Skip to main content
Erschienen in: European Journal of Nutrition 8/2012

01.12.2012 | Original Contribution

Pro-inflammatory effects of the mushroom Agaricus blazei and its consequences on atherosclerosis development

verfasst von: Juliana L. Gonçalves, Eric H. Roma, Ana Cristina Gomes-Santos, Edenil C. Aguilar, Daniel Cisalpino, Luciana R. Fernandes, Angélica T. Vieira, Dirce R. Oliveira, Valbert N. Cardoso, Mauro M. Teixeira, Jacqueline I. Alvarez-Leite

Erschienen in: European Journal of Nutrition | Ausgabe 8/2012

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Extracts of the mushroom Agaricus blazei (A. blazei) have been described as possessing immunomodulatory and potentially cancer-protective activities. However, these effects of A. blazei as a functional food have not been fully investigated in vivo.

Methods

Using apolipoprotein E-deficient (ApoE−/−) mice, an experimental model of atherosclerosis, we evaluated the effects of 6 or 12 weeks of A. blazei supplementation on the activation of immune cells in the spleen and blood and on the development of atherosclerosis.

Results

Food intake, weight gain, blood lipid profile, and glycemia were similar between the groups. To evaluate leukocyte homing and activation, mice were injected with 99mTc-radiolabeled leukocytes, which showed enhanced leukocyte migration to the spleen and heart of A. blazei-supplemented animals. Analysis of the spleen showed higher levels of activation of neutrophils, NKT cells, and monocytes as well as increased production of TNF-α and IFN-γ. Circulating NKT cells and monocytes were also more activated in the supplemented group. Atherosclerotic lesion areas were larger in the aorta of supplemented mice and exhibited increased numbers of macrophages and neutrophils and a thinner fibrous cap. A. blazei-induced transcriptional upregulation of molecules linked to macrophage activation (CD36, TLR4), neutrophil chemotaxy (CXCL1), leukocyte adhesion (VCAM-1), and plaque vulnerability (MMP9) were seen after 12 weeks of supplementation.

