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European Journal of Nutrition

Erschienen in:

30.01.2016 | Original Contribution

Effect of oleic acid on store-operated calcium entry in immune-competent cells

verfasst von: Celia Carrillo, María Giraldo, M. Mar Cavia, Sara R. Alonso-Torre

Erschienen in: European Journal of Nutrition | Ausgabe 3/2017

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Abstract

Purpose

To study the mechanism by which oleic acid (OA) (C18:1) exerts its beneficial effects on immune-competent cells. Since store-operated Ca²⁺ entry (SOCE) is a Ca²⁺ influx pathway involved in the control of multiple physiological processes including cell proliferation, we studied the effect of OA in Ca²⁺ signals of Jurkat T cells and THP-1 monocytes, paying particular attention to SOCE.

Methods

Changes in [Ca²⁺]_i were measured using the Fura-2 fluorescence dye. Mn²⁺ uptake was monitored as a rate of quenching of Fura-2 fluorescence measured at the Ca²⁺-insensitive wavelengths. Thapsigargin was used to induce SOCE in Fura-2-loaded cells.

Results

We showed a clear dose-dependent SOCE-inhibitory effect of OA in both cell lines. Such an inhibitory effect was PKC independent and totally restored by albumin, suggesting that OA exerts its effect somewhere in the membrane. We also demonstrated that OA induces increases in [Ca²⁺]_i partly mediated by an extracellular Ca²⁺ influx through econazole-insensitive channels. Finally, we compared the effect of OA with stearic acid (C18:0), assuming the emerged evidence concerning the link between saturated fats and inflammation disorders. Stearic acid failed to inhibit SOCE, independently on the concentration tested, thus intensifying the physiological relevance of our findings.

Conclusion

We suggest a physiological pathway for the beneficial effects of OA in inflammation.

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Titel: Effect of oleic acid on store-operated calcium entry in immune-competent cells
verfasst von: Celia Carrillo
María Giraldo
M. Mar Cavia
Sara R. Alonso-Torre
Publikationsdatum: 30.01.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 3/2017
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-016-1157-5

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Effect of oleic acid on store-operated calcium entry in immune-competent cells

Abstract

Purpose

Methods

Results

Conclusion

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