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Erschienen in: Zeitschrift für Epileptologie 2/2014

01.05.2014 | Leitthema

Mehr als Anfälle und Antiepileptika

Komorbiditäten bei Epilepsien

verfasst von: Dr. S. von Spiczak, U. Stephani

Erschienen in: Clinical Epileptology | Ausgabe 2/2014

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Zusammenfassung

Mehrfachbehinderungen kommen in der neuropädiatrischen Tätigkeit häufig vor; dabei steht nicht immer die Epilepsie im Vordergrund. Entwicklungsverzögerungen, kognitive Probleme und geistige Behinderungen können bei den verschiedenen Epilepsiesyndromen in unterschiedlichem Ausmaß auftreten. Patienten mit Verhaltensstörungen wie Aufmerksamkeitsdefizit und Hyperaktivität oder psychiatrischen Erkrankungen (z. B. Autismus und autistische Züge) sind therapeutisch besonders herausfordernd. Bewegungsstörungen können in Form der Zerebralparese mit Epilepsie in Erscheinung treten; die Ursache der Epilepsie kann mit Bewegungsstörungen, die der Bewegungsstörungen mit einer Epilepsie assoziiert sein. Syndromale Erkrankungen und Stoffwechselkrankheiten mit Epilepsie müssen zunächst ätiopathogenetisch diagnostiziert werden, um Betroffene und Angehörige unterstützen zu können. Progrediente Hirnerkrankungen und schwere Behinderungen erfordern oft palliativmedizinische Konzepte. In allen diesen Situationen bedarf es eines multidisziplinären Teams von spezialisierten Ärzten, Pflegenden, Therapeuten, Sozial- und Sonderpädagogen, um den Patienten und ihren Familien die optimale Behandlung mit dem Ziel einer hohen Lebensqualität zu ermöglichen.
Literatur
1.
Zurück zum Zitat Hamiwka LD, Wirrell EC (2009) Comorbidities in pediatric epilepsy: beyond „just’‘ treating the seizures. J Child Neurol 24:734–742PubMedCrossRef Hamiwka LD, Wirrell EC (2009) Comorbidities in pediatric epilepsy: beyond „just’‘ treating the seizures. J Child Neurol 24:734–742PubMedCrossRef
2.
Zurück zum Zitat Kerr M, Kluger G, Philip S (2011) Evolution and management of Lennox-Gastaut syndrome through adolescence and into adulthood: are seizures always the primary issue? Epileptic Disord 13(Suppl 1):S15–S26PubMed Kerr M, Kluger G, Philip S (2011) Evolution and management of Lennox-Gastaut syndrome through adolescence and into adulthood: are seizures always the primary issue? Epileptic Disord 13(Suppl 1):S15–S26PubMed
3.
Zurück zum Zitat Lv R, Wu L, Jin L et al (2009) Depression, anxiety and quality of life in parents of children with epilepsy. Acta Neurol Scand 120:335–341PubMedCrossRef Lv R, Wu L, Jin L et al (2009) Depression, anxiety and quality of life in parents of children with epilepsy. Acta Neurol Scand 120:335–341PubMedCrossRef
4.
Zurück zum Zitat Nolan K, Camfield CS, Camfield PR (2008) Coping with a child with Dravet syndrome: insights from families. J Child Neurol 23:690–694PubMedCrossRef Nolan K, Camfield CS, Camfield PR (2008) Coping with a child with Dravet syndrome: insights from families. J Child Neurol 23:690–694PubMedCrossRef
5.
Zurück zum Zitat Nolan KJ, Camfield CS, Camfield PR (2006) Coping with Dravet syndrome: parental experiences with a catastrophic epilepsy. Dev Med Child Neurol 48:761–765PubMedCrossRef Nolan KJ, Camfield CS, Camfield PR (2006) Coping with Dravet syndrome: parental experiences with a catastrophic epilepsy. Dev Med Child Neurol 48:761–765PubMedCrossRef
6.
Zurück zum Zitat Hames A, Appleton R (2009) Living with a brother or sister with epilepsy: siblings‘ experiences. Seizure 18:699–701PubMedCrossRef Hames A, Appleton R (2009) Living with a brother or sister with epilepsy: siblings‘ experiences. Seizure 18:699–701PubMedCrossRef
7.
