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Erschienen in: Journal of Neurology 1/2013

01.01.2013 | Original Communication

Antidepressant use is related to larger white matter lesion volume in patients with symptomatic atherosclerotic disease: the SMART-MR study

verfasst von: Anne M. Grool, Yolanda van der Graaf, Koen L. Vincken, Theo D. Witkamp, Willem P. Th. M. Mali, Mirjam I. Geerlings

Erschienen in: Journal of Neurology | Ausgabe 1/2013

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Abstract

Although a relation between depression and white matter lesions (WML) is frequently observed, the direction of causation remains unknown. We investigated whether depressed mood was associated with baseline severity and change in WML volume during 4 years of follow-up, and the relative contribution of mood symptoms and antidepressant use to this relation. Within the SMART-MR study 594 patients (58 ± 10 years) with symptomatic atherosclerotic disease had assessments of mood symptoms and antidepressant use and 1.5 T MRI at baseline and after 3.9 ± 0.4 years of follow-up. Mood symptoms were assessed using the Mental Health Index (MHI-5). Depressed mood was defined as antidepressant use and/or MHI-5 score ≤52. Volumetric WML measures (deep and periventricular) were obtained with automated segmentation. Linear regression analyses were adjusted for age, sex, baseline WML volume, follow-up time, vascular risk factors and infarcts. Depressed mood was not associated with larger WML volume at baseline. However, when separate contributions were distinguished, antidepressant use was associated with greater deep (B = 0.50 mL, 95 % CI 0.04–0.96) and periventricular WML volume (B = 0.47 mL, 95 % CI 0.05–0.89) at baseline, while mood symptoms were not. Antidepressants were associated with a modest but non-significant increase in progression of periventricular WML volume over 4 years of follow-up (B = 0.21 mL, 95 % CI −0.05 to 0.47). WML at baseline were not associated with new-onset depressed mood at follow-up. Antidepressants, but not mood symptoms, were associated with greater WML volume and a modest, although non-significant increase in periventricular WML volume in patients with symptomatic atherosclerotic disease. Future studies are needed to determine whether this may be a direct effect, or whether other underlying diseases for which antidepressants are prescribed influence this relation.
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Literatur
1.
Zurück zum Zitat Carney RM, Freedland KE (2008) Depression in patients with coronary heart disease. Am J Med 121:S20–S27PubMedCrossRef Carney RM, Freedland KE (2008) Depression in patients with coronary heart disease. Am J Med 121:S20–S27PubMedCrossRef
2.
Zurück zum Zitat van Melle JP, de Jonge P, Spijkerman TA, Tijssen JG, Ormel J, van Veldhuisen DJ et al (2004) Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis. Psychosom Med 66:814–822PubMedCrossRef van Melle JP, de Jonge P, Spijkerman TA, Tijssen JG, Ormel J, van Veldhuisen DJ et al (2004) Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis. Psychosom Med 66:814–822PubMedCrossRef
3.
Zurück zum Zitat Whyte EM, Mulsant BH, Vanderbilt J, Dodge HH, Ganguli M (2004) Depression after stroke: a prospective epidemiological study. J Am Geriatr Soc 52:774–778PubMedCrossRef Whyte EM, Mulsant BH, Vanderbilt J, Dodge HH, Ganguli M (2004) Depression after stroke: a prospective epidemiological study. J Am Geriatr Soc 52:774–778PubMedCrossRef
4.
Zurück zum Zitat Hackett ML, Yapa C, Parag V, Anderson CS (2005) Frequency of depression after stroke: a systematic review of observational studies. Stroke 36:1330–1340PubMedCrossRef Hackett ML, Yapa C, Parag V, Anderson CS (2005) Frequency of depression after stroke: a systematic review of observational studies. Stroke 36:1330–1340PubMedCrossRef
5.
Zurück zum Zitat Frasure-Smith N, Lesperance F (2006) Recent evidence linking coronary heart disease and depression. Can J Psychiatry 51:730–737PubMed Frasure-Smith N, Lesperance F (2006) Recent evidence linking coronary heart disease and depression. Can J Psychiatry 51:730–737PubMed
6.
