nach oben

Erschienen in:

01.01.2016 | Original Article

Prognostic value of CXCL12 and CXCR4 in inoperable head and neck squamous cell carcinoma

verfasst von: Margret Rave-Fränk, Narges Tehrany, Dr. med. Julia Kitz, Martin Leu, Dr. med. Hanne Elisabeth Weber, Prof. Dr. med. Peter Burfeind, Prof. Dr. med. Henning Schliephake, Prof. Dr. med. Martin Canis, Prof. Dr Tim Beissbarth, Prof. Dr Holger Michael Reichardt, PD Dr. med. Hendrik Andreas Wolff

Erschienen in: Strahlentherapie und Onkologie | Ausgabe 1/2016

Einloggen, um Zugang zu erhalten

Abstract

Objective

The chemokine CXCL12 and its receptor CXCR4 can affect tumor growth, recurrence, and metastasis. We tested the hypothesis that the CXCL12 and CXCR4 expression influences the prognosis of patients with inoperable head and neck cancer treated with definite radiotherapy or chemoradiotherapy.

Methods

Formalin-fixed paraffin-embedded pretreatment tumor tissue from 233 patients with known HPV/p16^INK4A status was analyzed. CXCL12 and CXCR4 expressions were correlated with pretreatment parameters and survival data by univariate and multivariate Cox regression.

Results

CXCL12 was expressed in 43.3 % and CXCR4 in 66.1 % of the samples and both were correlated with HPV/p16^INK4A positivity. A high CXCL12 expression was associated with increased overall survival (p = 0.036), while a high CXCR4 expression was associated with decreased metastasis-free survival (p = 0.034).

Conclusion

A high CXCR4 expression could be regarded as a negative prognostic factor in head and neck cancer because it may foster metastatic spread. This may recommend CXCR4 as therapeutic target for combating head and neck cancer metastasis.

Heiduschka G, Grah A, Oberndorfer F et al (2015) Improved survival in HPV/p16-positive oropharyngeal cancer patients treated with postoperative radiotherapy. Strahlenther Onkol 191:209–216PubMedCrossRef

Takes RP, Rinaldo A, Silver CE et al (2012) Distant metastases from head and neck squamous cell carcinoma. Part I. Basic aspects. Oral Oncol 48:775–779PubMedCrossRef

Domanska UM, Kruizinga RC, Nagengast WB et al (2013) A review on CXCR4/CXCL12 axis in oncology: no place to hide. Eur J Cancer 49:219–230PubMedCrossRef

Albert S, Riveiro ME, Halimi C et al (2013) Focus on the role of the CXCL12/CXCR4 chemokine axis in head and neck squamous cell carcinoma. Head Neck 35:1819–1828PubMedCrossRef

Katayama A, Ogino T, Bandoh N et al (2005) Expression of CXCR4 and its down-regulation by IFN-gamma in head and neck squamous cell carcinoma. Clin Cancer Res 11:2937–2946PubMedCrossRef

Uchida D, Onoue T, Tomizuka Y et al (2007) Involvement of an autocrine stromal cell derived factor-1/CXCR4 system on the distant metastasis of human oral squamous cell carcinoma. Mol Cancer Res 5:685–694PubMedCrossRef

Salcedo R, Wasserman K, Young HA et al (1999) Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: in vivo neovascularization induced by stromal-derived factor-1alpha. Am J Pathol 154:1125–1135PubMedPubMedCentralCrossRef

Ishikawa T, Nakashiro K, Hara S et al (2006) CXCR4 expression is associated with lymph-node metastasis of oral squamous cell carcinoma. Int J Oncol 28:61–66PubMed

Keeley EC, Mehrad B, Strieter RM (2010) CXC chemokines in cancer angiogenesis and metastases. Adv Cancer Res 106:91–111PubMedPubMedCentralCrossRef

10.

Ueda M, Shimada T, Goto Y et al (2010) Expression of CC-chemokine receptor 7 (CCR7) and CXC-chemokine receptor 4 (CXCR4) in head and neck squamous cell carcinoma. Auris Nasus Larynx 37:488–495PubMedCrossRef

11.

Clatot F, Picquenot JM, Choussy O et al (2011) Intratumoural level of SDF-1 correlates with survival in head and neck squamous cell carcinoma. Oral Oncol 47:1062–1068PubMedCrossRef

12.

Tehrany N, Kitz J, Rave-Fränk M et al (2015) High-grade acute organ toxicity and p16 expression as positive prognostic factors in primary radio(chemo)therapy for patients with head and neck squamous cell carcinoma. Strahlenther Onkol 191:566–572PubMedCrossRef

13.

