Epidemiologie des Kreislaufstillstands in Europa

1.

Grasner JT, Wnent J, Herlitz J et al (2020) Survival after out-of-hospital cardiac arrest in Europe—Results of the EuReCa TWO study. Resuscitation 148:218–226PubMed

2.

Andersen LW, Holmberg MJ, Berg KM, Donnino MW, Granfeldt A (2019) In-hospital cardiac arrest: a review. JAMA 321:1200–1210PubMedPubMedCentral

3.

Kiguchi T, Okubo M, Nishiyama C et al (2020) Out-of-hospital cardiac arrest across the World: First report from the International Liaison Committee on Resuscitation (ILCOR). Resuscitation 152:39–49PubMed

4.

Perkins GD, Brace-McDonnell SJ, Group OP. (2015) The UK Out of Hospital Cardiac Arrest Outcome (OHCAO) project. BMJ Open 5:e8736PubMedPubMedCentral

5.

Cummins RO, Chamberlain DA, Abramson NS et al (1991) Recommended guidelines for uniform reporting of data from out-of-hospital cardiac arrest: the Utstein Style. A statement for health professionals from a task force of the American Heart Association, the European Resuscitation Council, the Heart and Stroke Foundation of Canada, and the Australian Resuscitation Council. Circulation 84:960–975PubMed

6.

Perkins GD, Jacobs IG, Nadkarni VM et al (2015) Cardiac Arrest and Cardiopulmonary Resuscitation Outcome Reports: Update of the Utstein Resuscitation Registry Templates for Out-of-Hospital Cardiac Arrest: A Statement for Healthcare Professionals From a Task Force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian and New Zealand Council on Resuscitation, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Southern Africa, Resuscitation Council of Asia); and the American Heart Association Emergency Cardiovascular Care Committee and the Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation. Resuscitation 96:328–340PubMed

7.

Merchant RM, Yang L, Becker LB et al (2011) Incidence of treated cardiac arrest in hospitalized patients in the United States. Crit Care Med 39:2401–2406PubMedPubMedCentral

8.

Benjamin EJ, Virani SS, Callaway CW et al (2018) Heart disease and stroke statistics-2018 update: a report from the American Heart Association. Circulation 137:e67–e492PubMed

9.

Nolan JP, Soar J, Smith GB et al (2014) Incidence and outcome of in-hospital cardiac arrest in the United Kingdom National Cardiac Arrest Audit. Resuscitation 85:987–992PubMed

10.

Andersen LW, Holmberg MJ, Lofgren B, Kirkegaard H, Granfeldt A (2019) Adult in-hospital cardiac arrest in Denmark. Resuscitation 140:31–36PubMed

11.

Ong ME, Shin SD, De Souza NN et al (2015) Outcomes for out-of-hospital cardiac arrests across 7 countries in Asia: the Pan Asian Resuscitation Outcomes Study (PAROS). Resuscitation 96:100–108PubMed

12.

Beck B, Bray J, Cameron P et al (2018) Regional variation in the characteristics, incidence and outcomes of out-of-hospital cardiac arrest in Australia and New Zealand: Results from the Aus-ROC Epistry. Resuscitation 126:49–57PubMed

13.

Perkins GD, Gräsner J-T, Semeraro F et al (2021) Kurzfassung. Leitlinien des European Resuscitation Council 2021. Notfall Rettungsmed. https://doi.org/10.1007/s10049-021-00883-zCrossRef

14.

Grasner JT, Lefering R, Koster RW et al (2016) EuReCa ONE-27 Nations, ONE Europe, ONE Registry: a prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe. Resuscitation 105:188–195CrossRefPubMed

15.

Danielis M, Chittaro M, De Monte A, Trillo G, Duri D (2019) A five-year retrospective study of out-of-hospital cardiac arrest in a north-east Italian urban area. Eur J Cardiovasc Nurs 18:67–74PubMed

16.

Gach D, Nowak JU, Krzych LJ (2016) Epidemiology of out-of-hospital cardiac arrest in the Bielsko-Biala district: a 12-month analysis. Kardiol Pol 74:1180–1187PubMed

17.

Hawkes C, Booth S, Ji C et al (2017) Epidemiology and outcomes from out-of-hospital cardiac arrests in England. Resuscitation 110:133–140PubMed

18.

Mauri R, Burkart R, Benvenuti C et al (2016) Better management of out-of-hospital cardiac arrest increases survival rate and improves neurological outcome in the Swiss Canton Ticino. Europace 18:398–404PubMed

19.

Requena-Morales R, Palazon-Bru A, Rizo-Baeza MM, Adsuar-Quesada JM, Gil-Guillen VF, Cortes-Castell E (2017) Mortality after out-of-hospital cardiac arrest in a Spanish Region. PLoS ONE 12:e175818PubMedPubMedCentral

20.

Soholm H, Hassager C, Lippert F et al (2015) Factors associated with successful resuscitation after out-of-hospital cardiac arrest and temporal trends in survival and comorbidity. Ann Emerg Med 65:523–31e2PubMed

21.

Rosell-Ortiz F, Escalada-Roig X, Fernandez Del Valle P et al (2017) Out-of-hospital cardiac arrest (OHCA) attended by mobile emergency teams with a physician on board. Results of the Spanish OHCA Registry (OSHCAR). Resuscitation 113:90–95PubMed

22.

Tjelmeland IBM, Alm-Kruse K, Andersson LJ et al (2020) Cardiac arrest as a reportable condition: a cohort study of the first 6 years of the Norwegian out-of-hospital cardiac arrest registry. BMJ Open 10:e38133PubMedPubMedCentral

23.

Lee SCL, Mao DR, Ng YY et al (2020) Emergency medical dispatch services across Pan-Asian countries: a web-based survey. BMC Emerg Med 20:1PubMedPubMedCentral

24.

Sun KM, Song KJ, Shin SD et al (2017) Comparison of emergency medical services and trauma care systems among pan-asian countries: an international, multicenter, population-based survey. Prehosp Emerg Care 21:242–251PubMed

25.

Davis DP, Garberson LA, Andrusiek DL et al (2007) A descriptive analysis of Emergency Medical Service Systems participating in the Resuscitation Outcomes Consortium (ROC) network. Prehosp Emerg Care 11:369–382PubMed

26.

Govindarajan P, Lin L, Landman A et al (2012) Practice variability among the EMS systems participating in Cardiac Arrest Registry to Enhance Survival (CARES). Resuscitation 83:76–80PubMed

27.

Oving I, Masterson S, Tjelmeland IBM et al (2019) First-response treatment after out-of-hospital cardiac arrest: a survey of current practices across 29 countries in Europe. Scand J Trauma Resusc Emerg Med 27:112PubMedPubMedCentral

28.

Nolan JP, Soar J, Cariou A et al (2015) European Resuscitation Council and European Society of Intensive Care Medicine Guidelines for Post-resuscitation Care 2015: Section 5 of the European Resuscitation Council Guidelines for Resuscitation 2015. Resuscitation 95:202–222PubMed

29.

Aissaoui N, Bougouin W, Dumas F et al (2018) Age and benefit of early coronary angiography after out-of-hospital cardiac arrest in patients presenting with shockable rhythm: Insights from the Sudden Death Expertise Center registry. Resuscitation 128:126–131PubMed

30.

Cronier P, Vignon P, Bouferrache K et al (2011) Impact of routine percutaneous coronary intervention after out-of-hospital cardiac arrest due to ventricular fibrillation. Crit Care 15:R122PubMedPubMedCentral

31.

