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01.12.2012 | Übersichten

Genderaspekte bei koronarer Herzerkrankung

verfasst von: Dr. U. Seeland, S. Eifert, V. Regitz-Zagrosek

Erschienen in: Die Kardiologie | Ausgabe 6/2012

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Zusammenfassung

Unser medizinisches Wissen und Handeln bewusst aus einem Sex-/Gender-Blickwinkel zu betrachten, ist ein neuer Weg hin zur individualisierten Medizin und weg von der geschlechterneutralen Lehre, wie wir sie bisher in den Leitlinien finden. Wertet man Daten großer Studien nach dem Geschlecht getrennt aus, so ist es offensichtlich, dass es bedeutende Unterschiede in allen Teilbereichen der Medizin wie der Epidemiologie, der Pathophysiologie, der Klinik, Diagnostik, Therapie und Prognose gibt – so auch bei der KHK. Nachfolgend werden kardiovaskuläre Risikofaktoren, Symptome, Diagnostik, konservative und auch operative Therapieoptionen aus der Genderperspektive dargestellt, um eine größere Geschlechtergerechtigkeit und eine bessere Versorgung von Männern und Frauen mit kardiovaskulären Erkrankungen zu erreichen.

Alexander KP, Chen AY, Newby LK et al (2006) Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of unstable angina patients suppress adverse outcomes with early implementation of the ACC/AHA guidelines) initiative. Circulation 114:1380–1387PubMedCrossRef

Anand SS, Islam S, Rosengren A et al (2008) Risk factors for myocardial infarction in women and men: insights from the INTERHEART study. Eur Heart J 29:932–940PubMedCrossRef

Antman EM, Anbe DT, Armstrong PW et al (2004) ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction-executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction). Circulation 110:588–636PubMedCrossRef

Bairey Merz CN, Johnson BD, Sharaf BL et al (2003) Hypoestrogenemia of hypothalamic origin and coronary artery disease in premenopausal women: a report from the NHLBI-sponsored WISE study. J Am Coll Cardiol 41:413–419

Bairey Merz CN, Shaw LJ, Reis SE et al (2006) Insights from the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study: Part II: gender differences in presentation, diagnosis, and outcome with regard to gender-based pathophysiology of atherosclerosis and macrovascular and microvascular coronary disease. J Am Coll Cardiol 47:21–29CrossRef

Bugiardini R, Bairey Merz CN (2005) Angina with „normal“ coronary arteries: a changing philosophy. JAMA 293:477–484PubMedCrossRef

Burke AP, Farb A, Malcom GT et al (1998) Effect of risk factors on the mechanism of acute thrombosis and sudden coronary death in women. Circulation 97:2110–2116PubMedCrossRef

Castelli WP (1999) Cardiovascular disease: pathogenesis, epidemiology, and risk among users of oral contraceptives who smoke. Am J Obstet Gynecol 180:349–356CrossRef

Chobanian AV, Bakris GL, Black HR et al (2003) The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 289:2560–2572PubMedCrossRef

10.

Couillard C, Bergeron N, Prud’homme D et al (1999) Gender difference in postprandial lipemia: importance of visceral adipose tissue accumulation. Arterioscler Thromb Vasc Biol 19:2448–2455PubMedCrossRef

11.

Daviglus ML, Stamler J, Pirzada A et al (2004) Favorable cardiovascular risk profile in young women and long-term risk of cardiovascular and all-cause mortality. JAMA 292:1588–1592PubMedCrossRef

12.

Dunkel A, Kendel F, Lehmkuhl E et al (2011) Causal attributions among patients undergoing coronary artery bypass surgery: gender aspects and relation to depressive symptomatology. J Behav Med 34:351–359PubMedCrossRef

13.

Eifert S, Kilian E, Beiras-Fernandez A et al (2010) Early and mid term mortality after coronary artery bypass grafting in women depends on the surgical protocol: retrospective analysis of 3441 on- and off-pump coronary artery bypass grafting procedures. Journal of cardiothoracic surgery 5:90PubMedCrossRef

14.

Frasure-Smith N, Lesperance F, Juneau M et al (1999) Gender, depression, and one-year prognosis after myocardial infarction. Psychosom Med 61:26–37PubMed

15.

Gesundheitsberichterstattung (2000/02) MONICA/KORA Herzinfarktregister Augsburg: Letalität des Myokardinfarkt. In:Statistisches Bundesamt, Robert Koch -Institut Berlin

16.

