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Erschienen in: European Journal of Nutrition 1/2017

02.11.2015 | Original Contribution

Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program

verfasst von: Lisa Ceglia, Jason Nelson, James Ware, Konstantinos-Dionysios Alysandratos, George A. Bray, Cheryl Garganta, David M. Nathan, Frank B. Hu, Bess Dawson-Hughes, Anastassios G. Pittas, Diabetes Prevention Program Research Group

Erschienen in: European Journal of Nutrition | Ausgabe 1/2017

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Abstract

Objective

We examined associations between body weight and plasma 25-hydroxyvitamin D concentration (25OHD) in prediabetes and sought to estimate the impact of adiposity on these associations.

Methods

The study was conducted in the placebo (n = 1082) and intensive lifestyle (n = 1079) groups of the Diabetes Prevention Program (DPP), a multicenter trial to prevent type 2 diabetes in adults with prediabetes. Weight and 25OHD were measured at baseline, month 6, years 1 and 2. In a subset (n = 584), visceral (VAT) and subcutaneous (SAT) adiposity were assessed by computed tomography at baseline and year 1.

Results

In cross-sectional analyses, baseline body weight, total fat, VAT, and SAT were inversely associated with plasma 25OHD concentration after multivariable adjustment. VAT accounted for 40 % [95 % CI 11, 69] of the association of body weight with plasma 25OHD concentration. There was no significant contribution by total fat or SAT. Two-year changes in plasma 25OHD concentration varied inversely with changes in body weight (p < 0.0001). One-year changes in total fat, VAT, or SAT were not significant mediators of the association between change in plasma 25OHD concentration and body weight.

Conclusion

Our study found an inverse association between body weight and plasma 25OHD concentration at baseline and over a 2-year period in adults with prediabetes. These findings in the DPP, a weight loss intervention study, raise the possibility that weight loss increases plasma 25OHD concentration. Whether adiposity mediates this association remains inconclusive.
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Metadaten
Titel
Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program
verfasst von
Lisa Ceglia
Jason Nelson
James Ware
Konstantinos-Dionysios Alysandratos
George A. Bray
Cheryl Garganta
David M. Nathan
Frank B. Hu
Bess Dawson-Hughes
Anastassios G. Pittas
Diabetes Prevention Program Research Group
Publikationsdatum
02.11.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nutrition / Ausgabe 1/2017
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-015-1066-z

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