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Erschienen in: European Journal of Nutrition 1/2015

01.02.2015 | Original Contribution

Effects of a caloric restriction weight loss diet on tryptophan metabolism and inflammatory biomarkers in overweight adults

verfasst von: Barbara Strasser, Ken Berger, Dietmar Fuchs

Erschienen in: European Journal of Nutrition | Ausgabe 1/2015

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Abstract

Purpose

Recent data suggest that chronic low-grade inflammation, a characteristic of obesity, is associated with altered tryptophan (Trp) and tyrosine (Tyr) metabolism and plays a role in neuropsychiatric symptoms. The present study assessed the effect of an extreme short-term diet on Trp breakdown and inflammatory biomarkers in overweight adults.

Methods

Thirty-eight overweight participants (16 women, 22 men; average body mass index: 29 kg/m2, mean age 52.8 years) were randomized into two diet groups: a very low kcal diet group (VLCD; Ø 600 kcal/day, n = 21) and a low kcal diet group (LCD; Ø 1,200 kcal/day, n = 17). Assays included the measurement of Trp, kynurenine (Kyn), and their ratio, neopterin, phenylalanine (Phe), Tyr, as biologic markers; leptin, plasma insulin, glucose, and homeostatic model assessment-insulin resistance; and interleukin 6, tumor necrosis factor alpha, and C-reactive protein, as biochemical and inflammatory markers at baseline and after 2 weeks of treatment.

Results

Weight loss diet lowered leptin levels in both groups by 46 %, although not reaching significance. Trp and Kyn decreased significantly by 21 and 16 % for VLCD and by 15 and 17 % for the LCD group, respectively. A significant reduction in Phe was only seen after VLCD. Inflammatory biomarkers, neopterin, and Tyr were not significantly altered during the study period. Leptin was significantly correlated with Trp breakdown before and after the intervention (P < 0.02).

