nach oben

Erschienen in:

02.08.2015 | Original Contribution

Age-related changes in basal substrate oxidation and visceral adiposity and their association with metabolic syndrome

verfasst von: Mario Siervo, Jose Lara, Carlos Celis-Morales, Michele Vacca, Clio Oggioni, Alberto Battezzati, Alessandro Leone, Anna Tagliabue, Angela Spadafranca, Simona Bertoli

Erschienen in: European Journal of Nutrition | Ausgabe 4/2016

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Ageing is directly associated with visceral fat (VAT) deposition and decline of metabolically active cellular mass, which may determine age-related shifts in substrate oxidation and increased cardiometabolic risk. We tested whether VAT and fasting respiratory quotient (RQ, an index of macronutrient oxidation) changed with age and if they were associated with increased risk of metabolic syndrome (MetSyn).

Methods

A total of 2819 adult participants (age range: 18–81 years; men/women: 894/1925) were included; we collected history, anthropometric measures, biochemistry, smoking habits, and physical activity. The body mass index range was 18.5–60.2 kg/m². Gas exchanges (VO₂ and VCO₂) were measured by indirect calorimetry in fasting conditions, and RQ was calculated. Body composition was measured by bioelectrical impedance. Abdominal subcutaneous fat and VAT were measured by ultrasonography. MetSyn was diagnosed using harmonised international criteria. Multivariate linear and logistic regression models were utilised.

Results

VAT increased with age in both men (r = 0.31, p < 0.001) and women (r = 0.37, p < 0.001). Basal RQ was not significantly associated with age (p = 0.49) and VAT (p = 0.20); in addition, basal RQ was not a significant predictor of MetSyn (OR 3.31, 0.57–19.08, p = 0.27). VAT was the primary predictor of MetSyn risk in a fully adjusted logistic model (OR 4.25, 3.01–5.99, p < 0.001).

Conclusions

Visceral adiposity remains one of the most important risk factors for cardiometabolic risk and is a significant predictor of MetSyn. Post-absorptive substrate oxidation does not appear to play a significant role in age-related changes in body composition and cardiometabolic risk, except for a correlation with triglyceride concentration.

Nur mit Berechtigung zugänglich

Roberts SB, Rosenberg I (2006) Nutrition and aging: changes in the regulation of energy metabolism with aging. Physiol Rev 86:651–667CrossRef

Siervo M et al (2015) Age-related changes in resting energy expenditure in normal weight, overweight and obese men and women. Maturitas 80(4):406–413CrossRef

St-Onge MP, Gallagher D (2010) Body composition changes with aging: the cause or the result of alterations in metabolic rate and macronutrient oxidation? Nutrition 26:152–155CrossRef

Tchernof A, Després J-P (2013) Pathophysiology of human visceral obesity: an update. Physiol Rev 93:359–404CrossRef

Schutz Y (1995) Abnormalities of fuel utilization as predisposing to the development of obesity in humans. Obes Res 3(Suppl 2):173s–178sCrossRef

Astrup A (2011) The relevance of increased fat oxidation for body-weight management: metabolic inflexibility in the predisposition to weight gain. Obe Rev 12:859–865CrossRef

Sial S et al (1996) Fat and carbohydrate metabolism during exercise in elderly and young subjects. Am J Physiol 271:E983–E989

Solomon TP et al (2008) Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults. J Appl Physiol 104:1313–1319CrossRef

Kuk JL et al (2009) Age-related changes in total and regional fat distribution. Ageing Res Rev 8:339–348CrossRef

10.

Konopka AR, Sreekumaran Nair K (2013) Mitochondrial and skeletal muscle health with advancing age. Mol Cell Endocrinol 379:19–29CrossRef

11.

Huffman DM, Barzilai N (2009) Role of visceral adipose tissue in aging. Biochim Biophys Acta 1790:1117–1123CrossRef

12.

Manini TM (2010) Energy expenditure and aging. Ageing Res Rev 9:1–11CrossRef

13.

Slawik M, Vidal-Puig AJ (2006) Lipotoxicity, overnutrition and energy metabolism in aging. Age Res Rev 5:144–164CrossRef

14.

Bergouignan A et al (2014) Twenty-four hour total and dietary fat oxidation in lean, obese and reduced-obese adults with and without a bout of exercise. PLoS One 9:e94181CrossRef

15.

Croci I et al (2013) Whole-body substrate metabolism is associated with disease severity in patients with non-alcoholic fatty liver disease. Gut 62:1625–1633CrossRef

16.

Ferro Y et al (2013) Fat utilization and arterial hypertension in overweight/obese subjects. J Transl Med 11:159CrossRef

17.

Galgani JE et al (2014) Relationship between whole-body macronutrient oxidative partitioning and pancreatic insulin secretion/beta-cell function in non-diabetic humans. Metab Clin Exp 63:1426–1431CrossRef

18.

Montalcini T et al (2013) Metabolic fuel utilization and subclinical atherosclerosis in overweight/obese subjects. Endocrine 44:380–385CrossRef

19.

Montalcini T et al (2014) Subclinical cardiovascular damage and fat utilization in overweight/obese individuals receiving the same dietary and pharmacological interventions. Nutrients 6:5560–5571CrossRef

20.

Montalcini T et al (2014) Nutrients utilization in obese individuals with and without hypertriglyceridemia. Nutrients 6:790–798CrossRef

21.

Solomon TP et al (2008) Effects of aging on basal fat oxidation in obese humans. Metab Clin Exp 57:1141–1147CrossRef

22.