Zurück zum Zitat Siemes H, Bourgeois BFD (2001) Anfälle und Epilepsien bei Kindern und Jugendlichen. Thieme, Stuttgart Siemes H, Bourgeois BFD (2001) Anfälle und Epilepsien bei Kindern und Jugendlichen. Thieme, Stuttgart
8.
9.
Zurück zum Zitat Guerrini R, Falchi M (2011) Dravet syndrome and SCN1A gene mutation related-epilepsies: cognitive impairment and its determinants. Dev Med Child Neurol 53(Suppl 2):11–15PubMedCrossRef Guerrini R, Falchi M (2011) Dravet syndrome and SCN1A gene mutation related-epilepsies: cognitive impairment and its determinants. Dev Med Child Neurol 53(Suppl 2):11–15PubMedCrossRef
10.
Zurück zum Zitat Masur D, Shinnar S, Cnaan A et al (2013) Pretreatment cognitive deficits and treatment effects on attention in childhood absence epilepsy. Neurology 81:1572–1580PubMedCrossRef Masur D, Shinnar S, Cnaan A et al (2013) Pretreatment cognitive deficits and treatment effects on attention in childhood absence epilepsy. Neurology 81:1572–1580PubMedCrossRef
11.
Zurück zum Zitat Kernan CL, Asarnow R, Siddarth P et al (2012) Neurocognitive profiles in children with epilepsy. Epilepsia 53:2156–2163PubMedCrossRef Kernan CL, Asarnow R, Siddarth P et al (2012) Neurocognitive profiles in children with epilepsy. Epilepsia 53:2156–2163PubMedCrossRef
12.
Zurück zum Zitat Lopes R, Simoes MR, Leal AJ (2013) Neuropsychological abnormalities in children with the Panayiotopoulos syndrome point to parietal lobe dysfunction. Epilepsy Behav 31C:50–55 Lopes R, Simoes MR, Leal AJ (2013) Neuropsychological abnormalities in children with the Panayiotopoulos syndrome point to parietal lobe dysfunction. Epilepsy Behav 31C:50–55
13.
Zurück zum Zitat Braakman HM, Vaessen MJ, Hofman PA et al (2011) Cognitive and behavioral complications of frontal lobe epilepsy in children: a review of the literature. Epilepsia 52:849–856PubMedCrossRef Braakman HM, Vaessen MJ, Hofman PA et al (2011) Cognitive and behavioral complications of frontal lobe epilepsy in children: a review of the literature. Epilepsia 52:849–856PubMedCrossRef
14.
Zurück zum Zitat Laurent A, Arzimanoglou A (2006) Cognitive impairments in children with nonidiopathic temporal lobe epilepsy. Epilepsia 47(Suppl 2):99–102PubMedCrossRef Laurent A, Arzimanoglou A (2006) Cognitive impairments in children with nonidiopathic temporal lobe epilepsy. Epilepsia 47(Suppl 2):99–102PubMedCrossRef
15.
Zurück zum Zitat Stefanatos G (2011) Changing perspectives on Landau-Kleffner syndrome. Clin Neuropsychol 25:963–988PubMedCrossRef Stefanatos G (2011) Changing perspectives on Landau-Kleffner syndrome. Clin Neuropsychol 25:963–988PubMedCrossRef
16.
Zurück zum Zitat Dravet C, Bureau M, Oguni H et al (2005) Severe myoclonic epilepsy in infancy: Dravet syndrome. Adv Neurol 95:71–102PubMed Dravet C, Bureau M, Oguni H et al (2005) Severe myoclonic epilepsy in infancy: Dravet syndrome. Adv Neurol 95:71–102PubMed
17.
Zurück zum Zitat Giordani B, Caveney AF, Laughrin D et al (2006) Cognition and behavior in children with benign epilepsy with centrotemporal spikes (BECTS). Epilepsy Res 70:89–94PubMedCrossRef Giordani B, Caveney AF, Laughrin D et al (2006) Cognition and behavior in children with benign epilepsy with centrotemporal spikes (BECTS). Epilepsy Res 70:89–94PubMedCrossRef
18.
