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Erschienen in: European Archives of Psychiatry and Clinical Neuroscience 3/2016

04.09.2015 | Letter to the Editor

Ethnic differences in the serum levels of proBDNF, a precursor of brain-derived neurotrophic factor (BDNF), in mood disorders

verfasst von: Kenji Hashimoto

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 3/2016

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Excerpt

Brain-derived neurotrophic factor (BDNF), a major neurotrophic factor in the brain, plays an important role in the pathophysiology of mood disorders, such as depression and bipolar disorder (BD) [13]. BDNF (mature BDNF) is a 13-kDa polypeptide, synthesized initially as a precursor protein, preproBDNF, in the endoplasmic reticulum. Following cleavage of its signal peptide, proBDNF (~32 kDa) is converted to mature BDNF by intracellular or extracellular proteases. It was first thought that only secreted, mature BDNF possessed biological activity, and that proBDNF, which localizes intracellularly, served as an inactive precursor. However, accumulating evidence demonstrates that both proBDNF and mature BDNF are active, eliciting opposing effects via the p75NTR and TrkB receptors, respectively, and that both forms play a key role in several physiological functions [2, 3]. …
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Metadaten
Titel
Ethnic differences in the serum levels of proBDNF, a precursor of brain-derived neurotrophic factor (BDNF), in mood disorders
verfasst von
Kenji Hashimoto
Publikationsdatum
04.09.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 3/2016
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-015-0641-x

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