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Erschienen in: European Archives of Psychiatry and Clinical Neuroscience 6/2016

27.11.2015 | Original Paper

Relationship between hippocampal subfield volumes and memory deficits in patients with thalamus infarction

verfasst von: Li Chen, Tianyou Luo, Fajin Lv, Dandan Shi, Jiang Qiu, Qi Li, Weidong Fang, Juan Peng, Yongmei Li, Zhiwei Zhang, Yang Li

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 6/2016

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Abstract

Clinical studies have shown that thalamus infarction (TI) affects memory function. The thalamic nucleus is directly or indirectly connected to the hippocampal system in animal models. However, this connection has not been investigated using structural magnetic resonance imaging (MRI) in humans. From the pathological perspective, TI patients may serve as valid models for revealing the interaction between the thalamus and hippocampus in memory function. In this study, we aim to assess different hippocampal subfield volumes in TI patients and control subjects using MRI and test their associations with memory function. A total of 37 TI patients (TI group), 38 matched healthy control subjects (HC group), and 22 control patients with other stroke location (SC group) underwent 3.0-T MRI scans and clinical memory examinations. Hippocampal subfield volumes were measured and compared by using FreeSurfer software. We examined the correlation between hippocampal subfield volumes and memory scores. Smaller ipsilesional presubiculum and subiculum volumes were observed, and former was related to graphics recall in both left and right TI patients. The left subiculum volume was correlated with short-delayed recall in left TI patients. The right presubiculum volume was correlated with short- and long-delayed recall in right TI patients. TI was found to result in hippocampal abnormality and memory deficits, and its neural mechanisms might be related with and interaction between the thalamus and hippocampus.
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Metadaten
Titel
Relationship between hippocampal subfield volumes and memory deficits in patients with thalamus infarction
verfasst von
Li Chen
Tianyou Luo
Fajin Lv
Dandan Shi
Jiang Qiu
Qi Li
Weidong Fang
Juan Peng
Yongmei Li
Zhiwei Zhang
Yang Li
Publikationsdatum
27.11.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 6/2016
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-015-0654-5

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