Skip to main content
Erschienen in: European Child & Adolescent Psychiatry 1/2017

21.05.2016 | Original Contribution

Defining cognitive-behavior therapy response and remission in pediatric OCD: a signal detection analysis of the Children’s Yale-Brown Obsessive Compulsive Scale

verfasst von: Gudmundur Skarphedinsson, Alessandro S. De Nadai, Eric A. Storch, Adam B. Lewin, Tord Ivarsson

Erschienen in: European Child & Adolescent Psychiatry | Ausgabe 1/2017

Einloggen, um Zugang zu erhalten

Abstract

The objective of the study was to examine the optimal Children’s Yale-Brown Obsessive–Compulsive Scale (CY-BOCS) percent reduction and raw cutoffs for predicting cognitive-behavioral treatment (CBT) response among children and adolescents with obsessive–compulsive disorder (OCD). The sample consisted of children and adolescents with OCD (N = 241) participating in the first step of the Nordic long-term OCD treatment study and receiving 14 weekly sessions of CBT in the form of exposure and response prevention. Evaluations were conducted pre- and post-treatment, included the CY-BOCS, Clinical Global Impressions—severity/improvement. The results showed that the most efficient CY-BOCS cutoffs were 35 % reduction for treatment response, 55 % reduction for remission, and a post-treatment CY-BOCS raw total score of 11 for treatment remission. Overall, our results diverge from previous research on pediatric OCD with more conservative cutoffs (higher cutoff reduction for response and remission, and lower raw score for remission). Further research on optimal cutoffs is needed.
Literatur
1.
Zurück zum Zitat Rasmussen SA, Eisen JL (1992) The epidemiology and clinical features of obsessive compulsive disorder. Psychiatr Clin North Am 15:743–758PubMed Rasmussen SA, Eisen JL (1992) The epidemiology and clinical features of obsessive compulsive disorder. Psychiatr Clin North Am 15:743–758PubMed
2.
Zurück zum Zitat Ruscio AM, Stein DJ, Chiu WT, Kessler RC (2010) The epidemiology of obsessive–compulsive disorder in the national comorbidity survey replication. Mol Psychiatry 15:53–63CrossRefPubMed Ruscio AM, Stein DJ, Chiu WT, Kessler RC (2010) The epidemiology of obsessive–compulsive disorder in the national comorbidity survey replication. Mol Psychiatry 15:53–63CrossRefPubMed
3.
Zurück zum Zitat Stewart SE, Geller DA, Jenike M, Pauls D, Shaw D, Mullin B, Faraone SV (2004) Long-term outcome of pediatric obsessive–compulsive disorder: a meta-analysis and qualitative review of the literature. Acta Psychiat Scand 110:4–13CrossRefPubMed Stewart SE, Geller DA, Jenike M, Pauls D, Shaw D, Mullin B, Faraone SV (2004) Long-term outcome of pediatric obsessive–compulsive disorder: a meta-analysis and qualitative review of the literature. Acta Psychiat Scand 110:4–13CrossRefPubMed
4.
Zurück zum Zitat Flament MF, Whitaker A, Rapoport JL, Davies M, Berg CZ, Kalikow K, Sceery W, Shaffer D (1988) Obsessive compulsive disorder in adolescence: an epidemiological study. J Am Acad Child Adolesc Psychiatry 27:764–771CrossRefPubMed Flament MF, Whitaker A, Rapoport JL, Davies M, Berg CZ, Kalikow K, Sceery W, Shaffer D (1988) Obsessive compulsive disorder in adolescence: an epidemiological study. J Am Acad Child Adolesc Psychiatry 27:764–771CrossRefPubMed
5.
Zurück zum Zitat Valleni-Basile LA, Garrison CZ, Jackson KL, Waller JL, McKeown RE, Addy CL, Cuffe SP (1994) Frequency of obsessive–compulsive disorder in a community sample of young adolescents. J Am Acad Child Adolesc Psychiatry 33:782–791 (Erratum appears in J Am Acad Child Adolesc Psychiatry. 1995 Feb;34(2):128–129; PMID: 7896644) CrossRefPubMed Valleni-Basile LA, Garrison CZ, Jackson KL, Waller JL, McKeown RE, Addy CL, Cuffe SP (1994) Frequency of obsessive–compulsive disorder in a community sample of young adolescents. J Am Acad Child Adolesc Psychiatry 33:782–791 (Erratum appears in J Am Acad Child Adolesc Psychiatry. 1995 Feb;34(2):128–129; PMID: 7896644) CrossRefPubMed
6.