Demirel F, Rasoul S, Elvan A et al (2015) Impact of out-of-hospital cardiac arrest due to ventricular fibrillation in patients with ST-elevation myocardial infarction admitted for primary percutaneous coronary intervention: Impact of ventricular fibrillation in STEMI patients. Eur Heart J Acute Cardiovasc Care 4:16–23PubMed

32.

Dumas F, Bougouin W, Geri G et al (2016) Emergency percutaneous coronary intervention in post-cardiac arrest patients without ST-segment elevation pattern: insights from the PROCAT II registry. JACC Cardiovasc Interv 9:1011–1018PubMed

33.

Geri G, Dumas F, Bougouin W et al (2015) Immediate percutaneous coronary intervention is associated with improved short- and long-term survival after out-of-hospital cardiac arrest. Circ Cardiovasc Interv 8. https://doi.org/10.1161/CIRCINTERVENTIONS.114.002303

34.

Grasner JT, Meybohm P, Caliebe A et al (2011) Postresuscitation care with mild therapeutic hypothermia and coronary intervention after out-of-hospital cardiopulmonary resuscitation: a prospective registry analysis. Crit Care 15:R61PubMedPubMedCentral

35.

Lemkes JS, Janssens GN, van der Hoeven NW et al (2019) Coronary angiography after cardiac arrest without ST-segment elevation. N Engl J Med 380:1397–1407PubMed

36.

Tranberg T, Lippert FK, Christensen EF et al (2017) Distance to invasive heart centre, performance of acute coronary angiography, and angioplasty and associated outcome in out-of-hospital cardiac arrest: a nationwide study. Eur Heart J 38:1645–1652PubMedPubMedCentral

37.

Vadeboncoeur TF, Chikani V, Hu C, Spaite DW, Bobrow BJ (2018) Association between coronary angiography with or without percutaneous coronary intervention and outcomes after out-of-hospital cardiac arrest. Resuscitation 127:21–25PubMed

38.

Wnent J, Seewald S, Heringlake M et al (2012) Choice of hospital after out-of-hospital cardiac arrest—a decision with far-reaching consequences: a study in a large German city. Crit Care 16:R164PubMedPubMedCentral

39.

Greif R (2020) Education, implementation, and teams 2020 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation 156:A188–A239. https://doi.org/10.1016/j.resuscitation.2020.09.014

40.

von Vopelius-Feldt J, Brandling J, Benger J (2017) Systematic review of the effectiveness of prehospital critical care following out-of-hospital cardiac arrest. Resuscitation 114:40–46

41.

Bottiger BW, Bernhard M, Knapp J, Nagele P (2016) Influence of EMS-physician presence on survival after out-of-hospital cardiopulmonary resuscitation: systematic review and meta-analysis. Crit Care 20:4PubMedPubMedCentral

42.

Zive D, Koprowicz K, Schmidt T et al (2011) Variation in out-of-hospital cardiac arrest resuscitation and transport practices in the Resuscitation Outcomes Consortium: ROC Epistry-Cardiac Arrest. Resuscitation 82:277–284PubMed

43.

Okubo M, Schmicker RH, Wallace DJ et al (2018) Variation in survival after out-of-hospital cardiac arrest between emergency medical services agencies. JAMA Cardiol 3:989–999PubMed

44.

Nikolaou N, Castren M, Monsieurs KG et al (2017) Time delays to reach dispatch centres in different regions in Europe. Are we losing the window of opportunity?—The EUROCALL study. Resuscitation 111:8–13PubMed

45.

Ageron FX, Debaty G, Gayet-Ageron A et al (2016) Impact of an emergency medical dispatch system on survival from out-of-hospital cardiac arrest: a population-based study. Scand J Trauma Resusc Emerg Med 24:53PubMedPubMedCentral

46.

Considine J, Gazmuri RJ, Perkins GD et al (2020) Chest compression components (rate, depth, chest wall recoil and leaning): a scoping review. Resuscitation 146:188–202PubMed

47.

Newman MM (1989) Chain of Survival concept takes hold. J Emerg Med Serv 14:11–13

48.

Cummins RO, Ornato JP, Thies WH, Pepe PE (1991) Improving survival from sudden cardiac arrest: the “chain of survival” concept. A statement for health professionals from the Advanced Cardiac Life Support Subcommittee and the Emergency Cardiac Care Committee, American Heart Association. Circulation 83:1832–1847PubMed

49.

Hasselqvist-Ax I, Riva G, Herlitz J et al (2015) Early cardiopulmonary resuscitation in out-of-hospital cardiac arrest. N Engl J Med 372:2307–2315PubMed

50.

Christensen DM, Rajan S, Kragholm K et al (2019) Bystander cardiopulmonary resuscitation and survival in patients with out-of-hospital cardiac arrest of non-cardiac origin. Resuscitation 140:98–105PubMed

51.

Bottiger BW, Lockey A, Aickin R et al (2018) “All citizens of the world can save a life”—The World Restart a Heart (WRAH) initiative starts in 2018. Resuscitation 128:188–190PubMed

52.

Olasveengen TM, Mancini ME, Perkins GD et al (2020) Adult basic life support: 2020 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Circulation 142:S41–S91PubMed

53.

Maurer H, Masterson S, Tjelmeland IB et al (2019) When is a bystander not a bystander any more? A European survey. Resuscitation 136:78–84PubMed

54.

Blom MT, Beesems SG, Homma PC et al (2014) Improved survival after out-of-hospital cardiac arrest and use of automated external defibrillators. Circulation 130:1868–1875PubMed

55.

Zijlstra JA, Stieglis R, Riedijk F, Smeekes M, van der Worp WE, Koster RW (2014) Local lay rescuers with AEDs, alerted by text messages, contribute to early defibrillation in a Dutch out-of-hospital cardiac arrest dispatch system. Resuscitation 85:1444–1449PubMed

56.

Claesson A, Herlitz J, Svensson L et al (2017) Defibrillation before EMS arrival in western Sweden. Am J Emerg Med 35:1043–1048PubMed

57.

Agerskov M, Nielsen AM, Hansen CM et al (2015) Public Access Defibrillation: great benefit and potential but infrequently used. Resuscitation 96:53–58PubMed

58.

Claesson A, Fredman D, Svensson L et al (2016) Unmanned aerial vehicles (drones) in out-of-hospital-cardiac-arrest. Scand J Trauma Resusc Emerg Med 24:124PubMedPubMedCentral

59.

Caputo ML, Muschietti S, Burkart R et al (2017) Lay persons alerted by mobile application system initiate earlier cardio-pulmonary resuscitation: a comparison with SMS-based system notification. Resuscitation 114:73–78PubMed

60.

Berglund E, Claesson A, Nordberg P et al (2018) A smartphone application for dispatch of lay responders to out-of-hospital cardiac arrests. Resuscitation 126:160–165PubMed

61.

Sarkisian L, Mickley H, Schakow H et al (2020) Global positioning system alerted volunteer first responders arrive before emergency medical services in more than four out of five emergency calls. Resuscitation 152:170–176PubMed

62.

Verbrugghe M, De Ridder M, Kalaai M, Mortelmans K, Calle P, Braeckman L (2018) Presence and use of automated external defibrillators in occupational setting, Belgium. Int J Occup Med Environ Health 31:603–611PubMed

63.