Conclusions

This is the first in vivo study showing that the immunostimulatory effect of A. blazei has proatherogenic repercussions. A. blazei enhances local and systemic inflammation, upregulating pro-inflammatory molecules, and enhancing leukocyte homing to atherosclerosis sites without affecting the lipoprotein profile.
Literatur
1.
Zurück zum Zitat Firenzuoli F, Gori L, Lombardo G (2008) The medicinal mushroom Agaricus blazei Murrill: review of literature and pharmaco-toxicological problems. Evid Based Complement Altern Med 5:3–15CrossRef Firenzuoli F, Gori L, Lombardo G (2008) The medicinal mushroom Agaricus blazei Murrill: review of literature and pharmaco-toxicological problems. Evid Based Complement Altern Med 5:3–15CrossRef
2.
Zurück zum Zitat Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP (2004) Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer 14:589–594CrossRef Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP (2004) Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer 14:589–594CrossRef
3.
Zurück zum Zitat Chan Y, Chang T, Chan CH, Yeh YC, Chen CW, Shieh B, Li C (2007) Immunomodulatory effects of Agaricus blazei Murill in Balb/cByJ mice. J Microbiol Immunol Infect 40:201–208 Chan Y, Chang T, Chan CH, Yeh YC, Chen CW, Shieh B, Li C (2007) Immunomodulatory effects of Agaricus blazei Murill in Balb/cByJ mice. J Microbiol Immunol Infect 40:201–208
4.
Zurück zum Zitat Kaneno R, Fontanari LM, Santos SA, Di Stasi LC, Rodrigues Filho E, Eira AF (2004) Effects of extracts from Brazilian sun-mushroom (Agaricus blazei) on the NK activity and lymphoproliferative responsiveness of Ehrlich tumor-bearing mice. Food Chem Toxicol 42:909–916CrossRef Kaneno R, Fontanari LM, Santos SA, Di Stasi LC, Rodrigues Filho E, Eira AF (2004) Effects of extracts from Brazilian sun-mushroom (Agaricus blazei) on the NK activity and lymphoproliferative responsiveness of Ehrlich tumor-bearing mice. Food Chem Toxicol 42:909–916CrossRef
5.
Zurück zum Zitat Sorimachi K, Akimoto K, Ikehara Y, Inafuku K, Okubo A, Yamazaki S (2001) Secretion of TNF-alpha, IL-8 and nitric oxide by macrophages activated with Agaricus blazei Murill fractions in vitro. Cell Struct Funct 26:103–108CrossRef Sorimachi K, Akimoto K, Ikehara Y, Inafuku K, Okubo A, Yamazaki S (2001) Secretion of TNF-alpha, IL-8 and nitric oxide by macrophages activated with Agaricus blazei Murill fractions in vitro. Cell Struct Funct 26:103–108CrossRef
6.
Zurück zum Zitat Hetland G, Johnson E, Lyberg T, Bernardshaw S, Tryggestad AM, Grinde B (2008) Effects of the medicinal mushroom Agaricus blazei Murill on immunity, infection and cancer. Scand J Immunol 68:363–370CrossRef Hetland G, Johnson E, Lyberg T, Bernardshaw S, Tryggestad AM, Grinde B (2008) Effects of the medicinal mushroom Agaricus blazei Murill on immunity, infection and cancer. Scand J Immunol 68:363–370CrossRef
7.
Zurück zum Zitat Kuo YC, Huang YL, Chen CC, Lin YS, Chuang KA, Tsai WJ (2002) Cell cycle progression and cytokine gene expression of human peripheral blood mononuclear cells modulated by Agaricus blazei. J Lab Clin Med 140:176–187CrossRef Kuo YC, Huang YL, Chen CC, Lin YS, Chuang KA, Tsai WJ (2002) Cell cycle progression and cytokine gene expression of human peripheral blood mononuclear cells modulated by Agaricus blazei. J Lab Clin Med 140:176–187CrossRef
8.
Zurück zum Zitat Kim GY, Lee MY, Lee HJ, Moon DO, Lee CM, Jin CY, Choi YH, Jeong YK, Chung KT, Lee JY, Choi IH, Park YM (2005) Effect of water-soluble proteoglycan isolated from Agaricus blazei on the maturation of murine bone marrow-derived dendritic cells. Int Immunopharmacol 5:1523–1532CrossRef Kim GY, Lee MY, Lee HJ, Moon DO, Lee CM, Jin CY, Choi YH, Jeong YK, Chung KT, Lee JY, Choi IH, Park YM (2005) Effect of water-soluble proteoglycan isolated from Agaricus blazei on the maturation of murine bone marrow-derived dendritic cells. Int Immunopharmacol 5:1523–1532CrossRef
9.
Zurück zum Zitat Kawamura M, Kasai H, He L, Deng X, Yamashita A, Terunuma H, Horiuchi I, Tanabe F, Ito M (2005) Antithetical effects of hemicellulase-treated Agaricus blazei on the maturation of murine bone-marrow-derived dendritic cells. Immunology 114:397–409CrossRef Kawamura M, Kasai H, He L, Deng X, Yamashita A, Terunuma H, Horiuchi I, Tanabe F, Ito M (2005) Antithetical effects of hemicellulase-treated Agaricus blazei on the maturation of murine bone-marrow-derived dendritic cells. Immunology 114:397–409CrossRef
