Skip to main content
Erschienen in: Clinical Neuroradiology 1/2015

01.03.2015 | Original Article

Radiological Image Features of the Atypical Teratoid/Rhabdoid Tumor in Adults: A Systematic Review

verfasst von: M. Kanoto, MD, PhD, Y. Toyoguchi, MD, T. Hosoya, MD, PhD, M. Kuchiki, MD, PhD, Y. Sugai, MD, PhD

Erschienen in: Clinical Neuroradiology | Ausgabe 1/2015

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Atypical teratoid/rhabdoid tumor (AT/RT) occurs in children less than 3 years old, and has a very poor prognosis. AT/RT seldom occurs in adult. We have experienced four cases of AT/RT at our institute. The purpose of this study is to evaluate the radiological image findings of adult-onset AT/RT and to conduct a systematic review.

Methods

Image findings of four AT/RTs in our institute were retrospectively evaluated by an experienced neuroradiologist. If the images were unavailable, image findings were evaluated from the former image interpretation report. We assembled papers of adult-onset AT/RT (n = 38) and evaluated the image findings.

Results

AT/RT occurs in a variety of sites (spinal region, pineal region, suprasellar region, jugular foramen, and so on). High density on computed tomography (CT) was seen in 10 of 11 cases; mixed intensity in T2-weighted image was seen in 13 of 18 cases; and high intensity on diffusion-weighted image (DWI) was seen in 3 of 3 cases. Contrast enhancement was observed in all cases in which images were available.