Zurück zum Zitat Rapoport JL, Inoff-Germain G, Weissman MM, Greenwald S, Narrow WE, Jensen PS, Lahey BB, Canino G (2000) Childhood obsessive–compulsive disorder in the NIMH MECA study: parent versus child identification of cases. Methods for the epidemiology of child and adolescent mental disorders. J Anxiety Disord 14:535–548CrossRefPubMed Rapoport JL, Inoff-Germain G, Weissman MM, Greenwald S, Narrow WE, Jensen PS, Lahey BB, Canino G (2000) Childhood obsessive–compulsive disorder in the NIMH MECA study: parent versus child identification of cases. Methods for the epidemiology of child and adolescent mental disorders. J Anxiety Disord 14:535–548CrossRefPubMed
7.
Zurück zum Zitat Skarphedinsson G, Hanssen-Bauer K, Kornor H, Heiervang ER, Landro NI, Axelsdottir B, Biedilae S, Ivarsson T (2015) Standard individual cognitive behaviour therapy for paediatric obsessive–compulsive disorder: a systematic review of effect estimates across comparisons. Nord J Psychiatry 69:81–92CrossRefPubMed Skarphedinsson G, Hanssen-Bauer K, Kornor H, Heiervang ER, Landro NI, Axelsdottir B, Biedilae S, Ivarsson T (2015) Standard individual cognitive behaviour therapy for paediatric obsessive–compulsive disorder: a systematic review of effect estimates across comparisons. Nord J Psychiatry 69:81–92CrossRefPubMed
8.
Zurück zum Zitat Ivarsson T, Skarphedinsson G, Kornor H, Axelsdottir B, Biedilae S, Heyman I, Asbahr F, Thomsen PH, Fineberg N, March J (2015) The place of and evidence for serotonin reuptake inhibitors (SRIs) for obsessive compulsive disorder (OCD) in children and adolescents: views based on a systematic review and meta-analysis. Psychiatry Res 227:93–103CrossRefPubMed Ivarsson T, Skarphedinsson G, Kornor H, Axelsdottir B, Biedilae S, Heyman I, Asbahr F, Thomsen PH, Fineberg N, March J (2015) The place of and evidence for serotonin reuptake inhibitors (SRIs) for obsessive compulsive disorder (OCD) in children and adolescents: views based on a systematic review and meta-analysis. Psychiatry Res 227:93–103CrossRefPubMed
9.
Zurück zum Zitat Geller D, March J (2012) Practice parameter for the assessment and treatment of children and adolescents with obsessive–compulsive disorder. J Am Acad Child Adolesc Psychiatry 51:98–113CrossRef Geller D, March J (2012) Practice parameter for the assessment and treatment of children and adolescents with obsessive–compulsive disorder. J Am Acad Child Adolesc Psychiatry 51:98–113CrossRef
10.
Zurück zum Zitat NICE (2005) Obsessive compulsive disorder (OCD) and body dysmorphic disorder (BDD). In: Excellence NIfHaC (ed) National Institute for Health and Clinical Excellence, London NICE (2005) Obsessive compulsive disorder (OCD) and body dysmorphic disorder (BDD). In: Excellence NIfHaC (ed) National Institute for Health and Clinical Excellence, London
11.
Zurück zum Zitat Scahill L, Riddle MA, McSwiggin-Hardin M, Ort SI, King RA, Goodman WK, Cicchetti D, Leckman JF (1997) Children’s Yale-Brown obsessive compulsive scale: reliability and validity. J Am Acad Child Adolesc Psychiatry 36:844–852CrossRefPubMed Scahill L, Riddle MA, McSwiggin-Hardin M, Ort SI, King RA, Goodman WK, Cicchetti D, Leckman JF (1997) Children’s Yale-Brown obsessive compulsive scale: reliability and validity. J Am Acad Child Adolesc Psychiatry 36:844–852CrossRefPubMed
12.