Zurück zum Zitat Conant LL, Wilfong A, Inglese C, Schwarte A (2010) Dysfunction of executive and related processes in childhood absence epilepsy. Epilepsy Behav 18:414–423PubMedCrossRef Conant LL, Wilfong A, Inglese C, Schwarte A (2010) Dysfunction of executive and related processes in childhood absence epilepsy. Epilepsy Behav 18:414–423PubMedCrossRef
19.
Zurück zum Zitat D’Agati E, Cerminara C, Casarelli L et al (2012) Attention and executive functions profile in childhood absence epilepsy. Brain Dev 34:812–817CrossRef D’Agati E, Cerminara C, Casarelli L et al (2012) Attention and executive functions profile in childhood absence epilepsy. Brain Dev 34:812–817CrossRef
20.
Zurück zum Zitat Pera MC, Brazzo D, Altieri N et al (2013) Long-term evolution of neuropsychological competences in encephalopathy with status epilepticus during sleep: a variable prognosis. Epilepsia 54(Suppl 7):77–85PubMedCrossRef Pera MC, Brazzo D, Altieri N et al (2013) Long-term evolution of neuropsychological competences in encephalopathy with status epilepticus during sleep: a variable prognosis. Epilepsia 54(Suppl 7):77–85PubMedCrossRef
21.
Zurück zum Zitat Seri S, Thai JN, Brazzo D et al (2009) Neurophysiology of CSWS-associated cognitive dysfunction. Epilepsia 50(Suppl 7):33–36PubMedCrossRef Seri S, Thai JN, Brazzo D et al (2009) Neurophysiology of CSWS-associated cognitive dysfunction. Epilepsia 50(Suppl 7):33–36PubMedCrossRef
22.
Zurück zum Zitat Van Bogaert P, Urbain C, Galer S et al (2011) Impact of focal interictal epileptiform discharges on behaviour and cognition in children. Neurophysiol Clin 42(1–2):53–58 Van Bogaert P, Urbain C, Galer S et al (2011) Impact of focal interictal epileptiform discharges on behaviour and cognition in children. Neurophysiol Clin 42(1–2):53–58
23.
Zurück zum Zitat Overvliet GM,, Besseling RM, Vles JS et al (2010) Nocturnal epileptiform EEG discharges, nocturnal epileptic seizures, and language impairments in children: review of the literature. Epilepsy Behav 19:550–558PubMedCrossRef Overvliet GM,, Besseling RM, Vles JS et al (2010) Nocturnal epileptiform EEG discharges, nocturnal epileptic seizures, and language impairments in children: review of the literature. Epilepsy Behav 19:550–558PubMedCrossRef
24.
Zurück zum Zitat Ebus S, Arends J, Hendriksen J et al (2012) Cognitive effects of interictal epileptiform discharges in children. Eur J Paediatr Neurol 16:697–706PubMedCrossRef Ebus S, Arends J, Hendriksen J et al (2012) Cognitive effects of interictal epileptiform discharges in children. Eur J Paediatr Neurol 16:697–706PubMedCrossRef
25.
Zurück zum Zitat Overvliet GM, Besseling RM, Vles JS et al (2011) Association between frequency of nocturnal epilepsy and language disturbance in children. Pediatr Neurol 44:333–339PubMedCrossRef Overvliet GM, Besseling RM, Vles JS et al (2011) Association between frequency of nocturnal epilepsy and language disturbance in children. Pediatr Neurol 44:333–339PubMedCrossRef
26.
Zurück zum Zitat Venkateswaran S, Shevell M (2008) The case against routine electroencephalography in specific language impairment. Pediatrics 122:e911–e916PubMedCrossRef Venkateswaran S, Shevell M (2008) The case against routine electroencephalography in specific language impairment. Pediatrics 122:e911–e916PubMedCrossRef
27.
Zurück zum Zitat Berg AT, Berkovic SF, Brodie MJ et al (2010) Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia 51:676–685PubMedCrossRef Berg AT, Berkovic SF, Brodie MJ et al (2010) Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia 51:676–685PubMedCrossRef
28.
Zurück zum Zitat Nabbout R, Chemaly N, Chipaux M et al (2013) Encephalopathy in children with Dravet syndrome is not a pure consequence of epilepsy. Orphanet J Rare Dis 8:176PubMedCrossRef Nabbout R, Chemaly N, Chipaux M et al (2013) Encephalopathy in children with Dravet syndrome is not a pure consequence of epilepsy. Orphanet J Rare Dis 8:176PubMedCrossRef
29.
