRF/AICR lifestyle recommendations for cancer prevention and the risk of Barrett’s esophagus onset and evolution to esophageal adenocarcinoma: results from a pilot study in a high-risk population
verfasst von: Stefano Realdon
Alessandro Antonello
Diletta Arcidiacono
Elisa Dassie
Francesco Cavallin
Matteo Fassan
Maria Teresa Nardi
Alfredo Alberti
Massimo Rugge
Giorgio Battaglia
Publikationsdatum: 10.07.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 4/2016
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-015-0975-1

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Adherence to WCRF/AICR lifestyle recommendations for cancer prevention and the risk of Barrett’s esophagus onset and evolution to esophageal adenocarcinoma: results from a pilot study in a high-risk population

Abstract

Purpose

Methods

Results

Conclusion

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Antihypertensiva schützen auch alte Menschen noch vor Demenz

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Purpose

Methods

Results

Conclusion

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