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Erschienen in: Journal of Neurology 11/2015

01.11.2015 | Original Communication

Late-life memory trajectories in relation to incident dementia and regional brain atrophy

verfasst von: Laura B. Zahodne, Melanie M. Wall, Nicole Schupf, Richard Mayeux, Jennifer J. Manly, Yaakov Stern, Adam M. Brickman

Erschienen in: Journal of Neurology | Ausgabe 11/2015

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Abstract

The trajectory, or slope, of cognitive decline may provide differentiation of older adults with and without incipient neurodegenerative disease. Cognitive aging phenotypes based on memory trajectories could be used as outcome measures for clinical trials or observational studies of risk and protective factors for dementia. This study used growth mixture modeling (GMM) to identify trajectory groups based on age- and education-corrected composite memory scores derived from immediate, delayed and recognition trials of the Selective Reminding Test. Participants included 2593 participants initially without dementia (mean age at entry = 76) in a community-based study of aging and dementia in northern Manhattan. Trajectory groups were compared on consensus diagnoses of dementia and structural MRI measures of hippocampal volume and entorhinal cortical thickness. Heterogeneity in memory trajectories allowed us to identify four groups: Stable-High (43.5 %), Stable-Low (17.1 %), Decliner (26.8 %), and Rapid Decliner (12.5 %). Decliners had more brain atrophy and higher rates of conversion to dementia. This study highlights the heterogeneity in cognitive aging and provides evidence that most elderly maintain memory function as they age. Associations with dementia and imaging measures validate subgroups of older adults identified with GMM based on their memory trajectories. Future research should use these memory trajectory phenotypes to determine whether dementia risk and protective factors differ for individuals following different memory trajectories.
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Metadaten
Titel
Late-life memory trajectories in relation to incident dementia and regional brain atrophy
verfasst von
Laura B. Zahodne
Melanie M. Wall
Nicole Schupf
Richard Mayeux
Jennifer J. Manly
Yaakov Stern
Adam M. Brickman
Publikationsdatum
01.11.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Neurology / Ausgabe 11/2015
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-015-7871-8

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