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01.03.2015 | Original Paper

Neuropsychological impact of cerebral microemboli in ablation of atrial fibrillation

verfasst von: S. Kochhäuser, H. H. Lohmann, M. A. Ritter, P. Leitz, F. Güner, S. Zellerhoff, C. Korsukewitz, D. G. Dechering, J. Banken, N. M. Peters, L. Eckardt, G. Mönnig

Erschienen in: Clinical Research in Cardiology | Ausgabe 3/2015

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Abstract

Background

Clinically silent lesions on cerebral magnet resonance imaging have been found in larger numbers after pulmonary vein isolation (PVI) especially with phased radio frequency (pRF) using all ten electrodes. However, the neuropsychological effects of cerebral microembolism during the procedure remain unclear and data regarding this issue so far are inconsistent.

Methods

Between August 2011 and June 2012, 76 patients undergoing their first PVI were randomized to ablation with either phased (40) or irrigated (36) radio frequency (iRF). A comprehensive neuropsychological test battery was performed the day before and after PVI as well as 6 months after ablation. The occurrence of cerebral microemboli during the procedure was performed via a transcranial Doppler ultrasound device.

Results

PVI using pRF was associated with increased number of microembolic signals (MES) compared to iRF (1530.0 ± 979.8 vs. 645.7 ± 448.7; p < 0.001). Neuropsychological assessment did not reveal any changes in correlation with the used ablation technique. Besides an age-related effect there was a diffuse, sub-clinical impairment of neurologic function depending on age and the number of MES.

Conclusions

There was no clinical overt cognitive deficit and no significant difference in cognitive function correlating with the used ablation technique. The number of MES correlated with a subtle, diffuse post-procedural impairment of neuropsychological function highlighting the need to reduce microemboli during ablation.

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Titel: Neuropsychological impact of cerebral microemboli in ablation of atrial fibrillation
verfasst von: S. Kochhäuser
H. H. Lohmann
M. A. Ritter
P. Leitz
F. Güner
S. Zellerhoff
C. Korsukewitz
D. G. Dechering
J. Banken
N. M. Peters
L. Eckardt
G. Mönnig
Publikationsdatum: 01.03.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Research in Cardiology / Ausgabe 3/2015
Print ISSN: 1861-0684
Elektronische ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-014-0777-0

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Springer Medizin

Neuropsychological impact of cerebral microemboli in ablation of atrial fibrillation

Abstract

Background

Methods

Results

Conclusions

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Springer Medizin

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Conclusions

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