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Erschienen in: Social Psychiatry and Psychiatric Epidemiology 4/2016

06.02.2016 | Original Paper

Early traumatic experiences, perceived discrimination and conversion to psychosis in those at clinical high risk for psychosis

verfasst von: Jacqueline Stowkowy, Lu Liu, Kristin S. Cadenhead, Tyrone D. Cannon, Barbara A. Cornblatt, Thomas H. McGlashan, Diana O. Perkins, Larry J. Seidman, Ming T. Tsuang, Elaine F. Walker, Scott W. Woods, Carrie E. Bearden, Daniel H. Mathalon, Jean Addington

Erschienen in: Social Psychiatry and Psychiatric Epidemiology | Ausgabe 4/2016

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Abstract

Purpose

There is evidence to suggest that both early traumatic experiences and perceived discrimination are associated with later onset of psychosis. Less is known about the impact these two factors may have on conversion to psychosis in those who are at clinical high risk (CHR) of developing psychosis. The purpose of this study was to determine if trauma and perceived discrimination were predictors of conversion to psychosis.

Methods

The sample consisted of 764 individuals who were at CHR of developing psychosis and 280 healthy controls. All participants were assessed on past trauma, bullying and perceived discrimination.

Results

Individuals at CHR reported significantly more trauma, bullying and perceived discrimination than healthy controls. Only perceived discrimination was a predictor of later conversion to psychosis.

