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Erschienen in: European Journal of Nutrition 6/2015

01.09.2015 | Original Contribution

Effect of a combination GOS/FOS® prebiotic mixture and interaction with calcium intake on mineral absorption and bone parameters in growing rats

verfasst von: Gabriel Bryk, Magalí Zeni Coronel, Gretel Pellegrini, Patricia Mandalunis, María Ester Rio, María Luz Pita Martín de Portela, Susana Noemí Zeni

Erschienen in: European Journal of Nutrition | Ausgabe 6/2015

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Abstract

Aim

Increasing calcium intake is the most effective strategy for avoiding Ca deficit. However, if intake remains inadequate, improving Ca absorption becomes an important tool to optimize Ca homeostasis and bone health.

Purpose

The effect of a mixture of GOS/FOS® 9:1 added to a normal- or low-Ca diets on Ca absorption and bone mineralization, density and structure was investigated, in a model of growing rats. Several colonic parameters to help support the findings were also evaluated.

Results

Weanling Wistar rats received one of the four experimental AIN-93G diets: C5: 0.5 % Ca; C3: 0.3 % Ca; P5: 0.5 % Ca + 5.3 % GOS/FOS®; P3: 0.3 % Ca + 5.3 % GOS/FOS® until 50 days (T = 50). At T = 50, lactobacillus and cecum weights were higher, whereas cecum pH was lower in P5 and P3 versus C5 and C3 (p < 0.001). At T = 50, fecal Ca, Mg and P were lower and their absorptions (mg/dL) were higher in P5 and P3 versus C5 and C3, respectively (p < 0.05). Ca, Mg and P absorption % was higher in P5 and P3 versus C5 and C3 (p < 0.001). Femur Ca and P content, bone mineral content, trabecular bone mineral density, tibia length, bone volume, osteoblast surface, stiffness and elastic modulus were higher in P5 and P3 versus C5 and C3 (p < 0.05). Despite the lower Ca content, P3 group reached similar values than C5 in all these latter parameters.

Conclusions

Supplementing diets with the GOS/FOS® mixture increased bone mineralization, density and structure due to an increase in Ca, P and Mg absorptions. Thus, this prebiotic mixture may help to improve bone development in a period of high calcium requirements.
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Metadaten
Titel
Effect of a combination GOS/FOS® prebiotic mixture and interaction with calcium intake on mineral absorption and bone parameters in growing rats
verfasst von
Gabriel Bryk
Magalí Zeni Coronel
Gretel Pellegrini
Patricia Mandalunis
María Ester Rio
María Luz Pita Martín de Portela
Susana Noemí Zeni
Publikationsdatum
01.09.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nutrition / Ausgabe 6/2015
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-014-0768-y

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