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05.06.2015 | Zertifizierte Fortbildung

Interstitielle Zystitis

Individuelle Kombinationstherapien erhöhen den Behandlungserfolg

verfasst von: Dr. med. Claudia Lindig-Knopke, Dr. med. Juliane Marschke, Prof. Dr. med. Ralf Tunn, Dr. med. Kathrin Beilecke

Erschienen in: gynäkologie + geburtshilfe | Ausgabe 3/2015

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Zusammenfassung

Die interstitielle Zystitis wird nach wie vor zu selten diagnostiziert. Patienten haben oft einen langen Leidensweg hinter sich, bevor die richtige Diagnose gestellt und eine erfolgversprechende Therapie eingeleitet wird. Auch wenn die Pathophysiologie noch immer nicht ganz geklärt ist, existieren multiple Behandlungsansätze.

J. P. van de Merwe, J. Nordling, P. Bouchelouche, K. Bouchelouche, M. Cervigni, L. K. Daha, S. Elneil, M. Fall, G. Hohlbrugger, P. Irwin, S. Mortensen, A. van Ophoven, J. L. Osborne, R. Peeker, B. Richter, C. Riedl, J. Sairanen, M. Tinzl, and J.-J. Wyndaele, “Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal.,” European urology, vol. 53, no. 1, pp. 60–67, Jan. 2008.PubMedCrossRef

M. Fall, A. P. Baranowski, S. Elneil, D. Engeler, J. Hughes, E. J. Messelink, F. Oberpenning, and A. C. de C Williams, “EAU guidelines on chronic pelvic pain.,” European urology, vol. 57, no. 1, pp. 35–48, Jan. 2010.

R. Peeker and M. Fall, “Toward a precise definition of interstitial cystitis: further evidence of differences in classic and nonulcer disease.,” The Journal of urology, vol. 167, no. 6, pp. 2470–2472, Jun. 2002.PubMedCrossRef

P. Hanno, A. Lin, J. Nordling, L. Nyberg, A. van Ophoven, T. Ueda, and A. Wein, “Bladder Pain Syndrome Committee of the International Consultation on Incontinence.,” Neurourology and urodynamics, vol. 29, no. 1, pp. 191–198, Jan. 2010.PubMedCrossRef

I. Offiah, S. B. McMahon, and B. A. O’Reilly, “Interstitial cystitis/bladder pain syndrome: diagnosis and management.,” International urogynecology journal, vol. 24, no. 8, pp. 1243–1256, Aug. 2013.PubMedCrossRef

K. L. Lifford and G. C. Curhan, “Prevalence of painful bladder syndrome in older women., ” Urology, vol. 73, no. 3, pp. 494–498, Mar. 2009.

S. Keay, F. Seillier-Moiseiwitsch, C.-O. Zhang, T. C. Chai, and J. Zhang, “Changes in human bladder epithelial cell gene expression associated with interstitial cystitis or antiproliferative factor treatment.,” Physiological genomics, vol. 14, no. 2, pp. 107–115, Jul. 2003.PubMedCrossRef

C. L. Parsons, “The role of the urinary epithelium in the pathogenesis of interstitial cystitis/prostatitis/urethritis.,” Urology, vol. 69, no. 4 Suppl, pp. 9–16, Apr. 2007.PubMedCrossRef

J. M. H. Teichman and R. Moldwin, “The role of the bladder surface in interstitial cystitis/painful bladder syndrome.,” The Canadian journal of urology, vol. 14, no. 4, pp. 3599–3607, Aug. 2007.PubMed

10.

O. Nazif, J. M. H. Teichman, and G. F. Gebhart, “Neural upregulation in interstitial cystitis.,“ Urology, vol. 69, no. 4 Suppl, pp. 24–33, Apr. 2007.PubMedCrossRef

11.

S. D. Smith, M. A. Wheeler, H. E. Foster, and R. M. Weiss, “Urinary nitric oxide synthase activity and cyclic GMP levels are decreased with interstitial cystitis and increased with urinary tract infections.,” The Journal of urology, vol. 155, no. 4, pp. 1432–1445, Apr. 1996.PubMedCrossRef

12.

P. Stein, M. Rajasekaran, and C. L. Parsons, “Tamm-Horsfall protein protects urothelial permeability barrier.,” Urology, vol. 66, no. 4, pp. 903–907, Oct. 2005.PubMedCrossRef

13.

T. L. Ratliff, C. G. Klutke, M. Hofmeister, F. He, J. H. Russell, and M. J. Becich, “Role of the immune response in interstitial cystitis.,” Clinical immunology and immunopathology, vol. 74, no. 3, pp. 209–216, Mar. 1995.PubMedCrossRef

14.

J. W. Warren, T. L. Jackson, P. Langenberg, D. J. Meyers, and J. Xu, “Prevalence of interstitial cystitis in first-degree relatives of patients with interstitial cystitis.,” Urology, vol. 63, no. 1, pp. 17–21, Jan. 2004.PubMedCrossRef

15.

