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Erschienen in: Allergo Journal 2/2016

21.03.2016 | Übersicht

The glycan did it: how the α-gal story rescued carbohydrates for allergists — a US perspective

verfasst von: Scott P. Commins, MD, PhD, Maya R. Jerath, Thomas Platts-Mills

Erschienen in: Allergo Journal | Ausgabe 2/2016

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Abstract

IgE antibodies to carbohydrate epitopes on allergens are thought to be less common than IgE antibodies to protein epitopes and also of much less clinical significance. Our recent work, however, has identified a novel IgE antibody response to a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (alpha-gal). IgE to alpha-gal has been associated with two distinct forms of anaphylaxis including delayed allergic reactions after eating beef, pork or lamb. IgE antibody responses to alpha-gal have now been found globally. Therefore, establishing the mechanism of the specific IgE antibody response to alpha-gal will be an important aspect to address as this area of research continues.
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Metadaten
Titel
The glycan did it: how the α-gal story rescued carbohydrates for allergists — a US perspective
verfasst von
Scott P. Commins, MD, PhD
Maya R. Jerath
Thomas Platts-Mills
Publikationsdatum
21.03.2016
Verlag
Springer Medizin
Erschienen in
Allergo Journal / Ausgabe 2/2016
Print ISSN: 0941-8849
Elektronische ISSN: 2195-6405
DOI
https://doi.org/10.1007/s15007-016-1043-8

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