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Semin Musculoskelet Radiol 2008; 12(3): 266-280
DOI: 10.1055/s-0028-1083109
© Thieme Medical Publishers

Novel Contrast Mechanisms at 3 Tesla and 7 Tesla

Ravinder R. Regatte1 , Mark E. Schweitzer1
  • 1Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York
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Publication History

Publication Date:
10 October 2008 (online)

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ABSTRACT

Osteoarthritis (OA) is the most common musculoskeletal degenerative disease, affecting millions of people. Although OA has been considered primarily a cartilage disorder associated with focal cartilage degeneration, it is accompanied by well-known changes in subchondral and trabecular bone, including sclerosis and osteophyte formation. The exact cause of OA initiation and progression remains under debate, but OA typically first affects weightbearing joints such as the knee. Magnetic resonance imaging (MRI) has been recognized as a potential tool for quantitative assessment of cartilage abnormalities due to its excellent soft tissue contrast. Over the last two decades, several new MR biochemical imaging methods have been developed to characterize the disease process and possibly predict the progression of knee OA. These new MR biochemical methods play an important role not only for diagnosis of disease at an early stage, but also for their potential use in monitoring outcome of various drug therapies (success or failure). Recent advances in multicoil radiofrequency technology and high field systems (3 T and above) significantly improve the sensitivity and specificity of imaging studies for the diagnosis of musculoskeletal disorders. The current state-of-the-art MR imaging methods are briefly reviewed for the quantitative biochemical and functional imaging assessment of musculoskeletal systems.

KEYWORDS

Osteoarthritis - T2 - dGEMRIC - T1ρ - sodium MR - CEST

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Ravinder R RegattePh.D. 

NYU-Hospital for Joint Diseases, Department of Radiology

301 East 17th St., New York, NY 10003

Email: ravinder.regatte@med.nyu.edu

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