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Erschienen in: HNO 9/2015

01.09.2015 | Leitthema

Neue Aspekte in der Therapie von Schilddrüsenkarzinomen

Highlights des ASCO-Kongresses 2015

verfasst von: Dr. B.B. Lörincz, Prof. Dr. S. Topp, Prof. Dr. R. Knecht

Erschienen in: HNO | Ausgabe 9/2015

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Zusammenfassung

Anfang Juni 2015 fand der jährliche Kongress der American Society of Clinical Oncology (ASCO) in Chicago statt. Insgesamt wurden 24 Studien im Bereich der Schilddrüsenkarzinome vorgestellt, die in diesem Übersichtsartikel nach dem Grad der Differenzierung gruppiert sind. Die führende kurative Therapiemodalität ist nach wie vor die chirurgische Behandlung. Kinaseinhibitoren werden vor allem im Rahmen eines palliativen Konzeptes angewendet. Der neueste Stand der Wissenschaft zur Therapie von Schilddrüsenkarzinomen, sowohl chirurgisch als auch internistisch, wird nachfolgend zusammengefasst.
Literatur
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Zurück zum Zitat Wei T, Chen R, Zou X, Liu F, Li Z, Zhu J (2015) Predictive factors of contralateral paratracheal lymph node metastasis in unilateral papillary thyroid carcinoma. ASCO Meet Abstr 33(15 suppl):e17005 Wei T, Chen R, Zou X, Liu F, Li Z, Zhu J (2015) Predictive factors of contralateral paratracheal lymph node metastasis in unilateral papillary thyroid carcinoma. ASCO Meet Abstr 33(15 suppl):e17005
2.
Zurück zum Zitat Su A, Wei T, Liu F, Gong Y, Ma Y, Wen L, Zou X, Gong R, Li Z, Zhu J (2015) Use of carbon nanoparticles to identify parathyroid glands at thyroidectomy for patients of papillary thyroid cancer. ASCO Meet Abstr 33(15 suppl):e17006 Su A, Wei T, Liu F, Gong Y, Ma Y, Wen L, Zou X, Gong R, Li Z, Zhu J (2015) Use of carbon nanoparticles to identify parathyroid glands at thyroidectomy for patients of papillary thyroid cancer. ASCO Meet Abstr 33(15 suppl):e17006
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Zurück zum Zitat Newbold K, Elisei R, Taylor MH, Krzyzanowska MK, Shah MH, Hoff AO, Robinson B, Dutcus C, Song J, Habra MA (2015) Efficacy and safety of lenvatinib for the treatment of patients with131I-refractory differentiated thyroid cancer with and without prior VEGF-targeted therapy. ASCO Meet Abstr 33(15 suppl):6013 Newbold K, Elisei R, Taylor MH, Krzyzanowska MK, Shah MH, Hoff AO, Robinson B, Dutcus C, Song J, Habra MA (2015) Efficacy and safety of lenvatinib for the treatment of patients with131I-refractory differentiated thyroid cancer with and without prior VEGF-targeted therapy. ASCO Meet Abstr 33(15 suppl):6013
11.
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12.
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13.
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14.
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15.
Zurück zum Zitat Uziely B, Ratzon N, Rottenberg Y (2015) Unemployment risk and decreased income 2 and 4 years after thyroid cancer diagnosis: a population based study. ASCO Meet Abstr 33(15 suppl):e20618 Uziely B, Ratzon N, Rottenberg Y (2015) Unemployment risk and decreased income 2 and 4 years after thyroid cancer diagnosis: a population based study. ASCO Meet Abstr 33(15 suppl):e20618
16.
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18.
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19.
Zurück zum Zitat Johnson JM, Chen J, Dardi IK, Tuluc M, Ali SM, Cognetti D, Campling BG, Sama AR (2015) Molecular profile of synchronous metastatic colon cancer and anaplastic thyroid cancer in a patient with Lynch Syndrome. ASCO Meet Abstr 33(15 suppl):e22049 Johnson JM, Chen J, Dardi IK, Tuluc M, Ali SM, Cognetti D, Campling BG, Sama AR (2015) Molecular profile of synchronous metastatic colon cancer and anaplastic thyroid cancer in a patient with Lynch Syndrome. ASCO Meet Abstr 33(15 suppl):e22049
20.
Zurück zum Zitat Khan SA, Bauman JE, Burtness B, Frankel AE, Harper J, Hughes RS, Kurian P, Myers LL, Nedzi LA, Schwartz DL, Sumer BD, Truelson J, Zhu H (2015) Ceritinib in anaplastic thyroid cancer (ATC) with ALK abnormalities. ASCO Meet Abstr 33(15 suppl):TPS6085 Khan SA, Bauman JE, Burtness B, Frankel AE, Harper J, Hughes RS, Kurian P, Myers LL, Nedzi LA, Schwartz DL, Sumer BD, Truelson J, Zhu H (2015) Ceritinib in anaplastic thyroid cancer (ATC) with ALK abnormalities. ASCO Meet Abstr 33(15 suppl):TPS6085
21.
Zurück zum Zitat Yilmaz E, Champa D, Di Cristofano A (2015) Synergistic effect of combined PI3K and PLK1 inhibition in anaplastic thyroid carcinoma cells. ASCO Meet Abstr 33(15 suppl):e22205 Yilmaz E, Champa D, Di Cristofano A (2015) Synergistic effect of combined PI3K and PLK1 inhibition in anaplastic thyroid carcinoma cells. ASCO Meet Abstr 33(15 suppl):e22205
22.
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23.
Zurück zum Zitat Schlumberger M, Elisei R, Muller S, Schoffski P, Brose MS, Shah MH, Licitra LF, Jarzab B, Medvedev V, Kreissl M, Cohen EEW, Wirth LJ, Ali HY, Hessel C, Yaron Y, Ball DW, Nelkin B, Sherman SI (2015) Final overall survival analysis of EXAM, an international, double-blind, randomized, placebo-controlled phase III trial of cabozantinib (Cabo) in medullary thyroid carcinoma (MTC) patients with documented RECIST progression at baseline. ASCO Meet Abstr 33(15 suppl):6012 Schlumberger M, Elisei R, Muller S, Schoffski P, Brose MS, Shah MH, Licitra LF, Jarzab B, Medvedev V, Kreissl M, Cohen EEW, Wirth LJ, Ali HY, Hessel C, Yaron Y, Ball DW, Nelkin B, Sherman SI (2015) Final overall survival analysis of EXAM, an international, double-blind, randomized, placebo-controlled phase III trial of cabozantinib (Cabo) in medullary thyroid carcinoma (MTC) patients with documented RECIST progression at baseline. ASCO Meet Abstr 33(15 suppl):6012
24.
Zurück zum Zitat Malone ER, Gallagher DJ (2015) The rate of RET mutation testing in medullary thyroid cancer in the Republic of Ireland. ASCO Meet Abstr 33(15 suppl):e12516 Malone ER, Gallagher DJ (2015) The rate of RET mutation testing in medullary thyroid cancer in the Republic of Ireland. ASCO Meet Abstr 33(15 suppl):e12516
Metadaten
Titel
Neue Aspekte in der Therapie von Schilddrüsenkarzinomen
Highlights des ASCO-Kongresses 2015
verfasst von
Dr. B.B. Lörincz
Prof. Dr. S. Topp
Prof. Dr. R. Knecht
Publikationsdatum
01.09.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
HNO / Ausgabe 9/2015
Print ISSN: 0017-6192
Elektronische ISSN: 1433-0458
DOI
https://doi.org/10.1007/s00106-015-0052-3

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