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Erschienen in: Gynäkologische Endokrinologie 3/2015

01.09.2015 | Leitthema

Endokrin wirkende Umweltgifte

verfasst von: PD Dr. Roxana M. Popovici

Erschienen in: Gynäkologische Endokrinologie | Ausgabe 3/2015

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Zusammenfassung

Hintergrund

Seit einigen Jahrzehnten nimmt die Belastung des Menschen durch chemische Substanzen mit endokriner Wirkung zu.

Substanzen und Wirkungen

Der Körper nimmt diese Stoffe aus der Luft, dem Wasser, durch unsere Nahrung oder über Körperpflegeartikel auf. Dabei sind konkrete Veränderungen im Organismus zunehmend nachweisbar. Die Folgen, besonders die Langzeitfolgen, sind jedoch noch nicht abzusehen. Die hormonelle Wirkung wird nur bestimmten Stoffen zugeschrieben, die aber im Gegensatz zu herkömmlichen Giften in ihrer Wirkweise deutlich komplexer sind. Über ihre Effekte auf die Keimzellbahn können sie sowohl in der empfindlichen fetalen und neonatalen Periode als auch in nachfolgenden Generationen wirken. Hier sind besonders Phthalate und Bisphenol A zu nennen.

Datenlage

Der Nachweis spezifischer hormoneller Störungen durch einzelne Substanzen erscheint überschaubar. Die Interaktion der verschiedenen Substanzen, die im Einzelnen in nur sehr geringen Mengen beim Menschen, dem Ende der Nahrungskette, nachweisbar sind, ist jedoch nur unzulänglich analysiert und auch nur schwer messbar.

Intention des Beitrags

Der Beitrag gibt eine Übersicht der bekanntesten Stoffgruppen mit endokriner Wirkung. Beschrieben werden ihre individuelle Wirkweise, das Vorkommen und einige der bisher nachgewiesenen Effekte im Tierversuch und beim Menschen.
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Metadaten
Titel
Endokrin wirkende Umweltgifte
verfasst von
PD Dr. Roxana M. Popovici
Publikationsdatum
01.09.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Gynäkologische Endokrinologie / Ausgabe 3/2015
Print ISSN: 1610-2894
Elektronische ISSN: 1610-2908
DOI
https://doi.org/10.1007/s10304-015-0020-8

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