Zurück zum Zitat Nicholson A, Kuper H, Hemingway H (2006) Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies. Eur Heart J 27:2763–2774PubMedCrossRef Nicholson A, Kuper H, Hemingway H (2006) Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies. Eur Heart J 27:2763–2774PubMedCrossRef
7.
Zurück zum Zitat Frasure-Smith N, Lesperance F, Juneau M, Talajic M, Bourassa MG (1999) Gender, depression, and one-year prognosis after myocardial infarction. Psychosom Med 61:26–37PubMed Frasure-Smith N, Lesperance F, Juneau M, Talajic M, Bourassa MG (1999) Gender, depression, and one-year prognosis after myocardial infarction. Psychosom Med 61:26–37PubMed
8.
Zurück zum Zitat Barth J, Schumacher M, Herrmann-Lingen C (2004) Depression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis. Psychosom Med 66:802–813PubMedCrossRef Barth J, Schumacher M, Herrmann-Lingen C (2004) Depression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis. Psychosom Med 66:802–813PubMedCrossRef
9.
Zurück zum Zitat Van der Kooy K, van Hout H, Marwijk H, Marten H, Stehouwer C, Beekman A (2007) Depression and the risk for cardiovascular diseases: systematic review and meta analysis. Int J Geriatr Psychiatry 22:613–626PubMedCrossRef Van der Kooy K, van Hout H, Marwijk H, Marten H, Stehouwer C, Beekman A (2007) Depression and the risk for cardiovascular diseases: systematic review and meta analysis. Int J Geriatr Psychiatry 22:613–626PubMedCrossRef
10.
Zurück zum Zitat Carney RM, Freedland KE, Miller GE, Jaffe AS (2002) Depression as a risk factor for cardiac mortality and morbidity: a review of potential mechanisms. J Psychosom Res 53:897–902PubMedCrossRef Carney RM, Freedland KE, Miller GE, Jaffe AS (2002) Depression as a risk factor for cardiac mortality and morbidity: a review of potential mechanisms. J Psychosom Res 53:897–902PubMedCrossRef
11.
Zurück zum Zitat Pantoni L (2002) Pathophysiology of age-related cerebral white matter changes. Cerebrovasc Dis 13:S7–S10CrossRef Pantoni L (2002) Pathophysiology of age-related cerebral white matter changes. Cerebrovasc Dis 13:S7–S10CrossRef
12.
Zurück zum Zitat Geerlings MI, Appelman AP, Vincken KL, Algra A, Witkamp TD, Mali WP, van der Graaf Y (2010) Brain volumes and cerebrovascular lesions on MRI in patients with atherosclerotic disease. The SMART-MR study. Atherosclerosis 210:130–136PubMedCrossRef Geerlings MI, Appelman AP, Vincken KL, Algra A, Witkamp TD, Mali WP, van der Graaf Y (2010) Brain volumes and cerebrovascular lesions on MRI in patients with atherosclerotic disease. The SMART-MR study. Atherosclerosis 210:130–136PubMedCrossRef
13.
Zurück zum Zitat Conijn MM, Kloppenborg RP, Algra A, Mali WP, Kappelle LJ, Vincken KL et al (2011) Cerebral small vessel disease and risk of death, ischemic stroke, and cardiac complications in patients with atherosclerotic disease: the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study. Stroke 42:3105–3109PubMedCrossRef Conijn MM, Kloppenborg RP, Algra A, Mali WP, Kappelle LJ, Vincken KL et al (2011) Cerebral small vessel disease and risk of death, ischemic stroke, and cardiac complications in patients with atherosclerotic disease: the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study. Stroke 42:3105–3109PubMedCrossRef
14.
Zurück zum Zitat Taylor WD, MacFall JR, Payne ME, McQuoid DR, Steffens DC, Provenzale JM, Krishnan RR (2005) Greater MRI lesion volumes in elderly depressed subjects than in control subjects. Psychiatry Res 139:1–7PubMedCrossRef Taylor WD, MacFall JR, Payne ME, McQuoid DR, Steffens DC, Provenzale JM, Krishnan RR (2005) Greater MRI lesion volumes in elderly depressed subjects than in control subjects. Psychiatry Res 139:1–7PubMedCrossRef
15.