Monsieurs KG, Nolan JP, Bossaert LL et al (2015) European resuscitation council guidelines for resuscitation 2015: section 1. Executive summary. Resuscitation 95:1–80PubMed

64.

Yan S, Gan Y, Jiang N et al (2020) The global survival rate among adult out-of-hospital cardiac arrest patients who received cardiopulmonary resuscitation: a systematic review and meta-analysis. Crit Care 24:61PubMedPubMedCentral

65.

Luc G, Baert V, Escutnaire J et al (2019) Epidemiology of out-of-hospital cardiac arrest: A French national incidence and mid-term survival rate study. Anaesth Crit Care Pain Med 38:131–135PubMed

66.

Masterson S, Stromsoe A, Cullinan J, Deasy C, Vellinga A (2018) Apples to apples: can differences in out-of-hospital cardiac arrest incidence and outcomes between Sweden and Ireland be explained by core Utstein variables? Scand J Trauma Resusc Emerg Med 26:37PubMedPubMedCentral

67.

Blom MT, Oving I, Berdowski J, van Valkengoed IGM, Bardai A, Tan HL (2019) Women have lower chances than men to be resuscitated and survive out-of-hospital cardiac arrest. Eur Heart J 40:3824–3834PubMedPubMedCentral

68.

Nehme Z, Andrew E, Bernard S, Smith K (2019) Sex differences in the quality-of-life and functional outcome of cardiac arrest survivors. Resuscitation 137:21–28PubMed

69.

Andrew E, Nehme Z, Lijovic M, Bernard S, Smith K (2014) Outcomes following out-of-hospital cardiac arrest with an initial cardiac rhythm of asystole or pulseless electrical activity in Victoria, Australia. Resuscitation 85:1633–1639PubMed

70.

Dumas F, Rea TD (2012) Long-term prognosis following resuscitation from out-of-hospital cardiac arrest: role of aetiology and presenting arrest rhythm. Resuscitation 83:1001–1005PubMed

71.

Mader TJ, Nathanson BH, Millay S et al (2012) Out-of-hospital cardiac arrest outcomes stratified by rhythm analysis. Resuscitation 83:1358–1362PubMed

72.

Sasson C, Rogers MA, Dahl J, Kellermann AL (2010) Predictors of survival from out-of-hospital cardiac arrest: a systematic review and meta-analysis. Circ Cardiovasc Qual Outcomes 3:63–81PubMed

73.

Andrew E, Nehme Z, Bernard S, Smith K (2017) The influence of comorbidity on survival and long-term outcomes after out-of-hospital cardiac arrest. Resuscitation 110:42–47PubMed

74.

Hirlekar G, Jonsson M, Karlsson T, Hollenberg J, Albertsson P, Herlitz J (2018) Comorbidity and survival in out-of-hospital cardiac arrest. Resuscitation 133:118–123PubMed

75.

Herlitz J, Eek M, Holmberg M, Engdahl J, Holmberg S (2002) Characteristics and outcome among patients having out of hospital cardiac arrest at home compared with elsewhere. Heart 88:579–582PubMedPubMedCentral

76.

Iwami T, Hiraide A, Nakanishi N et al (2006) Outcome and characteristics of out-of-hospital cardiac arrest according to location of arrest: a report from a large-scale, population-based study in Osaka, Japan. Resuscitation 69:221–228PubMed

77.

Brown TP, Booth S, Hawkes CA et al (2019) Characteristics of neighbourhoods with high incidence of out-of-hospital cardiac arrest and low bystander cardiopulmonary resuscitation rates in England. Eur Heart J Qual Care Clin Outcomes 5:51–62PubMed

78.

Jonsson M, Harkonen J, Ljungman P et al (2019) Survival after out-of-hospital cardiac arrest is associated with area-level socioeconomic status. Heart 105:632–638PubMed

79.

Zhao D, Post WS, Blasco-Colmenares E et al (2019) Racial differences in sudden cardiac death. Circulation 139:1688–1697PubMedPubMedCentral

80.

Chocron R, Loeb T, Lamhaut L et al (2019) Ambulance density and outcomes after out-of-hospital cardiac arrest. Circulation 139:1262–1271PubMed

81.

Yeung J, Matsuyama T, Bray J, Reynolds J, Skrifvars MB (2019) Does care at a cardiac arrest centre improve outcome after out-of-hospital cardiac arrest?—a systematic review. Resuscitation 137:102–115PubMed

82.

Khera R, CarlLee S, Blevins A, Schweizer M, Girotra S (2018) Early coronary angiography and survival after out-of-hospital cardiac arrest: a systematic review and meta-analysis. Open Heart 5:e809PubMedPubMedCentral

83.

Arrich J, Holzer M, Havel C, Mullner M, Herkner H (2016) Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD004128.pub4CrossRefPubMedPubMedCentral

84.

Kirkegaard H, Soreide E, de Haas I et al (2017) Targeted temperature management for 48 vs 24 hours and neurologic outcome after out-of-hospital cardiac arrest: a randomized clinical trial. JAMA 318:341–350PubMedPubMedCentral

85.

Lascarrou JB, Merdji H, Le Gouge A et al (2019) Targeted temperature management for cardiac arrest with nonshockable rhythm. N Engl J Med 381:2327–2337PubMed

86.

Schenone AL, Cohen A, Patarroyo G et al (2016) Therapeutic hypothermia after cardiac arrest: a systematic review/meta-analysis exploring the impact of expanded criteria and targeted temperature. Resuscitation 108:102–110PubMed

87.

Balian S, Buckler DG, Blewer AL, Bhardwaj A, Abella BS, Group CS. (2019) Variability in survival and post-cardiac arrest care following successful resuscitation from out-of-hospital cardiac arrest. Resuscitation 137:78–86PubMed

88.

Stub D, Schmicker RH, Anderson ML et al (2015) Association between hospital post-resuscitative performance and clinical outcomes after out-of-hospital cardiac arrest. Resuscitation 92:45–52PubMed

89.

Soholm H, Wachtell K, Nielsen SL et al (2013) Tertiary centres have improved survival compared to other hospitals in the Copenhagen area after out-of-hospital cardiac arrest. Resuscitation 84:162–167PubMed

90.

Stub D, Smith K, Bray JE, Bernard S, Duffy SJ, Kaye DM (2011) Hospital characteristics are associated with patient outcomes following out-of-hospital cardiac arrest. Heart 97:1489–1494PubMed

91.

Worthington H, Pickett W, Morrison LJ et al (2017) The impact of hospital experience with out-of-hospital cardiac arrest patients on post cardiac arrest care. Resuscitation 110:169–175PubMed

92.

Iwami T, Nichol G, Hiraide A et al (2009) Continuous improvements in “chain of survival” increased survival after out-of-hospital cardiac arrests: a large-scale population-based study. Circulation 119:728–734PubMed

93.

Koyama S, Gibo K, Yamaguchi Y, Okubo M (2019) Variation in survival after out-of-hospital cardiac arrest between receiving hospitals in Japan: an observational study. BMJ Open 9:e33919PubMedPubMedCentral

94.

Stromsoe A, Svensson L, Axelsson AB et al (2015) Improved outcome in Sweden after out-of-hospital cardiac arrest and possible association with improvements in every link in the chain of survival. Eur Heart J 36:863–871PubMed

95.

Wissenberg M, Lippert FK, Folke F et al (2013) Association of national initiatives to improve cardiac arrest management with rates of bystander intervention and patient survival after out-of-hospital cardiac arrest. JAMA 310:1377–1384PubMed

96.