Gibbons RJ, Abrams J, Chatterjee K et al (2003) ACC/AHA 2002 guideline update for the management of patients with chronic stable angina-summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Chronic Stable Angina). Circulation 107:149–158PubMedCrossRef

17.

Grady D, Herrington D, Bittner V et al (2002) Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II). JAMA 288:49–57PubMedCrossRef

18.

Haffner SM, Lehto S, Ronnemaa T et al (1998) Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 339:229–234PubMedCrossRef

19.

Hu FB, Stampfer MJ, Manson JE et al (2000) Trends in the incidence of coronary heart disease and changes in diet and lifestyle in women. N Engl J Med 343:530–537PubMedCrossRef

20.

Humphries KH, Kerr CR, Connolly SJ et al (2001) New-onset atrial fibrillation: sex differences in presentation, treatment, and outcome. Circulation 103:2365–2370PubMedCrossRef

21.

Jensen J, Nilas L, Christiansen C (1990) Influence of menopause on serum lipids and lipoproteins. Maturitas 12:321–331PubMedCrossRef

22.

Kamran M, Guptan A, Bogal M (2008) Spontaneous coronary artery dissection: case series and review. J Invasive Cardiol 20:553–559PubMed

23.

Kawachi I, Colditz GA, Stampfer MJ et al (1993) Smoking cessation in relation to total mortality rates in women. A prospective cohort study. Ann Intern Med 119:992–1000PubMed

24.

Kendel F, Gelbrich G, Wirtz M et al (2010) Predictive relationship between depression and physical functioning after coronary surgery. Arch Intern Med 170:1717–1721PubMedCrossRef

25.

Kessler RC, Berglund P, Demler O et al (2003) The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 289:3095–3105PubMedCrossRef

26.

Koch CG, Nussmeier NA (2003) Gender and cardiac surgery. Anesthesiology clinics of North America 21:675–689PubMedCrossRef

27.

Kothawade K, Bairey Merz CN (2011) Microvascular coronary dysfunction in women: pathophysiology, diagnosis, and management. Curr Probl Cardiol 36:291–318PubMed

28.

Lehmkuhl E, Regitz-Zagrosek V (2007) Implications of gender-specific aspects in the therapy of cardiovascular diseases. Ther Umsch 64:311–317PubMedCrossRef

29.

Levy D, Larson MG, Vasan RS et al (1996) The progression from hypertension to congestive heart failure. JAMA 275:1557–1562PubMedCrossRef

30.

Liao Y, Cooper RS, Mensah GA et al (1995) Left ventricular hypertrophy has a greater impact on survival in women than in men. Circulation 92:805–810PubMedCrossRef

31.

Lundberg V, Stegmayr B, Asplund K et al (1997) Diabetes as a risk factor for myocardial infarction: population and gender perspectives. J Intern Med 241:485–492PubMedCrossRef

32.

Mahmoodzadeh S, Eder S, Nordmeyer J et al (2006) Estrogen receptor alpha up-regulation and redistribution in human heart failure. FASEB J 20:926–934PubMedCrossRef

33.

Majumdar SR, Almasi EA, Stafford RS (2004) Promotion and prescribing of hormone therapy after report of harm by the Women’s Health Initiative. JAMA 292:1983–1988PubMedCrossRef

34.

Mallik S, Spertus JA, Reid KJ et al (2006) Depressive symptoms after acute myocardial infarction: evidence for highest rates in younger women. Arch Intern Med 166:876–883PubMedCrossRef

35.

Mendelsohn ME, Karas RH (2005) Molecular and cellular basis of cardiovascular gender differences. Science 308:1583–1587PubMedCrossRef

36.

Merz CN, Kelsey SF, Pepine CJ et al (1999) The Women’s Ischemia Syndrome Evaluation (WISE) study: protocol design, methodology and feasibility report. J Am Coll Cardiol 33:1453–1461PubMedCrossRef

37.

Mosca L, Benjamin EJ, Berra K et al (2011) Effectiveness-based guidelines for the prevention of cardiovascular disease in women–2011 update: a guideline from the american heart association. Circulation 123:1243–1262PubMedCrossRef

38.

Nanchahal K, Ashton WD, Wood DA (2000) Association between blood pressure, the treatment of hypertension, and cardiovascular risk factors in women. J Hypertens 18:833–841PubMedCrossRef

39.

O’meara E, Clayton T, Mcentegart MB et al (2007) Sex differences in clinical characteristics and prognosis in a broad spectrum of patients with heart failure: results of the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program. Circulation 115:3111–3120CrossRef

40.