Zurück zum Zitat Lewin A, Piacentini J (2010) Evidence-based assessment of child obsessive compulsive disorder: recommendations for clinical practice and treatment research. Child Youth Care Forum 39:73–89CrossRefPubMedPubMedCentral Lewin A, Piacentini J (2010) Evidence-based assessment of child obsessive compulsive disorder: recommendations for clinical practice and treatment research. Child Youth Care Forum 39:73–89CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Storch EA, Murphy TK, Bagner DM, Johns NB, Baumeister AL, Goodman WK, Geffken GR (2006) Reliability and validity of the child behavior checklist obsessive–compulsive scale. J Anxiety Disord 20:473–485CrossRefPubMed Storch EA, Murphy TK, Bagner DM, Johns NB, Baumeister AL, Goodman WK, Geffken GR (2006) Reliability and validity of the child behavior checklist obsessive–compulsive scale. J Anxiety Disord 20:473–485CrossRefPubMed
14.
Zurück zum Zitat Lewin AB, Piacentini J, De Nadai AS, Jones AM, Peris TS, Geffken GR, Geller DA, Nadeau JM, Murphy TK, Storch EA (2014) Defining clinical severity in pediatric obsessive–compulsive disorder. Psychol Assess 26:679–684CrossRefPubMed Lewin AB, Piacentini J, De Nadai AS, Jones AM, Peris TS, Geffken GR, Geller DA, Nadeau JM, Murphy TK, Storch EA (2014) Defining clinical severity in pediatric obsessive–compulsive disorder. Psychol Assess 26:679–684CrossRefPubMed
15.
Zurück zum Zitat Busner J, Targum SD (2007) The clinical global impressions scale: applying a research tool in clinical practice. Psychiatry 4:28–37PubMedPubMedCentral Busner J, Targum SD (2007) The clinical global impressions scale: applying a research tool in clinical practice. Psychiatry 4:28–37PubMedPubMedCentral
16.
Zurück zum Zitat Garvey MA, Perlmutter SJ, Allen AJ, Hamburger S, Lougee L, Leonard HL, Witowski ME, Dubbert B, Swedo SE (1999) A pilot study of penicillin prophylaxis for neuropsychiatric exacerbations triggered by streptococcal infections. Biol Psychiatry 45:1564–1571CrossRefPubMed Garvey MA, Perlmutter SJ, Allen AJ, Hamburger S, Lougee L, Leonard HL, Witowski ME, Dubbert B, Swedo SE (1999) A pilot study of penicillin prophylaxis for neuropsychiatric exacerbations triggered by streptococcal infections. Biol Psychiatry 45:1564–1571CrossRefPubMed
17.
Zurück zum Zitat Tolin DF, Abramowitz JS, Diefenbach GJ (2005) Defining response in clinical trials for obsessive–compulsive disorder: a signal detection analysis of the Yale-Brown obsessive compulsive scale. J Clin Psychiatry 66:1549–1557CrossRefPubMed Tolin DF, Abramowitz JS, Diefenbach GJ (2005) Defining response in clinical trials for obsessive–compulsive disorder: a signal detection analysis of the Yale-Brown obsessive compulsive scale. J Clin Psychiatry 66:1549–1557CrossRefPubMed
18.
Zurück zum Zitat Frank E, Prien RF, Jarrett RB, Keller MB, Kupfer DJ, Lavori PW, Rush AJ, Weissman MM (1991) Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Remission, recovery, relapse, and recurrence. Arch Gen Psychiatry 48:851–855CrossRefPubMed Frank E, Prien RF, Jarrett RB, Keller MB, Kupfer DJ, Lavori PW, Rush AJ, Weissman MM (1991) Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Remission, recovery, relapse, and recurrence. Arch Gen Psychiatry 48:851–855CrossRefPubMed
19.
Zurück zum Zitat Pigott TA, Pato MT, Bernstein SE, Grover GN, Hill JL, Tolliver TJ, Murphy DL (1990) Controlled comparisons of clomipramine and fluoxetine in the treatment of obsessive–compulsive disorder. Behavioral and biological results. Arch Gen Psychiatry 47:926–932CrossRefPubMed Pigott TA, Pato MT, Bernstein SE, Grover GN, Hill JL, Tolliver TJ, Murphy DL (1990) Controlled comparisons of clomipramine and fluoxetine in the treatment of obsessive–compulsive disorder. Behavioral and biological results. Arch Gen Psychiatry 47:926–932CrossRefPubMed
20.
Zurück zum Zitat Cottraux J, Note I, Yao SN, Lafont S, Note B, Mollard E, Bouvard M, Sauteraud A, Bourgeois M, Dartigues JF (2001) A randomized controlled trial of cognitive therapy versus intensive behavior therapy in obsessive compulsive disorder. Psychother Psychosom 70:288–297CrossRefPubMed Cottraux J, Note I, Yao SN, Lafont S, Note B, Mollard E, Bouvard M, Sauteraud A, Bourgeois M, Dartigues JF (2001) A randomized controlled trial of cognitive therapy versus intensive behavior therapy in obsessive compulsive disorder. Psychother Psychosom 70:288–297CrossRefPubMed
21.