Moller SG, Wissenberg M, Moller-Hansen S et al (2020) Regional variation in out-of-hospital cardiac arrest: Incidence and survival—A nationwide study of regions in Denmark. Resuscitation 148:191–199PubMed

97.

Pasupula DK, Bhat AG, Meera SJ, Siddappa Malleshappa SK (2019) Influence of comorbidity on survival after out-of-hospital cardiac arrest in the United States. Resuscitation 145:21–25PubMed

98.

Perkins GD, Ji C, Deakin CD et al (2018) A randomized trial of epinephrine in out-of-hospital cardiac arrest. N Engl J Med 379:711–721PubMed

99.

Riva G, Ringh M, Jonsson M et al (2019) Survival in out-of-hospital cardiac arrest after standard cardiopulmonary resuscitation or chest compressions only before arrival of emergency medical services: nationwide study during three guideline periods. Circulation. https://doi.org/10.1161/CIRCULATIONAHA.118.038179

100.

Nordberg P, Taccone FS, Truhlar A et al (2019) Effect of trans-nasal evaporative intra-arrest cooling on functional neurologic outcome in out-of-hospital cardiac arrest: the PRINCESS randomized clinical trial. JAMA 321:1677–1685PubMedPubMedCentral

101.

Brooks SC, Schmicker RH, Cheskes S et al (2017) Variability in the initiation of resuscitation attempts by emergency medical services personnel during out-of-hospital cardiac arrest. Resuscitation 117:102–108PubMedPubMedCentral

102.

Grasner JT, Wnent J, Seewald S et al (2011) Cardiopulmonary resuscitation traumatic cardiac arrest—there are survivors. An analysis of two national emergency registries. Crit Care 15:R276PubMedPubMedCentral

103.

Leis CC, Hernandez CC, Blanco MJ, Paterna PC, Hernandez Rde E, Torres EC (2013) Traumatic cardiac arrest: should advanced life support be initiated? J Trauma Acute Care Surg 74:634–638PubMed

104.

Rosemurgy AS, Norris PA, Olson SM, Hurst JM, Albrink MH (1993) Prehospital traumatic cardiac arrest: the cost of futility. J Trauma 35:468–473PubMed

105.

Truhlar A, Deakin CD, Soar J et al (2015) European Resuscitation Council Guidelines for Resuscitation 2015: Section 4. Cardiac arrest in special circumstances. Resuscitation 95:148–201PubMed

106.

Nitta M, Iwami T, Kitamura T et al (2011) Age-specific differences in outcomes after out-of-hospital cardiac arrests. Pediatrics 128:e812–e820PubMed

107.

Goto Y, Funada A, Goto Y (2016) Duration of prehospital cardiopulmonary resuscitation and favorable neurological outcomes for pediatric out-of-hospital cardiac arrests: a nationwide, population-based cohort study. Circulation 134:2046–2059PubMed

108.

Fukuda T, Ohashi-Fukuda N, Kobayashi H et al (2016) Conventional versus compression-only versus no-bystander cardiopulmonary resuscitation for pediatric out-of-hospital cardiac arrest. Circulation 134:2060–2070PubMed

109.

Bardai A, Berdowski J, van der Werf C et al (2011) Incidence, causes, and outcomes of out-of-hospital cardiac arrest in children. A comprehensive, prospective, population-based study in the Netherlands. J Am Coll Cardiol 57:1822–1828PubMed

110.

Rosell-Ortiz F, Mellado-Vergel FJ, Lopez-Messa JB et al (2016) Survival and neurological status after out-of-hospital cardiac arrest in the pediatric population in Andalusia. Med Intensiva 40:163–168PubMed

111.

Herlitz J, Svensson L, Engdahl J et al (2007) Characteristics of cardiac arrest and resuscitation by age group: an analysis from the Swedish Cardiac Arrest Registry. Am J Emerg Med 25:1025–1031PubMed

112.

Gelberg J, Stromsoe A, Hollenberg J et al (2015) Improving survival and neurologic function for younger age groups after out-of-hospital cardiac arrest in Sweden: a 20-year comparison. Pediatr Crit Care Med 16:750–757PubMed

113.

Nolan JP, Berg RA, Andersen LW et al (2019) Cardiac arrest and cardiopulmonary resuscitation outcome reports: update of the Utstein resuscitation registry template for in-hospital cardiac arrest: a consensus report from a task force of the international liaison committee on resuscitation (American heart association, European resuscitation council, Australian and new zealand council on resuscitation, heart and stroke foundation of Canada, interAmerican heart foundation, resuscitation council of southern africa, resuscitation council of asia). Resuscitation 144:166–177PubMed

114.

Aune S, Herlitz J, Bang A (2005) Characteristics of patients who die in hospital with no attempt at resuscitation. Resuscitation 65:291–299PubMed

115.

van Delden JJ, Lofmark R, Deliens L et al (2006) Do-not-resuscitate decisions in six European countries. Crit Care Med 34:1686–1690PubMed

116.

Adamski J, Nowakowski P, Gorynski P, Onichimowski D, Weigl W (2016) Incidence of in-hospital cardiac arrest in Poland. Anaesthesiol Intensive Ther 48:288–293PubMed

117.

Hessulf F, Karlsson T, Lundgren P et al (2018) Factors of importance to 30-day survival after in-hospital cardiac arrest in Sweden—a population-based register study of more than 18,000 cases. Int J Cardiol 255:237–242PubMed

118.

Radeschi G, Mina A, Berta G et al (2017) Incidence and outcome of in-hospital cardiac arrest in Italy: a multicentre observational study in the Piedmont Region. Resuscitation 119:48–55PubMed

119.

Bergum D, Nordseth T, Mjolstad OC, Skogvoll E, Haugen BO (2015) Causes of in-hospital cardiac arrest—incidences and rate of recognition. Resuscitation 87:63–68PubMed

120.

Mosca L, Barrett-Connor E, Wenger NK (2011) Sex/gender differences in cardiovascular disease prevention: what a difference a decade makes. Circulation 124:2145–2154PubMedPubMedCentral

121.

Schwendimann R, Blatter C, Dhaini S, Simon M, Ausserhofer D (2018) The occurrence, types, consequences and preventability of in-hospital adverse events—a scoping review. BMC Health Serv Res 18:521PubMedPubMedCentral

122.

Pearse RM, Moreno RP, Bauer P et al (2012) Mortality after surgery in Europe: a 7 day cohort study. Lancet 380:1059–1065PubMedPubMedCentral

123.

Alam N, Hobbelink EL, van Tienhoven AJ, van de Ven PM, Jansma EP, Nanayakkara PW (2014) The impact of the use of the Early Warning Score (EWS) on patient outcomes: a systematic review. Resuscitation 85:587–594PubMed

124.

Whitaker DK, Nolan JP, Castren M, Abela C, Goldik Z (2017) Implementing a standard internal telephone number 2222 for cardiac arrest calls in all hospitals in Europe. Resuscitation 115:A14–A15PubMed

125.

Maharaj R, Raffaele I, Wendon J (2015) Rapid response systems: a systematic review and meta-analysis. Crit Care 19:254PubMedPubMedCentral

126.

Psirides AJ, Hill J, Jones D (2016) Rapid Response Team activation in New Zealand hospitals—a multicentre prospective observational study. Anaesth Intensive Care 44:391–397PubMed

127.

Bircher NG, Chan PS, Xu Y, American Heart Association (2019) Delays in cardiopulmonary resuscitation, defibrillation, and epinephrine administration all decrease survival in in-hospital cardiac arrest. Anesthesiology 130:414–422PubMed

128.

