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01.03.2015 | Original article

Increase of circulating stromal cell-derived factor-1 in heart failure patients

verfasst von: K. Liu, S. Yang, M. Hou, T. Chen, J. Liu, B. Yu, MD, PhD

Erschienen in: Herz | Sonderheft 1/2015

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Abstract

Background

The role of circulating stromal cell-derived factor-1 (SDF-1) in heart failure (HF) has not been defined. The aim of this study was to examine the circulating SDF-1 levels in hospitalized heart failure (HHF) patients.

Methods

Circulating SDF-1 and other clinical variables, including N-terminal pro-brain natriuretic peptide (NT-proBNP), C-reactive protein (CRP), and echocardiographic parameters, were measured in HHF patients (n = 69) and healthy control subjects (n = 35).

Results

The circulating SDF-1 level was significantly greater in patients with HF (5,101 ± 1,977 pg/ml) compared with the control subjects (1,879 ± 1,417 pg/ml; p < 0.001). Circulating SDF-1 levels were positively correlated with NT-proBNP (r = 0.46 p < 0.001) and CRP (r = 0.53 p < 0.001) levels, and negatively correlated with left ventricular ejection fraction values (r = − 0.41, p < 0.001).

Conclusion

The level of circulating SDF-1 increases in HHF patients.

Cleland JG, Khand A, Clark A (2001) The heart failure epidemic: exactly how big is it? Eur Heart J 22:623–626CrossRefPubMed

Go AS, Mozaffarian D, Roger VL et al (2013) Executive summary: heart disease and stroke statistics–2013 update: a report from the American Heart Association. Circulation 127:143–152CrossRefPubMed

Maisel AS, Krishnaswamy P, Nowak RM et al (2002) Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med 347:161–167CrossRefPubMed

Januzzi JL Jr, Camargo CA, Anwaruddin S et al (2005) The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study. Am J Cardiol 95:948–954CrossRefPubMed

Suleiman M, Khatib R, Agmon Y et al (2006) Early inflammation and risk of long-term development of heart failure and mortality in survivors of acute myocardial infarction predictive role of C-reactive protein. J Am Coll Cardiol 47:962–968CrossRefPubMed

Kimmenade RR van, Januzzi JL Jr, Ellinor PT et al (2006) Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure. J Am Coll Cardiol 48:1217–1224CrossRefPubMed

D’Apuzzo M, Rolink A, Loetscher M et al (1997) The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4. Eur J Immunol 27:1788–1793CrossRef

Nagasawa T, Kikutani H, Kishimoto T (1994) Molecular cloning and structure of a pre-B-cell growth-stimulating factor. Proc Natl Acad Sci U S A 91:2305–2309CrossRefPubMedCentralPubMed

Nagasawa T, Nakajima T, Tachibana K et al (1996) Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc Natl Acad Sci U S A 93:14726–14729CrossRefPubMedCentralPubMed

10.

Ratajczak MZ, Zuba-Surma E, Kucia M et al (2006) The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis. Leukemia 20:1915–1924CrossRefPubMed

11.

Lapidot T, Petit I (2002) Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. Exp Hematol 30:973–981CrossRefPubMed

12.

Aiuti A, Tavian M, Cipponi A et al (1999) Expression of CXCR4, the receptor for stromal cell-derived factor-1 on fetal and adult human lympho-hematopoietic progenitors. Eur J Immunol 29:1823–1831CrossRefPubMed

13.

Aiuti A, Turchetto L, Cota M et al (1999) Human CD34(+) cells express CXCR4 and its ligand stromal cell-derived factor-1. Implications for infection by T-cell tropic human immunodeficiency virus. Blood 94:62–73PubMed

14.

Ceradini DJ, Kulkarni AR, Callaghan MJ et al (2004) Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10:858–864CrossRefPubMed

15.

Tang YL, Zhu W, Cheng M et al (2009) Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ Res 104:1209–1216CrossRefPubMedCentralPubMed

16.