J. W. Warren, S. K. Keay, D. Meyers, and J. Xu, “Concordance of interstitial cystitis in monozygotic and dizygotic twin pairs.,” Urology, vol. 57, no. 6 Suppl 1, pp. 22–25, Jun. 2001.PubMedCrossRef

16.

D. Porru, R. Politanò, M. Gerardini, G. L. Giliberto, S. Stancati, L. Pasini, C. Tinelli, and B. Rovereto, “Different clinical presentation of interstitial cystitis syndrome.,” International urogynecology journal and pelvic floor dysfunction, vol. 15, no. 3, pp. 198-202.

17.

R. Braunstein, E. Shapiro, J. Kaye, and R. Moldwin, “The role of cystoscopy in the diagnosis of Hunner’s ulcer disease.,” The Journal of urology, vol. 180, no. 4, pp. 1383–1386, Oct. 2008.PubMedCrossRef

18.

K. Aihara, A. Hirayama, N. Tanaka, K. Fujimoto, K. Yoshida, and Y. Hirao, “Hydrodistension under local anesthesia for patients with suspected painful bladder syndrome/interstitial cystitis: safety, diagnostic potential and therapeutic efficacy.,” International journal of urology: official journal of the Japanese Urological Association, vol. 16, no. 12, pp. 947–952, Dec. 2009.CrossRef

19.

D. N. Sastry, K. M. Hunter, and K. E. Whitmore, “Urodynamic testing and interstitial cystitis/painful bladder syndrome.,” International urogynecology journal, vol. 21, no. 2, pp. 157–161, Feb. 2010.PubMedCrossRef

20.

R. Taneja, “Intravesical lignocaine in the diagnosis of bladder pain syndrome.,” International urogynecology journal, vol. 21, no. 3, pp. 321–324, Mar. 2010.PubMedCrossRef

21.

N. Geurts, J. Van Dyck, and J.-J. Wyndaele, “Bladder pain syndrome: do the different morphological and cystoscopic features correlate?,” Scandinavian journal of urology and nephrology, vol. 45, no. 1, pp. 20–23, Feb. 2011.PubMedCrossRef

22.

P. J. Hauser, M. G. Dozmorov, B. L. Bane, G. Slobodov, D. J. Culkin, and R. E. Hurst, “Abnormal expression of differentiation related proteins and proteoglycan core proteins in the urothelium of patients with interstitial cystitis.,” The Journal of urology, vol. 179, no. 2, pp. 764–769, Feb. 2008.PubMedCentralPubMedCrossRef

23.

F. M. E. Wagenlehner, G. Schmiemann, U. Hoyme, R. Fünfstück, E. Hummers-Pradier, M. Kaase, E. Kniehl, I. Selbach, U. Sester, W. Vahlensieck, D. Watermann, and K. G. Naber, “[National S3 guideline on uncomplicated urinary tract infection: recommendations for treatment and management of uncomplicated community-acquired bacterial urinary tract infections in adult patients].,” Der Urologe. Ausg. A, vol. 50, no. 2, pp. 153–169, Feb. 2011.PubMedCrossRef

24.

D. G. Moriel and M. A. Schembri, “Vaccination approaches for the prevention of urinary tract infection.,” Current pharmaceutical biotechnology, vol. 14, no. 11, pp. 967–974, Jan. 2013.PubMedCrossRef

25.

B. Kranjčec, D. Papeš, and S. Altarac, “D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial.,” World journal of urology, vol. 32, no. 1, pp. 79–84, Feb. 2014.PubMedCrossRef

26.

F. Vicariotto, “Effectiveness of an association of a cranberry dry extract, D-mannose, and the two microorganisms Lactobacillus plantarum LP01 and Lactobacillus paracasei LPC09 in women affected by cystitis: a pilot study.,” Journal of clinical gastroenterology, vol. 48 Suppl 1, pp. S96-101.

27.

G. C. Curhan, F. E. Speizer, D. J. Hunter, S. G. Curhan, and M. J. Stampfer, “Epidemiology of interstitial cystitis: a population based study.,” The Journal of urology, vol. 161, no. 2, pp. 549–552, Feb. 1999.PubMedCrossRef

28.

J. F. Metts, “Interstitial cystitis: urgency and frequency syndrome.,” American family physician, vol. 64, no. 7, pp. 1199–1206, Oct. 2001.PubMed

29.

J. Q. Clemens, E. A. Calhoun, M. S. Litwin, E. Walker-Corkery, T. Markossian, J. W. Kusek, and M. McNaughton-Collins, “A survey of primary care physician practices in the diagnosis and management of women with interstitial cystitis/painful bladder syndrome.,” Urology, vol. 76, no. 2, pp. 323–328, Aug. 2010.PubMedCentralPubMedCrossRef

30.