10.
Zurück zum Zitat Takimoto H, Wakita D, Kawaguchi K, Kumazawa Y (2004) Potentiation of cytotoxic activity in naive and tumor-bearing mice by oral administration of hot-water extracts from Agaricus brazei fruiting bodies. Biol Pharm Bull 27:404–406CrossRef Takimoto H, Wakita D, Kawaguchi K, Kumazawa Y (2004) Potentiation of cytotoxic activity in naive and tumor-bearing mice by oral administration of hot-water extracts from Agaricus brazei fruiting bodies. Biol Pharm Bull 27:404–406CrossRef
11.
Zurück zum Zitat Takimoto H, Kato H, Kaneko M, Kumazawa Y (2008) Amelioration of skewed Th1/Th2 balance in tumor-bearing and asthma-induced mice by oral administration of Agaricus blazei extracts. Immunopharmacol Immunotoxicol 30:747–760CrossRef Takimoto H, Kato H, Kaneko M, Kumazawa Y (2008) Amelioration of skewed Th1/Th2 balance in tumor-bearing and asthma-induced mice by oral administration of Agaricus blazei extracts. Immunopharmacol Immunotoxicol 30:747–760CrossRef
12.
Zurück zum Zitat Hansson GK, Libby P, Schonbeck U, Yan ZQ (2002) Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res 91:281–291CrossRef Hansson GK, Libby P, Schonbeck U, Yan ZQ (2002) Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res 91:281–291CrossRef
13.
Zurück zum Zitat Lundberg AM, Hansson GK (2010) Innate immune signals in atherosclerosis. Clin Immunol 134:5–24CrossRef Lundberg AM, Hansson GK (2010) Innate immune signals in atherosclerosis. Clin Immunol 134:5–24CrossRef
14.
Zurück zum Zitat (1989) Association of Official Analytical Chemists. General referee reports. J Assoc Off Anal Chem 72:62–137 (1989) Association of Official Analytical Chemists. General referee reports. J Assoc Off Anal Chem 72:62–137
15.
Zurück zum Zitat Reeves PG, Nielsen FH, Fahey GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123:1939–1951 Reeves PG, Nielsen FH, Fahey GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123:1939–1951
16.
Zurück zum Zitat Oliveira DR, Portugal LR, Cara DC, Vieira EC, Alvarez-Leite JI (2001) Gelatin intake increases the atheroma formation in apoE knock out mice. Atherosclerosis 154:71–77CrossRef Oliveira DR, Portugal LR, Cara DC, Vieira EC, Alvarez-Leite JI (2001) Gelatin intake increases the atheroma formation in apoE knock out mice. Atherosclerosis 154:71–77CrossRef
17.
Zurück zum Zitat Moghadasian MH (2006) Dietary phytosterols reduce cyclosporine-induced hypercholesterolemia in apolipoprotein E-knockout mice. Transplantation 81:207–213CrossRef Moghadasian MH (2006) Dietary phytosterols reduce cyclosporine-induced hypercholesterolemia in apolipoprotein E-knockout mice. Transplantation 81:207–213CrossRef
18.
Zurück zum Zitat Wallin B, Rosengren B, Shertzer HG, Camejo G (1993) Lipoprotein oxidation and measurement of thiobarbituric acid reacting substances formation in a single microtiter plate: its use for evaluation of antioxidants. Anal Biochem 208:10–15CrossRef Wallin B, Rosengren B, Shertzer HG, Camejo G (1993) Lipoprotein oxidation and measurement of thiobarbituric acid reacting substances formation in a single microtiter plate: its use for evaluation of antioxidants. Anal Biochem 208:10–15CrossRef
19.
Zurück zum Zitat Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275 Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275
20.
Zurück zum Zitat Roca M, Martin-Comin J, Becker W, Bernardo-Filho M, Gutfilen B, Moisan A, Peters M, Prats E, Rodrigues M, Sampson C, Signore A, Sinzinger H, Thakur M (1998) A consensus protocol for white blood cells labelling with technetium-99 m hexamethylpropylene amine oxime. International Society of Radiolabeled Blood Elements (ISORBE). Eur J Nucl Med 25:797–799CrossRef Roca M, Martin-Comin J, Becker W, Bernardo-Filho M, Gutfilen B, Moisan A, Peters M, Prats E, Rodrigues M, Sampson C, Signore A, Sinzinger H, Thakur M (1998) A consensus protocol for white blood cells labelling with technetium-99 m hexamethylpropylene amine oxime. International Society of Radiolabeled Blood Elements (ISORBE). Eur J Nucl Med 25:797–799CrossRef