Sweeney EA, Lortat-Jacob H, Priestley GV et al (2002) Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells. Blood 99:44–51CrossRefPubMed

17.

Zhang M, Mal N, Kiedrowski M et al (2007) SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction. FASEB J 21:3197–3207CrossRefPubMed

18.

Hu X, Dai S, Wu WJ et al (2007) Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis. Circulation 116:654–663CrossRefPubMedCentralPubMed

19.

Abbott JD, Huang Y, Liu D et al (2004) Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation 110:3300–3305CrossRefPubMed

20.

Elmadbouh I, Haider H, Jiang S et al (2007) Ex vivo delivered stromal cell-derived factor-1alpha promotes stem cell homing and induces angiomyogenesis in the infarcted myocardium. J Mol Cell Cardiol 42:792–803CrossRefPubMedCentralPubMed

21.

Deglurkar I, Mal N, Mills WR et al (2006) Mechanical and electrical effects of cell-based gene therapy for ischemic cardiomyopathy are independent. Hum Gene Ther 17:1144–1151CrossRefPubMed

22.

Sundararaman S, Miller TJ, Pastore JM et al (2011) Plasmid-based transient human stromal cell-derived factor-1 gene transfer improves cardiac function in chronic heart failure. Gene Ther 18:867–873CrossRefPubMedCentralPubMed

23.

Askari AT, Unzek S, Popovic ZB et al (2003) Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet 362:697–703CrossRefPubMed

24.

Stellos K, Bigalke B, Langer H et al (2009) Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34 + progenitor cells. Eur Heart J 30:584–593CrossRefPubMed

25.

Gazitt Y, Liu Q (2001) Plasma levels of SDF-1 and expression of SDF-1 receptor on CD34 + cells in mobilized peripheral blood of non-Hodgkin’s lymphoma patients. Stem Cells 19:37–45CrossRefPubMed

26.

Groves MD, Hess KR, Puduvalli VK et al (2009) Biomarkers of disease: cerebrospinal fluid vascular endothelial growth factor (VEGF) and stromal cell derived factor (SDF)-1 levels in patients with neoplastic meningitis (NM) due to breast cancer, lung cancer and melanoma. J Neurooncol 94:229–234CrossRefPubMed

27.

Wurster T, Stellos K, Geisler T et al (2012) Expression of stromal-cell-derived factor-1 (SDF-1): a predictor of ischaemic stroke? Eur J Neurol 19:395–401CrossRefPubMed

28.

Loader B, Stokic D, Riedl M et al (2008) Combined analysis of audiologic performance and the plasma biomarker stromal cell-derived factor 1a in type 2 diabetic patients. Otol Neurotol y 29:739–744CrossRef

29.

Li SL, Lin W, Zhang Y et al (2012) Stromal cell-derived factor-1alpha as a novel biomarker for hyperlipidemia. Tohoku J Exp Med 228:355–363CrossRefPubMed

30.

Lang RM, Bierig M, Devereux RB et al (2005) Recommendations for chamber quantification: a report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 18:1440–1463CrossRefPubMed

31.

Petit I, Szyper-Kravitz M, Nagler A et al (2002) G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol 3:687–694CrossRefPubMed

32.

Levesque JP, Hendy J, Takamatsu Y et al (2003) Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. J Clin Invest 111:187–196CrossRefPubMedCentralPubMed

33.

Laske C, Stellos K, Eschweiler GW et al (2008) Decreased CXCL12 (SDF-1) plasma levels in early Alzheimer’s disease: a contribution to a deficient hematopoietic brain support? J Alzheimers Dis 15:83–95PubMed

34.

Kim HK, Kim JE, Chung J et al (2007) Plasma level of stromal derived factor-1 (SDF-1) is increased in disseminated intravascular coagulation patients who have poor outcomes: in vitro effect of SDF-1 on coagulopathy. Thromb Res 120:559–566CrossRefPubMed

35.

