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Erschienen in: Social Psychiatry and Psychiatric Epidemiology 2/2015

01.02.2015 | Original Paper

Patterns and predictors of attrition in a trial of a housing intervention for homeless people with mental illness

verfasst von: Scott Veldhuizen, Carol E. Adair, Christian Methot, Brianna C. Kopp, Patricia O’Campo, Jimmy Bourque, David L. Streiner, Paula N. Goering

Erschienen in: Social Psychiatry and Psychiatric Epidemiology | Ausgabe 2/2015

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Abstract

Purpose

Participant retention is an important challenge in longitudinal research on homeless people. High attrition can threaten validity, and may represent lost opportunities to deliver interventions. In this article, we report on attrition in the At Home/Chez Soi study, a multi-site randomized controlled trial of a housing intervention for homeless people with mental illness.

Methods

We first calculate life tables, and then use clustered logistic regression to implement a discrete-time survival model. We use splines and indicator variables to capture non-linear and group-specific variation over time in the hazard function. As potential predictors, we consider study group, site, date of recruitment, age, sex, baseline substance dependence, baseline psychotic disorder, time homeless in life, community functioning, and education.

Results

The study recruited 2,148 homeless people with mental illness. Of these, 1,158 were randomized to the housing first intervention (HF), and 990 to treatment as usual (TAU). Excluding 79 people known to have died, attrition was 14 %. This proportion was higher in TAU than in HF (21 vs. 8 %, p < 0.01). Attrition was significantly lower in one site than elsewhere, and was also lower among those with substance dependence (13 vs. 18 %, p < 0.01) and among those enrolled earlier in the study. The hazard varied over time in complex ways.