G. Palleschi, A. Carbone, A. Ripoli, L. Silvestri, V. Petrozza, P. P. Zanello, and A. L. Pastore, “A prospective study to evaluate the efficacy of Cistiquer in improving lower urinary tract symptoms in females with urethral syndrome.,” Minerva urologica e nefrologica = The Italian journal of urology and nephrology, vol. 66, no. 4, pp. 225–232, Dec. 2014.PubMed

31.

S. Weinschenk, “Neuraltherapie in der Gynäkologie. Evidenz und Perspektiven der Therapie mit Lokalanästhetika,” Der Gynäkologe, pp. 48:20–27, 2015.CrossRef

32.

R. Anderson, D. Wise, T. Sawyer, and B. H. Nathanson, “Safety and effectiveness of an internal pelvic myofascial trigger point wand for urologic chronic pelvic pain syndrome.,” The Clinical journal of pain, vol. 27, no. 9, pp. 764-8.

33.

M. A. Colaco and R. J. Evans, “Current recommendations for bladder instillation therapy in the treatment of interstitial cystitis/bladder pain syndrome.,” Current urology reports, vol. 14, no. 5, pp. 442–447, Oct. 2013PubMedCrossRef

34.

J. Neuhaus and T. Schwalenberg, “Intravesical treatments of bladder pain syndrome/interstitial cystitis.,” Nature reviews. Urology, vol. 9, no. 12, pp. 707–720, Dec. 2012.PubMed

35.

L. A. Birder, A. J. Kanai, and W. C. de Groat, “DMSO: effect on bladder afferent neurons and nitric oxide release.,” The Journal of urology, vol. 158, no. 5, pp. 1989–1995, Nov. 1997.PubMedCrossRef

36.

R. Kim, W. Liu, X. Chen, K. J. Kreder, and Y. Luo, “Intravesical dimethyl sulfoxide inhibits acute and chronic bladder inflammation in transgenic experimental autoimmune cystitis models.,” Journal of biomedicine & biotechnology, vol. 2011, p. 937061, Jan. 2011.

37.

K. Shiga, K. Hirano, J. Nishimura, N. Niiro, S. Naito, and H. Kanaide, “Dimethyl sulphoxide relaxes rabbit detrusor muscle by decreasing the Ca2+ sensitivity of the contractile apparatus.,” British journal of pharmacology, vol. 151, no. 7, pp. 1014–1024, Aug. 2007PubMedCentralPubMedCrossRef

38.

K. Stav, I. Beberashvili, A. Lindner, and D. Leibovici, “Predictors of response to intravesical dimethyl-sulfoxide cocktail in patients with interstitial cystitis.,” Urology, vol. 80, no. 1, pp. 61–65, Jul. 2012.PubMedCrossRef

39.

S. W. Shirley, B. H. Stewart, and S. Mirelman, “Dimethyl sulfoxide in treatment of inflammatory genitourinary disorders.,” Urology, vol. 11, no. 3, pp. 215–220, Mar. 1978.PubMedCrossRef

40.

G. R. Sant and D. R. LaRock, “Standard intravesical therapies for interstitial cystitis.,” The Urologic clinics of North America, vol. 21, no. 1, pp. 73–83, Feb. 1994.PubMed

41.

K. D. Kyker, J. Coffman, and R. E. Hurst, “Exogenous glycosaminoglycans coat damaged bladder surfaces in experimentally damaged mouse bladder.,” BMC urology, vol. 5, p. 4, Jan. 2005.PubMedCentralPubMedCrossRef

42.

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44.

B. Shapiro, T. L. Redman, and P. Zvara, “Effects of vitamin D analog on bladder function and sensory signaling in animal models of cystitis.,” Urology, vol. 81, no. 2, pp. 466.e1-7, Feb. 2013.PubMedCrossRef

45.

R. Pinto, T. Lopes, J. Silva, C. Silva, P. Dinis, and F. Cruz, “Persistent therapeutic effect of repeated injections of onabotulinum toxin a in refractory bladder pain syndrome/interstitial cystitis.,” The Journal of urology, vol. 189, no. 2, pp. 548–553, Feb. 2013.PubMedCrossRef

46.

R. Pinto, T. Lopes, D. Costa, S. Barros, J. Silva, C. Silva, C. Cruz, P. Dinis, and F. Cruz, “Ulcerative and nonulcerative forms of bladder pain syndrome/interstitial cystitis do not differ in symptom intensity or response to onabotulinum toxin A.,” Urology, vol. 83, no. 5, pp. 1030–1034, May 2014.PubMedCrossRef

47.

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Titel: Interstitielle Zystitis
Individuelle Kombinationstherapien erhöhen den Behandlungserfolg
verfasst von: Dr. med. Claudia Lindig-Knopke
Dr. med. Juliane Marschke
Prof. Dr. med. Ralf Tunn
Dr. med. Kathrin Beilecke
Publikationsdatum: 05.06.2015
Verlag: Urban & Vogel
Erschienen in: gynäkologie + geburtshilfe / Ausgabe 3/2015
Print ISSN: 1439-3557
Elektronische ISSN: 2196-6435
DOI: https://doi.org/10.1007/s15013-015-0596-z

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