Tirkkonen J, Tamminen T, Skrifvars MB (2017) Outcome of adult patients attended by rapid response teams: a systematic review of the literature. Resuscitation 112:43–52PubMed

129.

Al-Dury N, Rawshani A, Israelsson J et al (2017) Characteristics and outcome among 14,933 adult cases of in-hospital cardiac arrest: a nationwide study with the emphasis on gender and age. Am J Emerg Med 35:1839–1844PubMed

130.

Hirlekar G, Karlsson T, Aune S et al (2017) Survival and neurological outcome in the elderly after in-hospital cardiac arrest. Resuscitation 118:101–106PubMed

131.

Adielsson A, Karlsson T, Aune S et al (2016) A 20-year perspective of in hospital cardiac arrest: experiences from a university hospital with focus on wards with and without monitoring facilities. Int J Cardiol 216:194–199PubMed

132.

Thoren A, Rawshani A, Herlitz J et al (2020) ECG-monitoring of in-hospital cardiac arrest and factors associated with survival. Resuscitation 150:130–138PubMed

133.

Herlitz J, Aune S, Bang A et al (2005) Very high survival among patients defibrillated at an early stage after in-hospital ventricular fibrillation on wards with and without monitoring facilities. Resuscitation 66:159–166PubMed

134.

Geddes LA, Roeder RA, Kemeny A, Otlewski M (2005) The duration of ventricular fibrillation required to produce pulseless electrical activity. Am J Emerg Med 23:138–141PubMed

135.

Memar M, Geara SJ, Hjalmarsson P, Allberg A, Bouzereau M, Djarv T (2018) Long-term mortality and morbidity among 30-day survivors after in-hospital cardiac arrests—a Swedish cohort study. Resuscitation 124:76–79PubMed

136.

Widestedt H, Giesecke J, Karlsson P, Jakobsson JG (2018) In-hospital cardiac arrest resuscitation performed by the hospital emergency team: a 6‑year retrospective register analysis at Danderyd University Hospital, Sweden. F1000Res 7:1013PubMedPubMedCentral

137.

O’Sullivan E, Deasy C (2016) In-hospital cardiac arrest at cork university hospital. Ir Med J 109:335–338PubMed

138.

Piscator E, Hedberg P, Goransson K, Djarv T (2016) Survival after in-hospital cardiac arrest is highly associated with the age-combined Charlson Co-morbidity Index in a cohort study from a two-site Swedish University hospital. Resuscitation 99:79–83PubMed

139.

Jennett B, Bond M (1975) Assessment of outcome after severe brain damage. Lancet 1:480–484PubMed

140.

van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJ, van Gijn J (1988) Interobserver agreement for the assessment of handicap in stroke patients. Stroke 19:604–607PubMed

141.

Whitehead L, Perkins GD, Clarey A, Haywood KL (2015) A systematic review of the outcomes reported in cardiac arrest clinical trials: the need for a core outcome set. Resuscitation 88:150–157PubMed

142.

Haywood K, Whitehead L, Nadkarni VM et al (2018) COSCA (core outcome set for cardiac arrest) in adults: an advisory statement from the international liaison committee on resuscitation. Resuscitation 127:147–163PubMed

143.

Haywood K, Whitehead L, Nadkarni VM et al (2018) COSCA (core outcome set for cardiac arrest) in adults: an advisory statement from the international liaison committee on resuscitation. Circulation 137:e783–e801PubMed

144.

Djarv T, Bremer A, Herlitz J et al (2020) Health-related quality of life after surviving an out-of-hospital compared to an in-hospital cardiac arrest: A Swedish population-based registry study. Resuscitation 151:77–84PubMed

145.

Scarpino M, Lolli F, Lanzo G et al (2019) Neurophysiology and neuroimaging accurately predict poor neurological outcome within 24 h after cardiac arrest: the ProNeCA prospective multicentre prognostication study. Resuscitation 143:115–123PubMed

146.

Polanowska KE, Sarzynska-Dlugosz IM, Paprot AE et al (2014) Neuropsychological and neurological sequelae of out-of-hospital cardiac arrest and the estimated need for neurorehabilitation: a prospective pilot study. Kardiol Pol 72:814–822PubMed

147.

Caro-Codon J, Rey JR, Lopez-de-Sa E et al (2018) Long-term neurological outcomes in out-of-hospital cardiac arrest patients treated with targeted-temperature management. Resuscitation 133:33–39PubMed

148.

Green CR, Botha JA, Tiruvoipati R (2015) Cognitive function, quality of life and mental health in survivors of our-of-hospital cardiac arrest: a review. Anaesth Intensive Care 43:568–576PubMed

149.

Lilja G, Nielsen N, Friberg H et al (2015) Cognitive function in survivors of out-of-hospital cardiac arrest after target temperature management at 33 degrees C versus 36 degrees C. Circulation 131:1340–1349PubMed

150.

Orbo M, Aslaksen PM, Larsby K et al (2014) Determinants of cognitive outcome in survivors of out-of-hospital cardiac arrest. Resuscitation 85:1462–1468PubMed

151.

Tiainen M, Poutiainen E, Oksanen T et al (2015) Functional outcome, cognition and quality of life after out-of-hospital cardiac arrest and therapeutic hypothermia: data from a randomized controlled trial. Scand J Trauma Resusc Emerg Med 23:12PubMedPubMedCentral

152.

Orbo M, Aslaksen PM, Larsby K, Schafer C, Tande PM, Anke A (2016) Alterations in cognitive outcome between 3 and 12 months in survivors of out-of-hospital cardiac arrest. Resuscitation 105:92–99PubMed

153.

Steinbusch CVM, van Heugten CM, Rasquin SMC, Verbunt JA, Moulaert VRM (2017) Cognitive impairments and subjective cognitive complaints after survival of cardiac arrest: A prospective longitudinal cohort study. Resuscitation 120:132–137PubMed

154.

Juan E, De Lucia M, Beaud V et al (2018) How do you feel? Subjective perception of recovery as a reliable surrogate of cognitive and functional outcome in cardiac arrest survivors. Crit Care Med 46:e286–e293PubMed

155.

van Zellem L, Buysse C, Madderom M et al (2015) Long-term neuropsychological outcomes in children and adolescents after cardiac arrest. Intensive Care Med 41:1057–1066PubMedPubMedCentral

156.

van Zellem L, Utens EM, Madderom M et al (2016) Cardiac arrest in infants, children, and adolescents: long-term emotional and behavioral functioning. Eur J Pediatr 175:977–986PubMedPubMedCentral

157.

van Zellem L, Utens EM, Legerstee JS et al (2015) Cardiac arrest in children: long-term health status and health-related quality of life. Pediatr Crit Care Med 16:693–702PubMed

158.

Haywood KL, Pearson N, Morrison LJ, Castren M, Lilja G, Perkins GD (2018) Assessing health-related quality of life (HRQoL) in survivors of out-of-hospital cardiac arrest: A systematic review of patient-reported outcome measures. Resuscitation 123:22–37PubMed

159.

Geri G, Dumas F, Bonnetain F et al (2017) Predictors of long-term functional outcome and health-related quality of life after out-of-hospital cardiac arrest. Resuscitation 113:77–82PubMed

160.