Conclusions

Since disturbed metabolism of Trp affects biosynthesis of serotonin and might be associated with increased susceptibility for mood disturbances and carbohydrate craving, strategies to supplement Trp while dieting could be highly useful in treating uncontrolled weight gain or in preventing neuropsychiatric symptoms.
Literatur
1.
Zurück zum Zitat Engström G, Hedblad B, Stavenow L, Jonsson S, Lind P, Janzon L, Lindgärde F (2004) Incidence of obesity-associated cardiovascular disease is related to inflammation-sensitive plasma proteins: a population-based cohort study. Arterioscler Thromb Vasc Biol 24:1498–1502CrossRef Engström G, Hedblad B, Stavenow L, Jonsson S, Lind P, Janzon L, Lindgärde F (2004) Incidence of obesity-associated cardiovascular disease is related to inflammation-sensitive plasma proteins: a population-based cohort study. Arterioscler Thromb Vasc Biol 24:1498–1502CrossRef
2.
Zurück zum Zitat Dyck DJ (2009) Adipokines as regulators of muscle metabolism and insulin sensitivity. Appl Physiol Nutr Metab 34:396–402CrossRef Dyck DJ (2009) Adipokines as regulators of muscle metabolism and insulin sensitivity. Appl Physiol Nutr Metab 34:396–402CrossRef
3.
Zurück zum Zitat Wang P, Mariman E, Renes J, Keijer J (2008) The secretory function of adipocytes in the physiology of white adipose tissue. J Cell Physiol 216:3–13CrossRef Wang P, Mariman E, Renes J, Keijer J (2008) The secretory function of adipocytes in the physiology of white adipose tissue. J Cell Physiol 216:3–13CrossRef
4.
Zurück zum Zitat Brandacher G, Hoeller E, Fuchs D, Weiss HG (2007) Chronic immune activation underlies morbid obesity: is IDO a key player? Curr Drug Metab 8:289–295CrossRef Brandacher G, Hoeller E, Fuchs D, Weiss HG (2007) Chronic immune activation underlies morbid obesity: is IDO a key player? Curr Drug Metab 8:289–295CrossRef
5.
Zurück zum Zitat Nduhirabandi F, du Toit EF, Lochner A (2012) Melatonin and the metabolic syndrome: a tool for effective therapy in obesity-associated abnormalities? Acta Physiol 205:209–223CrossRef Nduhirabandi F, du Toit EF, Lochner A (2012) Melatonin and the metabolic syndrome: a tool for effective therapy in obesity-associated abnormalities? Acta Physiol 205:209–223CrossRef
6.
Zurück zum Zitat Mangge H, Summers KL, Meinitzer A, Zelzer S, Almer G, Prassl R, Schnedl WJ, Reininghaus E, Paulmichl K, Weghuber D, Fuchs D (2013) Obesity-related dysregulation of the Tryptophan-Kynurenine metabolism: Role of age and parameters of the metabolic syndrome. Obesity. doi:10.1002/oby.20491 Mangge H, Summers KL, Meinitzer A, Zelzer S, Almer G, Prassl R, Schnedl WJ, Reininghaus E, Paulmichl K, Weghuber D, Fuchs D (2013) Obesity-related dysregulation of the Tryptophan-Kynurenine metabolism: Role of age and parameters of the metabolic syndrome. Obesity. doi:10.​1002/​oby.​20491
7.
Zurück zum Zitat Capuron L, Schroecksnadel S, Féart C, Aubert A, Higueret D, Barberger-Gateau P, Layé S, Fuchs D (2011) Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms. Biol Psychiatry 70:175–182CrossRef Capuron L, Schroecksnadel S, Féart C, Aubert A, Higueret D, Barberger-Gateau P, Layé S, Fuchs D (2011) Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms. Biol Psychiatry 70:175–182CrossRef
8.
Zurück zum Zitat Capuron L, Ravaud A, Neveu PJ, Miller AH, Maes M, Dantzer R (2007) Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy. Mol Psychiatry 7:468–473CrossRef Capuron L, Ravaud A, Neveu PJ, Miller AH, Maes M, Dantzer R (2007) Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy. Mol Psychiatry 7:468–473CrossRef
9.
Zurück zum Zitat Fontana L, Klein S (2007) Aging, adiposity, and calorie restriction. JAMA 297:986–994CrossRef Fontana L, Klein S (2007) Aging, adiposity, and calorie restriction. JAMA 297:986–994CrossRef
10.
Zurück zum Zitat Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419CrossRef Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419CrossRef
11.