Conclusions

We have experienced four adult-onset AT/RT cases at our institute and have evaluated image findings through systematic review. The image findings of high density on CT, high intensity on DWI, with low apparent diffusion coefficient, and a heterogenous component should lead to an inclusion of AT/RT in the differential diagnosis of a tumor; these findings may be able to suggest AT/RT; however, they cannot make the diagnosis.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Haas JE, Palmer NF, Weinberg AG, Beckwith JB. Ultrastructure of malignant rhabdoid tumor of the kidney. A distinctive renal tumor of children. Hum Pathol. 1981;12:646–57.CrossRefPubMed Haas JE, Palmer NF, Weinberg AG, Beckwith JB. Ultrastructure of malignant rhabdoid tumor of the kidney. A distinctive renal tumor of children. Hum Pathol. 1981;12:646–57.CrossRefPubMed
2.
Zurück zum Zitat Warmuth-Metz M, Bison B, Dannemann-Stern E, Kortmann R, Rutkowski S, Pietsch T. CT and MR imaging in atypical teratoid/rhabdoid tumors of the central nervous system. Neuroradiology. 2008;50(5):447–52.CrossRefPubMed Warmuth-Metz M, Bison B, Dannemann-Stern E, Kortmann R, Rutkowski S, Pietsch T. CT and MR imaging in atypical teratoid/rhabdoid tumors of the central nervous system. Neuroradiology. 2008;50(5):447–52.CrossRefPubMed
3.
Zurück zum Zitat Caldemeyer KS, Smith RR, Azzarelli B, Boaz JC. Primary central nervous system malignant rhabdoid tumor: CT and MR appearance simulates a primitive neuroectodermal tumor. Pediatr Neurosurg. 1994;21(4):232–6.CrossRefPubMed Caldemeyer KS, Smith RR, Azzarelli B, Boaz JC. Primary central nervous system malignant rhabdoid tumor: CT and MR appearance simulates a primitive neuroectodermal tumor. Pediatr Neurosurg. 1994;21(4):232–6.CrossRefPubMed
4.
Zurück zum Zitat Mirone G, Bouazza S, Chibbaro S, Bresson D, Pavlika M, George B. Primary malignant rhabdoid tumor of the brain in adults. J Clin Neurosci. 2009;16(11):1495–7.CrossRefPubMed Mirone G, Bouazza S, Chibbaro S, Bresson D, Pavlika M, George B. Primary malignant rhabdoid tumor of the brain in adults. J Clin Neurosci. 2009;16(11):1495–7.CrossRefPubMed
5.
Zurück zum Zitat Endo S, Terasaka S, Yamaguchi S, Ikeda H, Kato T, Kobayashi H, et al. Primary rhabdoid tumor with low grade glioma component of the central nervous system in a young adult. Neuropathology. 2013;33(2):185–91.CrossRefPubMed Endo S, Terasaka S, Yamaguchi S, Ikeda H, Kato T, Kobayashi H, et al. Primary rhabdoid tumor with low grade glioma component of the central nervous system in a young adult. Neuropathology. 2013;33(2):185–91.CrossRefPubMed
6.
Zurück zum Zitat Ingold B, Moschopulos M, Hutter G, Seeger H, Röthlisberger B, Landolt H, et al. Abdominal seeding of an atypical teratoid/rhabdoid tumor of the pineal gland along a ventriculoperitoneal shunt catheter. Acta Neuropathol. 2006;111(1):56–9.CrossRefPubMed Ingold B, Moschopulos M, Hutter G, Seeger H, Röthlisberger B, Landolt H, et al. Abdominal seeding of an atypical teratoid/rhabdoid tumor of the pineal gland along a ventriculoperitoneal shunt catheter. Acta Neuropathol. 2006;111(1):56–9.CrossRefPubMed
7.
Zurück zum Zitat Arrazola J, Pedrosa I, Méndez R, Saldaña C, Scheithauer BW, Martínez A. Primary malignant rhabdoid tumour of the brain in an adult. Neuroradiology. 2000;42(5):363–7.CrossRefPubMed Arrazola J, Pedrosa I, Méndez R, Saldaña C, Scheithauer BW, Martínez A. Primary malignant rhabdoid tumour of the brain in an adult. Neuroradiology. 2000;42(5):363–7.CrossRefPubMed
