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Erschienen in: Der Internist 9/2015

01.09.2015 | Hepatitisviren | Klinische Studien

Schritt für Schritt zur perfekten Hepatitis-C-Therapie für alle Genotypen

verfasst von: PD Dr. M. Cornberg, S. Nitschmann

Erschienen in: Die Innere Medizin | Ausgabe 9/2015

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  • Lawitz E, Gane E, Pearlman B et al. (2015) Efficacy and safety of 12 weeks versus 18 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin for hepatitis C virus genotype 1 infection in previously untreated patients with cirrhosis and patients with previous null response with or without cirrhosis (C-WORTHY): a randomised, open-label phase 2 trial. Lancet 385:1075–1086
  • Sulkowski M, Hezode C, Gerstoft J et al. (2015) Efficacy and safety of 8 weeks versus 12 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin in patients with hepatitis C virus genotype 1 mono-infection and HIV/hepatitis C virus co-infection (C-WORTHY): a randomised, open-label phase 2 trial. Lancet 385:1087–1097
  • Molina JM, Orkin C, Iser DM et al. (2015) Sofosbuvir plus ribavirin for treatment of hepatitis C virus in patients co-infected with HIV (PHOTON-2): a multicentre, open-label, non-randomised, phase 3 study. Lancet 385:1098–1106
  • Hézode C, Asselah T, Reddy KR et al. (2015) Ombitasvir plus paritaprevir plus ritonavir with or without ribavirin in treatment-naive and treatment-experienced patients with genotype 4 chronic hepatitis C virus infection (PEARL-I): a randomised, open-label trial. Lancet 385:2502–2509
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Zurück zum Zitat Hézode C, Asselah T, Reddy KR et al (2015) Ombitasvir plus paritaprevir plus ritonavir with or without ribavirin in treatment-naive and treatment-experienced patients with genotype 4 chronic hepatitis C virus infection (PEARL-I): a randomised, open-label trial. Lancet 385:2502–2509CrossRefPubMed Hézode C, Asselah T, Reddy KR et al (2015) Ombitasvir plus paritaprevir plus ritonavir with or without ribavirin in treatment-naive and treatment-experienced patients with genotype 4 chronic hepatitis C virus infection (PEARL-I): a randomised, open-label trial. Lancet 385:2502–2509CrossRefPubMed
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Zurück zum Zitat Honer zu Siederdissen C, Cornberg M (2014) All-oral, interferon-free therapies for patients with chronic genotype 1 hepatitis C virus infection. Dtsch Med Wochenschr 139:2411–2414CrossRef Honer zu Siederdissen C, Cornberg M (2014) All-oral, interferon-free therapies for patients with chronic genotype 1 hepatitis C virus infection. Dtsch Med Wochenschr 139:2411–2414CrossRef
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Zurück zum Zitat Lawitz E, Gane E, Pearlman B et al (2014) Efficacy and safety of 12 weeks versus 18 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin for hepatitis C virus genotype 1 infection in previously untreated patients with cirrhosis and patients with previous null response with or without cirrhosis (C-WORTHY): a randomised, open-label phase 2 trial. Lancet 385:1075–1086CrossRefPubMed Lawitz E, Gane E, Pearlman B et al (2014) Efficacy and safety of 12 weeks versus 18 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin for hepatitis C virus genotype 1 infection in previously untreated patients with cirrhosis and patients with previous null response with or without cirrhosis (C-WORTHY): a randomised, open-label phase 2 trial. Lancet 385:1075–1086CrossRefPubMed
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Zurück zum Zitat Sulkowski M, Hezode C, Gerstoft J et al (2014) Efficacy and safety of 8 weeks versus 12 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin in patients with hepatitis C virus genotype 1 mono-infection and HIV/hepatitis C virus co-infection (C-WORTHY): a randomised, open-label phase 2 trial. Lancet 385:1087–1097CrossRefPubMed Sulkowski M, Hezode C, Gerstoft J et al (2014) Efficacy and safety of 8 weeks versus 12 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin in patients with hepatitis C virus genotype 1 mono-infection and HIV/hepatitis C virus co-infection (C-WORTHY): a randomised, open-label phase 2 trial. Lancet 385:1087–1097CrossRefPubMed
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Zurück zum Zitat Wedemeyer H, Duberg AS, Buti M et al (2014) Strategies to manage hepatitis C virus (HCV) disease burden. J Viral Hepat 21(Suppl 1):60–89 Wedemeyer H, Duberg AS, Buti M et al (2014) Strategies to manage hepatitis C virus (HCV) disease burden. J Viral Hepat 21(Suppl 1):60–89
Metadaten
Titel
Schritt für Schritt zur perfekten Hepatitis-C-Therapie für alle Genotypen
verfasst von
PD Dr. M. Cornberg
S. Nitschmann
Publikationsdatum
01.09.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Die Innere Medizin / Ausgabe 9/2015
Print ISSN: 2731-7080
Elektronische ISSN: 2731-7099
DOI
https://doi.org/10.1007/s00108-015-3774-0

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