Zurück zum Zitat Alexopoulos GS, Meyers BS, Young RC, Campbell S, Silbersweig D, Charlson M (1997) ‘Vascular depression’ hypothesis. Arch Gen Psychiatry 54:915–922PubMedCrossRef Alexopoulos GS, Meyers BS, Young RC, Campbell S, Silbersweig D, Charlson M (1997) ‘Vascular depression’ hypothesis. Arch Gen Psychiatry 54:915–922PubMedCrossRef
16.
Zurück zum Zitat Krishnan KR, Hays JC, Blazer DG (1997) MRI-defined vascular depression. Am J Psychiatry 154:497–501PubMed Krishnan KR, Hays JC, Blazer DG (1997) MRI-defined vascular depression. Am J Psychiatry 154:497–501PubMed
17.
Zurück zum Zitat de Groot JC, de Leeuw FE, Oudkerk M, Hofman A, Jolles J, Breteler MM (2000) Cerebral white matter lesions and depressive symptoms in elderly adults. Arch Gen Psychiatry 57:1071–1076PubMedCrossRef de Groot JC, de Leeuw FE, Oudkerk M, Hofman A, Jolles J, Breteler MM (2000) Cerebral white matter lesions and depressive symptoms in elderly adults. Arch Gen Psychiatry 57:1071–1076PubMedCrossRef
18.
Zurück zum Zitat O’Brien JT, Firbank MJ, Krishnan MS, van Straaten EC, van der Flier WM, Petrovic K et al (2006) White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study. Am J Geriatr Psychiatry 14:834–841PubMedCrossRef O’Brien JT, Firbank MJ, Krishnan MS, van Straaten EC, van der Flier WM, Petrovic K et al (2006) White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study. Am J Geriatr Psychiatry 14:834–841PubMedCrossRef
19.
Zurück zum Zitat Godin O, Dufouil C, Maillard P, Delcroix N, Mazoyer B, Crivello F et al (2008) White matter lesions as a predictor of depression in the elderly: the 3C-Dijon study. Biol Psychiatry 63:663–669PubMedCrossRef Godin O, Dufouil C, Maillard P, Delcroix N, Mazoyer B, Crivello F et al (2008) White matter lesions as a predictor of depression in the elderly: the 3C-Dijon study. Biol Psychiatry 63:663–669PubMedCrossRef
20.
Zurück zum Zitat Steffens DC, Krishnan KR, Crump C, Burke GL (2002) Cerebrovascular disease and evolution of depressive symptoms in the cardiovascular health study. Stroke 33:1636–1644PubMedCrossRef Steffens DC, Krishnan KR, Crump C, Burke GL (2002) Cerebrovascular disease and evolution of depressive symptoms in the cardiovascular health study. Stroke 33:1636–1644PubMedCrossRef
21.
Zurück zum Zitat Teodorczuk A, O’Brien JT, Firbank MJ, Pantoni L, Poggesi A, Erkinjuntti T et al (2007) White matter changes and late-life depressive symptoms: longitudinal study. Br J Psychiatry 191:212–217PubMedCrossRef Teodorczuk A, O’Brien JT, Firbank MJ, Pantoni L, Poggesi A, Erkinjuntti T et al (2007) White matter changes and late-life depressive symptoms: longitudinal study. Br J Psychiatry 191:212–217PubMedCrossRef
22.
Zurück zum Zitat Versluis CE, van der Mast RC, van Buchem MA, Bollen EL, Blauw GJ, Eekhof JA et al (2006) Progression of cerebral white matter lesions is not associated with development of depressive symptoms in elderly subjects at risk of cardiovascular disease: the PROSPER Study. Int J Geriatr Psychiatry 21:375–381PubMedCrossRef Versluis CE, van der Mast RC, van Buchem MA, Bollen EL, Blauw GJ, Eekhof JA et al (2006) Progression of cerebral white matter lesions is not associated with development of depressive symptoms in elderly subjects at risk of cardiovascular disease: the PROSPER Study. Int J Geriatr Psychiatry 21:375–381PubMedCrossRef
23.
