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01.02.2015 | Original Contribution

Differential susceptibility to maternal expressed emotion in children with ADHD and their siblings? Investigating plasticity genes, prosocial and antisocial behaviour

verfasst von: Jennifer S. Richards, Catharina A. Hartman, Barbara Franke, Pieter J. Hoekstra, Dirk J. Heslenfeld, Jaap Oosterlaan, Alejandro Arias Vásquez, Jan K. Buitelaar

Erschienen in: European Child & Adolescent Psychiatry | Ausgabe 2/2015

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Abstract

The differential susceptibility theory states that children differ in their susceptibility towards environmental experiences, partially due to plasticity genes. Individuals carrying specific variants in such genes will be more disadvantaged in negative but, conversely, more advantaged in positive environments. Understanding gene–environment interactions may help unravel the causal mechanisms involved in multifactorial psychiatric disorders such as Attention-Deficit/Hyperactivity Disorder (ADHD). The differential susceptibility theory was examined by investigating the presence of interaction effects between maternal expressed emotion (EE; warmth and criticism) and the solitary and combined effects of plasticity genes (DAT1, DRD4, 5-HTT) on prosocial and antisocial behaviour (measured with parent- and self-reports) in children with ADHD and their siblings (N = 366, M = 17.11 years, 74.9 % male). Maternal warmth was positively associated with prosocial behaviour and negatively with antisocial behaviour, while maternal criticism was positively associated with antisocial behaviour and negatively with prosocial behaviour. No evidence of differential susceptibility was found. The current study found no evidence for differential susceptibility based on the selected plasticity genes, in spite of strong EE–behaviour associations. It is likely that additional factors play a role in the complex relationship between genes, environment and behaviour.

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Titel: Differential susceptibility to maternal expressed emotion in children with ADHD and their siblings? Investigating plasticity genes, prosocial and antisocial behaviour
verfasst von: Jennifer S. Richards
Catharina A. Hartman
Barbara Franke
Pieter J. Hoekstra
Dirk J. Heslenfeld
Jaap Oosterlaan
Alejandro Arias Vásquez
Jan K. Buitelaar
Publikationsdatum: 01.02.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Child & Adolescent Psychiatry / Ausgabe 2/2015
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-014-0567-2

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Differential susceptibility to maternal expressed emotion in children with ADHD and their siblings? Investigating plasticity genes, prosocial and antisocial behaviour

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