Zurück zum Zitat Simpson HB, Gorfinkle KS, Liebowitz MR (1999) Cognitive-behavioral therapy as an adjunct to serotonin reuptake inhibitors in obsessive–compulsive disorder: an open trial. J Clin Psychiatry 60:584–590CrossRefPubMed Simpson HB, Gorfinkle KS, Liebowitz MR (1999) Cognitive-behavioral therapy as an adjunct to serotonin reuptake inhibitors in obsessive–compulsive disorder: an open trial. J Clin Psychiatry 60:584–590CrossRefPubMed
22.
Zurück zum Zitat Sookman D, Steketee G (2007) Directions in specialized cognitive behavior therapy for resistant obsessive–compulsive disorder: theory and practice of two approaches. Cognit Behav Pract 14:1–17CrossRef Sookman D, Steketee G (2007) Directions in specialized cognitive behavior therapy for resistant obsessive–compulsive disorder: theory and practice of two approaches. Cognit Behav Pract 14:1–17CrossRef
23.
Zurück zum Zitat Wagner KD, Cook EH, Chung H, Messig M (2003) Remission status after long-term sertraline treatment of pediatric obsessive–compulsive disorder. J Child Adoles Psychopharmacol 13(Suppl 1):S53–S60CrossRef Wagner KD, Cook EH, Chung H, Messig M (2003) Remission status after long-term sertraline treatment of pediatric obsessive–compulsive disorder. J Child Adoles Psychopharmacol 13(Suppl 1):S53–S60CrossRef
24.
Zurück zum Zitat Piacentini J, Bergman RL, Chang S, Langley A, Peris T, Wood JJ, McCracken J (2011) Controlled comparison of family cognitive behavioral therapy and psychoeducation/relaxation training for child obsessive–compulsive disorder. J Am Acad Child Adolesc Psychiatry 50:1149–1161CrossRefPubMedPubMedCentral Piacentini J, Bergman RL, Chang S, Langley A, Peris T, Wood JJ, McCracken J (2011) Controlled comparison of family cognitive behavioral therapy and psychoeducation/relaxation training for child obsessive–compulsive disorder. J Am Acad Child Adolesc Psychiatry 50:1149–1161CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat POTS Study Team (2004) Cognitive-behavior therapy, sertraline, and their combination for children and adolescents with obsessive–compulsive disorder: the Pediatric OCD Treatment Study (POTS) randomized controlled trial. JAMA 292:1969–1976CrossRef POTS Study Team (2004) Cognitive-behavior therapy, sertraline, and their combination for children and adolescents with obsessive–compulsive disorder: the Pediatric OCD Treatment Study (POTS) randomized controlled trial. JAMA 292:1969–1976CrossRef
26.
Zurück zum Zitat Torp NC, Dahl K, Skarphedinsson G, Thomsen P, Valderhaug R, Weidle B, Melin K, Hybel K, Nissen JB, Lenhard F, Wentzel-Larsen T, Franklin M, Ivarsson T (2015) Effectiveness of cognitive behavior treatment for pediatric obsessive–compulsive disorder: acute outcomes from the Nordic long-term OCD treatment study (NordLOTS). Behav Res Ther 64:15–23CrossRefPubMed Torp NC, Dahl K, Skarphedinsson G, Thomsen P, Valderhaug R, Weidle B, Melin K, Hybel K, Nissen JB, Lenhard F, Wentzel-Larsen T, Franklin M, Ivarsson T (2015) Effectiveness of cognitive behavior treatment for pediatric obsessive–compulsive disorder: acute outcomes from the Nordic long-term OCD treatment study (NordLOTS). Behav Res Ther 64:15–23CrossRefPubMed
27.
Zurück zum Zitat Turner CM, Mataix-Cols D, Lovell K, Krebs G, Lang K, Byford S, Heyman I (2014) Telephone cognitive-behavioral therapy for adolescents with obsessive–compulsive disorder: a randomized controlled non-inferiority trial. J Am Acad Child Adolesc Psychiatry 53:1298–1307.e1292CrossRefPubMedPubMedCentral Turner CM, Mataix-Cols D, Lovell K, Krebs G, Lang K, Byford S, Heyman I (2014) Telephone cognitive-behavioral therapy for adolescents with obsessive–compulsive disorder: a randomized controlled non-inferiority trial. J Am Acad Child Adolesc Psychiatry 53:1298–1307.e1292CrossRefPubMedPubMedCentral
28.