Wolff HA, Bosch J, Jung K et al (2010) High-grade acute organ toxicity as positive prognostic factor in primary radio(chemo)therapy for locally advanced, inoperable head and neck cancer. Strahlenther Onkol 186:262–268PubMedCrossRef

14.

Wolff HA, Daldrup B, Jung K et al (2011) High-grade acute organ toxicity as positive prognostic factor in adjuvant radiation and chemotherapy for locally advanced head and neck cancer. Radiology 258:864–871PubMedCrossRef

15.

Meng X, Wuyi L, Yuhong X et al (2010) Expression of CXCR4 in oral squamous cell carcinoma: correlations with clinicopathology and pivotal role of proliferation. J Oral Pathol Med 39:63–68PubMedCrossRef

16.

Li KC, Huang YH, Ho CY et al (2012) The role of IL-8 in the SDF-1alpha/CXCR4-induced angiogenesis of laryngeal and hypopharyngeal squamous cell carcinoma. Oral Oncol 48:507–515PubMedCrossRef

17.

Uchida D, Onoue T, Kuribayashi N et al (2011) Blockade of CXCR4 in oral squamous cell carcinoma inhibits lymph node metastases. Eur J Cancer 47:452–459PubMedCrossRef

18.

Ou DL, Chien HF, Chen CL et al (2008) Role of Twist in head and neck carcinoma with lymph node metastasis. Anticancer Res 28:1355–1359PubMed

19.

Taki M, Higashikawa K, Yoneda S et al (2008) Up-regulation of stromal cell-derived factor-1alpha and its receptor CXCR4 expression accompanied with epithelial-mesenchymal transition in human oral squamous cell carcinoma. Oncol Rep 19:993–998PubMed

20.

Ishikawa T, Nakashiro K, Klosek SK et al (2009) Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma. Oncol Rep 21:707–712PubMed

21.

Ramsey DM, McAlpine SR (2013) Halting metastasis through CXCR4 inhibition. Bioorg Med Chem Lett 23:20–25PubMedCrossRef

22.

McDermott DH, Liu Q, Velez D et al (2014) A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor. Blood 123:2308–2316PubMedPubMedCentralCrossRef

23.

Cipriani NA, Blair E, Taxy JB (2010) WHIM syndrome and oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:105–108PubMedCrossRef

24.

Clatot F, Gouerant S, Mareschal S et al (2014) The gene expression profile of inflammatory, hypoxic and metabolic genes predicts the metastatic spread of human head and neck squamous cell carcinoma. Oral Oncol 50:200–207PubMedCrossRef

25.

Rainsbury JW, Ahmed W, Williams HK et al (2013) Prognostic biomarkers of survival in oropharyngeal squamous cell carcinoma: systematic review and meta-analysis. Head Neck 35:1048–1055PubMedCrossRef

Titel: Prognostic value of CXCL12 and CXCR4 in inoperable head and neck squamous cell carcinoma
verfasst von: Margret Rave-Fränk
Narges Tehrany
Dr. med. Julia Kitz
Martin Leu
Dr. med. Hanne Elisabeth Weber
Prof. Dr. med. Peter Burfeind
Prof. Dr. med. Henning Schliephake
Prof. Dr. med. Martin Canis
Prof. Dr Tim Beissbarth
Prof. Dr Holger Michael Reichardt
PD Dr. med. Hendrik Andreas Wolff
Publikationsdatum: 01.01.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Strahlentherapie und Onkologie / Ausgabe 1/2016
Print ISSN: 0179-7158
Elektronische ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-015-0892-5

Neu im Fachgebiet Onkologie

24.04.2024 | DGIM 2024 | Nachrichten

Springer Medizin

Prognostic value of CXCL12 and CXCR4 in inoperable head and neck squamous cell carcinoma

Abstract

Objective

Methods

Results

Conclusion

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie

Springer Medizin

Abstract

Objective

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2016

Undetected human papillomavirus DNA and uterine cervical carcinoma

Überlebensvorteil durch Kombination von Bevacizumab mit konventioneller Radiochemotherapie bei Glioblastomen vom proneuralen Subtyp?

Comparative treatment planning study on sequential vs. simultaneous integrated boost in head and neck cancer patients

Survival and local control rates of triple-negative breast cancer patients treated with boost-IOERT during breast-conserving surgery

Hedgehog pathway inhibitor in combination with radiation therapy for basal cell carcinomas of the head and neck

Abskopale Effekte der lokalen Radiotherapie in Kombination mit systemischer Immuntherapie bei Patienten mit metastasierten soliden Tumoren

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie