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01.09.2014 | Intensivmedizin

Einsatz von Biomarkern in der Sepsis

Update und Ausblick

verfasst von: B.H. Siegler, S. Weiterer, C. Lichtenstern, D. Stumpp, T. Brenner, S. Hofer, Prof. Dr. M.A. Weigand, F. Uhle

Erschienen in: Die Anaesthesiologie | Ausgabe 8-9/2014

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Zusammenfassung

Die Sepsis und damit verbundene Komplikationen sind eine große Herausforderung für die Intensivmedizin. Trotz vieler Fortschritte in der antibiotischen Therapie gehört die Sepsis zu den häufigsten Krankheitsentitäten auf Intensivstationen und ist als Haupttodesursache kritisch kranker Patienten beschrieben. Persistiert die Sepsis, kommt es zu einer Störung der Immunität bis zur Immunsuppression. Unspezifische Frühzeichen erschweren oftmals eine schnelle Diagnose. Der rasche Beginn einer adäquaten Therapie ist allerdings für die Prognose von besonderer Bedeutung. Scoring-Systeme dienen der initialen Evaluation, werden aber in Bezug auf Verlaufs- und Therapie-Monitoring sowie Vorhersagekraft für die Sterblichkeit kontrovers diskutiert. Biomarker gelten hierfür als ergänzender Ansatz.

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Adamzik M, Eggmann M, Frey UH et al (2010) Comparison of thromboelastometry with procalcitonin, interleukin 6, and C-reactive protein as diagnostic tests for severe sepsis in critically ill adults. Crit Care 14:R178PubMedPubMedCentral

Ahmad S, Ramsay T, Huebsch L et al (2009) Continuous multi-parameter heart rate variability analysis heralds onset of sepsis in adults. PLoS One 4:e6642PubMedPubMedCentral

Aneja R, Carcillo J (2011) Differences between adult and pediatric septic shock. Minerva Anestesiol 77:986–992PubMed

Angus DC, Linde-Zwirble WT, Lidicker J et al (2001) Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29:1303–1310PubMed

Annane D, Bellissant E, Cavaillon JM (2005) Septic shock. Lancet 365:63–78PubMed

Atkinson AJ (2001) Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 69:89–95

Bantel H, Lugering A, Heidemann J et al (2004) Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury. Hepatology 40:1078–1087PubMed

Barbic J, Ivic D, Alkhamis T et al (2013) Kinetics of changes in serum concentrations of procalcitonin, interleukin-6, and C-reactive protein after elective abdominal surgery. Can it be used to detect postoperative complications? Coll Antropol 37:195–201PubMed

Barnaby D, Ferrick K, Kaplan DT et al (2002) Heart rate variability in emergency department patients with sepsis. Acad Emerg Med 9:661–670PubMed

10.

Bayes T (1991) An essay towards solving a problem in the doctrine of chances. 1763. MD Comput 8:157–171PubMed

11.

Becker KL, Snider R, Nylen ES (2008) Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations. Crit Care Med 36:941–952PubMed

12.

Billeter A, Turina M, Seifert B et al (2009) Early serum procalcitonin, interleukin-6, and 24-hour lactate clearance: useful indicators of septic infections in severely traumatized patients. World J Surg 33:558–566PubMed

13.

Bloos F, Reinhart K (2014) Rapid diagnosis of sepsis. Virulence 5:154–160PubMedPubMedCentral

14.

Bone RC, Grodzin CJ, Balk RA (1997) Sepsis: a new hypothesis for pathogenesis of the disease process. Chest 112:235–243PubMed

15.

Boomer JS, To K, Chang KC et al (2011) Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 306:2594–2605PubMedPubMedCentral

16.

Bopp C, Hofer S, Bouchon A et al (2009) Soluble TREM-1 is not suitable for distinguishing between systemic inflammatory response syndrome and sepsis survivors and nonsurvivors in the early stage of acute inflammation. Eur J Anaesthesiol 26:504–507PubMed

17.

Borovikova LV, Ivanova S, Zhang M et al (2000) Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405:458–462PubMed

18.

Bouchon A, Facchetti F, Weigand MA, Colonna M (2001) TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 410:1103–1107PubMed

19.

Boudjeltia KZ, Ollieuz S, Piagnerelli M et al (2009) Plasma fibrinolysis is related to the degree of organ dysfunction but not to the concentration of von Willebrand Factor in critically ill patients. Thromb J 7:1477–9560

20.

Brenner T, Rosenhagen C, Hornig I et al (2012) Viral infections in septic shock (VISS-trial) - crosslinks between inflammation and immunosuppression. J Surg Res 176:571–582PubMed

21.

Brenner T, Schmidt K, Delang M et al (2012) Viscoelastic and aggregometric point-of-care testing in patients with septic shock – cross-links between inflammation and haemostasis. Acta Anaesthesiol Scand 56:1277–1290PubMed

22.

Brunkhorst FM, Heinz U, Forycki ZF (1998) Kinetics of procalcitonin in iatrogenic sepsis. Intensive Care Med 24:888–889PubMed

23.

Cavaillon JM (2009) Monocyte TREM-1 membrane expression in non-infectious inflammation. Crit Care 13:152PubMedPubMedCentral

24.

Chen WL, Kuo CD (2007) Characteristics of heart rate variability can predict impending septic shock in emergency department patients with sepsis. Acad Emerg Med 14:392–397PubMed

25.

Cid J, Aguinaco R, Sanchez R et al (2010) Neutrophil CD64 expression as marker of bacterial infection: a systematic review and meta-analysis. J Infect 60:313–319PubMed

26.

Clyne B, Olshaker JS (1999) The C-reactive protein. J Emerg Med 17:1019–1025PubMed

27.

Dandona P, Nix D, Wilson MF et al (1994) Procalcitonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metab 79:1605–1608PubMed

28.

David S, Kumpers P, Slyke P van, Parikh SM (2013) Mending leaky blood vessels: the angiopoietin-Tie2 pathway in sepsis. J Pharmacol Exp Ther 345:2–6PubMed

29.

David S, Mukherjee A, Ghosh CC et al (2013) Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis. Crit Care Med 40:3034–3041

30.

Groot B de, Verdoorn RC, Lameijer J, Velden J van der (2013) High-sensitivity cardiac troponin T is an independent predictor of inhospital mortality in emergency department patients with suspected infection: a prospective observational derivation study. DOI 10.1136/emermed-2013-202865

31.

Dellinger RP, Levy MM, Rhodes A et al (2013) Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 41:580–637PubMed

32.

Dhainaut JF, Shorr AF, Macias WL et al (2005) Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure. Crit Care Med 33:341–348PubMed

33.

Dimoula A, Pradier O, Kassengera Z et al (2014) Serial determinations of neutrophil CD64 expression for the diagnosis and monitoring of sepsis in critically ill patients. Clin Infect Dis 58:820–829PubMed

34.

Docke WD, Hoflich C, Davis KA et al (2005) Monitoring temporary immunodepression by flow cytometric measurement of monocytic HLA-DR expression: a multicenter standardized study. Clin Chem 51:2341–2347PubMed

35.

Docke WD, Randow F, Syrbe U et al (1997) Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 3:678–681PubMed

36.

Dombrovskiy VY, Martin AA, Sunderram J, Paz HL (2007) Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med 35:1244–1250PubMed

37.

Donadello K, Scolletta S, Taccone FS et al (2014) Soluble urokinase-type plasminogen activator receptor as a prognostic biomarker in critically ill patients. J Crit Care 29:144–149PubMed

38.

Drewry AM, Fuller BM, Bailey TC, Hotchkiss RS (2013) Body temperature patterns as a predictor of hospital-acquired sepsis in afebrile adult intensive care unit patients: a case-control study. Crit Care 17:1–11

39.

Endo S, Suzuki Y, Takahashi G et al (2012) Usefulness of presepsin in the diagnosis of sepsis in a multicenter prospective study. J Infect Chemother 18:891–897PubMed

40.

Ferat-Osorio E, Wong-Baeza I, Esquivel-Callejas N et al (2009) Triggering receptor expressed on myeloid cells-1 expression on monocytes is associated with inflammation but not with infection in acute pancreatitis. Crit Care 13:R69PubMedPubMedCentral

41.

Fleig V, Brenck F, Wolff M, Weigand MA (2011) Scoring systems in intensive care medicine: principles, models, application and limits. Anaesthesist 60:963–974PubMed

42.

Ganter MT, Hofer CK (2008) Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices. Anesth Analg 106:1366–1375PubMed

43.

Garnacho-Montero J, Ortiz-Leyba C, Herrera-Melero I et al (2008) Mortality and morbidity attributable to inadequate empirical antimicrobial therapy in patients admitted to the ICU with sepsis: a matched cohort study. J Antimicrob Chemother 61:436–441PubMed

44.

Gerrits JH, McLaughlin PM, Nienhuis BN et al (2013) Polymorphic mononuclear neutrophils CD64 index for diagnosis of sepsis in postoperative surgical patients and critically ill patients. Clin Chem Lab Med 51:897–905PubMed

45.

Gibot S, Bene MC, Noel R et al (2012) Combination biomarkers to diagnose sepsis in the critically ill patient. Am J Respir Crit Care Med 186:65–71PubMed

46.

Godin PJ, Fleisher LA, Eidsath A et al (1996) Experimental human endotoxemia increases cardiac regularity: results from a prospective, randomized, crossover trial. Crit Care Med 24:1117–1124PubMed

47.

Goldstein B, Kempski MH, Stair D et al (1995) Autonomic modulation of heart rate variability during endotoxin shock in rabbits. Crit Care Med 23:1694–1702PubMed

48.

Gonzalvez F, Ashkenazi A (2010) New insights into apoptosis signaling by Apo2L/TRAIL. Oncogene 29:4752–4765PubMed

49.

Grassi A, Susca M, Ferri S et al (2004) Detection of the M30 neoepitope as a new tool to quantify liver apoptosis: timing and patterns of positivity on frozen and paraffin-embedded sections. Am J Clin Pathol 121:211–219PubMed

50.

Hamilton MA, Toner A, Cecconi M (2012) Troponin in critically ill patients. Minerva Anestesiol 78:1039–1045PubMed

51.

Hamm CW, Bassand JP, Agewall S et al (2011) ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: the Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 32:2999–3054PubMed

52.

Haveman JW, Muller Kobold AC, Tervaert JW et al (1999) The central role of monocytes in the pathogenesis of sepsis: consequences for immunomonitoring and treatment. Neth J Med 55:132–141PubMed

53.

Heyland DK, Johnson AP, Reynolds SC, Muscedere J (2011) Procalcitonin for reduced antibiotic exposure in the critical care setting: a systematic review and an economic evaluation. Crit Care Med 39:1792–1799PubMed

54.

Hofer N, Zacharias E, Muller W, Resch B (2012) An update on the use of C-reactive protein in early-onset neonatal sepsis: current insights and new tasks. Neonatology 102:25–36PubMed

55.

Hofer S, Brenner T, Bopp C et al (2009) Cell death serum biomarkers are early predictors for survival in severe septic patients with hepatic dysfunction. Crit Care 13:R93PubMedPubMedCentral

56.

Hoffmann JJ (2011) Neutrophil CD64 as a sepsis biomarker. Biochem Med (Zagreb) 21:282–290

57.

Hotchkiss RS, Swanson PE, Freeman BD et al (1999) Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 27:1230–1251PubMed

58.

Huttunen R, Syrjanen J, Vuento R et al (2011) Plasma level of soluble urokinase-type plasminogen activator receptor as a predictor of disease severity and case fatality in patients with bacteraemia: a prospective cohort study. J Intern Med 270:32–40PubMed

59.

Icardi M, Erickson Y, Kilborn S et al (2009) CD64 index provides simple and predictive testing for detection and monitoring of sepsis and bacterial infection in hospital patients. J Clin Microbiol 47:3914–3919PubMedPubMedCentral

60.

Iking-Konert C, Bartz-Bazzanella P, Falagan D et al (2014) Interleukin-6 inhibition as a potential therapeutic target in rheumatic diseases. Z Rheumatol 73:269–276

61.

Jansen TC, Bommel J van, Schoonderbeek FJ et al (2010) Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. Am J Respir Crit Care Med 182:752–761PubMed

62.

Jensen JU, Hein L, Lundgren B et al (2011) Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial. Crit Care Med 39:2048–2058PubMed

63.

Jiyong J, Tiancha H, Wei C, Huahao S (2009) Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med 35:587–595PubMed

64.

Jo YH, Kim K, Lee JH et al (2012) Heart-type fatty acid-binding protein as a prognostic factor in patients with severe sepsis and septic shock. Am J Emerg Med 30:1749–1755PubMed

65.

Jung B, Embriaco N, Roux F et al (2010) Microbiogical data, but not procalcitonin improve the accuracy of the clinical pulmonary infection score. Intensive Care Med 36:790–798PubMed

66.

Jung B, Rimmele T, Le Goff C et al (2011) Severe metabolic or mixed acidemia on intensive care unit admission: incidence, prognosis and administration of buffer therapy. A prospective, multiple-center study. Crit Care 15:R238PubMedPubMedCentral

67.

Kakoti A, Goswami P (2013) Heart type fatty acid binding protein: structure, function and biosensing applications for early detection of myocardial infarction. Biosens Bioelectron 43:400–411PubMed

68.

Kleiger RE, Stein PK, Bigger JT Jr (2005) Heart rate variability: measurement and clinical utility. Ann Noninvasive Electrocardiol 10:88–101PubMed

69.

Knapp S, Gibot S, Vos A de et al (2004) Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia. J Immunol 173:7131–7134PubMed

70.

Knaus WA, Draper EA, Wagner DP, Zimmerman JE (1985) APACHE II: a severity of disease classification system. Crit Care Med 13:818–829PubMed

71.

Koch A, Voigt S, Kruschinski C et al (2011) Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients. Crit Care 15:R63PubMedPubMedCentral

72.

Kofoed K, Andersen O, Kronborg G et al (2007) Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study. Crit Care 11:R38PubMedPubMedCentral

73.

Kopterides P, Siempos, II, Tsangaris I et al (2010) Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: a systematic review and meta-analysis of randomized controlled trials. Crit Care Med 38:2229–2241PubMed

74.

Korach M, Sharshar T, Jarrin I et al (2001) Cardiac variability in critically ill adults: influence of sepsis. Crit Care Med 29:1380–1385PubMed

75.

Kramer G, Erdal H, Mertens HJ et al (2004) Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18. Cancer Res 64:1751–1756PubMed

76.

Kumpers P, David S (2013) Angiopoietin-2 in sepsis: lost in translation? Nephrol Dial Transplant 28:487–489PubMed

77.

Laupland KB, Shahpori R, Kirkpatrick AW et al (2008) Occurrence and outcome of fever in critically ill adults. Crit Care Med 36:1531–1535PubMed

78.

Leers MP, Kolgen W, Bjorklund V et al (1999) Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis. J Pathol 187:567–572PubMed

79.

Levy MM, Fink MP, Marshall JC et al (2003) 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 29:530–538PubMed

80.

Levy MM, Macias WL, Vincent JL et al (2005) Early changes in organ function predict eventual survival in severe sepsis. Crit Care Med 33:2194–2201PubMed

81.

Lichtenstern C, Brenner T, Bardenheuer HJ, Weigand MA (2012) Predictors of survival in sepsis: what is the best inflammatory marker to measure? Curr Opin Infect Dis 25:328–336PubMed

82.

Liu B, Chen YX, Yin Q et al (2013) Diagnostic value and prognostic evaluation of presepsin for sepsis in an emergency department. Crit Care 17:R244PubMedPubMedCentral

83.

Livaditi O, Kotanidou A, Psarra A et al (2006) Neutrophil CD64 expression and serum IL-8: sensitive early markers of severity and outcome in sepsis. Cytokine 36:283–290PubMed

84.

Luft T, Conzelmann M, Benner A et al (2007) Serum cytokeratin-18 fragments as quantitative markers of epithelial apoptosis in liver and intestinal graft-versus-host disease. Blood 110:4535–4542PubMed

85.

Lyn-Kew K, Standiford TJ (2008) Immunosuppression in sepsis. Curr Pharm Des 14:1870–1881PubMed

86.

Maeder M, Fehr T, Rickli H, Ammann P (2006) Sepsis-associated myocardial dysfunction: diagnostic and prognostic impact of cardiac troponins and natriuretic peptides. Chest 129:1349–1366PubMed

87.

Malik M (1996) Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93:1043–1065

88.

Margetic S (2012) Inflammation and haemostasis. Biochem Med (Zagreb) 22:49–62

89.

Marshall JC (2008) Sepsis: rethinking the approach to clinical research. J Leukoc Biol 83:471–482PubMed

90.

Masson S, Caironi P, Spanuth E et al (2014) Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from the Albumin Italian Outcome Sepsis trial. Crit Care 18:R6PubMedPubMedCentral

91.

Meisel C, Schefold JC, Pschowski R et al (2009) Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med 180:640–648PubMed

92.

Meisner M, Adina H, Schmidt J (2006) Correlation of procalcitonin and C-reactive protein to inflammation, complications, and outcome during the intensive care unit course of multiple-trauma patients. Crit Care 10:R1PubMedPubMedCentral

93.

Mikkelsen ME, Miltiades AN, Gaieski DF et al (2009) Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med 37:1670–1677PubMed

94.

Mohr NM, Hotchkiss RS, Micek ST et al (2011) Change in temperature profile may precede fever and be an early indicator of sepsis: a case report. Shock 36:318–320PubMed

95.

Monneret G, Lepape A, Voirin N et al (2006) Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock. Intensive Care Med 32:1175–1183PubMed

96.

Moore DJ, Greystoke A, Butt F et al (2012) A pilot study assessing the prognostic value of CK18 and nDNA biomarkers in severe sepsis patients. Clin Drug Investig 32:179–187PubMed

97.

Morgenthaler NG, Struck J, Alonso C, Bergmann A (2005) Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay. Clin Chem 51:1823–1829PubMed

98.

Oberhoffer M, Russwurm S, Bredle D et al (2000) Discriminative power of inflammatory markers for prediction of tumor necrosis factor-alpha and interleukin-6 in ICU patients with systemic inflammatory response syndrome (SIRS) or sepsis at arbitrary time points. Intensive Care Med 26:170–174

99.

Oberholzer A, Oberholzer C, Moldawer LL (2001) Sepsis syndromes: understanding the role of innate and acquired immunity. Shock 16:83–96PubMed

100.

Oliveira CF, Botoni FA, Oliveira CR et al (2013) Procalcitonin versus C-reactive protein for guiding antibiotic therapy in sepsis: a randomized trial. Crit Care Med 41:2336–2343PubMed

101.

Ono T (2005) Studies of the FABP family: a retrospective. Mol Cell Biochem 277:1–6PubMed

102.

Ossowski L, Aguirre-Ghiso JA (2000) Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth. Curr Opin Cell Biol 12:613–620PubMed

103.

Panacek EA, Marshall JC, Albertson TE et al (2004) Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab‘)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med 32:2173–2182PubMed

104.

Pene F, Courtine E, Cariou A, Mira JP (2009) Toward theragnostics. Crit Care Med 37:50–58

105.

Pepys MB, Hirschfield GM (2003) C-reactive protein: a critical update. J Clin Invest 111:1805–1812PubMedPubMedCentral

106.

Pierrakos C, Vincent JL (2010) Sepsis biomarkers: a review. Crit Care 14:R15PubMedPubMedCentral

107.

Povoa P, Coelho L, Almeida E et al (2005) C-reactive protein as a marker of infection in critically ill patients. Clin Microbiol Infect 11:101–108PubMed

108.

Prkno A, Wacker C, Brunkhorst FM, Schlattmann P (2013) Procalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock – a systematic review and meta-analysis. Crit Care 17:R291PubMedPubMedCentral

109.

Ratzinger F, Schuardt M, Eichbichler K et al (2013) Utility of sepsis biomarkers and the infection probability score to discriminate sepsis and systemic inflammatory response syndrome in standard care patients. PLoS One 8:e82946PubMedPubMedCentral

110.

Reinhart K, Brunkhorst FM, Bone HG et al (2010) Prevention, diagnosis, treatment, and follow-up care of sepsis. First revision of the S2k Guidelines of the German Sepsis Society (DSG) and the German Interdisciplinary Association for Intensive and Emergency Care Medicine (DIVI). Anaesthesist 59:347–370PubMed

111.

Reinhart K, Wiegand-Lohnert C, Grimminger F et al (1996) Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: a multicenter, randomized, placebo-controlled, dose-ranging study. Crit Care Med 24:733–742PubMed

112.

Roth GA, Krenn C, Brunner M et al (2004) Elevated serum levels of epithelial cell apoptosis-specific cytokeratin 18 neoepitope m30 in critically ill patients. Shock 22:218–220PubMed

113.

Sakr Y, Burgett U, Nacul FE et al (2008) Lipopolysaccharide binding protein in a surgical intensive care unit: a marker of sepsis? Crit Care Med 36:2014–2022PubMed

114.

Sakr Y, Lobo SM, Moreno RP et al (2012) Patterns and early evolution of organ failure in the intensive care unit and their relation to outcome. Crit Care 16:R222PubMedPubMedCentral

115.

Schluter B, Konig B, Bergmann U et al (1991) Interleukin 6 – a potential mediator of lethal sepsis after major thermal trauma: evidence for increased IL-6 production by peripheral blood mononuclear cells. J Trauma 31:1663–1670PubMed

116.

Schmit X, Vincent JL (2008) The time course of blood C-reactive protein concentrations in relation to the response to initial antimicrobial therapy in patients with sepsis. Infection 36:213–219PubMed

117.

Scott EC, Ho HC, Yu M et al (2008) Pre-existing cardiac disease, troponin I elevation and mortality in patients with severe sepsis and septic shock. Anaesth Intensive Care 36:51–59PubMed

118.

Seigel TA, Cocchi MN, Salciccioli J et al (2012) Inadequacy of temperature and white blood cell count in predicting bacteremia in patients with suspected infection. J Emerg Med 42:254–259PubMed

119.

Shapiro NI, Howell MD, Talmor D et al (2005) Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med 45:524–528PubMed

120.

Shozushima T, Takahashi G, Matsumoto N et al (2011) Usefulness of presepsin (sCD14-ST) measurements as a marker for the diagnosis and severity of sepsis that satisfied diagnostic criteria of systemic inflammatory response syndrome. J Infect Chemother 17:764–769PubMed

121.

Simon L, Gauvin F, Amre DK et al (2004) Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis 39:206–217PubMed

122.

Suberviola B, Castellanos-Ortega A, Llorca J et al (2012) Prognostic value of proadrenomedullin in severe sepsis and septic shock patients with community-acquired pneumonia. Swiss Med Wkly 19:w13542

123.

Suberviola B, Castellanos-Ortega A, Ruiz Ruiz A et al (2013) Hospital mortality prognostication in sepsis using the new biomarkers suPAR and proADM in a single determination on ICU admission. Intensive Care Med 39:1945–1952PubMed

124.

Tang BM, Eslick GD, Craig JC, McLean AS (2007) Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis. Lancet Infect Dis 7:210–217PubMed

125.

Tian Y, Tao T, Zhu J et al (2013) Soluble tumor necrosis factor related apoptosis inducing ligand level as a predictor of severity of sepsis and the risk of mortality in septic patients. PLoS One 8:e82204PubMedPubMedCentral

126.

Tsalik EL, Jaggers LB, Glickman SW et al (2012) Discriminative value of inflammatory biomarkers for suspected sepsis. J Emerg Med 43:97–106PubMedPubMedCentral

127.

Tschaikowsky K, Hedwig-Geissing M, Braun GG, Radespiel-Troeger M (2011) Predictive value of procalcitonin, interleukin-6, and C-reactive protein for survival in postoperative patients with severe sepsis. J Crit Care 26:54–64PubMed

128.