Conclusions

Results imply that study factors are more important than participant characteristics as determinants of retention, and that the immediate period after randomization is a crucial one. The high overall retention demonstrates the effectiveness of existing techniques for retaining participants.
Literatur
1.
Zurück zum Zitat McKenzie M, Tulsky JP, Long HL, Chesney M, Moss A (1999) Tracking and follow-up of marginalized populations: a review. J Health Care Poor Underserved 10(4):409–429PubMedCrossRef McKenzie M, Tulsky JP, Long HL, Chesney M, Moss A (1999) Tracking and follow-up of marginalized populations: a review. J Health Care Poor Underserved 10(4):409–429PubMedCrossRef
2.
Zurück zum Zitat Hough RL, Tarke H, Renker V, Shields P, Gletstein P (1996) Recruitment and retention of homeless mentally ill participants in research. J Consult Clin Psychol 64(5):881–891PubMedCrossRef Hough RL, Tarke H, Renker V, Shields P, Gletstein P (1996) Recruitment and retention of homeless mentally ill participants in research. J Consult Clin Psychol 64(5):881–891PubMedCrossRef
3.
Zurück zum Zitat Amico KR, Harman JJ, O’Grady MA (2008) Attrition and related trends in scientific rigor: a score card for ART adherence intervention research and recommendations for future directions. Curr HIV/AIDS Rep 5(4):172–185PubMedCrossRef Amico KR, Harman JJ, O’Grady MA (2008) Attrition and related trends in scientific rigor: a score card for ART adherence intervention research and recommendations for future directions. Curr HIV/AIDS Rep 5(4):172–185PubMedCrossRef
5.
Zurück zum Zitat Hewitt CE, Kumaravel B, Dumville JC, Torgerson DJ, Trial attrition study group (2010) Assessing the impact of attrition in randomized controlled trials. J Clin Epidemiol 63(11):1264–1270PubMedCrossRef Hewitt CE, Kumaravel B, Dumville JC, Torgerson DJ, Trial attrition study group (2010) Assessing the impact of attrition in randomized controlled trials. J Clin Epidemiol 63(11):1264–1270PubMedCrossRef
7.
Zurück zum Zitat Garfein RS, Swartzendruber A, Ouellet LJ, Kapadia F, Hudson SM, Thiede H, Strathdee SA, Williams IT, Bailey SL, Hagan H, Golub ET, Kerndt P, Hanson DL, Latka MH; DUIT Study Team (2007) Methods to recruit and retain a cohort of young-adult injection drug users for the Third Collaborative Injection Drug Users Study/Drug Users Intervention Trial (CIDUS III/DUIT). Drug Alcohol Depend. 2007 Nov; 91 Suppl 1:S4–17. Epub 2007 Jun 19 Garfein RS, Swartzendruber A, Ouellet LJ, Kapadia F, Hudson SM, Thiede H, Strathdee SA, Williams IT, Bailey SL, Hagan H, Golub ET, Kerndt P, Hanson DL, Latka MH; DUIT Study Team (2007) Methods to recruit and retain a cohort of young-adult injection drug users for the Third Collaborative Injection Drug Users Study/Drug Users Intervention Trial (CIDUS III/DUIT). Drug Alcohol Depend. 2007 Nov; 91 Suppl 1:S4–17. Epub 2007 Jun 19
8.
Zurück zum Zitat Ziek K, Beardsley M, Deren S, Tortu S (1996) Predictors of follow-up in a sample of urban crack users. Eval Progr Plan 19(3):219–224CrossRef Ziek K, Beardsley M, Deren S, Tortu S (1996) Predictors of follow-up in a sample of urban crack users. Eval Progr Plan 19(3):219–224CrossRef
9.
Zurück zum Zitat Conwell DS, Mosher A, Khan A, Tapy J, Sandman L, Vernon A, Horsburgh CR (2007) Factors associated with loss to follow-up in a large tuberculosis treatment trial (TBTC Study 22). Contemp Clin Trials 28:288–294PubMedCrossRef Conwell DS, Mosher A, Khan A, Tapy J, Sandman L, Vernon A, Horsburgh CR (2007) Factors associated with loss to follow-up in a large tuberculosis treatment trial (TBTC Study 22). Contemp Clin Trials 28:288–294PubMedCrossRef
10.
Zurück zum Zitat Fazel S, Khosla V, Doll H, Geddes J (2008) The prevalence of mental disorders among the homeless in Western Countries: systematic review and meta-regression analysis. PLoS Med 5(12):e255CrossRef Fazel S, Khosla V, Doll H, Geddes J (2008) The prevalence of mental disorders among the homeless in Western Countries: systematic review and meta-regression analysis. PLoS Med 5(12):e255CrossRef
12.
Zurück zum Zitat Wright JD, Allen TL, Devine JA (1995) Tracking non-traditional populations in longitudinal studies. Eval Progr Plan 18(3):267–277CrossRef Wright JD, Allen TL, Devine JA (1995) Tracking non-traditional populations in longitudinal studies. Eval Progr Plan 18(3):267–277CrossRef
