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Horm Metab Res 1982; 14(5): 271-274
DOI: 10.1055/s-2007-1018990
© Georg Thieme Verlag, Stuttgart · New York

Serum 1,25-Dihydroxyvitamin D in Normal Subjects and in Patients with Postmenopausal Osteopenia. Influence of Age, Renal Function and Oestrogen Therapy

Bj. Lund, O. H. Sørensen, Bi. Lund, E. Agner
  • Department of Orthopedic Surgery and Clinical Physiology, Frederiksborg County Hospital, Hillerød
  • Department of Medicine, Sundby Hospital, Copenhagen
  • Department of Physical Medicine, Hvidovre University Hospital, Hvidovre
  • Department of Medicine E, Frederiksberg University Hospital, Copenhagen, Denmark
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Publication History

1980

1981

Publication Date:
23 April 2008 (online)

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Summary

The serum concentrations of 1,25-dihydroxyvitamin D (1,25-(OH)2 D) were measured in 194 healthy subjects aged 15-90 years. The mean level was 32.8±12.5 pg/ml (SD) without agedependent changes. The mean serum concentration was reduced (26.9±13.6 pg/ml) in 55 patients with postmenopausal osteopenia compared to 62 non-osteopenic age-matched controls (32.8±11.6 pg/ml) (p < 0.02). The serum concentrations correlated positively with the creatinine clearances in 23 osteopenic patients studied. Treatment with oestradiol increased serum 1,25-(OH)2 D significantly in postmenopausal women. A reduced production of 1,25-(OH)2 D or a reduced sensitivity to this hormone may play a significant role in the pathogenesis of postmenopausal osteopenia.

Key-Words:

Serum 1,25-Dihydroxyvitamin D - Age - Renal Function - Oestrogens - Postmenopausal Osteopenia

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