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European Archives of Psychiatry and Clinical Neuroscience

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01.06.2014 | Original Paper

S100B is downregulated in the nuclear proteome of schizophrenia corpus callosum

verfasst von: Johann Steiner, Andrea Schmitt, Matthias L. Schroeter, Bernhard Bogerts, Peter Falkai, Christoph W. Turck, Daniel Martins-de-Souza

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 4/2014

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Abstract

Here we report the downregulation of S100B in the nuclear proteome of the corpus callosum from nine schizophrenia patients compared to seven mentally healthy controls. Our data have been obtained primarily by mass spectrometry and later confirmed by Western blot. This is an intriguing finding coming from a brain region which is essentially composed by white matter, considering the potential role of S100B in the control of oligodendrocyte maturation. This data reinforce the importance of oligodendrocytes in schizophrenia, shedding more light to its pathobiology.

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Titel: S100B is downregulated in the nuclear proteome of schizophrenia corpus callosum
verfasst von: Johann Steiner
Andrea Schmitt
Matthias L. Schroeter
Bernhard Bogerts
Peter Falkai
Christoph W. Turck
Daniel Martins-de-Souza
Publikationsdatum: 01.06.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 4/2014
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-014-0490-z

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S100B is downregulated in the nuclear proteome of schizophrenia corpus callosum

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