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Social Psychiatry and Psychiatric Epidemiology

Erschienen in:

01.09.2014 | Editorial

Universal prevention of schizophrenia and surrogate endpoints at population level

verfasst von: A. Szöke, J. B. Kirkbride, F. Schürhoff

Erschienen in: Social Psychiatry and Psychiatric Epidemiology | Ausgabe 9/2014

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Abstract

Despite significant progresses in our knowledge of the risk factors for schizophrenia, we still are several steps short of implementing effective prevention strategies. Universal prevention strategies have several theoretical advantages but their implementation has been limited to date by their costs and lack of methods to assess their efficiency. To overcome this limitation, we suggest, based on research from therapeutic trials at individual level, the use of surrogate endpoints (SEs) at population level. We further suggest that subclinical measures of psychosis at population level are good SEs candidates for assessing universal measures for schizophrenia prevention.

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Amminger GP, Harris MG, Conus P, Lambert M, Elkins KS, Yuen HP, McGorry PD (2006) Treated incidence of first-episode psychosis in the catchment area of EPPIC between 1997 and 2000. Acta Psychiatr Scand 114:337–345PubMedCrossRef

Boissel JP, Collet JP, Moleur P, Haugh M (1992) Surrogate endpoints: a basis for a rational approach. Eur J Clin Pharmacol 43:235–244PubMedCrossRef

Cuijpers P, Van Straten A, Smit F (2005) Preventing the incidence of new cases of mental disorders: a meta-analytic review. J Nerv Mental Dis 193:119–125CrossRef

Green MJ, Boyle GJ, Raine A (2008) Schizotypal personality models (Chapter 19). In: Boyle GJ, Matthews G, Saklofske DH (eds) The SAGE handbook of personality theory and assessment: Vol 1, Personality theories and models. SAGE Publications Ltd, London

Lassere MN, Johnson KR, Boers M, Tugwell P, Brooks P, Simon L, Strand V, Conaghan PG, Ostergaard M, Maksymowych WP, Landewe R, Bresnihan B, Tak PP, Wakefield R, Mease P, Bingham CO 3rd, Hughes M, Altman D, Buyse M, Galbraith S, Wells G (2007) Definitions and validation criteria for biomarkers and surrogate endpoints: development and testing of a quantitative hierarchical levels of evidence schema. J Rheumatol 34:607–615PubMed

Lesko LJ, Atkinson AJ Jr (2001) Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: criteria, validation, strategies. Annu Rev Pharmacol Toxicol 41:347–366PubMedCrossRef

Lin A. (2010) Why Transition is not the whole story: neurocognitive function and risk for psychosis. Thesis for the degree of Doctor of Philosophy. Department of Psychology. The University of Melbourne

Linscott RJ, van Os J (2013) An updated and conservative systematic review and meta-analysis of epidemiological evidence on psychotic experiences in children and adults: on the pathway from proneness to persistence to dimensional expression across mental disorders. Psychol Med 43(6):1133–1149PubMedCrossRef

Rose G, Day S (1990) The population mean predicts the number of deviant individuals. Br Med J 301:1031–1034CrossRef

10.

Shochet IM, Dadds MR, Holland D, Whitefield K, Harnett PH, Osgarby SM (2001) The efficacy of a universal school-based program to prevent adolescent depression. Journal of Clinical Child Psychology 30:303–315PubMedCrossRef

11.

Stafford MR, Jackson H, Mayo-Wilson E, Morrison AP, Kendall T (2013) Early interventions to prevent psychosis: systematic review and meta-analysis. BMJ 346:f185. doi:10.1136/bmj.f185 PubMedCentralPubMedCrossRef

12.

van Os J, Hanssen M, Bijl RV, Vollebergh W (2001) Prevalence of psychotic disorder and community level of psychotic symptoms: an urban-rural comparison. Arch Gen Psychiatry 58:663–668PubMedCrossRef

13.

van Os J, Linscott RJ, Myin-Germeys I, Delespaul P, Krabbendam L (2009) A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder. Psychol Med 39:179–195PubMedCrossRef

14.

Whittington JE, Huppert FA (1996) Changes in the prevalence of psychiatric disorder in a community are related to changes in the mean level of psychiatric symptoms. Psychol Med 26:1253–1260PubMedCrossRef

15.

Yung AR, Killackey E, Hetrick SE, Parker AG, Schultze-Lutter F, Klosterkoetter J, Purcell R, Mcgorry PD (2007) The prevention of schizophrenia. Int Rev Psychiatry 19:633–646PubMedCrossRef

16.

Yung AR, Yuen HP, Berger G, Francey S, Hung TC, Nelson B, Phillips L, McGorry P (2007) Declining transition rate in ultra high risk (prodromal) services: dilution or reduction of risk? Schizophr Bull 33:673–681PubMedCentralPubMedCrossRef

17.

Yung AR, Nelson B, Stanford C, Simmons MB, Cosgrave EM, Killackey E, Phillips LJ, Bechdolf A, Buckby J, McGorry PD (2008) Validation of “prodromal” criteria to detect individuals at ultra high risk of psychosis: 2 year follow-up. Schizophr Res 105:10–17PubMedCrossRef

Titel: Universal prevention of schizophrenia and surrogate endpoints at population level
verfasst von: A. Szöke
J. B. Kirkbride
F. Schürhoff
Publikationsdatum: 01.09.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Social Psychiatry and Psychiatric Epidemiology / Ausgabe 9/2014
Print ISSN: 0933-7954
Elektronische ISSN: 1433-9285
DOI: https://doi.org/10.1007/s00127-014-0829-9

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