21.
Zurück zum Zitat Cardoso VN, Plaza PJ, Roca M, Armero F, Martin-Comin J (2002) Assessment of inflammatory bowel disease by using two different (99 m)Tc leucocyte labelling methods. Nucl Med Commun 23:715–720CrossRef Cardoso VN, Plaza PJ, Roca M, Armero F, Martin-Comin J (2002) Assessment of inflammatory bowel disease by using two different (99 m)Tc leucocyte labelling methods. Nucl Med Commun 23:715–720CrossRef
22.
Zurück zum Zitat Portugal LR, Fernandes LR, Pietra Pedroso VS, Santiago HC, Gazzinelli RT, Alvarez-Leite JI (2008) Influence of low-density lipoprotein (LDL) receptor on lipid composition, inflammation and parasitism during Toxoplasma gondii infection. Microbes Infect 10:276–284CrossRef Portugal LR, Fernandes LR, Pietra Pedroso VS, Santiago HC, Gazzinelli RT, Alvarez-Leite JI (2008) Influence of low-density lipoprotein (LDL) receptor on lipid composition, inflammation and parasitism during Toxoplasma gondii infection. Microbes Infect 10:276–284CrossRef
23.
Zurück zum Zitat Portugal LR, Goncalves JL, Fernandes LR, Silva HP, Arantes RM, Nicoli JR, Vieira LQ, Alvarez-Leite JI (2006) Effect of Lactobacillus delbrueckii on cholesterol metabolism in germ-free mice and on atherogenesis in apolipoprotein E knock-out mice. Braz J Med Biol Res 39:629–635CrossRef Portugal LR, Goncalves JL, Fernandes LR, Silva HP, Arantes RM, Nicoli JR, Vieira LQ, Alvarez-Leite JI (2006) Effect of Lactobacillus delbrueckii on cholesterol metabolism in germ-free mice and on atherogenesis in apolipoprotein E knock-out mice. Braz J Med Biol Res 39:629–635CrossRef
24.
Zurück zum Zitat Paigen B, Morrow A, Holmes PA, Mitchell D, Williams RA (1987) Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis 68:231–240CrossRef Paigen B, Morrow A, Holmes PA, Mitchell D, Williams RA (1987) Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis 68:231–240CrossRef
25.
Zurück zum Zitat Gupta S, Pablo AM, Jiang X, Wang N, Tall AR, Schindler C (1997) IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. J Clin Invest 99:2752–2761CrossRef Gupta S, Pablo AM, Jiang X, Wang N, Tall AR, Schindler C (1997) IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. J Clin Invest 99:2752–2761CrossRef
26.
Zurück zum Zitat Bailey PJ (1988) Sponge implants as models. Methods Enzymol 162:327–334CrossRef Bailey PJ (1988) Sponge implants as models. Methods Enzymol 162:327–334CrossRef
27.
Zurück zum Zitat Belo AV, Barcelos LS, Ferreira MA, Teixeira MM, Andrade SP (2004) Inhibition of inflammatory angiogenesis by distant subcutaneous tumor in mice. Life Sci 74:2827–2837CrossRef Belo AV, Barcelos LS, Ferreira MA, Teixeira MM, Andrade SP (2004) Inhibition of inflammatory angiogenesis by distant subcutaneous tumor in mice. Life Sci 74:2827–2837CrossRef
28.
Zurück zum Zitat Souza DG, Soares AC, Pinho V, Torloni H, Reis LF, Teixeira MM, Dias AA (2002) Increased mortality and inflammation in tumor necrosis factor-stimulated gene-14 transgenic mice after ischemia and reperfusion injury. Am J Pathol 160:1755–1765CrossRef Souza DG, Soares AC, Pinho V, Torloni H, Reis LF, Teixeira MM, Dias AA (2002) Increased mortality and inflammation in tumor necrosis factor-stimulated gene-14 transgenic mice after ischemia and reperfusion injury. Am J Pathol 160:1755–1765CrossRef
29.
Zurück zum Zitat Vieira AT, Fagundes CT, Alessandri AL, Castor MG, Guabiraba R, Borges VO, Silveira KD, Vieira EL, Goncalves JL, Silva TA, Deruaz M, Proudfoot AE, Sousa LP, Teixeira MM (2009) Treatment with a novel chemokine-binding protein or eosinophil lineage-ablation protects mice from experimental colitis. Am J Pathol 175:2382–2391CrossRef Vieira AT, Fagundes CT, Alessandri AL, Castor MG, Guabiraba R, Borges VO, Silveira KD, Vieira EL, Goncalves JL, Silva TA, Deruaz M, Proudfoot AE, Sousa LP, Teixeira MM (2009) Treatment with a novel chemokine-binding protein or eosinophil lineage-ablation protects mice from experimental colitis. Am J Pathol 175:2382–2391CrossRef
30.