Levadoux E et al (2001) Reduced whole-body fat oxidation in women and in the elderly. Int J Obes Relat Metab Disord 25:39–44CrossRef

23.

Nagy TR et al (1996) Determinants of basal fat oxidation in healthy Caucasians. J Appl Physiol 80:1743–1748CrossRef

24.

Toth MJ et al (1999) Hormonal and physiological correlates of energy expenditure and substrate oxidation in middle-aged, premenopausal women. J Clin Endocrinol Metab 84:2771–2775

25.

Craig CL et al (2003) International Physical Activity Questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 35:1381–1395CrossRef

26.

Armellini F et al (1990) The contribution of sonography to the measurement of intra-abdominal fat. J Clin Ultrasound 18:563–567CrossRef

27.

Isbell TR et al (1991) Measurement reliability and reactivity using repeated measurements of resting energy expenditure with a face mask, mouthpiece, and ventilated canopy. JPEN J Parenter Enteral Nutr 15:165–168CrossRef

28.

Weir JBdV (1949) New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 109:1–9CrossRef

29.

Lusk G (1924) Animal calorimetry. Analysis of the oxidation of mixtures of carbohydrate and fat. J Biol Chem 59:41–42

30.

Schutz Y et al (1992) Role of fat oxidation in the long-term stabilization of body weight in obese women. Am J Clin Nutr 55:670–674

31.

Chobanian AV et al (2003) Seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 42:1206–1252CrossRef

32.

Alberti KGMM et al (2009) Harmonizing the Metabolic Syndrome: a Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120:1640–1645CrossRef

33.

Siervo M et al (2010) First-borns carry a higher metabolic risk in early adulthood: evidence from a prospective cohort study. PLoS One 5:e13907CrossRef

34.

Klein S et al (2007) Waist circumference and cardiometabolic risk: a consensus statement from Shaping America’s Health: association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Am J Clin Nutr 85:1197–1202

35.

Astrup A et al (1994) Obesity as an adaptation to a high-fat diet: evidence from a cross-sectional study. Am J Clin Nutr 59:350–355

36.

Calles-Escandon J et al (1995) Basal fat oxidation decreases with aging in women. J Appl Physiol 78:266–271

37.

Seidell JC et al (1992) Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: the Baltimore Longitudinal Study on Aging. Int J Obes Relat Metab Disord 16:667–674

38.

Toth MJ et al (1998) Gender differences in fat oxidation and sympathetic nervous system activity at rest and during submaximal exercise in older individuals. Clin Sci 95:59–66CrossRef

39.

Valtuena S et al (1997) The respiratory quotient as a prognostic factor in weight-loss rebound. Int J Obes Relat Metab Disord 21:811–817CrossRef

40.

Weyer C et al (1999) Determinants of energy expenditure and fuel utilization in man: effects of body composition, age, sex, ethnicity and glucose tolerance in 916 subjects. Int J Obes Relat Metab Disord 23:715–722CrossRef

41.

Zurlo F et al (1990) Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. Am J Physiol 259:E650–E657

42.

Soares MJ et al (2000) Plasma leptin concentrations, basal metabolic rates and respiratory quotients in young and older adults. Int J Obes Relat Metab Disord 24:1592–1599CrossRef

43.

López-Otín C et al (2013) The hallmarks of aging. Cell 153:1194–1217CrossRef

44.

Navaratnarajah A, Jackson SHD (2013) The physiology of ageing. Medicine 41:5–8CrossRef

45.

Raben A et al (1994) Evidence for an abnormal postprandial response to a high-fat meal in women predisposed to obesity. Am J Physiol 267:E549–E559

46.

North BJ, Sinclair DA (2012) The intersection between aging and cardiovascular disease. Circ Res 110:1097–1108CrossRef

47.

Pontiroli AE et al (2002) Ultrasound measurement of visceral and subcutaneous fat in morbidly obese patients before and after laparoscopic adjustable gastric banding: comparison with computerized tomography and with anthropometric measurements. Obes Surg 12:648–651CrossRef

Titel: Age-related changes in basal substrate oxidation and visceral adiposity and their association with metabolic syndrome
verfasst von: Mario Siervo
Jose Lara
Carlos Celis-Morales
Michele Vacca
Clio Oggioni
Alberto Battezzati
Alessandro Leone
Anna Tagliabue
Angela Spadafranca
Simona Bertoli
Publikationsdatum: 02.08.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 4/2016
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-015-0993-z

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

18.04.2024 | Wirbelsäulenmetastase | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Age-related changes in basal substrate oxidation and visceral adiposity and their association with metabolic syndrome

Abstract

Purpose

Methods

Results

Conclusions

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

Adjuvante Brustkrebstherapie: Doppelt hält besser

Delir kann Demenz begünstigen

Update Innere Medizin

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2016

Grape skin extract-derived polyphenols modify programming-induced renal endowment in prenatal protein-restricted male mouse offspring

Caffeine and cardiovascular diseases: critical review of current research

Effects of high doses of vitamin D3 on mucosa-associated gut microbiome vary between regions of the human gastrointestinal tract

Folic acid supplementation, dietary folate intake and risk of preterm birth in China

Effects of low-fat milk consumption at breakfast on satiety and short-term energy intake in 10- to 12-year-old obese boys

Fatty acid supply with complementary foods and LC-PUFA status in healthy infants: results of a randomised controlled trial

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

Adjuvante Brustkrebstherapie: Doppelt hält besser

Delir kann Demenz begünstigen

Update Innere Medizin