Zurück zum Zitat Ikram MA, Luijendijk HJ, Vernooij MW, Hofman A, Niessen WJ, van der Lugt A et al (2010) Vascular brain disease and depression in the elderly. Epidemiology 21:78–81PubMedCrossRef Ikram MA, Luijendijk HJ, Vernooij MW, Hofman A, Niessen WJ, van der Lugt A et al (2010) Vascular brain disease and depression in the elderly. Epidemiology 21:78–81PubMedCrossRef
24.
Zurück zum Zitat Steffens DC, Chung H, Krishnan KR, Longstreth WT Jr, Carlson M, Burke GL (2008) Antidepressant treatment and worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study. Stroke 39:857–862PubMedCrossRef Steffens DC, Chung H, Krishnan KR, Longstreth WT Jr, Carlson M, Burke GL (2008) Antidepressant treatment and worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study. Stroke 39:857–862PubMedCrossRef
25.
Zurück zum Zitat Pan A, Okereke OI, Sun Q, Logroscino G, Manson JE, Willett WC et al (2011) Depression and incident stroke in women. Stroke 42:2770–2775PubMedCrossRef Pan A, Okereke OI, Sun Q, Logroscino G, Manson JE, Willett WC et al (2011) Depression and incident stroke in women. Stroke 42:2770–2775PubMedCrossRef
26.
Zurück zum Zitat Muller M, Appelman AP, van der Graaf Y, Vincken KL, Mali WP, Geerlings MI (2011) Brain atrophy and cognition: interaction with cerebrovascular pathology? Neurobiol Aging 32:885–893PubMedCrossRef Muller M, Appelman AP, van der Graaf Y, Vincken KL, Mali WP, Geerlings MI (2011) Brain atrophy and cognition: interaction with cerebrovascular pathology? Neurobiol Aging 32:885–893PubMedCrossRef
27.
Zurück zum Zitat Anbeek P, Vincken KL, van Osch MJ, Bisschops RH, van der Grond J (2004) Probabilistic segmentation of white matter lesions in MR imaging. Neuroimage 21:1037–1044PubMedCrossRef Anbeek P, Vincken KL, van Osch MJ, Bisschops RH, van der Grond J (2004) Probabilistic segmentation of white matter lesions in MR imaging. Neuroimage 21:1037–1044PubMedCrossRef
28.
Zurück zum Zitat Anbeek P, Vincken KL, van Bochove GS, van Osch MJ, van der Grond J (2005) Probabilistic segmentation of brain tissue in MR imaging. Neuroimage 27:795–804PubMedCrossRef Anbeek P, Vincken KL, van Bochove GS, van Osch MJ, van der Grond J (2005) Probabilistic segmentation of brain tissue in MR imaging. Neuroimage 27:795–804PubMedCrossRef
29.
Zurück zum Zitat Ware JE Jr, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30:473–483PubMedCrossRef Ware JE Jr, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30:473–483PubMedCrossRef
30.
Zurück zum Zitat Berwick DM, Murphy JM, Goldman PA, Ware JE Jr, Barsky AJ, Weinstein MC (1991) Performance of a five-item mental health screening test. Med Care 29:169–176PubMedCrossRef Berwick DM, Murphy JM, Goldman PA, Ware JE Jr, Barsky AJ, Weinstein MC (1991) Performance of a five-item mental health screening test. Med Care 29:169–176PubMedCrossRef
31.
Zurück zum Zitat Rumpf HJ, Meyer C, Hapke U, John U (2001) Screening for mental health: validity of the MHI-5 using DSM-IV Axis I psychiatric disorders as gold standard. Psychiatry Res 105:243–253PubMedCrossRef Rumpf HJ, Meyer C, Hapke U, John U (2001) Screening for mental health: validity of the MHI-5 using DSM-IV Axis I psychiatric disorders as gold standard. Psychiatry Res 105:243–253PubMedCrossRef
32.
Zurück zum Zitat Yamazaki S, Fukuhara S, Green J (2005) Usefulness of five-item and three-item Mental Health Inventories to screen for depressive symptoms in the general population of Japan. Health Qual Life Outcomes 3:48PubMedCrossRef Yamazaki S, Fukuhara S, Green J (2005) Usefulness of five-item and three-item Mental Health Inventories to screen for depressive symptoms in the general population of Japan. Health Qual Life Outcomes 3:48PubMedCrossRef
33.