Conclusions

Given that CHR individuals are reporting increased rates of trauma and perceived discrimination, these should be routinely assessed, with the possibility of offering interventions aimed at ameliorating the impact of past traumas as well as improving self-esteem and coping strategies in an attempt to reduce perceived discrimination.
Literatur
1.
Zurück zum Zitat van Os J, Rutten BP, Poulton R (2008) Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. Schizophr Bull 34(6):1066–1082CrossRefPubMedPubMedCentral van Os J, Rutten BP, Poulton R (2008) Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. Schizophr Bull 34(6):1066–1082CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Houston JE et al (2008) Childhood sexual abuse, early cannabis use, and psychosis: testing an interaction model based on the National Comorbidity Survey. Schizophr Bull 34(3):580–585CrossRefPubMedPubMedCentral Houston JE et al (2008) Childhood sexual abuse, early cannabis use, and psychosis: testing an interaction model based on the National Comorbidity Survey. Schizophr Bull 34(3):580–585CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat Konings M et al (2012) Replication in two independent population-based samples that childhood maltreatment and cannabis use synergistically impact on psychosis risk. Psychol Med 42(1):149–159CrossRefPubMed Konings M et al (2012) Replication in two independent population-based samples that childhood maltreatment and cannabis use synergistically impact on psychosis risk. Psychol Med 42(1):149–159CrossRefPubMed
4.
Zurück zum Zitat Read J et al (2005) Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatr Scand 112(5):330–350CrossRefPubMed Read J et al (2005) Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatr Scand 112(5):330–350CrossRefPubMed
5.
6.
Zurück zum Zitat Kraan T et al (2015) Trauma and recent life events in individuals at ultra high risk for psychosis: review and meta-analysis. Schizophr Res 161(2–3):143–149CrossRefPubMed Kraan T et al (2015) Trauma and recent life events in individuals at ultra high risk for psychosis: review and meta-analysis. Schizophr Res 161(2–3):143–149CrossRefPubMed
7.
Zurück zum Zitat Trotta A, Murray RM, Fisher HL (2015) The impact of childhood adversity on the persistence of psychotic symptoms: a systematic review and meta-analysis. Psychol Med 45(12):2481–2498CrossRefPubMed Trotta A, Murray RM, Fisher HL (2015) The impact of childhood adversity on the persistence of psychotic symptoms: a systematic review and meta-analysis. Psychol Med 45(12):2481–2498CrossRefPubMed
8.
Zurück zum Zitat Veling W et al (2007) Discrimination and the incidence of psychotic disorders among ethnic minorities in The Netherlands. Int J Epidemiol 36(4):761–768CrossRefPubMed Veling W et al (2007) Discrimination and the incidence of psychotic disorders among ethnic minorities in The Netherlands. Int J Epidemiol 36(4):761–768CrossRefPubMed
9.
Zurück zum Zitat Karlsen S et al (2005) Racism, psychosis and common mental disorder among ethnic minority groups in England. Psychol Med 35(12):1795–1803CrossRefPubMed Karlsen S et al (2005) Racism, psychosis and common mental disorder among ethnic minority groups in England. Psychol Med 35(12):1795–1803CrossRefPubMed
10.
11.
Zurück zum Zitat Russo DA et al (2014) Trauma history characteristics associated with mental states at clinical high risk for psychosis. Psychiatry Res 220(1–2):237–244CrossRefPubMedPubMedCentral Russo DA et al (2014) Trauma history characteristics associated with mental states at clinical high risk for psychosis. Psychiatry Res 220(1–2):237–244CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Sahin S et al (2013) The history of childhood trauma among individuals with ultra high risk for psychosis is as common as among patients with first-episode schizophrenia. Early Interv Psychiatry 7(4):414–420CrossRefPubMed Sahin S et al (2013) The history of childhood trauma among individuals with ultra high risk for psychosis is as common as among patients with first-episode schizophrenia. Early Interv Psychiatry 7(4):414–420CrossRefPubMed
13.
Zurück zum Zitat Velthorst E et al (2013) History of trauma and the association with baseline symptoms in an Ultra-High Risk for psychosis cohort. Psychiatry Res 210(1):75–81CrossRefPubMed Velthorst E et al (2013) History of trauma and the association with baseline symptoms in an Ultra-High Risk for psychosis cohort. Psychiatry Res 210(1):75–81CrossRefPubMed
14.
Zurück zum Zitat Tikka M et al (2013) Childhood trauma and premorbid adjustment among individuals at clinical high risk for psychosis and normal control subjects. Early Interv Psychiatry 7(1):51–57CrossRefPubMed Tikka M et al (2013) Childhood trauma and premorbid adjustment among individuals at clinical high risk for psychosis and normal control subjects. Early Interv Psychiatry 7(1):51–57CrossRefPubMed
15.
Zurück zum Zitat Yung AR et al (2015) Childhood maltreatment and transition to psychotic disorder independently predict long-term functioning in young people at ultra-high risk for psychosis. Psychol Med:1–13 Yung AR et al (2015) Childhood maltreatment and transition to psychotic disorder independently predict long-term functioning in young people at ultra-high risk for psychosis. Psychol Med:1–13
16.
Zurück zum Zitat Bernstein DP et al (2003) Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Negl 27(2):169–190CrossRefPubMed Bernstein DP et al (2003) Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Negl 27(2):169–190CrossRefPubMed
17.
Zurück zum Zitat Bechdolf A et al (2010) Experience of trauma and conversion to psychosis in an ultra-high-risk (prodromal) group. Acta Psychiatr Scand 121(5):377–384CrossRefPubMed Bechdolf A et al (2010) Experience of trauma and conversion to psychosis in an ultra-high-risk (prodromal) group. Acta Psychiatr Scand 121(5):377–384CrossRefPubMed
18.
Zurück zum Zitat Thompson AD et al (2014) Sexual trauma increases the risk of developing psychosis in an ultra high-risk “prodromal” population. Schizophr Bull 40(3):697–706CrossRefPubMedPubMedCentral Thompson AD et al (2014) Sexual trauma increases the risk of developing psychosis in an ultra high-risk “prodromal” population. Schizophr Bull 40(3):697–706CrossRefPubMedPubMedCentral
19.
20.
Zurück zum Zitat Oh H et al (2014) Perceived discrimination and psychotic experiences across multiple ethnic groups in the US. Schizophr Res 157(1–3):259–265CrossRefPubMed Oh H et al (2014) Perceived discrimination and psychotic experiences across multiple ethnic groups in the US. Schizophr Res 157(1–3):259–265CrossRefPubMed
22.
Zurück zum Zitat Miller TJ et al (2003) Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability. Schizophr Bull 29(4):703–715CrossRefPubMed Miller TJ et al (2003) Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability. Schizophr Bull 29(4):703–715CrossRefPubMed
23.
24.
Zurück zum Zitat McGlashan TH, Walsh BC, Woods SW (2010) The psychosis risk syndrome: handbook for diagnosis and follow-up. Oxford University Press, New York McGlashan TH, Walsh BC, Woods SW (2010) The psychosis risk syndrome: handbook for diagnosis and follow-up. Oxford University Press, New York
25.
Zurück zum Zitat Addington J, Liu L, Buchy L, Cadenhead KS, Cannon TD, Cornblatt BA, Perkins DO, Seidman LJ, Tsuang MT, Walker EF, Woods SD, Bearden CE, Mathalon DH, McGlashan TH (2015) North American Prodrome Longitudinal Study (NAPLS2): the prodromal symptoms. J Nerv Ment Dis 203(5):328–335CrossRefPubMed Addington J, Liu L, Buchy L, Cadenhead KS, Cannon TD, Cornblatt BA, Perkins DO, Seidman LJ, Tsuang MT, Walker EF, Woods SD, Bearden CE, Mathalon DH, McGlashan TH (2015) North American Prodrome Longitudinal Study (NAPLS2): the prodromal symptoms. J Nerv Ment Dis 203(5):328–335CrossRefPubMed
26.
Zurück zum Zitat Janssen I et al (2004) Childhood abuse as a risk factor for psychotic experiences. Acta Psychiatr Scand 109(1):38–45CrossRefPubMed Janssen I et al (2004) Childhood abuse as a risk factor for psychotic experiences. Acta Psychiatr Scand 109(1):38–45CrossRefPubMed
27.
Zurück zum Zitat Bresnahan M, Begg MD, Brown A, Schaefer C, Sohler N, Insel B, Vella L, Susser E (2007) Race and risk of schizophrenia in a US birth cohort: another example of health disparity? Int J Epidemiol 36:751–758CrossRefPubMed Bresnahan M, Begg MD, Brown A, Schaefer C, Sohler N, Insel B, Vella L, Susser E (2007) Race and risk of schizophrenia in a US birth cohort: another example of health disparity? Int J Epidemiol 36:751–758CrossRefPubMed
28.
Zurück zum Zitat Gevonden MJ, Selten JP, Myin-Germeys I, de Graaf R, ten Have M, van Dorsselaer S, van Os J, Veling W (2014) Sexual minority status and psychotic symptoms: findings from the Netherlands Mental Health Survey and Incidence Studies (NEMESIS). Psychol Med 44:421–433CrossRefPubMed Gevonden MJ, Selten JP, Myin-Germeys I, de Graaf R, ten Have M, van Dorsselaer S, van Os J, Veling W (2014) Sexual minority status and psychotic symptoms: findings from the Netherlands Mental Health Survey and Incidence Studies (NEMESIS). Psychol Med 44:421–433CrossRefPubMed
29.
Zurück zum Zitat Selten JP, Cantor-Graae E (2007) Hypothesis: social defeat is a risk factor for schizophrenia? Br J Psychiatry Suppl 51:s9–s12CrossRefPubMed Selten JP, Cantor-Graae E (2007) Hypothesis: social defeat is a risk factor for schizophrenia? Br J Psychiatry Suppl 51:s9–s12CrossRefPubMed
30.
Zurück zum Zitat Gevonden M, Booij J, van den Brink W, Heijtel D, van Os J, Selten J-P (2014) Increased release of dopamine in the striata of young adults with hearing impairment and its relevance for the social defeat hypothesis of schizophrenia. JAMA Psychiatry 71(12):1364–1372CrossRefPubMed Gevonden M, Booij J, van den Brink W, Heijtel D, van Os J, Selten J-P (2014) Increased release of dopamine in the striata of young adults with hearing impairment and its relevance for the social defeat hypothesis of schizophrenia. JAMA Psychiatry 71(12):1364–1372CrossRefPubMed
31.
Zurück zum Zitat Kelleher I et al (2013) Childhood trauma and psychosis in a prospective cohort study: cause, effect, and directionality. Am J Psychiatry 170(7):734–741CrossRefPubMed Kelleher I et al (2013) Childhood trauma and psychosis in a prospective cohort study: cause, effect, and directionality. Am J Psychiatry 170(7):734–741CrossRefPubMed
Metadaten
Titel
Early traumatic experiences, perceived discrimination and conversion to psychosis in those at clinical high risk for psychosis
verfasst von
Jacqueline Stowkowy
Lu Liu
Kristin S. Cadenhead
Tyrone D. Cannon
Barbara A. Cornblatt
Thomas H. McGlashan
Diana O. Perkins
Larry J. Seidman
Ming T. Tsuang
Elaine F. Walker
Scott W. Woods
Carrie E. Bearden
Daniel H. Mathalon
Jean Addington
Publikationsdatum
06.02.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Social Psychiatry and Psychiatric Epidemiology / Ausgabe 4/2016
Print ISSN: 0933-7954
Elektronische ISSN: 1433-9285
DOI
https://doi.org/10.1007/s00127-016-1182-y

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