Erschienen in:
01.03.2015 | Schwerpunkt
K-complex amplitude as a marker of sleep homeostasis in obstructive sleep apnea syndrome and healthy controls
verfasst von:
S. Parapatics, P. Anderer, G. Gruber, B. Saletu, G. Saletu-Zyhlarz, G. Dorffner
Erschienen in:
Somnologie
|
Ausgabe 1/2015
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Abstract
Background
Numerous studies indicate that K-complexes (KC), like slow waves, appear to be homeostatically regulated. In comparison to healthy controls, patients suffering from obstructive sleep apnea syndrome (OSAS) show a different time course of slow wave activity (SWA), enhanced sleep pressure, and impaired restorative sleep function.
Objective
The main goal of this study was to investigate homeostatic sleep regulation based on KC amplitude in sleep stage 2 in OSAS, prior to and under continuous positive airway pressure (CPAP) treatment.
Subjects and methods
The study participants comprised 22 patients suffering from OSAS (mean age of 59.7 years) and 22 age- and gender-matched healthy controls selected from the SIESTA database (mean age 59.3 years). Patients had one polysomnography (PSG) night before the start of CPAP treatment and one after 3–6 months of treatment. KC detection in sleep stage 2 was based on a validated automatic KC detection algorithm.
Results
As expected, in untreated patients, the KC amplitudes did not decrease significantly during the course of the night. However, under CPAP treatment we observed a significant decrease in KC amplitudes from the first to the fourth quarter of the night, similar to healthy controls.
Conclusion
The present study confirms that KC amplitude can be considered as a marker for sleep homeostasis in healthy controls and patients.