Moulaert VRM, van Heugten CM, Gorgels TPM, Wade DT, Verbunt JA (2017) Long-term outcome after survival of a cardiac arrest: a prospective longitudinal cohort study. Neurorehabil Neural Repair 31:530–539PubMed

161.

Ketilsdottir A, Albertsdottir HR, Akadottir SH, Gunnarsdottir TJ, Jonsdottir H (2014) The experience of sudden cardiac arrest: becoming reawakened to life. Eur J Cardiovasc Nurs 13:429–435PubMed

162.

Lilja G, Nielsen N, Bro-Jeppesen J et al (2018) Return to work and participation in society after out-of-hospital cardiac arrest. Circ Cardiovasc Qual Outcomes 11:e3566PubMed

163.

Bohm M, Lilja G, Finnbogadottir H et al (2019) Detailed analysis of health-related quality of life after out-of-hospital cardiac arrest. Resuscitation 135:197–204PubMed

164.

Cronberg T, Lilja G, Horn J et al (2015) Neurologic function and health-related quality of life in patients following targeted temperature management at 33 degrees C vs 36 degrees C after out-of-hospital cardiac arrest: a randomized clinical trial. JAMA Neurol 72:634–641PubMed

165.

Tiainen M, Vaahersalo J, Skrifvars MB, Hastbacka J, Gronlund J, Pettila V (2018) Surviving out-of-hospital cardiac arrest: the neurological and functional outcome and health-related quality of life one year later. Resuscitation 129:19–23PubMed

166.

Baldi E, Vanini B, Savastano S, Danza AI, Martinelli V, Politi P (2018) Depression after a cardiac arrest: an unpredictable issue to always investigate for. Resuscitation 127:e10–e11PubMed

167.

Mion M, Al-Janabi F, Islam S et al (2020) Care after REsuscitation: implementation of the united kingdom’s first dedicated multidisciplinary follow-up program for survivors of out-of-hospital cardiac arrest. Ther Hypothermia Temp Manag 10:53–59PubMed

168.

Verberne D, Moulaert V, Verbunt J, van Heugten C (2018) Factors predicting quality of life and societal participation after survival of a cardiac arrest: a prognostic longitudinal cohort study. Resuscitation 123:51–57PubMed

169.

Viktorisson A, Sunnerhagen KS, Johansson D, Herlitz J, Axelsson A (2019) One-year longitudinal study of psychological distress and self-assessed health in survivors of out-of-hospital cardiac arrest. BMJ Open 9:e29756PubMedPubMedCentral

170.

Israelsson J, Bremer A, Herlitz J et al (2017) Health status and psychological distress among in-hospital cardiac arrest survivors in relation to gender. Resuscitation 114:27–33PubMed

171.

Lilja G, Nilsson G, Nielsen N et al (2015) Anxiety and depression among out-of-hospital cardiac arrest survivors. Resuscitation 97:68–75PubMed

172.

Wilson M, Staniforth A, Till R, das Nair R, Vesey P (2014) The psychosocial outcomes of anoxic brain injury following cardiac arrest. Resuscitation 85:795–800PubMed

173.

Davies SE, Rhys M, Voss S, Greenwood R, Thomas M, Benger JR (2017) Psychological wellbeing in survivors of cardiac arrest, and its relationship to neurocognitive function. Resuscitation 111:22–25PubMed

174.

Wachelder EM, Moulaert VR, van Heugten C, Gorgels T, Wade DT, Verbunt JA (2016) Dealing with a life changing event: the influence of spirituality and coping style on quality of life after survival of a cardiac arrest or myocardial infarction. Resuscitation 109:81–86PubMed

175.

Frisch S, Thiel F, Schroeter ML, Jentzsch RT (2017) Apathy and cognitive deficits in patients with transient global Ischemia after cardiac arrest. Cogn Behav Neurol 30:172–175PubMed

176.

Beesems SG, Wittebrood KM, de Haan RJ, Koster RW (2014) Cognitive function and quality of life after successful resuscitation from cardiac arrest. Resuscitation 85:1269–1274PubMed

177.

Van’t Wout Hofland J, Moulaert V, van Heugten C, Verbunt J (2018) Long-term quality of life of caregivers of cardiac arrest survivors and the impact of witnessing a cardiac event of a close relative. Resuscitation 128:198–203PubMed

178.

Zimmerli M, Tisljar K, Balestra GM, Langewitz W, Marsch S, Hunziker S (2014) Prevalence and risk factors for post-traumatic stress disorder in relatives of out-of-hospital cardiac arrest patients. Resuscitation 85:801–808PubMed

179.

van Wijnen HG, Rasquin SM, van Heugten CM, Verbunt JA, Moulaert VR (2017) The impact of cardiac arrest on the long-term wellbeing and caregiver burden of family caregivers: a prospective cohort study. Clin Rehabil 31:1267–1275PubMed

180.

Orbo M, Aslaksen PM, Larsby K et al (2015) Relevance of cognition to health-related quality of life in good-outcome survivors of out-of-hospital cardiac arrest. J Rehabil Med 47:860–866PubMed

181.

Kragholm K, Wissenberg M, Mortensen RN et al (2015) Return to work in out-of-hospital cardiac arrest survivors: a nationwide register-based follow-up study. Circulation 131:1682–1690PubMed

182.

Descatha A, Dumas F, Bougouin W, Cariou A, Geri G (2018) Work factors associated with return to work in out-of-hospital cardiac arrest survivors. Resuscitation 128:170–174PubMed

183.

Elliott VJ, Rodgers DL, Brett SJ (2011) Systematic review of quality of life and other patient-centred outcomes after cardiac arrest survival. Resuscitation 82:247–256PubMed

184.

Moulaert VRMP, Verbunt JA, van Heugten CM, Wade DT (2009) Cognitive impairments in survivors of out-of-hospital cardiac arrest: a systematic review. Resuscitation 80:297–305PubMed

185.

Wilder Schaaf KP, Artman LK, Peberdy MA et al (2013) Anxiety, depression, and PTSD following cardiac arrest: a systematic review of the literature. Resuscitation 84:873–877PubMed

186.

Adiguzel E, Yasar E, Kesikburun S et al (2018) Are rehabilitation outcomes after severe anoxic brain injury different from severe traumatic brain injury? A matched case-control study. Int J Rehabil Res 41:47–51PubMed

187.

Smania N, Avesani R, Roncari L et al (2013) Factors predicting functional and cognitive recovery following severe traumatic, anoxic, and cerebrovascular brain damage. J Head Trauma Rehabil 28:131–140PubMed

188.

Tazopoulou E, Miljkovitch R, Truelle JL et al (2016) Rehabilitation following cerebral anoxia: an assessment of 27 patients. Brain Inj 30:95–103PubMed

189.

van Erp WS, Lavrijsen JC, Vos PE, Bor H, Laureys S, Koopmans RT (2015) The vegetative state: prevalence, misdiagnosis, and treatment limitations. JAMA 16:85 e9–e14

190.

Howell K, Grill E, Klein AM, Straube A, Bender A (2013) Rehabilitation outcome of anoxic-ischaemic encephalopathy survivors with prolonged disorders of consciousness. Resuscitation 84:1409–1415PubMed

191.

Heinz UE, Rollnik JD (2015) Outcome and prognosis of hypoxic brain damage patients undergoing neurological early rehabilitation. BMC Res Notes 8:243PubMedPubMedCentral

192.

Estraneo A, Moretta P, Loreto V et al (2013) Predictors of recovery of responsiveness in prolonged anoxic vegetative state. Neurology 80:464–470PubMed

193.