13.
Zurück zum Zitat Dumville JC, Torgerson DJ, Hewitt CE (2006) Reporting attrition in randomised controlled trials. Br Med J 332(7547):969–971CrossRef Dumville JC, Torgerson DJ, Hewitt CE (2006) Reporting attrition in randomised controlled trials. Br Med J 332(7547):969–971CrossRef
14.
Zurück zum Zitat North CS, Black M, Pollio DE (2012) Predictors of successful tracking over time in a homeless population. Soc Work Res 36(2):153–159CrossRef North CS, Black M, Pollio DE (2012) Predictors of successful tracking over time in a homeless population. Soc Work Res 36(2):153–159CrossRef
15.
Zurück zum Zitat Morse GA, Calsyn RJ, Allen G, Tempelhoff B, Smith R (1992) Experimental comparison of the effects of three treatment programs for homeless mentally ill people. Hosp Community Psychiatry 43(10):1005–1010PubMed Morse GA, Calsyn RJ, Allen G, Tempelhoff B, Smith R (1992) Experimental comparison of the effects of three treatment programs for homeless mentally ill people. Hosp Community Psychiatry 43(10):1005–1010PubMed
16.
Zurück zum Zitat Nomamiukor N, Brown ES (2009) Attrition factors in clinical trials of comorbid bipolar and substance-related disorders. J Affect Disord 112(1–3):284–8. doi:10.1016/j.jad.2008.04.0 Epub 2008 May 29 Nomamiukor N, Brown ES (2009) Attrition factors in clinical trials of comorbid bipolar and substance-related disorders. J Affect Disord 112(1–3):284–8. doi:10.​1016/​j.​jad.​2008.​04.​0 Epub 2008 May 29
17.
Zurück zum Zitat Primm AB, Gomez MB, Tzolova-Iontchev I, Walter P et al (2000) Severely mentally ill patients with and without substance use disorders: characteristics associated with treatment attrition. Community Ment Health J 36(3):235–246PubMedCrossRef Primm AB, Gomez MB, Tzolova-Iontchev I, Walter P et al (2000) Severely mentally ill patients with and without substance use disorders: characteristics associated with treatment attrition. Community Ment Health J 36(3):235–246PubMedCrossRef
18.
Zurück zum Zitat Walton ME, Chathapuram SR, Reischl TM (1998) Tracking substance abusers in longitudinal research: understanding follow-up contact difficulty. Am J Community Psychol 26(2):233–253PubMedCrossRef Walton ME, Chathapuram SR, Reischl TM (1998) Tracking substance abusers in longitudinal research: understanding follow-up contact difficulty. Am J Community Psychol 26(2):233–253PubMedCrossRef
19.
Zurück zum Zitat Cottler LB, Compton WM, Ben-Abdallah A, Horne M, Claverie D (1996) Achieving a 96.6 percent follow-up rate in a longitudinal study of drug abusers. Drug Alcohol Depend 41:209–217PubMedCrossRef Cottler LB, Compton WM, Ben-Abdallah A, Horne M, Claverie D (1996) Achieving a 96.6 percent follow-up rate in a longitudinal study of drug abusers. Drug Alcohol Depend 41:209–217PubMedCrossRef
20.
Zurück zum Zitat Johnson MO, Dilworth SE, Neilands TB, Chesney MA, Rotheram-Borus MJ, Remien RH, Weinhardt L, Ehrhardt AA, Morin SF, NIMH HLP team (2008) Predictors of attrition among high risk HIV-infected participants enrolled in a multi-site prevention trial. AIDS Behav 12(6):974–977. doi:10.1007/s10461-007-9356-y PubMedCentralPubMedCrossRef Johnson MO, Dilworth SE, Neilands TB, Chesney MA, Rotheram-Borus MJ, Remien RH, Weinhardt L, Ehrhardt AA, Morin SF, NIMH HLP team (2008) Predictors of attrition among high risk HIV-infected participants enrolled in a multi-site prevention trial. AIDS Behav 12(6):974–977. doi:10.​1007/​s10461-007-9356-y PubMedCentralPubMedCrossRef
22.
Zurück zum Zitat Matthews FE, Chatfield M, Freeman C, McCracken C, Brayne C, MRC CFAS (2004) Attrition and bias in the MRC cognitive function and ageing study: an epidemiological investigation. BMC Public Health 4:12PubMedCentralPubMedCrossRef Matthews FE, Chatfield M, Freeman C, McCracken C, Brayne C, MRC CFAS (2004) Attrition and bias in the MRC cognitive function and ageing study: an epidemiological investigation. BMC Public Health 4:12PubMedCentralPubMedCrossRef
23.