Zurück zum Zitat Whang W, Kubzansky LD, Kawachi I, Rexrode KM, Kroenke CH, Glynn RJ et al (2009) Depression and risk of sudden cardiac death and coronary heart disease in women: results from the Nurses’ Health Study. J Am Coll Cardiol 53:950–958PubMedCrossRef Whang W, Kubzansky LD, Kawachi I, Rexrode KM, Kroenke CH, Glynn RJ et al (2009) Depression and risk of sudden cardiac death and coronary heart disease in women: results from the Nurses’ Health Study. J Am Coll Cardiol 53:950–958PubMedCrossRef
34.
Zurück zum Zitat Rubin DB, Schenker N (1991) Multiple imputation in health-care databases: an overview and some applications. Stat Med 10:585–598PubMedCrossRef Rubin DB, Schenker N (1991) Multiple imputation in health-care databases: an overview and some applications. Stat Med 10:585–598PubMedCrossRef
35.
Zurück zum Zitat Yoshita M, Fletcher E, DeCarli C (2005) Current concepts of analysis of cerebral white matter hyperintensities on magnetic resonance imaging. Top Magn Reson Imaging 16:399–407PubMedCrossRef Yoshita M, Fletcher E, DeCarli C (2005) Current concepts of analysis of cerebral white matter hyperintensities on magnetic resonance imaging. Top Magn Reson Imaging 16:399–407PubMedCrossRef
36.
Zurück zum Zitat van den Heuvel DM, ten Dam V, de Craen AJ, Admiraal-Behloul F, van Es AC, Palm WM et al (2006) Measuring longitudinal white matter changes: comparison of a visual rating scale with a volumetric measurement. Am J Neuroradiol 27:875–878PubMed van den Heuvel DM, ten Dam V, de Craen AJ, Admiraal-Behloul F, van Es AC, Palm WM et al (2006) Measuring longitudinal white matter changes: comparison of a visual rating scale with a volumetric measurement. Am J Neuroradiol 27:875–878PubMed
37.
Zurück zum Zitat Wu CS, Wang SC, Cheng YC, Gau SS (2011) Association of cerebrovascular events with antidepressant use: a case-crossover study. Am J Psychiatry 168:511–521PubMedCrossRef Wu CS, Wang SC, Cheng YC, Gau SS (2011) Association of cerebrovascular events with antidepressant use: a case-crossover study. Am J Psychiatry 168:511–521PubMedCrossRef
38.
Zurück zum Zitat Geerlings MI, Appelman AP, Vincken KL, Algra A, Witkamp TD, Mali WP, van der Graaf Y (2010) Brain volumes and cerebrovascular lesions on MRI in patients with atherosclerotic disease. The SMART-MR study. Atherosclerosis 210:130–136CrossRef Geerlings MI, Appelman AP, Vincken KL, Algra A, Witkamp TD, Mali WP, van der Graaf Y (2010) Brain volumes and cerebrovascular lesions on MRI in patients with atherosclerotic disease. The SMART-MR study. Atherosclerosis 210:130–136CrossRef
39.
Zurück zum Zitat Levy R, Dubois B (2006) Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cereb Cortex 16:916–928PubMedCrossRef Levy R, Dubois B (2006) Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cereb Cortex 16:916–928PubMedCrossRef
40.
Zurück zum Zitat Smoller JW, Allison M, Cochrane BB, Curb JD, Perlis RH, Robinson JG et al (2009) Antidepressant use and risk of incident cardiovascular morbidity and mortality among postmenopausal women in the Women’s Health Initiative study. Arch Intern Med 169:2128–2139PubMedCrossRef Smoller JW, Allison M, Cochrane BB, Curb JD, Perlis RH, Robinson JG et al (2009) Antidepressant use and risk of incident cardiovascular morbidity and mortality among postmenopausal women in the Women’s Health Initiative study. Arch Intern Med 169:2128–2139PubMedCrossRef
41.