Zurück zum Zitat Agranovich S, Rachinsky I, Pak I, Benkovich E, Lantsberg S (2004) The usefulness of Tc-99 m-HMPAO-labeled leukocyte scintigraphy in the diagnosis of multiple intra-abdominal abscesses following in vitro fertilization (IVF) procedure. Eur J Obstet Gynecol Reprod Biol 116:103–105CrossRef Agranovich S, Rachinsky I, Pak I, Benkovich E, Lantsberg S (2004) The usefulness of Tc-99 m-HMPAO-labeled leukocyte scintigraphy in the diagnosis of multiple intra-abdominal abscesses following in vitro fertilization (IVF) procedure. Eur J Obstet Gynecol Reprod Biol 116:103–105CrossRef
31.
Zurück zum Zitat Bennink R, Peeters M, D’Haens G, Rutgeerts P, Mortelmans L (2001) Tc-99 m HMPAO white blood cell scintigraphy in the assessment of the extent and severity of an acute exacerbation of ulcerative colitis. Clin Nucl Med 26:99–104CrossRef Bennink R, Peeters M, D’Haens G, Rutgeerts P, Mortelmans L (2001) Tc-99 m HMPAO white blood cell scintigraphy in the assessment of the extent and severity of an acute exacerbation of ulcerative colitis. Clin Nucl Med 26:99–104CrossRef
32.
Zurück zum Zitat Ebina T, Fujimiya Y (1998) Antitumor effect of a peptide-glucan preparation extracted from Agaricus blazei in a double-grafted tumor system in mice. Biotherapy 11:259–265CrossRef Ebina T, Fujimiya Y (1998) Antitumor effect of a peptide-glucan preparation extracted from Agaricus blazei in a double-grafted tumor system in mice. Biotherapy 11:259–265CrossRef
33.
Zurück zum Zitat Fukushima M, Nakano M, Morii Y, Ohashi T, Fujiwara Y, Sonoyama K (2000) Hepatic LDL receptor mRNA in rats is increased by dietary mushroom (Agaricus bisporus) fiber and sugar beet fiber. J Nutr 130:2151–2156 Fukushima M, Nakano M, Morii Y, Ohashi T, Fujiwara Y, Sonoyama K (2000) Hepatic LDL receptor mRNA in rats is increased by dietary mushroom (Agaricus bisporus) fiber and sugar beet fiber. J Nutr 130:2151–2156
34.
Zurück zum Zitat Kaneto H, Katakami N, Matsuhisa M, Matsuoka TA (2010) Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis. Mediat Inflamm 2010:453892CrossRef Kaneto H, Katakami N, Matsuhisa M, Matsuoka TA (2010) Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis. Mediat Inflamm 2010:453892CrossRef
35.
Zurück zum Zitat Izawa S, Inoue Y (2004) A screening system for antioxidants using thioredoxin-deficient yeast: discovery of thermostable antioxidant activity from Agaricus blazei Murill. Appl Microbiol Biotechnol 64:537–542CrossRef Izawa S, Inoue Y (2004) A screening system for antioxidants using thioredoxin-deficient yeast: discovery of thermostable antioxidant activity from Agaricus blazei Murill. Appl Microbiol Biotechnol 64:537–542CrossRef
36.
Zurück zum Zitat Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull W Jr, Rosenfeld ME, Schwartz CJ, Wagner WD, Wissler RW (1995) A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 92:1355–1374CrossRef Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull W Jr, Rosenfeld ME, Schwartz CJ, Wagner WD, Wissler RW (1995) A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 92:1355–1374CrossRef
37.
Zurück zum Zitat Major AS, Wilson MT, McCaleb JL, Ru Su Y, Stanic AK, Joyce S, Van Kaer L, Fazio S, Linton MF (2004) Quantitative and qualitative differences in proatherogenic NKT cells in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 24:2351–2357CrossRef Major AS, Wilson MT, McCaleb JL, Ru Su Y, Stanic AK, Joyce S, Van Kaer L, Fazio S, Linton MF (2004) Quantitative and qualitative differences in proatherogenic NKT cells in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 24:2351–2357CrossRef
38.
Zurück zum Zitat Tupin E, Nicoletti A, Elhage R, Rudling M, Ljunggren HG, Hansson GK, Berne GP (2004) CD1d-dependent activation of NKT cells aggravates atherosclerosis. J Exp Med 199:417–422CrossRef Tupin E, Nicoletti A, Elhage R, Rudling M, Ljunggren HG, Hansson GK, Berne GP (2004) CD1d-dependent activation of NKT cells aggravates atherosclerosis. J Exp Med 199:417–422CrossRef
39.
Zurück zum Zitat Buttice G, Miller J, Wang L, Smith BD (2006) Interferon-gamma induces major histocompatibility class II transactivator (CIITA), which mediates collagen repression and major histocompatibility class II activation by human aortic smooth muscle cells. Circ Res 98:472–479CrossRef Buttice G, Miller J, Wang L, Smith BD (2006) Interferon-gamma induces major histocompatibility class II transactivator (CIITA), which mediates collagen repression and major histocompatibility class II activation by human aortic smooth muscle cells. Circ Res 98:472–479CrossRef