Matsuda M, Morita Y, Hanamoto H et al (2004) CD34 + progenitors from MDS patients are unresponsive to SDF-1, despite high levels of SDF-1 in bone marrow plasma. Leukemia 18:1038–1040CrossRefPubMed

36.

Jorbenadze R, Schleicher E, Bigalke B et al (2014) Expression of platelet-bound stromal-cell derived factor-1 (SDF-1) and number of CD34(+) progenitor cells in patients with congestive heart failure. Platelets 25:409–415CrossRefPubMed

37.

Lee SH, Wolf PL, Escudero R et al (2000) Early expression of angiogenesis factors in acute myocardial ischemia and infarction. N Engl J Med 342:626–633CrossRefPubMed

38.

Semenza GL (2011) Oxygen sensing, homeostasis, and disease. N Engl J Med 365:537–547CrossRefPubMed

39.

Yndestad A, Damas JK, Oie E et al (2007) Role of inflammation in the progression of heart failure. Curr Cardiol Rep 9:236–241CrossRefPubMed

40.

Torre-Amione G (2005) Immune activation in chronic heart failure. Am J Cardiol 95:3C–8C; (discussion 38C–40C)CrossRefPubMed

41.

Deswal A, Petersen NJ, Feldman AM et al (2001) Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST). Circulation 103:2055–2059CrossRefPubMed

42.

Santiago B, Baleux F, Palao G et al (2006) CXCL12 is displayed by rheumatoid endothelial cells through its basic amino-terminal motif on heparan sulfate proteoglycans. Arthritis Res Ther 8:R43CrossRefPubMedCentralPubMed

43.

Wang A, Guilpain P, Chong BF et al (2010) Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus. Arthritis Rheum 62:3436–3446CrossRefPubMed

44.

Nanki T, Hayashida K, El-Gabalawy HS et al (2000) Stromal cell-derived factor-1-CXC chemokine receptor 4 interactions play a central role in CD4 + T cell accumulation in rheumatoid arthritis synovium. J Immunol 165:6590–6598CrossRefPubMed

45.

Calderon TM, Eugenin EA, Lopez L et al (2006) A role for CXCL12 (SDF-1alpha) in the pathogenesis of multiple sclerosis: regulation of CXCL12 expression in astrocytes by soluble myelin basic protein. J Neuroimmunol 177:27–39CrossRefPubMed

46.

Krumbholz M, Theil D, Cepok S et al (2006) Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment. Brain 129:200–211CrossRefPubMed

47.

Weiss JM, Cufi P, Bismuth J et al (2013) SDF-1/CXCL12 recruits B cells and antigen-presenting cells to the thymus of autoimmune myasthenia gravis patients. Immunobiology 218:373–381CrossRefPubMed

48.

Banisadr G, Skrzydelski D, Kitabgi P et al (2003) Highly regionalized distribution of stromal cell-derived factor-1/CXCL12 in adult rat brain: constitutive expression in cholinergic, dopaminergic and vasopressinergic neurons. Eur J Neurosci 18:1593–1606CrossRefPubMed

49.

Wei SG, Zhang ZH, Yu Y et al (2012) Central actions of the chemokine stromal cell-derived factor 1 contribute to neurohumoral excitation in heart failure rats. Hypertension 59:991–998CrossRefPubMedCentralPubMed

Titel: Increase of circulating stromal cell-derived factor-1 in heart failure patients
verfasst von: K. Liu
S. Yang
M. Hou
T. Chen
J. Liu
B. Yu, MD, PhD
Publikationsdatum: 01.03.2015
Verlag: Urban & Vogel
Erschienen in: Herz / Ausgabe Sonderheft 1/2015
Print ISSN: 0340-9937
Elektronische ISSN: 1615-6692
DOI: https://doi.org/10.1007/s00059-014-4169-z

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