8.
Zurück zum Zitat Ashraf R, Bentley RC, Awan AN, McLendon RE, Ragozzino MW. Implantation metastasis of primary malignant rhabdoid tumor of the brain in an adult (one case report). Med Pediatr Oncol. 1997;28(3):223–7.CrossRefPubMed Ashraf R, Bentley RC, Awan AN, McLendon RE, Ragozzino MW. Implantation metastasis of primary malignant rhabdoid tumor of the brain in an adult (one case report). Med Pediatr Oncol. 1997;28(3):223–7.CrossRefPubMed
9.
Zurück zum Zitat Chacko G, Chacko AG, Dunham CP, Judkins AR, Biegel JA, Perry A. Atypical teratoid/rhabdoid tumor arising in the setting of a pleomorphic xanthoastrocytoma. J Neurooncol. 2007;84(2):217–22.CrossRefPubMed Chacko G, Chacko AG, Dunham CP, Judkins AR, Biegel JA, Perry A. Atypical teratoid/rhabdoid tumor arising in the setting of a pleomorphic xanthoastrocytoma. J Neurooncol. 2007;84(2):217–22.CrossRefPubMed
10.
Zurück zum Zitat Erickson ML, Johnson R, Bannykh SI, de Lotbiniere A, Kim JH. Malignant rhabdoid tumor in a pregnant adult female: literature review of central nervous system rhabdoid tumors. Neurooncol. 2005;74(3):311–9.CrossRef Erickson ML, Johnson R, Bannykh SI, de Lotbiniere A, Kim JH. Malignant rhabdoid tumor in a pregnant adult female: literature review of central nervous system rhabdoid tumors. Neurooncol. 2005;74(3):311–9.CrossRef
11.
Zurück zum Zitat Fuller CE, Pfeifer J, Humphrey P, Bruch LA, Dehner LP, Perry A. Chromosome 22q dosage in composite extrarenal rhabdoid tumors: clonal evolution or a phenotypic mimic? Hum Pathol. 2001;32(10):1102–8.CrossRefPubMed Fuller CE, Pfeifer J, Humphrey P, Bruch LA, Dehner LP, Perry A. Chromosome 22q dosage in composite extrarenal rhabdoid tumors: clonal evolution or a phenotypic mimic? Hum Pathol. 2001;32(10):1102–8.CrossRefPubMed
12.
Zurück zum Zitat Horn M, Schlote W, Lerch KD, Steudel WI, Harms D, Thomas E. Malignant rhabdoid tumor: primary intracranial manifestation in an adult. Acta Neuropathol. 1992;83(4):445–8.CrossRefPubMed Horn M, Schlote W, Lerch KD, Steudel WI, Harms D, Thomas E. Malignant rhabdoid tumor: primary intracranial manifestation in an adult. Acta Neuropathol. 1992;83(4):445–8.CrossRefPubMed
13.
Zurück zum Zitat Kachhara R, Retnam TM, Kumar S, Nair S, Bahattacharya RN, Krishnamoorthy T, et al. Rhabdoid tumor of the thalamus. Neurol India. 2003;51(2):273–4.PubMed Kachhara R, Retnam TM, Kumar S, Nair S, Bahattacharya RN, Krishnamoorthy T, et al. Rhabdoid tumor of the thalamus. Neurol India. 2003;51(2):273–4.PubMed
14.
Zurück zum Zitat Kawaguchi T, Kumabe T, Watanabe M, Tominaga T. Atypical teratoid/rhabdoid tumour with leptomeningeal dissemination in an adult. Acta Neurochir (Wien). 2004;146(9):1033–8.CrossRef Kawaguchi T, Kumabe T, Watanabe M, Tominaga T. Atypical teratoid/rhabdoid tumour with leptomeningeal dissemination in an adult. Acta Neurochir (Wien). 2004;146(9):1033–8.CrossRef
15.
Zurück zum Zitat Lutterbach J, Liegibel J, Koch D, Madlinger A, Frommhold H, Pagenstecher A. Atypical teratoid/rhabdoid tumors in adult patients: case report and review of the literature. J Neurooncol. 2001;52(1):49–56.CrossRefPubMed Lutterbach J, Liegibel J, Koch D, Madlinger A, Frommhold H, Pagenstecher A. Atypical teratoid/rhabdoid tumors in adult patients: case report and review of the literature. J Neurooncol. 2001;52(1):49–56.CrossRefPubMed
16.