Israelsson J, Lilja G, Bremer A, Stevenson-Agren J, Arestedt K (2016) Post cardiac arrest care and follow-up in Sweden—a national web-survey. BMC Nurs 15:1PubMedPubMedCentral

194.

Israelsson J, Lilja G (2019) Post cardiac arrest follow-up—Swedish guidelines available. Lakartidningen 116:FIIP

195.

Moulaert VR, Goossens M, Heijnders IL, Verbunt JA, Heugten CM (2016) Early neurologically focused follow-up after cardiac arrest is cost-effective: a trial-based economic evaluation. Resuscitation 106:30–36PubMed

196.

Moulaert VR, van Haastregt JC, Wade DT, van Heugten CM, Verbunt JA (2014) “Stand still …, and move on” , an early neurologically-focused follow-up for cardiac arrest survivors and their caregivers: a process evaluation. BMC Health Serv Res 14:34PubMedPubMedCentral

197.

Moulaert VR, van Heugten CM, Winkens B et al (2015) Early neurologically-focused follow-up after cardiac arrest improves quality of life at one year: a randomised controlled trial. Int J Cardiol 193:8–16PubMed

198.

Moulaert VR, Verbunt JA, Bakx WG et al (2011) “Stand still …, and move on”, a new early intervention service for cardiac arrest survivors and their caregivers: rationale and description of the intervention. Clin Rehabil 25:867–879PubMedPubMedCentral

199.

Moulaert VR, Wachelder EM, Verbunt JA, Wade DT, van Heugten CM (2010) Determinants of quality of life in survivors of cardiac arrest. J Rehabil Med 42:553–558PubMed

200.

Boyce LW, Goossens PH (2017) Rehabilitation after cardiac arrest: integration of neurologic and cardiac rehabilitation. Semin Neurol 37:94–102PubMed

201.

Boyce-van der Wal LW, Volker WG, Vliet Vlieland TP, van den Heuvel DM, van Exel HJ, Goossens PH (2015) Cognitive problems in patients in a cardiac rehabilitation program after an out-of-hospital cardiac arrest. Resuscitation 93:63–68PubMed

202.

Tan HL, Dagres N, Böttiger BW, Schwartz PJ (2018) European Sudden Cardiac Arrest network: towards Prevention, Education and New Effective Treatments (ESCAPE-NET): a major European Horizon 2020 project focused on cardiac arrest. Eur Heart J 39:86–88

203.

Novotny T, Kadlecova J, Raudenska M et al (2011) Mutation analysis ion channel genes ventricular fibrillation survivors with coronary artery disease. Pacing Clin Electrophysiol 34:742–749PubMed

204.

Christiansen SL, Hertz CL, Ferrero-Miliani L et al (2016) Genetic investigation of 100 heart genes in sudden unexplained death victims in a forensic setting. Eur J Hum Genet 24:1797–1802PubMedPubMedCentral

205.

Kumar S, Peters S, Thompson T et al (2013) Familial cardiological and targeted genetic evaluation: low yield in sudden unexplained death and high yield in unexplained cardiac arrest syndromes. Heart Rhythm 10:1653–1660PubMed

206.

Earle N, Yeo HD, Pilbrow A et al (2014) Single nucleotide polymorphisms in arrhythmia genes modify the risk of cardiac events and sudden death in long QT syndrome. Heart Rhythm 11:76–82PubMed

207.

Horr S, Goldenberg I, Moss AJ et al (2011) Ion channel mechanisms related to sudden cardiac death in phenotype-negative long-QT syndrome genotype-phenotype correlations of the KCNQ1(S349W) mutation. J Cardiovasc Electrophysiol 22:193–200PubMedPubMedCentral

208.

Hendrix A, Borleffs CJ, Vink A et al (2011) Cardiogenetic screening of first-degree relatives after sudden cardiac death in the young: a population-based approach. Europace 13:716–722PubMed

209.

Jouven X, Desnos M, Guerot C, Ducimetiere P (1999) Predicting sudden death in the population: the Paris Prospective Study I. Circulation 99:1978–1983PubMed

210.

Tester DJ, Medeiros-Domingo A, Will ML, Haglund CM, Ackerman MJ (2012) Cardiac channel molecular autopsy: insights from 173 consecutive cases of autopsy-negative sudden unexplained death referred for postmortem genetic testing. Mayo Clin Proc 87:524–539PubMedPubMedCentral

211.

McGorrian C, Constant O, Harper N et al (2013) Family-based cardiac screening in relatives of victims of sudden arrhythmic death syndrome. Europace 15:1050–1058PubMed

212.

Ashar FN, Mitchell RN, Albert CM et al (2018) A comprehensive evaluation of the genetic architecture of sudden cardiac arrest. Eur Heart J 39:3961–3969PubMedPubMedCentral

213.

Bezzina CR, Lahrouchi N, Priori SG (2015) Genetics of sudden cardiac death. Circ Res 116:1919–1936PubMed

214.

Nakano Y, Shimizu W (2016) Genetics of long-QT syndrome. J Hum Genet 61:51–55PubMed

215.

Myerburg RJ, Junttila MJ (2012) Sudden cardiac death caused by coronary heart disease. Circulation 125:1043–1052PubMed

216.

Jouven X, Lemaitre RN, Rea TD, Sotoodehnia N, Empana JP, Siscovick DS (2005) Diabetes, glucose level, and risk of sudden cardiac death. Eur Heart J 26:2142–2147PubMed

217.

Roden DM (2004) Drug-induced prolongation of the QT interval. N Engl J Med 350:1013–1022PubMed

218.

Clancy CE, Rudy Y (2001) Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovasc Res 50:301–313PubMed

219.

Lahtinen AM, Havulinna AS, Noseworthy PA et al (2013) Prevalence of arrhythmia-associated gene mutations and risk of sudden cardiac death in the Finnish population. Ann Med 45:328–335PubMed

220.

Nemec J, Hejlik JB, Shen WK, Ackerman MJ (2003) Catecholamine-induced T‑wave lability in congenital long QT syndrome: a novel phenomenon associated with syncope and cardiac arrest. Mayo Clin Proc 78:40–50PubMed

221.

Farrugia A, Keyser C, Hollard C, Raul JS, Muller J, Ludes B (2015) Targeted next generation sequencing application in cardiac channelopathies: analysis of a cohort of autopsy-negative sudden unexplained deaths. Forensic Sci Int 254:5–11PubMed

222.

Zhang M, Xue A, Shen Y et al (2015) Mutations of desmoglein‑2 in sudden death from arrhythmogenic right ventricular cardiomyopathy and sudden unexplained death. Forensic Sci Int 255:85–88PubMed

223.

Bagnall RD, Das KJ, Duflou J, Semsarian C (2014) Exome analysis-based molecular autopsy in cases of sudden unexplained death in the young. Heart Rhythm 11:655–662PubMed

224.

Steinberg C, Padfield GJ, Champagne J et al (2016) Cardiac abnormalities in first-degree relatives of unexplained cardiac arrest victims: a report from the cardiac arrest survivors with preserved ejection fraction registry. Circ Arrhythm Electrophysiol 9. https://doi.org/10.1161/CIRCEP.115.004274

225.

Kong T, Feulefack J, Ruether K et al (2017) Ethnic differences in genetic Ion channelopathies associated with sudden cardiac death: a systematic review and meta-analysis. Ann Clin Lab Sci 47:481–490PubMed

226.