Zurück zum Zitat Covanis A (2012) Epileptic encephalopathies (including severe epilepsy syndromes). Epilepsia 53(Suppl 4):114–126PubMedCrossRef Covanis A (2012) Epileptic encephalopathies (including severe epilepsy syndromes). Epilepsia 53(Suppl 4):114–126PubMedCrossRef
30.
Zurück zum Zitat Besag FM (2006) Cognitive and behavioral outcomes of epileptic syndromes: implications for education and clinical practice. Epilepsia 47(Suppl 2):119–125PubMedCrossRef Besag FM (2006) Cognitive and behavioral outcomes of epileptic syndromes: implications for education and clinical practice. Epilepsia 47(Suppl 2):119–125PubMedCrossRef
31.
Zurück zum Zitat Lo-Castro A, Curatolo P (2013) Epilepsy associated with autism and attention deficit hyperactivity disorder: is there a genetic link? Brain Dev Lo-Castro A, Curatolo P (2013) Epilepsy associated with autism and attention deficit hyperactivity disorder: is there a genetic link? Brain Dev
32.
Zurück zum Zitat Eddy CM, Rickards HE, Cavanna AE (2012) Behavioral adverse effects of antiepileptic drugs in epilepsy. J Clin Psychopharmacol 32:362–375PubMedCrossRef Eddy CM, Rickards HE, Cavanna AE (2012) Behavioral adverse effects of antiepileptic drugs in epilepsy. J Clin Psychopharmacol 32:362–375PubMedCrossRef
33.
Zurück zum Zitat Glauser TA (2004) Behavioral and psychiatric adverse events associated with antiepileptic drugs commonly used in pediatric patients. J Child Neurol 19(Suppl 1):S25–S38PubMedCrossRef Glauser TA (2004) Behavioral and psychiatric adverse events associated with antiepileptic drugs commonly used in pediatric patients. J Child Neurol 19(Suppl 1):S25–S38PubMedCrossRef
34.
Zurück zum Zitat Helmstaedter C, Aldenkamp AP, Baker GA et al (2013) Disentangling the relationship between epilepsy and its behavioral comorbidities – The need for prospective studies in new-onset epilepsies. Epilepsy Behav 31C:43–47 Helmstaedter C, Aldenkamp AP, Baker GA et al (2013) Disentangling the relationship between epilepsy and its behavioral comorbidities – The need for prospective studies in new-onset epilepsies. Epilepsy Behav 31C:43–47
36.
Zurück zum Zitat Grayton HM, Fernandes C, Rujescu D, Collier DA (2012) Copy number variations in neurodevelopmental disorders. Prog Neurobiol 99:81–91PubMedCrossRef Grayton HM, Fernandes C, Rujescu D, Collier DA (2012) Copy number variations in neurodevelopmental disorders. Prog Neurobiol 99:81–91PubMedCrossRef
37.
Zurück zum Zitat Lesca G, Rudolf G, Labalme A et al (2012) Epileptic encephalopathies of the Landau-Kleffner and continuous spike and waves during slow-wave sleep types: genomic dissection makes the link with autism. Epilepsia 53:1526–1538PubMedCrossRef Lesca G, Rudolf G, Labalme A et al (2012) Epileptic encephalopathies of the Landau-Kleffner and continuous spike and waves during slow-wave sleep types: genomic dissection makes the link with autism. Epilepsia 53:1526–1538PubMedCrossRef
38.
Zurück zum Zitat Tuchman R (2013) Autism and social cognition in epilepsy: implications for comprehensive epilepsy care. Curr Opin Neurol 26:214–218PubMedCrossRef Tuchman R (2013) Autism and social cognition in epilepsy: implications for comprehensive epilepsy care. Curr Opin Neurol 26:214–218PubMedCrossRef
39.
Zurück zum Zitat Kaufmann R, Goldberg-Stern H, Shuper A (2009) Attention-deficit disorders and epilepsy in childhood: incidence, causative relations and treatment possibilities. J Child Neurol 24:727–733PubMedCrossRef Kaufmann R, Goldberg-Stern H, Shuper A (2009) Attention-deficit disorders and epilepsy in childhood: incidence, causative relations and treatment possibilities. J Child Neurol 24:727–733PubMedCrossRef
40.