Zurück zum Zitat Makuria AT, Rushing EJ, McGrail KM, Hartmann DP, Azumi N, Ozdemirli M. Atypical teratoid rhabdoid tumor (AT/RT) in adults: review of four cases. J Neurooncol. 2008;88(3):321–30.CrossRefPubMed Makuria AT, Rushing EJ, McGrail KM, Hartmann DP, Azumi N, Ozdemirli M. Atypical teratoid rhabdoid tumor (AT/RT) in adults: review of four cases. J Neurooncol. 2008;88(3):321–30.CrossRefPubMed
17.
Zurück zum Zitat Mutou J, Hirose Y, Ikeda E, Yoshida K, Nakazato Y, Kawase T. Malignant brain tumor with rhabdoid feature in an adult. Neurol Med Chir (Tokyo). 2011;51:449–54.CrossRef Mutou J, Hirose Y, Ikeda E, Yoshida K, Nakazato Y, Kawase T. Malignant brain tumor with rhabdoid feature in an adult. Neurol Med Chir (Tokyo). 2011;51:449–54.CrossRef
18.
Zurück zum Zitat Raisanen J, Biegel JA, Hatanpaa KJ, Judkins A, White CL, Perry A. Chromosome 22q deletions in atypical teratoid/rhabdoid tumors in adults. Brain Pathol. 2005;15(1):23–8.CrossRefPubMed Raisanen J, Biegel JA, Hatanpaa KJ, Judkins A, White CL, Perry A. Chromosome 22q deletions in atypical teratoid/rhabdoid tumors in adults. Brain Pathol. 2005;15(1):23–8.CrossRefPubMed
19.
Zurück zum Zitat Raisanen J, Hatanpaa KJ, Mickey BE, White CL 3rd. Atypical teratoid/rhabdoid tumor: cytology and differential diagnosis in adults. Diagn Cytopathol. 2004;31(1):60–3.CrossRefPubMed Raisanen J, Hatanpaa KJ, Mickey BE, White CL 3rd. Atypical teratoid/rhabdoid tumor: cytology and differential diagnosis in adults. Diagn Cytopathol. 2004;31(1):60–3.CrossRefPubMed
20.
Zurück zum Zitat Rezanko T, Tunakan M, Kahraman A, Sucu HK, Gelal F, Akkol I. Primary rhabdoid tumor of the brain in an adult. Neuropathology. 2006;26(1):57–61.CrossRefPubMed Rezanko T, Tunakan M, Kahraman A, Sucu HK, Gelal F, Akkol I. Primary rhabdoid tumor of the brain in an adult. Neuropathology. 2006;26(1):57–61.CrossRefPubMed
21.
Zurück zum Zitat Jose P, Rita S, Teresa P. Primary malignant rhabdoid tumors of the central nervous system: considerations about two cases of adulthood presentation. J Neurooncol. 2003;61:121–6.CrossRef Jose P, Rita S, Teresa P. Primary malignant rhabdoid tumors of the central nervous system: considerations about two cases of adulthood presentation. J Neurooncol. 2003;61:121–6.CrossRef
22.
Zurück zum Zitat Samaras V, Stamatelli A, Samaras E, Stergiou I, Konstantopoulou P, Varsos V, et al. Atypical teratoid/rhabdoid tumor of the central nervous system in an 18-year-old patient. Clin Neuropathol. 2009;28(1):1–10.CrossRefPubMedCentralPubMed Samaras V, Stamatelli A, Samaras E, Stergiou I, Konstantopoulou P, Varsos V, et al. Atypical teratoid/rhabdoid tumor of the central nervous system in an 18-year-old patient. Clin Neuropathol. 2009;28(1):1–10.CrossRefPubMedCentralPubMed
23.
Zurück zum Zitat Shonka NA, Armstrong TS, Prabhu SS, Childress A, Choi S, Langford LA, et al. Atypical teratoid/rhabdoid tumors in adults: a case report and treatment-focused review. J Clin Med Res. 2011;3(2):85–92.PubMedCentralPubMed Shonka NA, Armstrong TS, Prabhu SS, Childress A, Choi S, Langford LA, et al. Atypical teratoid/rhabdoid tumors in adults: a case report and treatment-focused review. J Clin Med Res. 2011;3(2):85–92.PubMedCentralPubMed
24.
Zurück zum Zitat Sugita Y, Takahashi Y, Hayashi I, Morimatsu M, Okamoto K, Shigemori M. Pineal malignant rhabdoid tumor with chondroid formation in an adult. Pathol Int. 1999;49(12):1114–8.CrossRefPubMed Sugita Y, Takahashi Y, Hayashi I, Morimatsu M, Okamoto K, Shigemori M. Pineal malignant rhabdoid tumor with chondroid formation in an adult. Pathol Int. 1999;49(12):1114–8.CrossRefPubMed
25.