40.
Zurück zum Zitat Rus HG, Niculescu F, Vlaicu R (1991) Tumor necrosis factor-alpha in human arterial wall with atherosclerosis. Atherosclerosis 89:247–254CrossRef Rus HG, Niculescu F, Vlaicu R (1991) Tumor necrosis factor-alpha in human arterial wall with atherosclerosis. Atherosclerosis 89:247–254CrossRef
41.
Zurück zum Zitat Ridker PM, Rifai N, Pfeffer M, Sacks F, Lepage S, Braunwald E (2000) Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction. Circulation 101:2149–2153CrossRef Ridker PM, Rifai N, Pfeffer M, Sacks F, Lepage S, Braunwald E (2000) Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction. Circulation 101:2149–2153CrossRef
42.
Zurück zum Zitat Baetta R, Corsini A (2010) Role of polymorphonuclear neutrophils in atherosclerosis: current state and future perspectives. Atherosclerosis 210:1–13CrossRef Baetta R, Corsini A (2010) Role of polymorphonuclear neutrophils in atherosclerosis: current state and future perspectives. Atherosclerosis 210:1–13CrossRef
43.
Zurück zum Zitat van Leeuwen M, Gijbels MJ, Duijvestijn A, Smook M, van de Gaar MJ, Heeringa P, de Winther MP, Tervaert JW (2008) Accumulation of myeloperoxidase-positive neutrophils in atherosclerotic lesions in LDLR−/− mice. Arterioscler Thromb Vasc Biol 28:84–89CrossRef van Leeuwen M, Gijbels MJ, Duijvestijn A, Smook M, van de Gaar MJ, Heeringa P, de Winther MP, Tervaert JW (2008) Accumulation of myeloperoxidase-positive neutrophils in atherosclerotic lesions in LDLR−/− mice. Arterioscler Thromb Vasc Biol 28:84–89CrossRef
44.
Zurück zum Zitat Nambi V (2005) The use of myeloperoxidase as a risk marker for atherosclerosis. Curr Atheroscler Rep 7:127–131CrossRef Nambi V (2005) The use of myeloperoxidase as a risk marker for atherosclerosis. Curr Atheroscler Rep 7:127–131CrossRef
45.
Zurück zum Zitat Raju R, Malloy A, Shah T, Smith R, Oaks M, Hosenpud JD (2003) Alloimmune induction of endothelial cell-derived interferon-gamma-inducible chemokines. Transplantation 75:1072–1074CrossRef Raju R, Malloy A, Shah T, Smith R, Oaks M, Hosenpud JD (2003) Alloimmune induction of endothelial cell-derived interferon-gamma-inducible chemokines. Transplantation 75:1072–1074CrossRef
46.
Zurück zum Zitat Bosisio D, Polentarutti N, Sironi M, Bernasconi S, Miyake K, Webb GR, Martin MU, Mantovani A, Muzio M (2002) Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma: a molecular basis for priming and synergism with bacterial lipopolysaccharide. Blood 99:3427–3431CrossRef Bosisio D, Polentarutti N, Sironi M, Bernasconi S, Miyake K, Webb GR, Martin MU, Mantovani A, Muzio M (2002) Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma: a molecular basis for priming and synergism with bacterial lipopolysaccharide. Blood 99:3427–3431CrossRef
47.
Zurück zum Zitat Kasai H, He LM, Kawamura M, Yang PT, Deng XW, Munkanta M, Yamashita A, Terunuma H, Hirama M, Horiuchi I, Natori T, Koga T, Amano Y, Yamaguchi N, Ito M (2004) IL-12 production induced by Agaricus blazei fraction H (ABH) involves toll-like receptor (TLR). Evid Based Complement Altern Med 1:259–267CrossRef Kasai H, He LM, Kawamura M, Yang PT, Deng XW, Munkanta M, Yamashita A, Terunuma H, Hirama M, Horiuchi I, Natori T, Koga T, Amano Y, Yamaguchi N, Ito M (2004) IL-12 production induced by Agaricus blazei fraction H (ABH) involves toll-like receptor (TLR). Evid Based Complement Altern Med 1:259–267CrossRef
Metadaten
Titel
Pro-inflammatory effects of the mushroom Agaricus blazei and its consequences on atherosclerosis development
verfasst von
Juliana L. Gonçalves
Eric H. Roma
Ana Cristina Gomes-Santos
Edenil C. Aguilar
Daniel Cisalpino
Luciana R. Fernandes
Angélica T. Vieira
Dirce R. Oliveira
Valbert N. Cardoso
Mauro M. Teixeira
Jacqueline I. Alvarez-Leite
Publikationsdatum
01.12.2012
Verlag
Springer-Verlag
Erschienen in
European Journal of Nutrition / Ausgabe 8/2012
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-011-0270-8

Weitere Artikel der Ausgabe 8/2012

European Journal of Nutrition 8/2012 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.