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Erschienen in: European Child & Adolescent Psychiatry 4/2016

29.10.2015 | Review

Serum concentration of 25-hydroxyvitamin D in autism spectrum disorder: a systematic review and meta-analysis

verfasst von: Tiantian Wang, Ling Shan, Lin Du, Junyan Feng, Zhida Xu, Wouter G. Staal, Feiyong Jia

Erschienen in: European Child & Adolescent Psychiatry | Ausgabe 4/2016

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Abstract

Vitamin D may play an important role in the etiology of Autism Spectrum Disorders (ASD). Vitamin D is regarded as a neuroactive steroid affecting brain development and function. It plays an essential role in myelination, which is important for connectivity in the brain. Studies have shown that decreased vitamin D levels in patients, decreased maternal vitamin D levels during pregnancy, and decreased exposure to solar UVB might increase the risk for ASD. In addition, autism symptoms and global functioning may improve after vitamin D supplementation. Here, we sought to aggregate information from previous publications on vitamin D levels and ASD, in order to achieve a higher statistical power and thereby to determine the validity of vitamin D deficiency as a risk factor for ASD. For this meta-analysis, 11 studies met the inclusion and exclusion criteria, accounting for a total of 870 ASD patients and 782 healthy controls. Levels of serum 25(OH) D in participants with ASD were significantly lower than controls, suggesting that lower vitamin D level might be a risk factor for ASD.
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Metadaten
Titel
Serum concentration of 25-hydroxyvitamin D in autism spectrum disorder: a systematic review and meta-analysis
verfasst von
Tiantian Wang
Ling Shan
Lin Du
Junyan Feng
Zhida Xu
Wouter G. Staal
Feiyong Jia
Publikationsdatum
29.10.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Child & Adolescent Psychiatry / Ausgabe 4/2016
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-015-0786-1

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