Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin 2008; 18(3): 145-149
DOI: 10.1055/s-2008-1065341
Weiter- und Fortbildung

© Georg Thieme Verlag KG Stuttgart · New York

Interdisziplinäres Therapiemanagement bei Phantomschmerz

Interdisciplinary Management of Phantom Limb PainC. Zorn 1 , G. Fraberger 2 , K. Pieber 1 , M. Keilani 1 , T. Sycha 3 , S. Seidel 3 , V. Fialka-Moser 1 , G. Holzer 2 , R. Crevenna 1
  • 1Universitätsklinik für Physikalische Medizin und Rehabilitation, AKH Wien (Vorstand: Univ.-Prof. Dr. V. Fialka-Moser)
  • 2Universitätsklinik für Orthopädie, AKH Wien (Vorstand: Univ. Prof. Dr. R. Kotz)
  • 3Universitätsklinik für Neurologie, AKH Wien (Vorstand: Univ. Prof. Dr. E. Auff)
Further Information

Publication History

eingereicht: 25.4.2007

angenommen: 2.4.2008

Publication Date:
05 June 2008 (online)

Zusammenfassung

Über 70% aller Patienten mit Amputationen leiden an Phantomgefühlen oder Phantomschmerzen und sind auch deswegen in ihrer Funktion, Aktivität, Partizipation und Lebensqualität beeinträchtigt. Die Entstehung der Postamputationsphänomene wird durch Reorganisation des somatosensorischen Kortex, durch Entwicklung eines Schmerzgedächtnisses und mithilfe verschiedener psychologischer Theorien zu erklären versucht. Basierend auf diesen Ansätzen sind in den letzten Jahrhunderten verschiedene Therapien entwickelt worden, von denen bis heute keine einzige überzeugende Ergebnisse erzielt hat. Trotzdem scheint ein individuelles, meist multimodales und interdisziplinäres Eingehen auf den jeweiligen Patienten mit physikalisch-medizinischen, medikamentösen, psychologischen und chirurgischen Interventionen in vielen Fällen eine vorübergehende oder permanente Schmerzerleichterung zu erzielen.

Abstract

More than 70% of all patients undergoing amputation develop phantom limb sensation or phantom limb pain and consequently display deficiencies in function, activity, participation and quality of life. Cortical reorganisation, existence of a pain memory and several psychological theories are put forward to explain the development of postamputation phenomena. In the last centuries, several therapies have been developed on the basis of these concepts with none of them producing convincing results. However, in many cases, a transitory or permanent pain relief seems to be achieved by individual, multimodal and interdisciplinary focus on the patient using physical-medical, pharmacological, psychological and surgical interventions.

Literatur

  • 1 Steffen P. Phantomschmerz: Diagnostik und Therapie.  Anästhesiol Intensivmed Notfallmed Schmerzther. 2006;  6 378-386
  • 2 Manchikanti L, Singh VS. Managing Phantom Pain.  Pain Physician. 2004;  7 365-375
  • 3 Haug M. Phantomschmerz nach Beinamputation - ist die Lösung in Sicht?.  Zentralbl Chir. 2005;  130 55-59
  • 4 Ehde DM, Czerniecki JM, Smith DG, Campbell KM, Edwards WT, Jensen MP, Robinson LR. Chronic phantom sensations, phantom pain, residual limb pain, and other regional pain after lower limb amputation.  Arch Phys Med Rehabil. 2000;  81 1039-1044
  • 5 Jensen TS, Krebs B, Nielsen J, Rasmussen P. Phantom limb, phantom pain and stump pain in amputees during the first 6 months following limb amputation.  Pain. 1983;  17 243-256
  • 6 Wilkins KL, MacGrath PJ, Finley GA, Katz J. Phantom limb sensations and phantom limb pain in child and adolescent amputees.  Pain. 1998;  78 7-12
  • 7 Ramachandran SV, Blakeslee S. Die blinde Frau, die sehen kann. Rowohlt. Reinbek bei Hamburg 2002
  • 8 Melzack R. Labat lecture. Phatonm limbs.  Reg Anesth. 1989;  14 208-211
  • 9 Sherman RA. Stump and phantom limb pain.  Neurol Clin. 1989;  7 249-264
  • 10 Saris SC, Iacono RP, Nashold  Jr  BS. Dorsal root entry zone lesions for post-amputation pain.  J Neurosurg. 1985;  62 72-76
  • 11 Jensen TS, Krebs B, Nielsen J, Rasmussen P. Immediate and long-term phantom limb pain in amputees. Incidence, clinical characteristics and relationship to pre-amputation limb pain.  Pain. 1985;  21 267-278
  • 12 Sherman RA, Sherman CJ. Prevalence and characteristics of chronic phantom limb pain among American veterans: Results of a trail survey.  Am J phys Med. 1983;  62 227-238
  • 13 Borsje S, Bosmans JC, Schans CP Van der, Geertzen JHB, Dijkstra PU. Phantom pain: A sensitivity analysis.  Disabil Rehabil. 2004;  26 905-910
  • 14 Carlen PL, Wall PD, Nadvorna H, Steinbach T. Phantom limbs and related phenomena in recent traumatic amputations.  Neurology. 1978;  28 211-217
  • 15 Richardson C, Glenn S, Nurmikko T, Horgan M. Incidence of phantom phenomena including phantom limb pain 6 months after major lower limb amputation in patients with peripheral vascular disease.  Clin J Pain. 2006;  22 353-358
  • 16 Nikolajsen L, Jensen TS. Phantom limb pain.  Curr Rev Pain. 2000;  4 166-170
  • 17 Gallagher P, Allen D, MacLachlan M. Phantom limb pain and residual limb pain following lower limb amputation: a descriptive analysis.  Disabil Rehabil. 2001;  23 522-530
  • 18 Weiss SA, Lindell B. Phantom limb pain and aetiology of amputation in unilateral lower extremity amputees.  Journal of Pain and Symptom Management. 1996;  1 3-17
  • 19 Dijkstra PU, Geertzen JHB, Stewart R, Schans CP van der. Phantom pain and risk factors: A multivariate analysis.  Journal of Pain and Symptom Management. 2002;  24 578-585
  • 20 Nikolajsen L, Ilkjaer S, Kroner K, Christensen JH, Jensen TS. The influence of preamputation pain on postamputation stump and phantom pain.  Pain. 1997;  72 393-405
  • 21 Hanley MA, Jensen MP, Smith DG, Ehde DM, Edwards WT, Robinson LR. Preamputation pain and acute pain predict chronic pain after lower extremity amputation.  J Pain. 2006;  , (Epub ahead of print)
  • 22 Nikolajsen L, Ilkjaer S, Jensen TS. Relationship between mechanical sensitivity and postamputation pain: a prospective study.  Eur J Pain. 2000;  4 327-334
  • 23 Wartan SW, Hamann W, Wedley JR, MacColl I. Phantom pain and sensations among British veteran amputees.  British Journal of Anaesthesia. 1997;  78 652-659
  • 24 Jones LE, Davidson JH. The long-term outcome of upper limb amputees treated in a rehabilitation centre in Sydney, Australia.  Disabil Rehabil. 1995;  17 437-442
  • 25 Lotze M, Grodd W, Birbaumer N, Erb M, Huse E, Flor H. Does use of a myoelectric prosthesis prevent cortical reorganization and phantom limb pain?.  Nature Neuroscience. 1999;  2 501-502
  • 26 Grüsser SM, Diers M, Flor H. Phantomschmerz: Aspekte der Neuroplastizität und Intervention.  Anästhesiol Intensivmed Notfallmed Schmerzther. 2003;  38 762-766