Zurück zum Zitat Caporino NE, Brodman DM, Kendall PC, Albano AM, Sherrill J, Piacentini J, Sakolsky D, Birmaher B, Compton SN, Ginsburg G, Rynn M, McCracken J, Gosch E, Keeton C, March J, Walkup JT (2013) Defining treatment response and remission in child anxiety: signal detection analysis using the pediatric anxiety rating scale. J Am Acad Child Adolesc Psychiatry 52:57–67CrossRefPubMed Caporino NE, Brodman DM, Kendall PC, Albano AM, Sherrill J, Piacentini J, Sakolsky D, Birmaher B, Compton SN, Ginsburg G, Rynn M, McCracken J, Gosch E, Keeton C, March J, Walkup JT (2013) Defining treatment response and remission in child anxiety: signal detection analysis using the pediatric anxiety rating scale. J Am Acad Child Adolesc Psychiatry 52:57–67CrossRefPubMed
29.
Zurück zum Zitat Storch EA, Lewin AB, De Nadai AS, Murphy TK (2010) Defining treatment response and remission in obsessive–compulsive disorder: a signal detection analysis of the children’s Yale-Brown obsessive compulsive scale. J Am Acad Child Adolesc Psychiatry 49:708–717PubMed Storch EA, Lewin AB, De Nadai AS, Murphy TK (2010) Defining treatment response and remission in obsessive–compulsive disorder: a signal detection analysis of the children’s Yale-Brown obsessive compulsive scale. J Am Acad Child Adolesc Psychiatry 49:708–717PubMed
30.
Zurück zum Zitat Lewin AB, De Nadai AS, Park J, Goodman WK, Murphy TK, Storch EA (2011) Refining clinical judgment of treatment outcome in obsessive–compulsive disorder. Psychiatry Res 185:394–401CrossRefPubMed Lewin AB, De Nadai AS, Park J, Goodman WK, Murphy TK, Storch EA (2011) Refining clinical judgment of treatment outcome in obsessive–compulsive disorder. Psychiatry Res 185:394–401CrossRefPubMed
31.
Zurück zum Zitat Swets JA, Pickett RM (1982) Evaluation of Diagnostic Systems: Methods from signal detection theory. Academic Press, New York Swets JA, Pickett RM (1982) Evaluation of Diagnostic Systems: Methods from signal detection theory. Academic Press, New York
32.
Zurück zum Zitat Thomsen PH, Torp NC, Dahl K, Christensen K, Englyst I, Melin KH, Nissen JB, Hybel KA, Valderhaug R, Weidle B, Skarphedinsson G, von Bahr PL, Ivarsson T (2013) The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods. Child Adolesc Psychiatry Mental Health 7:41CrossRef Thomsen PH, Torp NC, Dahl K, Christensen K, Englyst I, Melin KH, Nissen JB, Hybel KA, Valderhaug R, Weidle B, Skarphedinsson G, von Bahr PL, Ivarsson T (2013) The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods. Child Adolesc Psychiatry Mental Health 7:41CrossRef
33.
Zurück zum Zitat Skarphedinsson G, Weidle B, Thomsen PH, Dahl K, Torp NC, Nissen JB, Melin KH, Hybel K, Valderhaug R, Wentzel-Larsen T, Compton SN, Ivarsson T (2015) Continued cognitive-behavior therapy versus sertraline for children and adolescents with obsessive–compulsive disorder that were non-responders to cognitive-behavior therapy: a randomized controlled trial. Eur Child Adolesc Psychiatry 24:591–602CrossRefPubMed Skarphedinsson G, Weidle B, Thomsen PH, Dahl K, Torp NC, Nissen JB, Melin KH, Hybel K, Valderhaug R, Wentzel-Larsen T, Compton SN, Ivarsson T (2015) Continued cognitive-behavior therapy versus sertraline for children and adolescents with obsessive–compulsive disorder that were non-responders to cognitive-behavior therapy: a randomized controlled trial. Eur Child Adolesc Psychiatry 24:591–602CrossRefPubMed
34.