Zurück zum Zitat Takahashi K, Nishihara H, Katoh M, Yoshinaga T, Mahabir R, Kanno H, et al. Case of atypical teratoid/rhabdoid tumor in an adult, with long survival. Brain Tumor Pathol. 2011;28(1):71–6.CrossRefPubMed Takahashi K, Nishihara H, Katoh M, Yoshinaga T, Mahabir R, Kanno H, et al. Case of atypical teratoid/rhabdoid tumor in an adult, with long survival. Brain Tumor Pathol. 2011;28(1):71–6.CrossRefPubMed
26.
Zurück zum Zitat Zarovnaya EL, Pallatroni HF, Hug EB, Ball PA, Cromwell LD, Pipas JM, Fadul CE, Meyer LP, Park JP, Biegel JA, Perry A, Rhodes CH. Atypical teratoid/rhabdoid tumor of the spine in an adult: case report and review of the literature. J Neurooncol. 2007;84(1):49–55.CrossRefPubMed Zarovnaya EL, Pallatroni HF, Hug EB, Ball PA, Cromwell LD, Pipas JM, Fadul CE, Meyer LP, Park JP, Biegel JA, Perry A, Rhodes CH. Atypical teratoid/rhabdoid tumor of the spine in an adult: case report and review of the literature. J Neurooncol. 2007;84(1):49–55.CrossRefPubMed
27.
Zurück zum Zitat Fisher BJ, Siddiqui J, Macdonald D, Cairney AE, Ramsey D, Munoz D, et al. Malignant rhabdoid tumor of brain: an aggressive clinical entity. Can J Neurol Sci. 1996;23(4):257–63.PubMed Fisher BJ, Siddiqui J, Macdonald D, Cairney AE, Ramsey D, Munoz D, et al. Malignant rhabdoid tumor of brain: an aggressive clinical entity. Can J Neurol Sci. 1996;23(4):257–63.PubMed
28.
Zurück zum Zitat Kuge A, Kayama T, Tsuchiya D, Kawakami K, Saito S, Nakazato Y, et al. Suprasellar primary malignant rhabdoid tumor in an adult: a case report. Noshinkei Geka. 2000;28(4):351–8. Kuge A, Kayama T, Tsuchiya D, Kawakami K, Saito S, Nakazato Y, et al. Suprasellar primary malignant rhabdoid tumor in an adult: a case report. Noshinkei Geka. 2000;28(4):351–8.
29.
Zurück zum Zitat Han L, Qiu Y, Xie C, Zhang J, Lv X, Xiong W, et al. Atypical teratoid/rhabdoid tumors in adult patients: CT and MR imaging features. AJNR Am J Neuroradiol. 2011;32(1):103–8.PubMed Han L, Qiu Y, Xie C, Zhang J, Lv X, Xiong W, et al. Atypical teratoid/rhabdoid tumors in adult patients: CT and MR imaging features. AJNR Am J Neuroradiol. 2011;32(1):103–8.PubMed
30.
Zurück zum Zitat Kuge A, Sato S, Sakurada K, Takemura S, Kayama T. Atypical teratoid rhabdoid tumor located in the pineal region following prophylactic irradiation for acute lymphoblastic leukemia. Brain Tumor Pathol. 2012;29:177–81.CrossRefPubMed Kuge A, Sato S, Sakurada K, Takemura S, Kayama T. Atypical teratoid rhabdoid tumor located in the pineal region following prophylactic irradiation for acute lymphoblastic leukemia. Brain Tumor Pathol. 2012;29:177–81.CrossRefPubMed
31.
Zurück zum Zitat Kanoto M, Toyoguchi Y, Hosoya T, Oda A. Image findings of atypical teratoid/rhabdoid tumors in adult. Poster. doi:10.1594/ecr2013/C-0765. Kanoto M, Toyoguchi Y, Hosoya T, Oda A. Image findings of atypical teratoid/rhabdoid tumors in adult. Poster. doi:10.1594/ecr2013/C-0765.
32.
Zurück zum Zitat Han SR, Sohn MJ, Yoon SW, Yee GT, Choi CY, Lee DJ, et al. Extracranial metastases of a supratentorial primitive neuroectodermal tumour. J Clin Neurosci. 2007;14(1):55–8.CrossRefPubMed Han SR, Sohn MJ, Yoon SW, Yee GT, Choi CY, Lee DJ, et al. Extracranial metastases of a supratentorial primitive neuroectodermal tumour. J Clin Neurosci. 2007;14(1):55–8.CrossRefPubMed
33.