Zurück zum Zitat Altunel A, Altunel EO, Sever A (2013) Electroencephalogram in attention deficit hyperactivity disorder: spike and wave paroxysms, foci, and seizures. J Clin Neurophysiol 30:357–361PubMedCrossRef Altunel A, Altunel EO, Sever A (2013) Electroencephalogram in attention deficit hyperactivity disorder: spike and wave paroxysms, foci, and seizures. J Clin Neurophysiol 30:357–361PubMedCrossRef
41.
Zurück zum Zitat Socanski Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=Socanski%20D%5BAuthor%5D&cauthor=true&cauthor_uid=23711613, Aurlien D, Herigstad A et al (2013) Epilepsy in a large cohort of children diagnosed with attention deficit/hyperactivity disorders (ADHD). Seizure 22:651–655PubMedCrossRef Socanski Dhttp://​www.​ncbi.​nlm.​nih.​gov/​pubmed?​term=​Socanski%20D%5BAuthor%5D&cauthor=true&cauthor_uid=23711613, Aurlien D, Herigstad A et al (2013) Epilepsy in a large cohort of children diagnosed with attention deficit/hyperactivity disorders (ADHD). Seizure 22:651–655PubMedCrossRef
42.
Zurück zum Zitat Pineda E, Jentsch JD, Shin D et al (2013) Behavioral impairments in rats with chronic epilepsy suggest comorbidity between epilepsy and attention deficit/hyperactivity disorder. Epilepsy Behav 31:267–275PubMedCrossRef Pineda E, Jentsch JD, Shin D et al (2013) Behavioral impairments in rats with chronic epilepsy suggest comorbidity between epilepsy and attention deficit/hyperactivity disorder. Epilepsy Behav 31:267–275PubMedCrossRef
43.
Zurück zum Zitat Chou IC, Chang YT, Chin ZN et al (2013) Correlation between epilepsy and attention deficit hyperactivity disorder: a population-based cohort study. PLoS One 8:e57926PubMedCentralPubMedCrossRef Chou IC, Chang YT, Chin ZN et al (2013) Correlation between epilepsy and attention deficit hyperactivity disorder: a population-based cohort study. PLoS One 8:e57926PubMedCentralPubMedCrossRef
44.
Zurück zum Zitat Cerminara C, D’Agati E, Casarelli L et al (2013) Attention impairment in childhood absence epilepsy: an impulsivity problem? Epilepsy Behav 27:337–341PubMedCrossRef Cerminara C, D’Agati E, Casarelli L et al (2013) Attention impairment in childhood absence epilepsy: an impulsivity problem? Epilepsy Behav 27:337–341PubMedCrossRef
45.
Zurück zum Zitat Parisi P, Moavero R, Verrotti A, Curatolo P (2010) Attention deficit hyperactivity disorder in children with epilepsy. Brain Dev 32:10–16PubMedCrossRef Parisi P, Moavero R, Verrotti A, Curatolo P (2010) Attention deficit hyperactivity disorder in children with epilepsy. Brain Dev 32:10–16PubMedCrossRef
46.
Zurück zum Zitat Santos K, Palmini A, Radziuk AL et al (2013) The impact of methylphenidate on seizure frequency and severity in children with attention-deficit-hyperactivity disorder and difficult-to-treat epilepsies. Dev Med Child Neurol 55:654–660PubMedCrossRef Santos K, Palmini A, Radziuk AL et al (2013) The impact of methylphenidate on seizure frequency and severity in children with attention-deficit-hyperactivity disorder and difficult-to-treat epilepsies. Dev Med Child Neurol 55:654–660PubMedCrossRef
47.
Zurück zum Zitat Fosi T, Lax-Pericall MT, Scott RC et al (2013) Methylphenidate treatment of attention deficit hyperactivity disorder in young people with learning disability and difficult-to-treat epilepsy: evidence of clinical benefit. Epilepsia 54:2071–2081PubMedCrossRef Fosi T, Lax-Pericall MT, Scott RC et al (2013) Methylphenidate treatment of attention deficit hyperactivity disorder in young people with learning disability and difficult-to-treat epilepsy: evidence of clinical benefit. Epilepsia 54:2071–2081PubMedCrossRef
48.