Zurück zum Zitat Tsemberis S, Eisenberg RF (2000) Pathways to housing: supported housing for street-dwelling homeless individuals. Psychiatr Serv 51:487–493PubMedCrossRef Tsemberis S, Eisenberg RF (2000) Pathways to housing: supported housing for street-dwelling homeless individuals. Psychiatr Serv 51:487–493PubMedCrossRef
24.
Zurück zum Zitat Goering PN, Streiner DL, Adair C, Barker J, Disastio J, Hwang SW, Komaroff J, Latimer E, Somers J, Zabkiewicz DM (2011) The At Home/Chez Soi trial protocol: a pragmatic, multi-site, randomized controlled trial of a housing first intervention for homeless individuals with mental illness in five Canadian cities. BMJ Open 1:e000323. doi:10.1136/bmjopen-2011-00323 PubMedCentralPubMedCrossRef Goering PN, Streiner DL, Adair C, Barker J, Disastio J, Hwang SW, Komaroff J, Latimer E, Somers J, Zabkiewicz DM (2011) The At Home/Chez Soi trial protocol: a pragmatic, multi-site, randomized controlled trial of a housing first intervention for homeless individuals with mental illness in five Canadian cities. BMJ Open 1:e000323. doi:10.​1136/​bmjopen-2011-00323 PubMedCentralPubMedCrossRef
25.
Zurück zum Zitat Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(s20):22–33PubMed Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(s20):22–33PubMed
26.
Zurück zum Zitat Barker S, Barron N, McFarland BH, Bigelow DA (1994) A community ability scale for chronically mentally ill consumers: part I. Reliability and validity. Community Ment Health J 30(4):363–383PubMedCrossRef Barker S, Barron N, McFarland BH, Bigelow DA (1994) A community ability scale for chronically mentally ill consumers: part I. Reliability and validity. Community Ment Health J 30(4):363–383PubMedCrossRef
27.
Zurück zum Zitat Strehlau V, Torchalla I, Patterson M, Moniruzzaman A, Laing A, Addorisio S, Frankish J, Krausz M, Somers J (forthcoming). Recruitment and retention of homeless individuals with mental illness in a housing first intervention study Strehlau V, Torchalla I, Patterson M, Moniruzzaman A, Laing A, Addorisio S, Frankish J, Krausz M, Somers J (forthcoming). Recruitment and retention of homeless individuals with mental illness in a housing first intervention study
28.
Zurück zum Zitat Dennis ML, Chan YF, Funk RR (2006) Development and validation of the GAIN short screener (GSS) for internalizing, externalizing and substance use disorders and crime/violence problems among adolescents and adults. Am J Addictions 15:80–91CrossRef Dennis ML, Chan YF, Funk RR (2006) Development and validation of the GAIN short screener (GSS) for internalizing, externalizing and substance use disorders and crime/violence problems among adolescents and adults. Am J Addictions 15:80–91CrossRef
29.
Zurück zum Zitat Singer JD, Willett JB (2003) Applied longitudinal data analysis: modelling change and event occurrence. Oxford University Press, New YorkCrossRef Singer JD, Willett JB (2003) Applied longitudinal data analysis: modelling change and event occurrence. Oxford University Press, New YorkCrossRef
30.
Zurück zum Zitat Royston P, Ambler G, Sauerbrei W (1999) The use of fractional polynomials to model continuous risk variables in epidemiology. Int J Epidemiol 28(5):964–974PubMedCrossRef Royston P, Ambler G, Sauerbrei W (1999) The use of fractional polynomials to model continuous risk variables in epidemiology. Int J Epidemiol 28(5):964–974PubMedCrossRef
31.
Zurück zum Zitat Holm S (1979) A simple sequentially rejective multiple test procedure. Scand J Stat 6(2):65–70 Holm S (1979) A simple sequentially rejective multiple test procedure. Scand J Stat 6(2):65–70
32.
Zurück zum Zitat StataCorp (2013) Stata Statistical Software: Release 13. College Station, TX: StataCorp LP StataCorp (2013) Stata Statistical Software: Release 13. College Station, TX: StataCorp LP
Metadaten
Titel
Patterns and predictors of attrition in a trial of a housing intervention for homeless people with mental illness
verfasst von
Scott Veldhuizen
Carol E. Adair
Christian Methot
Brianna C. Kopp
Patricia O’Campo
Jimmy Bourque
David L. Streiner
Paula N. Goering
Publikationsdatum
01.02.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Social Psychiatry and Psychiatric Epidemiology / Ausgabe 2/2015
Print ISSN: 0933-7954
Elektronische ISSN: 1433-9285
DOI
https://doi.org/10.1007/s00127-014-0909-x

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