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Social Psychiatry and Psychiatric Epidemiology

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01.01.2015 | Original Paper

Externalizing disorders and substance use: empirically derived subtypes in a population-based sample of adults

verfasst von: Stephanie Rodgers, Mario Müller, Wulf Rössler, Enrique Castelao, Martin Preisig, Vladeta Ajdacic-Gross

Erschienen in: Social Psychiatry and Psychiatric Epidemiology | Ausgabe 1/2015

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Abstract

Purpose

Attention-deficit/hyperactivity disorder (ADHD), conduct disorder (CD), and oppositional defiant disorder (ODD) are common externalizing disorders of childhood. The common effects of these disorders on substance abuse need further investigation. The current study investigated the joint clusters of childhood/adolescence ADHD, CD, and ODD, and their influence on substance abuse/dependence in a population-based sample of adults.

Methods

The data were drawn from the PsyCoLaus study (n = 3,720) conducted in Lausanne, Switzerland. The population-based sample included 238 subjects meeting criteria for ADHD/ODD/CD diagnoses before the age of 15. Latent class analyses (LCA) were performed to derive comorbidity subtypes, which were subsequently characterized with respect to psychosocial correlates and substance use.

Results

The best fit in LCAs was achieved with three latent classes: an ADHD subtype (35.7 %); an externalizing multimorbid subtype (33.6 %) involving ODD, ADHD, and CD; and a third subtype with CD (30.7 %). The CD subtype showed the highest association with substance use. Apart from this, the externalizing multimorbid subtype was also significantly linked to substance use. The ADHD subtype had only elevated frequencies for alcohol dependence in comparison with subjects that had no history of ADHD, ODD, and CD during childhood or adolescence. Finally, important interactions between subtypes and sex were observed with regard to substance use.

Conclusions

This study provides evidence showing that subtyping the externalizing disorders, ADHD, ODD and CD, along their comorbidity patterns leads to important differences regarding substance use. This could have implications for the etiology, prevention, and treatment of substance use disorders.

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Titel: Externalizing disorders and substance use: empirically derived subtypes in a population-based sample of adults
verfasst von: Stephanie Rodgers
Mario Müller
Wulf Rössler
Enrique Castelao
Martin Preisig
Vladeta Ajdacic-Gross
Publikationsdatum: 01.01.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Social Psychiatry and Psychiatric Epidemiology / Ausgabe 1/2015
Print ISSN: 0933-7954
Elektronische ISSN: 1433-9285
DOI: https://doi.org/10.1007/s00127-014-0898-9

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Externalizing disorders and substance use: empirically derived subtypes in a population-based sample of adults

Abstract

Purpose

Methods

Results

Conclusions

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