Zurück zum Zitat Kanemura H, Sano F, Tando T et al (2013) EEG improvements with antiepileptic drug treatment can show a high correlation with behavioral recovery in children with ADHD. Epilepsy Behav 27:443–448PubMedCrossRef Kanemura H, Sano F, Tando T et al (2013) EEG improvements with antiepileptic drug treatment can show a high correlation with behavioral recovery in children with ADHD. Epilepsy Behav 27:443–448PubMedCrossRef
49.
Zurück zum Zitat Wirrell E, Ho AW, Hamiwka L (2006) Sulthiame therapy for continuous spike and wave in slow-wave sleep. Pediatr Neurol 35:204–208PubMedCrossRef Wirrell E, Ho AW, Hamiwka L (2006) Sulthiame therapy for continuous spike and wave in slow-wave sleep. Pediatr Neurol 35:204–208PubMedCrossRef
50.
Zurück zum Zitat Krägeloh-Mann I, Sellier E, Horber V (2013) Schwere einer Epilepsie. Z Epileptol 26:6–9CrossRef Krägeloh-Mann I, Sellier E, Horber V (2013) Schwere einer Epilepsie. Z Epileptol 26:6–9CrossRef
51.
Zurück zum Zitat Suls A, Dedeken P, Goffin K et al (2008) Paroxysmal exercise-induced dyskinesia and epilepsy is due to mutations in SLC2A1, encoding the glucose transporter GLUT1. Brain 131:1831–1844PubMedCentralPubMedCrossRef Suls A, Dedeken P, Goffin K et al (2008) Paroxysmal exercise-induced dyskinesia and epilepsy is due to mutations in SLC2A1, encoding the glucose transporter GLUT1. Brain 131:1831–1844PubMedCentralPubMedCrossRef
52.
Zurück zum Zitat Yamada Khttp://www.ncbi.nlm.nih.gov/pubmed?term=Yamada%20K%5BAuthor%5D&cauthor=true&cauthor_uid=21176162, Miura K, Hara K et al (2010) A wide spectrum of clinical and brain MRI findings in patients with SLC19A3 mutations. BMC Med Genet 11:171PubMedCentralPubMedCrossRef Yamada Khttp://​www.​ncbi.​nlm.​nih.​gov/​pubmed?​term=​Yamada%20K%5BAuthor%5D&cauthor=true&cauthor_uid=21176162, Miura K, Hara K et al (2010) A wide spectrum of clinical and brain MRI findings in patients with SLC19A3 mutations. BMC Med Genet 11:171PubMedCentralPubMedCrossRef
53.
Zurück zum Zitat Mangold S, Blau N, Opladen T et al (2011) Cerebral folate deficiency: a neurometabolic syndrome? Mol Genet Metab 104:369–372PubMedCrossRef Mangold S, Blau N, Opladen T et al (2011) Cerebral folate deficiency: a neurometabolic syndrome? Mol Genet Metab 104:369–372PubMedCrossRef
54.
Zurück zum Zitat Steinfeld R, Grapp M, Kraetzner R et al (2009) Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism. Am J Hum Genet 85:354–363PubMedCentralPubMedCrossRef Steinfeld R, Grapp M, Kraetzner R et al (2009) Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism. Am J Hum Genet 85:354–363PubMedCentralPubMedCrossRef
55.
Zurück zum Zitat Bizzi A, Bugiani M, Salomons GS et al (2002) X-linked creatine deficiency syndrome: a novel mutation in creatine transporter gene SLC6A8. Ann Neurol 52:227–231PubMedCrossRef Bizzi A, Bugiani M, Salomons GS et al (2002) X-linked creatine deficiency syndrome: a novel mutation in creatine transporter gene SLC6A8. Ann Neurol 52:227–231PubMedCrossRef
56.
Zurück zum Zitat Guerrini R, Bonanni P, Nardocci N et al (1999) Autosomal recessive rolandic epilepsy with paroxysmal exercise-induced dystonia and writer’s cramp: delineation of the syndrome and gene mapping to chromosome 16p12–11.2. Ann Neurol 45:344–352PubMedCrossRef Guerrini R, Bonanni P, Nardocci N et al (1999) Autosomal recessive rolandic epilepsy with paroxysmal exercise-induced dystonia and writer’s cramp: delineation of the syndrome and gene mapping to chromosome 16p12–11.2. Ann Neurol 45:344–352PubMedCrossRef
57.