Zurück zum Zitat Neurauter G, Scholl-Bürgi S, Haara A, Geisler S, Mayersbach P, Schennach H, Fuchs D (2013) Simultaneous measurement of phenylalanine and tyrosine by high performance liquid chromatography (HPLC) with fluorescence detection. Clin Biochem 46:1848–1851CrossRef Neurauter G, Scholl-Bürgi S, Haara A, Geisler S, Mayersbach P, Schennach H, Fuchs D (2013) Simultaneous measurement of phenylalanine and tyrosine by high performance liquid chromatography (HPLC) with fluorescence detection. Clin Biochem 46:1848–1851CrossRef
12.
Zurück zum Zitat Blüher M, Rudich A, Klöting N, Golan R, Henkin Y, Rubin E, Schwarzfuchs D, Gepner Y, Stampfer MJ, Fiedler M, Thiery J, Stumvoll M, Shai I (2012) Two patterns of adipokine and other biomarker dynamics in a long-term weight loss intervention. Diabetes Care 35:342–349CrossRef Blüher M, Rudich A, Klöting N, Golan R, Henkin Y, Rubin E, Schwarzfuchs D, Gepner Y, Stampfer MJ, Fiedler M, Thiery J, Stumvoll M, Shai I (2012) Two patterns of adipokine and other biomarker dynamics in a long-term weight loss intervention. Diabetes Care 35:342–349CrossRef
13.
Zurück zum Zitat Itoh K, Imai K, Masuda T, Abe S, Tanaka M, Koga R, Itoh H, Matsuyama T, Nakamura M (2002) Relationship between changes in serum leptin levels and blood pressure after weight loss. Hypertens Res 25:881–886CrossRef Itoh K, Imai K, Masuda T, Abe S, Tanaka M, Koga R, Itoh H, Matsuyama T, Nakamura M (2002) Relationship between changes in serum leptin levels and blood pressure after weight loss. Hypertens Res 25:881–886CrossRef
14.
Zurück zum Zitat Oberhauser F, Schulte DM, Faust M, Güdelhöfer H, Hahn M, Müller N, Neumann K, Krone W, Laudes M (2012) Weight loss due to a very low calorie diet nondiabetic obese human subjects. Horm Metab Res 44:465–470CrossRef Oberhauser F, Schulte DM, Faust M, Güdelhöfer H, Hahn M, Müller N, Neumann K, Krone W, Laudes M (2012) Weight loss due to a very low calorie diet nondiabetic obese human subjects. Horm Metab Res 44:465–470CrossRef
15.
Zurück zum Zitat Ruge T, Lockton JA, Renstrom F, Lystig T, Sukonina V, Svensson MK, Eriksson JW (2009) Acute hyperinsulinemia raises plasma interleukin-6 in both nondiabetic and type 2 diabetes mellitus subjects, and this effect is inversely associated with body mass index. Metabolism 58:860–866CrossRef Ruge T, Lockton JA, Renstrom F, Lystig T, Sukonina V, Svensson MK, Eriksson JW (2009) Acute hyperinsulinemia raises plasma interleukin-6 in both nondiabetic and type 2 diabetes mellitus subjects, and this effect is inversely associated with body mass index. Metabolism 58:860–866CrossRef
16.
Zurück zum Zitat Häfner S, Zierer A, Emeny RT, Thorand B, Herder C, Koenig W, Rupprecht R, Ladwig KH, KORA Study Investigators (2011) Social isolation and depressed mood are associated with elevated serum leptin levels in men but not in women. Psychoneuroendocrinology 36:200–209CrossRef Häfner S, Zierer A, Emeny RT, Thorand B, Herder C, Koenig W, Rupprecht R, Ladwig KH, KORA Study Investigators (2011) Social isolation and depressed mood are associated with elevated serum leptin levels in men but not in women. Psychoneuroendocrinology 36:200–209CrossRef
17.
Zurück zum Zitat Widner B, Laich A, Sperner-Unterweger B, Ledochowski M, Fuchs D (2002) Neopterin production tryptophan degradation and mental depression: what is the link? Brain Behav Immun 16:590–595CrossRef Widner B, Laich A, Sperner-Unterweger B, Ledochowski M, Fuchs D (2002) Neopterin production tryptophan degradation and mental depression: what is the link? Brain Behav Immun 16:590–595CrossRef
18.
Zurück zum Zitat Reibnegger G, Vrecko K, Mlekusch W, Lamprecht M (1997) Influence of three different diet modes combined with exercise loads on urinary and plasma neopterin concentrations: a longitudinal study. Pteridines 8:211–215 Reibnegger G, Vrecko K, Mlekusch W, Lamprecht M (1997) Influence of three different diet modes combined with exercise loads on urinary and plasma neopterin concentrations: a longitudinal study. Pteridines 8:211–215
19.
Zurück zum Zitat Anderson IM, Parry-Billings M, Newsholme EA, Fairburn CH, Cowen PJ (1990) Dieting reduces plasma tryptophan and alters brain 5-HT function in women. Psychol Med 20:785–791CrossRef Anderson IM, Parry-Billings M, Newsholme EA, Fairburn CH, Cowen PJ (1990) Dieting reduces plasma tryptophan and alters brain 5-HT function in women. Psychol Med 20:785–791CrossRef
