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Erschienen in:
12.09.2015 | Originalien
Vitamin D receptor FokI, BsmI, and TaqI polymorphisms and susceptibility to rheumatoid arthritis
A meta-analysis
Erschienen in: Zeitschrift für Rheumatologie | Ausgabe 3/2016
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Objective
The aim of this study was to explore whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA).
Methods
Meta-analyses were conducted on the associations between the VDR
FokI, BsmI, and TaqI polymorphisms and RA.
Results
A total of seven studies were considered in the meta-analysis, involving a total of 923 patients and 912 controls. Meta-analysis of the VDR
FokI polymorphism showed no association between RA and the F allele in the entire studied cohort (odds ratio, OR = 1.1740, 95 % confidence interval, CI = 0.994–1.387, p = 0.059). However, stratification by ethnicity revealed a significant association between the F allele and RA in Europeans (OR = 1.402, 95 % CI = 1.126–1.746, p = 0.003). Furthermore, an association was found between RA and the VDR
FokI polymorphism using both the dominant model and homozygote contrast. Meta-analysis revealed no association between RA and the VDR BsmI B and TaqI T polymorphisms in Europeans (OR for the B allele = 1.065, 95 % CI = 0.911–1.245, p = 0.427; OR for the T allele = 1.065, 95 % CI = 0.834–1.361, p = 0.613).
Conclusion
This meta-analysis suggests that the VDR
FokI polymorphism is associated with susceptibility to RA in European populations.