Introduction
Methods
Patients and autopsy
Patient | Sex | Age | DD (years) | PMD (h:min) | Scannera
| MS type | Cause of death |
---|---|---|---|---|---|---|---|
1 | F | 44 | 8 | 10:15 | 1 | PPMS | Heart failure |
2 | M | 63 | 24 | 7:05 | 1 | SPMS | Cardiac arrest |
3 | F | 69 | 53 | 7:30 | 1 | SPMS | Heart failure |
4 | F | 70 | 40 | 6:55 | 1 | SPMS | Urine tract infection |
5 | F | 57 | 21 | 20:00 | 1 | SPMS | Decubitus |
6 | F | 76 | 19 | 9:45 | 1 | SPMS | Unknown |
7 | F | 81 | 64 | 4:00 | 1 | SPMS | Unknown |
8 | M | 50 | 15 | 5:25 | 2 | PPMS | Pulmonary carcinoma |
9 | F | 66 | 22 | 6:00 | 2 | SPMS | Unknown |
10 | M | 49 | 24 | 8:00 | 2 | SPMS | Pneumonia |
11 | F | 77 | 24 | 10:00 | 2 | SPMS | Euthanasia |
12 | M | 72 | 23 | 7:55 | 2 | SPMS | Pneumonia |
13 | M | 56 | 14 | 5:00 | 2 | SPMS | Cachexia |
14 | F | 60 | 7 | 8:50 | 2 | PPMS | Euthanasia |
15 | M | 54 | 12 | 8:15 | 2 | PPMS | Euthanasia |
16 | M | 75 | 50 | 10:10 | 2 | SPMS | Pneumonia |
17 | F | 50 | 17 | 7:35 | 2 | SPMS | Euthanasia |
18 | M | 67 | 37 | 11:00 | 2 | SPMS | Heart failure |
19 | M | 54 | 29 | 7:00 | 2 | SPMS | Euthanasia |
20 | F | 81 | 21 | 6:30 | 2 | PPMS | Heart failure |
Mean ± SD | 63.6 ± 11.5 | 26.2 ± 15.3 | 8:21 |
MRI protocol and qMRI maps
Image analysis
Histopathology and immunohistochemistry
Scoring, classification and matching
Statistical analysis
Results
Lesion type/tissue | Mean | Standard deviation | Minimum | Maximum |
---|---|---|---|---|
NAWMc
| 785.15 | 78.69 | 704.20 | 981.22 |
Preactivec
| 846.15 | 66.11 | 744.50 | 939.00 |
Activea,b
| 1140.89 | 204.82 | 839.50 | 1432.45 |
Chronic activea,b
| 1225.58 | 197.77 | 1003.03 | 1561.04 |
Chronic inactivea,b,d
| 1320.32 | 370.05 | 942.97 | 2171.69 |