20.
Zurück zum Zitat Raison CL, Dantzer R, Kelley KW, Lawson MA, Woolwine BJ, Vogt G, Spivey JR, Saito K, Miller AH (2010) CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression. Mol Psychiatry 15:393–403CrossRef Raison CL, Dantzer R, Kelley KW, Lawson MA, Woolwine BJ, Vogt G, Spivey JR, Saito K, Miller AH (2010) CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression. Mol Psychiatry 15:393–403CrossRef
21.
Zurück zum Zitat Dantzer R, O’Connor JC, Lawson MA, Kelley KW (2011) Inflammation-associated depression: from serotonin to kynurenine. Psychoneuroendocrinology 36:426–436CrossRef Dantzer R, O’Connor JC, Lawson MA, Kelley KW (2011) Inflammation-associated depression: from serotonin to kynurenine. Psychoneuroendocrinology 36:426–436CrossRef
22.
Zurück zum Zitat Young SN (2013) The effect of raising and lowering tryptophan levels on human mood and social behaviour. Philos Trans R Soc Lond B Biol Sci 368:20110375CrossRef Young SN (2013) The effect of raising and lowering tryptophan levels on human mood and social behaviour. Philos Trans R Soc Lond B Biol Sci 368:20110375CrossRef
23.
Zurück zum Zitat Gatti E, Porrini M, Noe D, Crovetti R, Testolin G (1994) Plasma amino acids changes in obese patients on very low-calorie diets. Int J Vitam Nutr Res 64:81–85 Gatti E, Porrini M, Noe D, Crovetti R, Testolin G (1994) Plasma amino acids changes in obese patients on very low-calorie diets. Int J Vitam Nutr Res 64:81–85
24.
Zurück zum Zitat Wurtman RJ, Wurtman JJ (1995) Brain serotonin, carbohydrate-craving, obesity and depression. Obes Res 3:477S–480SCrossRef Wurtman RJ, Wurtman JJ (1995) Brain serotonin, carbohydrate-craving, obesity and depression. Obes Res 3:477S–480SCrossRef
25.
Zurück zum Zitat Amigo I, Fernández C (2007) Effects of diets and their role in weight control. Psychol Health Med 12:321–327CrossRef Amigo I, Fernández C (2007) Effects of diets and their role in weight control. Psychol Health Med 12:321–327CrossRef
26.
Zurück zum Zitat Kajioka T, Tsuzuku S, Shimokata H, Sato Y (2002) Effects of intentional weight cycling on non-obese young women. Metabolism 51:149–154CrossRef Kajioka T, Tsuzuku S, Shimokata H, Sato Y (2002) Effects of intentional weight cycling on non-obese young women. Metabolism 51:149–154CrossRef
27.
Zurück zum Zitat Banasik JL, Walker MK, Randall JM, Netjes RB, Foutz MS (2013) Low-calorie diet induced weight loss may alter regulatory hormones and contribute to rebound visceral adiposity in obese persons with a family history of type-2 diabetes. J Am Assoc Nurse Pract 25:440–448 Banasik JL, Walker MK, Randall JM, Netjes RB, Foutz MS (2013) Low-calorie diet induced weight loss may alter regulatory hormones and contribute to rebound visceral adiposity in obese persons with a family history of type-2 diabetes. J Am Assoc Nurse Pract 25:440–448
28.
Zurück zum Zitat Mason C, Foster-Schubert KE, Imayama I, Xiao L, Kong A, Campbell KL, Duggan CR, Wang CY, Alfano CM, Ulrich CM, Blackburn GL, McTiernan A (2013) History of weight cycling does not impede future weight loss or metabolic improvements in postmenopausal women. Metabolism 62:127–136CrossRef Mason C, Foster-Schubert KE, Imayama I, Xiao L, Kong A, Campbell KL, Duggan CR, Wang CY, Alfano CM, Ulrich CM, Blackburn GL, McTiernan A (2013) History of weight cycling does not impede future weight loss or metabolic improvements in postmenopausal women. Metabolism 62:127–136CrossRef
29.
Zurück zum Zitat Parker G, Brotchie H (2011) Mood effects of the amino acids tryptophan and tyrosine: ‘Food for Thought’ III. Acta Psychiatr Scand 124:417–426CrossRef Parker G, Brotchie H (2011) Mood effects of the amino acids tryptophan and tyrosine: ‘Food for Thought’ III. Acta Psychiatr Scand 124:417–426CrossRef
30.
Zurück zum Zitat Chen Y, Guillemin GJ (2009) Kynurenine pathway metabolites in humans: disease and healthy states. Int J Tryptophan Res 2:1–19 Chen Y, Guillemin GJ (2009) Kynurenine pathway metabolites in humans: disease and healthy states. Int J Tryptophan Res 2:1–19