  • 27 Karl A, Birbaumer N, Lutzenberger W, Cohen LG, Flor H. Reorganization of motor and somatosensory cortex in upper extremity amputees with phantom limb pain.  The Journal of Neuroscience. 2001;  21 3609-3618
  • 28 Hunter JP, Katz J, Davis KD. The effect of tactile and visual sensory inputs on phantom limb awareness.  Brain. 2003;  126 579-589
  • 29 Davis RW. Phantom sensation, phantom pain, and stump pain.  Arch Phys Med Rehabil. 1993;  74 79-91
  • 30 Melzack R. Phantom limbs and the concept of a neuromatrix.  TINS. 1990;  13 88-92
  • 31 Flor H, Elbert T, Knecht S. et al . Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation.  Nature. 1995;  375 482-484
  • 32 Rüegg JC. Psychosomatik, Psychotherapie und Gehirn - Neuronale Plastizität als Grundlage einer biopsychosozialen Medizin. Schattauer, Stuttgart, New York 2001
  • 33 Besson JM. The neurobiology of pain.  Lancet. 1999;  353 1610-1615
  • 34 Woolf CJ, Mannion RJ. Neuropathic pain, aetiology, symptoms, mechanisms, and management.  Lancet. 1999;  353 1959-1964
  • 35 Geertzen J, Martina J, Rietman H. Lower limb amputation Part2: Rehabilitation - a 10 year literatur review.  Prosthet Orthot Int. 2001;  25 14-20
  • 36 Matsen S, Malchow D, Matsen F. Correlations with Patient's Perspectives of the Result of Lower-Extremity Amputation.  J Bone Joint Surg. 2000;  82 1089-1095
  • 37 Houghton AD, Nicholls G, Houghton AL, Saadah E, MacColl I. Phantom pain: natural history and association with rehabilitation.  Ann R Coll Surg Engl. 1994;  76 22-25
  • 38 Jensen TS, Rasmussen P. Phantom pain and related phenomena after amputation. In: Wall PD, Melzack R (Eds). Textbook of pain. Edinburgh: Churchill Livingstone 1989: 508-521
  • 39 Melzack R. Phantomschmerz. In: Melzack R (Hrsg). Das Rätsel des Schmerzes. Stuttgart: Hippokrates 1978: 47-57
  • 40 Mickorey M. Phantome und Doppelgänger. München: J. F. Lehmanns 1952
  • 41 Frank B, Lorenzoni E. Phantomerleben und Phantomschmerz.  Fortschr Neurol Psychiat. 1992;  60 74-85
  • 42 Arena J, Sherman R, Bruno G, Sherman C. The relationship between situational stress and phantom limb pain.  J Psychosom Res. 1990;  34 71-77
  • 43 MacLachlan M, Desmond D, Horgan O. Psychological correlates of illusory body experiences.  J Rehabil Res Dev. 2003;  40 59-66
  • 44 Sherman RA, Sherman CJ, Bruno GM. Psychological factors influencing chronic phantom limb pain: an analysis of the literature.  Pain. 1987;  28 285-295
  • 45 Patterson JF. Carbamazepine in the treatment of phantom limb pain.  South Med J. 1988;  81 1100-1102
  • 46 Bone M, Critchley P, Buggy DJ. Gabapentin in postamputation phantom limb pain: A randomized, double-blind, placebo-controlled, cross-over study.  Reg Anesth Pain Med. 2002;  27 481-486
  • 47 Logan TP. Persistent phantom limb pain: Dramatic response to chlorpromazine.  South Med J. 1983;  76 1585
  • 48 Stannard CF, Porter GE. Ketamine hydrochloride in the treatment of phantom limb pain.  Pain. 1993;  54 227-230
  • 49 Nikolajsen L, Gottrup H, Kristensen AGD, Jensen TS. Memantine (a N-methyl D-aspartate receptor antagonist) in the treatment of neuropathic pain following amputation or surgery: A randomized, double-blind, cross-over study.  Anesth Analg. 2000;  91 960-966
  • 50 Maier C, Dertwinkel R, Mansourian N, Hosbach I, Schwenkreis P, Senne I, Skipka G, Zenz M, Tegenthoff M. Efficacy of the NMDA-receptor antagonist memantine in patients with chronic phantom limb pain - Results of a randomized double-blinded, placebo-controlled trial.  Pain. 2003;  103 277-283
  • 51 Bergmans L, Snijdelaar DG, Katz J, Crul BJ. Methadone for phantom limb pain.  Clin J Pain. 2002;  18 203-205
  • 52 Wu CL, Tella P, Staats PS, Vaslav R, Kazim DA, Wesselmann U, Raia SN. Analgesic effects of intravenous lidocaine and morphine on postamputation pain: A randomized double-blind, active placebo-controlled, crossover trial.  Anesthesiology. 2002;  96 841-848
  • 53 Marsland AR, Weekes JW, Atkinson RL, Leong MJ. Phantom limb pain: A case for beta blockers?.  Pain. 1982;  14 295-297