Frontera A, Vlachos K, Kitamura T et al (2019) Long-term follow-up of idiopathic ventricular fibrillation in a pediatric population: clinical characteristics, management, and complications. JAHA 8:e11172PubMedPubMedCentral

227.

Jia PL, Wang YB, Fu H et al (2018) Postmortem analysis of 4 mutation hotspots of KCNQ1, KCNH2, and SCN5A genes in sudden unexplained death in southwest of China. Am J Forensic Med Pathol 39:218–222PubMed

228.

Ackerman MJ, Tester DJ, Jones GS, Will ML, Burrow CR, Curran ME (2003) Ethnic differences in cardiac potassium channel variants: implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndrome. Mayo Clin Proc 78:1479–1487PubMed

229.

Coll M, Ferrer-Costa C, Pich S et al (2018) Role of genetic and electrolyte abnormalities in prolonged QTc interval and sudden cardiac death in end-stage renal disease patients. PLoS ONE 13:e200756PubMedPubMedCentral

230.

Kohli U, Aziz Z, Beaser AD, Nayak HM (2019) A large deletion in RYR2 exon 3 is associated with nadolol and flecainide refractory catecholaminergic polymorphic ventricular tachycardia. Pacing Clin Electrophysiol 42:1146–1154PubMed

231.

Kaab S, Crawford DC, Sinner MF et al (2012) A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. Circ Cardiovasc Genet 5:91–99PubMed

232.

Veerman CC, Verkerk AO, Blom MT et al (2013) Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome. Circ Arrhythm Electrophysiol 6:1002–1009PubMed

233.

Tadros R, Tan HL, Investigators E‑N et al (2019) Predicting cardiac electrical response to sodium-channel blockade and Brugada syndrome using polygenic risk scores. Eur Heart J 40:3097–3107PubMedPubMedCentral

234.

Hofman N, Tan HL, Alders M et al (2013) Yield of molecular and clinical testing for arrhythmia syndromes: report of 15 years’ experience. Circulation 128:1513–1521PubMed

235.

Schwartz PJ, Ackerman MJ, George AL Jr., Wilde AAM (2013) Impact of genetics on the clinical management of channelopathies. J Am Coll Cardiol 62:169–180PubMedPubMedCentral

236.

Marsman RF, Tan HL, Bezzina CR (2014) Genetics of sudden cardiac death caused by ventricular arrhythmias. Nat Rev Cardiol 11:96–111PubMed

237.

Milano A, Blom MT, Lodder EM et al (2016) Sudden cardiac arrest and rare genetic variants in the community. Circ Cardiovasc Genet 9:147–153PubMed

238.

Kolder IC, Tanck MW, Bezzina CR (2012) Common genetic variation modulating cardiac ECG parameters and susceptibility to sudden cardiac death. J Mol Cell Cardiol 52:620–629PubMed

239.

Snapir A, Mikkelsson J, Perola M, Penttila A, Scheinin M, Karhunen PJ (2003) Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death. J Am Coll Cardiol 41:190–194PubMed

240.

Sotoodehnia N, Siscovick DS, Vatta M et al (2006) Beta2-adrenergic receptor genetic variants and risk of sudden cardiac death. Circulation 113:1842–1848PubMed

241.

Schwartz PJ, Crotti L, George AL Jr. (2018) Modifier genes for sudden cardiac death. Eur Heart J 39:3925–3931PubMedPubMedCentral

242.

Ter Bekke RMA, Isaacs A, Barysenka A et al (2017) Heritability in a SCN5A-mutation founder population with increased female susceptibility to non-nocturnal ventricular tachyarrhythmia and sudden cardiac death. Heart Rhythm 14:1873–1881PubMed

243.

Pham TV, Rosen MR (2002) Sex, hormones, and repolarization. Cardiovasc Res 53:740–751PubMed

244.

Antzelevitch C, Brugada P, Borggrefe M et al (2005) Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation 111:659–670PubMed

245.

Pham TV, Robinson RB, Danilo P Jr., Rosen MR (2002) Effects of gonadal steroids on gender-related differences in transmural dispersion of L‑type calcium current. Cardiovasc Res 53:752–762PubMed

246.

Giudicessi JR, Ackerman MJ (2019) Exercise testing oversights underlie missed and delayed diagnosis of catecholaminergic polymorphic ventricular tachycardia in young sudden cardiac arrest survivors. Heart Rhythm 16:1232–1239PubMed

247.

Longo UG, Risi Ambrogioni L, Ciuffreda M, Maffulli N, Denaro V (2018) Sudden cardiac death in young athletes with long QT syndrome: the role of genetic testing and cardiovascular screening. Br Med Bull 127:43–53PubMed

248.

Wisten A, Bostrom IM, Morner S, Stattin EL (2012) Mutation analysis of cases of sudden unexplained death, 15 years after death: prompt genetic evaluation after resuscitation can save future lives. Resuscitation 83:1229–1234PubMed

249.

Stattin EL, Westin IM, Cederquist K et al (2016) Genetic screening in sudden cardiac death in the young can save future lives. Int J Legal Med 130:59–66PubMed

250.

Hertz CL, Christiansen SL, Ferrero-Miliani L et al (2015) Next-generation sequencing of 34 genes in sudden unexplained death victims in forensics and in patients with channelopathic cardiac diseases. Int J Legal Med 129:793–800PubMed

251.

Nunn LM, Lopes LR, Syrris P et al (2016) Diagnostic yield of molecular autopsy in patients with sudden arrhythmic death syndrome using targeted exome sequencing. Europace 18:888–896PubMed

252.

Neubauer J, Lecca MR, Russo G et al (2018) Exome analysis in 34 sudden unexplained death (SUD) victims mainly identified variants in channelopathy-associated genes. Int J Legal Med 132:1057–1065PubMed

253.

Hertz CL, Christiansen SL, Ferrero-Miliani L et al (2016) Next-generation sequencing of 100 candidate genes in young victims of suspected sudden cardiac death with structural abnormalities of the heart. Int J Legal Med 130:91–102PubMed

254.

Mates J, Mademont-Soler I, Del Olmo B et al (2018) Role of copy number variants in sudden cardiac death and related diseases: genetic analysis and translation into clinical practice. Eur J Hum Genet 26:1014–1025PubMedPubMedCentral

255.

Stepien-Wojno M, Poninska J, Rydzanicz M et al (2018) Sudden cardiac arrest in patients without overt heart disease: a limited value of next generation sequencing. Pol Arch Intern Med 128:721–730PubMed

256.

Lahrouchi N, Raju H, Lodder EM et al (2017) Utility of post-mortem genetic testing in cases of sudden arrhythmic death syndrome. J Am Coll Cardiol 69:2134–2145PubMedPubMedCentral

257.

Scheiper S, Ramos-Luis E, Blanco-Verea A et al (2018) Sudden unexpected death in the young—Value of massive parallel sequencing in postmortem genetic analyses. Forensic Sci Int 293:70–76PubMed

258.

Anderson JH, Tester DJ, Will ML, Ackerman MJ (2016) Whole-Exome Molecular Autopsy After Exertion-Related Sudden Unexplained Death in the Young. Circ Cardiovasc Genet 9:259–265PubMed

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Epidemiologie des Kreislaufstillstands in Europa

Leitlinien des European Resuscitation Council 2021

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Neu im Fachgebiet AINS

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Hochrisiko-Eingriffe für postoperative Übelkeit

Diclofenac-Gel versus Ibuprofen bei akuten Rückenschmerzen

Update AINS

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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