31.
Zurück zum Zitat Dekker MJ, Lee S, Hudson R, Kilpatrick K, Graham TE, Ross R, Robinson LE (2007) An exercise intervention without weight loss decreases circulating interleukin-6 in lean and obese men with and without type 2 diabetes mellitus. Metabolism 56:332–338CrossRef Dekker MJ, Lee S, Hudson R, Kilpatrick K, Graham TE, Ross R, Robinson LE (2007) An exercise intervention without weight loss decreases circulating interleukin-6 in lean and obese men with and without type 2 diabetes mellitus. Metabolism 56:332–338CrossRef
32.
Zurück zum Zitat Balducci S, Zanuso S, Nicolucci A, Fernando F, Cavallo S, Cardelli P, Fallucca S, Alessi E, Letizia C, Jimenez A, Fallucca F, Pugliese G (2010) Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis 20:608–617CrossRef Balducci S, Zanuso S, Nicolucci A, Fernando F, Cavallo S, Cardelli P, Fallucca S, Alessi E, Letizia C, Jimenez A, Fallucca F, Pugliese G (2010) Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis 20:608–617CrossRef
33.
Zurück zum Zitat Strasser B, Arvandi M, Siebert U (2012) Resistance training, visceral obesity and inflammatory response: a review of the evidence. Obes Rev 13:578–591CrossRef Strasser B, Arvandi M, Siebert U (2012) Resistance training, visceral obesity and inflammatory response: a review of the evidence. Obes Rev 13:578–591CrossRef
34.
Zurück zum Zitat Dey S, Singh RH, Dey PK (1992) Exercise training: significance of regional alterations in serotonin metabolism of rat brain in relation to antidepressant effect of exercise. Physiol Behav 52:1095–1099CrossRef Dey S, Singh RH, Dey PK (1992) Exercise training: significance of regional alterations in serotonin metabolism of rat brain in relation to antidepressant effect of exercise. Physiol Behav 52:1095–1099CrossRef
35.
Zurück zum Zitat Meeusen R, Thorré K, Chaouloff F, Sarre S, De Meirleir K, Ebinger G, Michotte Y (1996) Effects of tryptophan and/or acute running on extracellular 5-HT and 5-HIAA levels in the hippocampus of food-deprived rats. Brain Res 740:245–252CrossRef Meeusen R, Thorré K, Chaouloff F, Sarre S, De Meirleir K, Ebinger G, Michotte Y (1996) Effects of tryptophan and/or acute running on extracellular 5-HT and 5-HIAA levels in the hippocampus of food-deprived rats. Brain Res 740:245–252CrossRef
36.
Zurück zum Zitat Dunn AL, Trivedi MH, Kampert JB, Clark CG, Chambliss HO (2005) Exercise treatment for depression: efficacy and dose response. Am J Prev Med 28:1–8CrossRef Dunn AL, Trivedi MH, Kampert JB, Clark CG, Chambliss HO (2005) Exercise treatment for depression: efficacy and dose response. Am J Prev Med 28:1–8CrossRef
37.
Zurück zum Zitat Babyak M, Blumenthal JA, Herman S, Khatri P, Doraiswamy M, Moore K, Craighead WE, Baldewicz TT, Krishnan KR (2000) Exercise treatment for major depression: maintenance of therapeutic benefit at 10 months. Psychosom Med 62:633–638CrossRef Babyak M, Blumenthal JA, Herman S, Khatri P, Doraiswamy M, Moore K, Craighead WE, Baldewicz TT, Krishnan KR (2000) Exercise treatment for major depression: maintenance of therapeutic benefit at 10 months. Psychosom Med 62:633–638CrossRef
38.
Zurück zum Zitat Blake CE, Hébert JR, Lee DC, Adams SA, Steck SE, Sui X, Kuk JL, Baruth M, Blair SN (2013) Adults with greater weight satisfaction report more positive health behaviors and have better health status regardless of BMI. J Obes 2013:291371CrossRef Blake CE, Hébert JR, Lee DC, Adams SA, Steck SE, Sui X, Kuk JL, Baruth M, Blair SN (2013) Adults with greater weight satisfaction report more positive health behaviors and have better health status regardless of BMI. J Obes 2013:291371CrossRef
Metadaten
Titel
Effects of a caloric restriction weight loss diet on tryptophan metabolism and inflammatory biomarkers in overweight adults
verfasst von
Barbara Strasser
Ken Berger
Dietmar Fuchs
Publikationsdatum
01.02.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nutrition / Ausgabe 1/2015
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-014-0690-3

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