Ulla M, Pizzolato E, Lucchiari M et al (2013) Diagnostic and prognostic value of presepsin in the management of sepsis in the emergency department: a multicenter prospective study. Crit Care 17:R168PubMedPubMedCentral

129.

Uusitalo-Seppala R, Koskinen P, Leino A et al (2011) Early detection of severe sepsis in the emergency room: diagnostic value of plasma C-reactive protein, procalcitonin, and interleukin-6. Scand J Infect Dis 43:883–890PubMed

130.

Uzzan B, Cohen R, Nicolas P et al (2006) Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med 34:1996–2003PubMed

131.

Zanten AR van, Brinkman S, Arbous MS et al (2014) Guideline bundles adherence and mortality in severe sepsis and septic shock. Crit Care Med. DOI: 10.1097/CCM.0000000000000297

132.

Vander Stichele RH, Elseviers MM, Ferech M et al (2006) Hospital consumption of antibiotics in 15 European countries: results of the ESAC Retrospective Data Collection (1997–2002). J Antimicrob Chemother 58:159–167

133.

Vasile VC, Chai HS, Abdeldayem D et al (2013) Elevated cardiac troponin T levels in critically ill patients with sepsis. Am J Med 126:1114–1121PubMed

134.

Vidaur L, Gualis B, Rodriguez A et al (2005) Clinical resolution in patients with suspicion of ventilator-associated pneumonia: a cohort study comparing patients with and without acute respiratory distress syndrome. Crit Care Med 33:1248–1253PubMed

135.

Vincent JL, Moreno R, Takala J et al (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22:707–710PubMed

136.

Vincent JL, Opal SM, Marshall JC (2010) Ten reasons why we should NOT use severity scores as entry criteria for clinical trials or in our treatment decisions. Crit Care Med 38:283–287PubMed

137.

Vincent JL, Opal SM, Marshall JC, Tracey KJ (2013) Sepsis definitions: time for change. Lancet 381:774–775PubMed

138.

Vincent JL, Sakr Y, Sprung CL et al (2006) Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 34:344–353PubMed

139.

Wacker C, Prkno A, Brunkhorst FM, Schlattmann P (2013) Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis 13:426–435PubMed

140.

Wang Q, Li H, Liu S et al (2005) Cloning and tissue expression of chicken heart fatty acid-binding protein and intestine fatty acid-binding protein genes. Anim Biotechnol 16:191–201PubMed

141.

Wong HR, Lindsell CJ, Pettila V et al (2014) A multibiomarker-based outcome risk stratification model for adult septic shock. Crit Care Med 42:781–789PubMed

142.

Wu Y, Wang F, Fan X et al (2012) Accuracy of plasma sTREM-1 for sepsis diagnosis in systemic inflammatory patients: a systematic review and meta-analysis. Crit Care 16:R229PubMedPubMedCentral

143.

Yaegashi Y, Shirakawa K, Sato N et al (2005) Evaluation of a newly identified soluble CD14 subtype as a marker for sepsis. J Infect Chemother 11:234–238PubMed

144.

Yan GT, Lin J, Hao XH et al (2009) Heart-type fatty acid-binding protein is a useful marker for organ dysfunction and leptin alleviates sepsis-induced organ injuries by restraining its tissue levels. Eur J Pharmacol 616:244–250PubMed

145.

Zhang ZC, Dai HW, Yu YH et al (2012) Usefulness of heart-type fatty acid-binding protein in patients with severe sepsis. J Crit Care 27:13–18

Titel: Einsatz von Biomarkern in der Sepsis
Update und Ausblick
verfasst von: B.H. Siegler
S. Weiterer
C. Lichtenstern
D. Stumpp
T. Brenner
S. Hofer
Prof. Dr. M.A. Weigand
F. Uhle
Publikationsdatum: 01.09.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Die Anaesthesiologie / Ausgabe 8-9/2014
Print ISSN: 2731-6858
Elektronische ISSN: 2731-6866
DOI: https://doi.org/10.1007/s00101-014-2347-2

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Zusammenfassung

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Zusammenfassung

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