Von Hippel Lindau Disease with Colon Adenocarcinoma, Renal Cell Carcinoma and Adrenal Pheochromocytoma

Laura Zinnamosca; Anastasia Laudisi; Luigi Petramala; Cristiano Marinelli; Mario Roselli; Domenico Vitolo; Chiara Montesani; Claudio Letizia

doi:10.2169/internalmedicine.52.8278

CASE REPORTS

Von Hippel Lindau Disease with Colon Adenocarcinoma, Renal Cell Carcinoma and Adrenal Pheochromocytoma

Laura Zinnamosca, Anastasia Laudisi, Luigi Petramala, Cristiano Marinelli, Mario Roselli, Domenico Vitolo, Chiara Montesani, Claudio Letizia

Author information

Laura Zinnamosca
Department Unit of Secondary Hypertension, Department of Internal Medicine and Medical Specialities, "Sapienza" University of Rome, Italy
Anastasia Laudisi
Department of Internal Medicine, Medical Oncology Unit, University of Rome "Tor Vergata", Italy
Luigi Petramala
Department Unit of Secondary Hypertension, Department of Internal Medicine and Medical Specialities, "Sapienza" University of Rome, Italy
Cristiano Marinelli
Department Unit of Secondary Hypertension, Department of Internal Medicine and Medical Specialities, "Sapienza" University of Rome, Italy
Mario Roselli
Department of Internal Medicine, Medical Oncology Unit, University of Rome "Tor Vergata", Italy
Domenico Vitolo
Department of Surgery, "Sapienza" University of Rome, Italy
Chiara Montesani
Department of Surgery, "Sapienza" University of Rome, Italy
Claudio Letizia
Department Unit of Secondary Hypertension, Department of Internal Medicine and Medical Specialities, "Sapienza" University of Rome, Italy

Keywords: VHL, colon adenocarcinoma, pheochromocytoma, clear cell renal carcinoma

JOURNAL OPEN ACCESS

2013 Volume 52 Issue 14 Pages 1599-1603

DOI https://doi.org/10.2169/internalmedicine.52.8278

Details

Abstract

Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited tumor syndrome characterized by the presence of heterogeneous tumors derived from different organs. VHL is caused by germline mutations in the VHL tumor suppressor gene located on chromosome 3p25-26. The loss of functional VHL protein contributes to tumorigenesis. VHL tumors are most frequently derived from the kidneys, adrenal gland, central nervous system, eyes, inner ear, epididymis and pancreas. We herein describe the case of a 64-year-old man carrying the VHL gene mutation affected by simultaneous colon adenocarcinoma, renal clear cell carcinoma and adrenal pheochromocytoma.

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