Zurück zum Zitat Nishio S, Morioka T, Suzuki S, Hamada Y, Kaneko Y, Fukui M. Supratentorial primitive neuroectodermal tumours: a report of four cases with an unusual clinical course in one patient. Acta Neurochir (Wien). 1998;140(3):207–13.CrossRef Nishio S, Morioka T, Suzuki S, Hamada Y, Kaneko Y, Fukui M. Supratentorial primitive neuroectodermal tumours: a report of four cases with an unusual clinical course in one patient. Acta Neurochir (Wien). 1998;140(3):207–13.CrossRef
34.
Zurück zum Zitat Niwa T, Aida N, Tanaka M, Okubo J, Sasano M, Shishikura A, et al. Diffusion-weighted imaging of an atypical teratoid/rhabdoid tumor of the cervical spine. Magn Reson Med Sci. 2009;8(3):135–8.CrossRefPubMed Niwa T, Aida N, Tanaka M, Okubo J, Sasano M, Shishikura A, et al. Diffusion-weighted imaging of an atypical teratoid/rhabdoid tumor of the cervical spine. Magn Reson Med Sci. 2009;8(3):135–8.CrossRefPubMed
35.
Zurück zum Zitat Yamashita Y, Kumabe T, Higano S, Watanabe M, Tominaga T. Minimum apparent diffusion coefficient is significantly correlated with cellularity in medulloblastomas. Neurol Res. 2009;31(9):940–6.CrossRefPubMed Yamashita Y, Kumabe T, Higano S, Watanabe M, Tominaga T. Minimum apparent diffusion coefficient is significantly correlated with cellularity in medulloblastomas. Neurol Res. 2009;31(9):940–6.CrossRefPubMed
36.
Zurück zum Zitat Douglas-Akinwande AC, Ying J, Momin Z, Mourad A, Hattab EM. Diffusion-weighted imaging characteristics of primary central nervous system germinoma with histopathologic correlation: a retrospective study. Acad Radiol. 2009;16(11):1356–65.CrossRefPubMed Douglas-Akinwande AC, Ying J, Momin Z, Mourad A, Hattab EM. Diffusion-weighted imaging characteristics of primary central nervous system germinoma with histopathologic correlation: a retrospective study. Acad Radiol. 2009;16(11):1356–65.CrossRefPubMed
37.
Zurück zum Zitat Horger M, Fenchel M, Nägele T, Moehle R, Claussen CD, Beschorner R, et al. Water diffusivity: comparison of primary CNS lymphoma and astrocytic tumor infiltrating the corpus callosum. AJR Am J Roentgenol. 2009;193(5):1384–7.CrossRef Horger M, Fenchel M, Nägele T, Moehle R, Claussen CD, Beschorner R, et al. Water diffusivity: comparison of primary CNS lymphoma and astrocytic tumor infiltrating the corpus callosum. AJR Am J Roentgenol. 2009;193(5):1384–7.CrossRef
38.
Zurück zum Zitat Meyers SP, Khademian ZP, Biegel JA, Chuang SH, Korones DN, Zimmerman RA. Primary intracranial atypical teratoid/rhabdoid tumors of infancy and childhood: MRI features and patient outcomes. AJNR Am J Neuroradiol. 2006;27(5):962–71.PubMed Meyers SP, Khademian ZP, Biegel JA, Chuang SH, Korones DN, Zimmerman RA. Primary intracranial atypical teratoid/rhabdoid tumors of infancy and childhood: MRI features and patient outcomes. AJNR Am J Neuroradiol. 2006;27(5):962–71.PubMed
39.
Zurück zum Zitat Eran A, Ozturk A, Aygun N, Izbudak I. Medulloblastoma: atypical CT and MRI findings in children. Pediatr Radiol. 2010;40(7):1254–62.CrossRefPubMed Eran A, Ozturk A, Aygun N, Izbudak I. Medulloblastoma: atypical CT and MRI findings in children. Pediatr Radiol. 2010;40(7):1254–62.CrossRefPubMed
Metadaten
Titel
Radiological Image Features of the Atypical Teratoid/Rhabdoid Tumor in Adults: A Systematic Review
verfasst von
M. Kanoto, MD, PhD
Y. Toyoguchi, MD
T. Hosoya, MD, PhD
M. Kuchiki, MD, PhD
Y. Sugai, MD, PhD
Publikationsdatum
01.03.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Neuroradiology / Ausgabe 1/2015
Print ISSN: 1869-1439
Elektronische ISSN: 1869-1447
DOI
https://doi.org/10.1007/s00062-013-0282-2

Weitere Artikel der Ausgabe 1/2015

Clinical Neuroradiology 1/2015 Zur Ausgabe

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.