Zurück zum Zitat American Psychiatric Association (2000) Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR Fourth Edition (Text Revision). American Psychiatric Association, Washington, DCCrossRef American Psychiatric Association (2000) Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR Fourth Edition (Text Revision). American Psychiatric Association, Washington, DCCrossRef
35.
Zurück zum Zitat Torp NC, Dahl K, Skarphedinsson G, Thomsen PH, Valderhaug R, Weidle B, Hybel K, Compton S, Ivarsson T (2015) Predictors associated with improved cognitive-behavioral therapy outcome in pediatric obsessive–compulsive disorder. J Am Acad Child Adolesc Psychiatry 54:200–207CrossRefPubMed Torp NC, Dahl K, Skarphedinsson G, Thomsen PH, Valderhaug R, Weidle B, Hybel K, Compton S, Ivarsson T (2015) Predictors associated with improved cognitive-behavioral therapy outcome in pediatric obsessive–compulsive disorder. J Am Acad Child Adolesc Psychiatry 54:200–207CrossRefPubMed
36.
Zurück zum Zitat Kaufman J, Birmaher B, Brent D, Rao U et al (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980–988CrossRefPubMed Kaufman J, Birmaher B, Brent D, Rao U et al (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980–988CrossRefPubMed
37.
Zurück zum Zitat Lauth B, Arnkelsson GB, Magnusson P, Skarphedinsson G, Ferrari P, Petursson H (2010) Validity of K-SADS-PL (schedule for affective disorders and schizophrenia for school-age children-present and lifetime version) depression diagnoses in an adolescent clinical population. Nord J Psychiatry 64:409–420CrossRefPubMed Lauth B, Arnkelsson GB, Magnusson P, Skarphedinsson G, Ferrari P, Petursson H (2010) Validity of K-SADS-PL (schedule for affective disorders and schizophrenia for school-age children-present and lifetime version) depression diagnoses in an adolescent clinical population. Nord J Psychiatry 64:409–420CrossRefPubMed
38.
Zurück zum Zitat Lauth B, Magnusson P, Ferrari P, Petursson H (2008) An Icelandic version of the kiddie-SADS-PL: translation, cross-cultural adaptation and inter-rater reliability. Nord J Psychiatry 62:379–385CrossRefPubMed Lauth B, Magnusson P, Ferrari P, Petursson H (2008) An Icelandic version of the kiddie-SADS-PL: translation, cross-cultural adaptation and inter-rater reliability. Nord J Psychiatry 62:379–385CrossRefPubMed
39.
Zurück zum Zitat Valderhaug R, Larsson B, Gotestam KG, Piacentini J (2007) An open clinical trial of cognitive-behaviour therapy in children and adolescents with obsessive–compulsive disorder administered in regular outpatient clinics. Behav Res Ther 45:577–589CrossRefPubMed Valderhaug R, Larsson B, Gotestam KG, Piacentini J (2007) An open clinical trial of cognitive-behaviour therapy in children and adolescents with obsessive–compulsive disorder administered in regular outpatient clinics. Behav Res Ther 45:577–589CrossRefPubMed
40.
Zurück zum Zitat Freeman JB, Garcia AM, Coyne L, Ale C, Przeworski A, Himle M, Compton S, Leonard HL (2008) Early childhood OCD: preliminary findings from a family-based cognitive-behavioral approach. J Am Acad Child Adolesc Psychiatry 47:593–602CrossRefPubMedPubMedCentral Freeman JB, Garcia AM, Coyne L, Ale C, Przeworski A, Himle M, Compton S, Leonard HL (2008) Early childhood OCD: preliminary findings from a family-based cognitive-behavioral approach. J Am Acad Child Adolesc Psychiatry 47:593–602CrossRefPubMedPubMedCentral
41.
Zurück zum Zitat Scahill L, Riddle MA, McSwiggin-Hardin M, Ort SI (1997) Children’s Yale-Brown obsessive compulsive scale: reliability and validity. J Am Acad Child Adolesc Psychiatry 36:844–852CrossRefPubMed Scahill L, Riddle MA, McSwiggin-Hardin M, Ort SI (1997) Children’s Yale-Brown obsessive compulsive scale: reliability and validity. J Am Acad Child Adolesc Psychiatry 36:844–852CrossRefPubMed
42.
Zurück zum Zitat Storch EA, Murphy TK, Geffken GR, Soto O, Sajid M, Allen P, Roberti JW, Killiany EM, Goodman WK (2004) Psychometric evaluation of the children’s Yale-Brown obsessive–compulsive scale. Psychiatry Res 129:91–98CrossRefPubMed Storch EA, Murphy TK, Geffken GR, Soto O, Sajid M, Allen P, Roberti JW, Killiany EM, Goodman WK (2004) Psychometric evaluation of the children’s Yale-Brown obsessive–compulsive scale. Psychiatry Res 129:91–98CrossRefPubMed
43.
Zurück zum Zitat Gallant J, Storch EA, Merlo LJ, Ricketts ED, Geffken GR, Goodman WK, Murphy TK (2008) Convergent and discriminant validity of the children’s Yale-Brown obsessive compulsive scale-symptom checklist. J Anxiety Disord 22:1369–1376CrossRefPubMed Gallant J, Storch EA, Merlo LJ, Ricketts ED, Geffken GR, Goodman WK, Murphy TK (2008) Convergent and discriminant validity of the children’s Yale-Brown obsessive compulsive scale-symptom checklist. J Anxiety Disord 22:1369–1376CrossRefPubMed
44.
Zurück zum Zitat Guy W (1976) ECDEU assessment manual for psychopharmacology. Government Printing Office, Washington Guy W (1976) ECDEU assessment manual for psychopharmacology. Government Printing Office, Washington
45.
Zurück zum Zitat Kraemer H, Periyakoil VS, Noda A (2002) Kappa coefficients in medical research. Stat Med 21:2109–2129CrossRef Kraemer H, Periyakoil VS, Noda A (2002) Kappa coefficients in medical research. Stat Med 21:2109–2129CrossRef
46.
Zurück zum Zitat Kraemer H (1992) Evaluating medical tests: objective and quantitative guidelines. Sage Publications, Thousand Oaks Kraemer H (1992) Evaluating medical tests: objective and quantitative guidelines. Sage Publications, Thousand Oaks
47.
Zurück zum Zitat Pallanti S, Hollander E, Bienstock C, Koran L, Leckman J, Marazziti D, Pato M, Stein D, Zohar J, International Treatment Refractory OCDC (2002) Treatment non-response in OCD: methodological issues and operational definitions. Int J Neuropsychopharmacol 5:181–191CrossRefPubMed Pallanti S, Hollander E, Bienstock C, Koran L, Leckman J, Marazziti D, Pato M, Stein D, Zohar J, International Treatment Refractory OCDC (2002) Treatment non-response in OCD: methodological issues and operational definitions. Int J Neuropsychopharmacol 5:181–191CrossRefPubMed
48.
Zurück zum Zitat Leucht S, Davis JM, Engel RR, Kane JM, Wagenpfeil S (2007) Defining ‘response’ in antipsychotic drug trials: recommendations for the use of scale-derived cutoffs. Neuropsychopharmacology 32:1903–1910CrossRefPubMed Leucht S, Davis JM, Engel RR, Kane JM, Wagenpfeil S (2007) Defining ‘response’ in antipsychotic drug trials: recommendations for the use of scale-derived cutoffs. Neuropsychopharmacology 32:1903–1910CrossRefPubMed
49.
Zurück zum Zitat Mataix-Cols D, de la Cruz LF, Nordsletten AE, Lenhard F, Isomura K, Simpson HB (2016) Towards an international expert consensus for defining treatment response, remission, recovery and relapse in obsessive–compulsive disorder. World Psychiatry 15:80–81CrossRefPubMedPubMedCentral Mataix-Cols D, de la Cruz LF, Nordsletten AE, Lenhard F, Isomura K, Simpson HB (2016) Towards an international expert consensus for defining treatment response, remission, recovery and relapse in obsessive–compulsive disorder. World Psychiatry 15:80–81CrossRefPubMedPubMedCentral
50.
Zurück zum Zitat Farris SG, McLean CP, Van Meter PE, Simpson HB, Foa EB (2013) Treatment response, symptom remission, and wellness in obsessive–compulsive disorder. J Clin Psychiatry 74:685–690CrossRefPubMedPubMedCentral Farris SG, McLean CP, Van Meter PE, Simpson HB, Foa EB (2013) Treatment response, symptom remission, and wellness in obsessive–compulsive disorder. J Clin Psychiatry 74:685–690CrossRefPubMedPubMedCentral
51.
Zurück zum Zitat Frank E, Kupfer DJ, Wagner EF, McEachran AB, Cornes C (1991) Efficacy of interpersonal psychotherapy as a maintenance treatment of recurrent depression: contributing factors. Arch Gen Psychiatry 48:1053–1059 [Erratum appears in Arch Gen Psychiatry 1992 May; 49(5):401] CrossRefPubMed Frank E, Kupfer DJ, Wagner EF, McEachran AB, Cornes C (1991) Efficacy of interpersonal psychotherapy as a maintenance treatment of recurrent depression: contributing factors. Arch Gen Psychiatry 48:1053–1059 [Erratum appears in Arch Gen Psychiatry 1992 May; 49(5):401] CrossRefPubMed
52.
Zurück zum Zitat Kennard BD, Emslie GJ, Mayes TL, Nakonezny PA, Jones JM, Foxwell AA, King J (2014) Sequential treatment with fluoxetine and relapse–prevention CBT to improve outcomes in pediatric depression. Am J Psychiatry 171:1083–1090CrossRefPubMedPubMedCentral Kennard BD, Emslie GJ, Mayes TL, Nakonezny PA, Jones JM, Foxwell AA, King J (2014) Sequential treatment with fluoxetine and relapse–prevention CBT to improve outcomes in pediatric depression. Am J Psychiatry 171:1083–1090CrossRefPubMedPubMedCentral
53.
Zurück zum Zitat Franklin ME, Sapyta J, Freeman JB, Khanna M, Compton S, Almirall D, Moore P, Choate-Summers M, Garcia A, Edson AL, Foa EB, March JS (2011) Cognitive behavior therapy augmentation of pharmacotherapy in pediatric obsessive–compulsive disorder: the pediatric OCD treatment study II (POTS II) randomized controlled trial. J Am Med Assoc. 306:1224–1232CrossRef Franklin ME, Sapyta J, Freeman JB, Khanna M, Compton S, Almirall D, Moore P, Choate-Summers M, Garcia A, Edson AL, Foa EB, March JS (2011) Cognitive behavior therapy augmentation of pharmacotherapy in pediatric obsessive–compulsive disorder: the pediatric OCD treatment study II (POTS II) randomized controlled trial. J Am Med Assoc. 306:1224–1232CrossRef
54.
Zurück zum Zitat Eisen JL, Goodman WK, Keller MB, Warshaw MG, DeMarco LM, Luce DD, Rasmussen SA (1999) Patterns of remission and relapse in obsessive–compulsive disorder: a 2-year prospective study. J Clin Psychiatry 60:346–351 (quiz 352) CrossRefPubMed Eisen JL, Goodman WK, Keller MB, Warshaw MG, DeMarco LM, Luce DD, Rasmussen SA (1999) Patterns of remission and relapse in obsessive–compulsive disorder: a 2-year prospective study. J Clin Psychiatry 60:346–351 (quiz 352) CrossRefPubMed
55.
Zurück zum Zitat Leckman JF, Sholomskas D, Thompson D, Belanger A, Weissman MM (1982) Best estimate of lifetime psychiatric diagnosis: a methodological study. Arch Gen Psychiatry 39:879–883CrossRefPubMed Leckman JF, Sholomskas D, Thompson D, Belanger A, Weissman MM (1982) Best estimate of lifetime psychiatric diagnosis: a methodological study. Arch Gen Psychiatry 39:879–883CrossRefPubMed
56.
Zurück zum Zitat Højgaard DRMA, Mortensen E, Ivarsson T, Valderhaug R, Hybel K, Skarphedinsson G, Dahl K, Weidle B, Torp N, Grados M (2015) Child and adolescent OCD symptom patterns: a factor analytic study. In: 16th International ESCAP congress, Madrid, Spain, pp S187–S187 Højgaard DRMA, Mortensen E, Ivarsson T, Valderhaug R, Hybel K, Skarphedinsson G, Dahl K, Weidle B, Torp N, Grados M (2015) Child and adolescent OCD symptom patterns: a factor analytic study. In: 16th International ESCAP congress, Madrid, Spain, pp S187–S187
Metadaten
Titel
Defining cognitive-behavior therapy response and remission in pediatric OCD: a signal detection analysis of the Children’s Yale-Brown Obsessive Compulsive Scale
verfasst von
Gudmundur Skarphedinsson
Alessandro S. De Nadai
Eric A. Storch
Adam B. Lewin
Tord Ivarsson
Publikationsdatum
21.05.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Child & Adolescent Psychiatry / Ausgabe 1/2017
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-016-0863-0

Weitere Artikel der Ausgabe 1/2017

European Child & Adolescent Psychiatry 1/2017 Zur Ausgabe

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.