Zurück zum Zitat Chen Y, Guo JJ, Li H, Wulsin L, Patel NC (2008) Risk of cerebrovascular events associated with antidepressant use in patients with depression: a population-based, nested case-control study. Ann Pharmacother 42:177–184PubMedCrossRef Chen Y, Guo JJ, Li H, Wulsin L, Patel NC (2008) Risk of cerebrovascular events associated with antidepressant use in patients with depression: a population-based, nested case-control study. Ann Pharmacother 42:177–184PubMedCrossRef
42.
Zurück zum Zitat Cohen HW, Gibson G, Alderman MH (2000) Excess risk of myocardial infarction in patients treated with antidepressant medications: association with use of tricyclic agents. Am J Med 108:2–8PubMedCrossRef Cohen HW, Gibson G, Alderman MH (2000) Excess risk of myocardial infarction in patients treated with antidepressant medications: association with use of tricyclic agents. Am J Med 108:2–8PubMedCrossRef
43.
Zurück zum Zitat Bushnell C (2011) Depression and the risk of stroke in women: an identification and treatment paradox. Stroke 42:2718–2719PubMedCrossRef Bushnell C (2011) Depression and the risk of stroke in women: an identification and treatment paradox. Stroke 42:2718–2719PubMedCrossRef
44.
Zurück zum Zitat van Straaten EC, Harvey D, Scheltens P, Barkhof F, Petersen RC, Thal LJ et al (2008) Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia. J Neurol 255:1302–1308PubMedCrossRef van Straaten EC, Harvey D, Scheltens P, Barkhof F, Petersen RC, Thal LJ et al (2008) Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia. J Neurol 255:1302–1308PubMedCrossRef
45.
Zurück zum Zitat Yoshita M, Fletcher E, Harvey D, Ortega M, Martinez O, Mungas DM et al (2006) Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD. Neurology 67:2192–2198PubMedCrossRef Yoshita M, Fletcher E, Harvey D, Ortega M, Martinez O, Mungas DM et al (2006) Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD. Neurology 67:2192–2198PubMedCrossRef
46.
Zurück zum Zitat van den Heuvel DM, ten Dam V, de Craen AJ, dmiraal-Behloul F, Olofsen H, Bollen EL et al (2006) Increase in periventricular white matter hyperintensities parallels decline in mental processing speed in a non-demented elderly population. J Neurol Neurosurg Psychiatry 77:149–153CrossRef van den Heuvel DM, ten Dam V, de Craen AJ, dmiraal-Behloul F, Olofsen H, Bollen EL et al (2006) Increase in periventricular white matter hyperintensities parallels decline in mental processing speed in a non-demented elderly population. J Neurol Neurosurg Psychiatry 77:149–153CrossRef
47.
Zurück zum Zitat Delano-Wood L, Abeles N, Sacco JM, Wierenga CE, Horne NR, Bozoki A (2008) Regional white matter pathology in mild cognitive impairment: differential influence of lesion type on neuropsychological functioning. Stroke 39:794–799PubMedCrossRef Delano-Wood L, Abeles N, Sacco JM, Wierenga CE, Horne NR, Bozoki A (2008) Regional white matter pathology in mild cognitive impairment: differential influence of lesion type on neuropsychological functioning. Stroke 39:794–799PubMedCrossRef
48.
Zurück zum Zitat Grool AM, van der Graaf Y, Mali WP, Geerlings MI (2011) Location of cerebrovascular and degenerative changes, depressive symptoms and cognitive functioning in later life: the SMART-Medea study. J Neurol Neurosurg Psychiatry 82:1093–1100PubMedCrossRef Grool AM, van der Graaf Y, Mali WP, Geerlings MI (2011) Location of cerebrovascular and degenerative changes, depressive symptoms and cognitive functioning in later life: the SMART-Medea study. J Neurol Neurosurg Psychiatry 82:1093–1100PubMedCrossRef
Metadaten
Titel
Antidepressant use is related to larger white matter lesion volume in patients with symptomatic atherosclerotic disease: the SMART-MR study
verfasst von
Anne M. Grool
Yolanda van der Graaf
Koen L. Vincken
Theo D. Witkamp
Willem P. Th. M. Mali
Mirjam I. Geerlings
Publikationsdatum
01.01.2013
Verlag
Springer-Verlag
Erschienen in
Journal of Neurology / Ausgabe 1/2013
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-012-6616-1

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