Zurück zum Zitat Ramantani G, Kohlhase J, Hertzberg C et al (2010) Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutieres syndrome. Arthritis Rheum 62:1469–1477PubMedCrossRef Ramantani G, Kohlhase J, Hertzberg C et al (2010) Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutieres syndrome. Arthritis Rheum 62:1469–1477PubMedCrossRef
58.
Zurück zum Zitat O’Riordan S, Ozelius LJ, de Carvalho Aguiar P et al (2004) Inherited myoclonus-dystonia and epilepsy: further evidence of an association? Mov Disord 19:1456–1459CrossRef O’Riordan S, Ozelius LJ, de Carvalho Aguiar P et al (2004) Inherited myoclonus-dystonia and epilepsy: further evidence of an association? Mov Disord 19:1456–1459CrossRef
59.
Zurück zum Zitat Cleary MA, Green A (2005) Developmental delay: when to suspect and how to investigate for an inborn error of metabolism. Arch Dis Child 90:1128–1132PubMedCentralPubMedCrossRef Cleary MA, Green A (2005) Developmental delay: when to suspect and how to investigate for an inborn error of metabolism. Arch Dis Child 90:1128–1132PubMedCentralPubMedCrossRef
60.
Zurück zum Zitat Kumada T, Ito M, Miyajima T et al (2005) Multi-institutional study on the correlation between chromosomal abnormalities and epilepsy. Brain Dev 27:127–134PubMedCrossRef Kumada T, Ito M, Miyajima T et al (2005) Multi-institutional study on the correlation between chromosomal abnormalities and epilepsy. Brain Dev 27:127–134PubMedCrossRef
61.
Zurück zum Zitat Ohtsuka Y, Kobayashi K, Yoshinaga H et al (2005) Relationship between severity of epilepsy and developmental outcome in Angelman syndrome. Brain Dev 27:95–100PubMedCrossRef Ohtsuka Y, Kobayashi K, Yoshinaga H et al (2005) Relationship between severity of epilepsy and developmental outcome in Angelman syndrome. Brain Dev 27:95–100PubMedCrossRef
62.
Zurück zum Zitat Valente KD, Freitas A, Fiore LA, Kim CA (2003) A study of EEG and epilepsy profile in Wolf-Hirschhorn syndrome and considerations regarding its correlation with other chromosomal disorders. Brain Dev 25:283–287PubMedCrossRef Valente KD, Freitas A, Fiore LA, Kim CA (2003) A study of EEG and epilepsy profile in Wolf-Hirschhorn syndrome and considerations regarding its correlation with other chromosomal disorders. Brain Dev 25:283–287PubMedCrossRef
63.
Zurück zum Zitat Warrier V, Vieira M, Mole SE (2013) Genetic basis and phenotypic correlations of the neuronal ceroid lipofusinoses. Biochim Biophys Acta 1832:1827–1830PubMedCrossRef Warrier V, Vieira M, Mole SE (2013) Genetic basis and phenotypic correlations of the neuronal ceroid lipofusinoses. Biochim Biophys Acta 1832:1827–1830PubMedCrossRef
64.
Zurück zum Zitat Mink JW, Augustine EF, Adams HR et al (2013) Classification and natural history of the neuronal ceroid lipofuscinoses. J Child Neurol 28:1101–1105PubMedCrossRef Mink JW, Augustine EF, Adams HR et al (2013) Classification and natural history of the neuronal ceroid lipofuscinoses. J Child Neurol 28:1101–1105PubMedCrossRef
65.
Zurück zum Zitat Franceschett S, Michelucci R, Canafoglia L et al (2014) Progressive myoclonic epilepsies: definitive and still undetermined causes. Neurology 82:405–411CrossRef Franceschett S, Michelucci R, Canafoglia L et al (2014) Progressive myoclonic epilepsies: definitive and still undetermined causes. Neurology 82:405–411CrossRef
Metadaten
Titel
Mehr als Anfälle und Antiepileptika
Komorbiditäten bei Epilepsien
verfasst von
Dr. S. von Spiczak
U. Stephani
Publikationsdatum
01.05.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Epileptology / Ausgabe 2/2014
Print ISSN: 2948-104X
Elektronische ISSN: 2948-1058
DOI
https://doi.org/10.1007/s10309-013-0355-x

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