Patel H, Rosengren A, Ekman I (2004) Symptoms in acute coronary syndromes: does sex make a difference? Am Heart J 148:27–33PubMedCrossRef

41.

Puskas JD, Kilgo PD, Kutner M et al (2007) Off-pump techniques disproportionately benefit women and narrow the gender disparity in outcomes after coronary artery bypass surgery. Circulation 116:192–199CrossRef

42.

Puskas JD, Kilgo PD, Lattouf OM et al (2008) Off-pump coronary bypass provides reduced mortality and morbidity and equivalent 10-year survival. The Annals of thoracic surgery 86:1139–1146, discussion 1146PubMedCrossRef

43.

Regitz-Zagrosek V (2011) Sex and gender differences in symptoms of myocardial ischaemia. Eur Heart J 32:3064–3066PubMedCrossRef

44.

Regitz-Zagrosek V, Lehmkuhl E, Hocher B et al (2004) Gender as a risk factor in young, not in old, women undergoing coronary artery bypass grafting. J Am Coll Cardiol 44:2413–2414PubMedCrossRef

45.

Regitz-Zagrosek V, Petrov G, Lehmkuhl E et al (2010) Heart transplantation in women with dilated cardiomyopathy. Transplantation 89:236–244PubMedCrossRef

46.

Reiner Z, Catapano AL, De Backer G et al (2011) ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J 32:1769–1818PubMedCrossRef

47.

Ridker PM, Cook NR, Lee IM et al (2005) A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med 352:1293–1304PubMedCrossRef

48.

Ross RL, Serock MR, Khalil RA (2008) Experimental benefits of sex hormones on vascular function and the outcome of hormone therapy in cardiovascular disease. Curr Cardiol Rev 4:309–322PubMedCrossRef

49.

Samim A, Nugent L, Mehta PK et al (2010) Treatment of angina and microvascular coronary dysfunction. Curr Treat Options Cardiovasc Med 12:355–364PubMedCrossRef

50.

Shaw LJ, Bairey Merz CN, Azziz R et al (2008) Postmenopausal women with a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: results from the National Institutes of Health-National Heart, Lung, and Blood Institute sponsored Women’s Ischemia Syndrome Evaluation. J Clin Endocrinol Metab 93:1276–1284PubMedCrossRef

51.

Shroyer AL, Grover FL, Hattler B et al (2009) On-pump versus off-pump coronary-artery bypass surgery. N Engl J Med 361:1827–1837PubMedCrossRef

52.

Singh M, Rihal CS, Gersh BJ et al (2008) Mortality differences between men and women after percutaneous coronary interventions. A 25-year, single-center experience. J Am Coll Cardiol 51:2313–2320PubMedCrossRef

53.

Solomon CG, Hu FB, Dunaif A et al (2001) Long or highly irregular menstrual cycles as a marker for risk of type 2 diabetes mellitus. JAMA 286:2421–2426PubMedCrossRef

54.

Tunstall-Pedoe H, Vanuzzo D, Hobbs M et al (2000) Estimation of contribution of changes in coronary care to improving survival, event rates, and coronary heart disease mortality across the WHO MONICA Project populations. Lancet 355:688–700PubMedCrossRef

55.

Vaccarino V (2010) Ischemic heart disease in women: many questions, few facts. Circ Cardiovasc Qual Outcomes 3:111–115PubMedCrossRef

56.

Vaccarino V, Parsons L, Every NR et al (1999) Sex-based differences in early mortality after myocardial infarction. National Registry of Myocardial Infarction 2 Participants. N Engl J Med 341:217–225PubMedCrossRef

57.

Wang F, Keimig T, He Q et al (2007) Augmented healing process in female mice with acute myocardial infarction. Gend Med 4:230–247PubMedCrossRef

58.

Yusuf S, Hawken S, Ounpuu S et al (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 364:937–952PubMedCrossRef

59.

Oertelt-Prigione S, Regitz-Zagrosek V (Hrsg) (2012) Sex and Gender Aspects in Clinical Medicine, Springer, London

Titel: Genderaspekte bei koronarer Herzerkrankung
verfasst von: Dr. U. Seeland
S. Eifert
V. Regitz-Zagrosek
Publikationsdatum: 01.12.2012
Verlag: Springer-Verlag
Erschienen in: Die Kardiologie / Ausgabe 6/2012
Print ISSN: 2731-7129
Elektronische ISSN: 2731-7137
DOI: https://doi.org/10.1007/s12181-012-0474-z

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