  • 54 Jaeger H, Maier C. Calcitonin in phantom limb pain: A double-blind study.  Pain. 1992;  48 21-27
  • 55 Kessel C, Wörz R. Clinical note: Immediate response of phantom limb pain to calcitonine.  Pain. 1987;  30 79-87
  • 56 Rayner HC, Atkins RC, Westerman RA. Relief of local stump pain by capsaicin cream.  Lancet. 1989;  2 1276-1277
  • 57 Bartusch SL, Sanders J, D’Alessio JG, Jernigan JR. Clonazepam for the treatment of lancinating phantom pain.  Clin J Pain. 1996;  12 59-62
  • 58 Nikolajsen L, Ilkjaer S, Christensen JH, Krøner K, Jensen TS. Randomised trial of epidural bupivacaine and morphine in prevention of stump and phantom pain in lower-limp amputation.  Lancet. 1997;  350 1353-1357
  • 59 Bach S, Noreng MF, Tjéllden NU. Phantom limb pain in amputees during the first 12 months following limb amputation, after preoperative lumbar epidural blockade.  Pain. 1988;  33 297-301
  • 60 Miles J, Lipton S. Phantom limb pain treated by electrical stimulation.  Pain. 1978;  5 373-382
  • 61 Winnem MF, Amundsen T. Treatment of phantom limb pain with TENS.  Pain. 1982;  12 299-300
  • 62 Carabelli RA, Kellermann WC. Phantom limb pain: Relief by application of TENS to contralateral extremity.  Arch Phys Med Rehabil. 1985;  66 466-467
  • 63 Rasmussen KG, Rummans TA. Electroconvulsive therapy for phantom limb pain.  Pain. 2000;  85 297-299
  • 64 Sherman RA, Sherman CJ, Gall NG. A survey of current phantom limb pain treatment in the United States.  Pain. 1980;  8 85-99
  • 65 Kern U, Altkemper B, Kohl M. Management of phantom pain with a textile, electromagnetically-acting stump liner: a randomized, double-blind, crossover study.  J Pain Symptom Manage. 2006;  32 352-360
  • 66 Bradbrook D. Acupuncture treatment of phantom limb pain and phantom limb sensation in amputees.  Acupuncture in Medicine. 2004;  22 93-97
  • 67 Monga TN, Jaksic T. Acupuncture in phantom limb pain.  Arch Phys Med Rehabil. 1981;  62 229-231
  • 68 Egle UT, Hoffmann SO. Psychotherapy and its efficacy for chronic pain syndromes.  Pain. 1989;  3 8-21
  • 69 Gawlik R. Autogenes Training. In: Handwörterbuch der Psychologie. Weinheim: Psychologie Verlags Union 1992: 71-73
  • 70 Flor H, Denke C, Grüsser S, Schaefer M. Effect of sensory discrimination training on cortical reorganization and phantom limb.  Lancet. 2001;  357 1763-1764
  • 71 Lotze M, Grodd W, Birbaumer N, Erb M, Huse E, Flor H. Does use of a myoelectric prothesis prevent cortical reorganization and phantom limb pain?.  Nature Neuroscience. 1999;  2 501-502
  • 72 Weiss T, Miltner WH, Adler T, Bruckner L, Taub E. Decrease in phantom limb pain associated with prosthesis-induced increased use of an amputation stump in humans.  Neurosci Lett. 1999;  272 131-134
  • 73 MacLachlan M, MacDonald D, Waloch J. Mirror treatment of lower limb phantom pain: A case study.  Disabil Rehabil. 2004;  26( (14/17)) 901-904
  • 74 Ramachandran VS, Rogers-Ramachandran D. Synaesthesia in phantom limbs induced with mirrors.  Proc R Soc Lond B. 1996;  263 377-386
  • 75 Murray CD, Patchick EL, Caillette F, Howard T, Pettifer S. Can immersive virtual reality reduce phantom limb pain?.  Stud Health Technol Inform. 2006;  119 407-412
  • 76 Murray CD, Patchick E, Pattifer S, Caillette F, Howard T. Immersive reality as a rehabilitative technology for phantom limb experience: a protocol.  Cyberpsychol Behav. 2006;  9 167-170
  • 77 Rosen B, Lundborg G. Training with a mirror in rehabilitation of the hand.  Scand J Plast Reconstr Surg Hand Surg. 2005;  39 104-108
  • 78 Brodie EE, Whyte A, Niven CA. Analgesia through the looking-glass? A randomized controlled trial investigating the effect of viewing a “virtual” limb upon phantom limb pain, sensation and movement.  European Journal of Pain. 2006;  , (epub ahead of print)

Korrespondenzadresse

ao. Univ.-Prof. Dr. R. Crevenna

Universitätsklinik für Physikalische Medizin und Rehabilitation

AKH Wien

Währinger Gürtel 18-20

1090 Wien

Österreich

Phone: +43/1/404 00 43 30

Fax: +43/1/404 00 52 81

Email: richard.crevenna@meduniwien.ac.at

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