nach oben

European Archives of Psychiatry and Clinical Neuroscience

Erschienen in:

09.12.2015 | Original Paper

Variation at NRG1 genotype related to modulation of small-world properties of the functional cortical network

verfasst von: Alba Lubeiro, Javier Gomez-Pilar, Oscar Martín, Aitor Palomino, Myriam Fernández, Ana González-Pinto, Jesús Poza, Roberto Hornero, Vicente Molina

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 1/2017

Einloggen, um Zugang zu erhalten

Abstract

Functional brain networks possess significant small-world (SW) properties. Genetic variation relevant to both inhibitory and excitatory transmission may contribute to modulate these properties. In healthy controls, genotypic variation in Neuregulin 1 (NRG1) related to the risk of psychosis (risk alleles) would contribute to functional SW modulation of the cortical network. Electroencephalographic activity during an odd-ball task was recorded in 144 healthy controls. Then, small-worldness (SWn) was calculated in five frequency bands (i.e., theta, alpha, beta1, beta2 and gamma) for baseline (from −300 to the stimulus onset) and response (150–450 ms post-target stimulus) windows. The SWn modulation was defined as the difference in SWn between both windows. Association between SWn modulation and carrying the risk allele for three single nucleotide polymorphisms (SNP) of NRG1 (i.e., rs6468119, rs6994992 and rs7005606) was assessed. A significant association between three SNPs of NRG1 and the SWn modulation was found, specifically: NRG1 rs6468119 in alpha and beta1 bands; NRG1 rs6994992 in theta band; and NRG1 rs7005606 in theta and beta1 bands. Genetic variation at NRG1 may influence functional brain connectivity through the modulation of SWn properties of the cortical network.

Varela F, Lachaux JP, Rodriguez E, Martinerie J (2001) The brainweb: phase synchronization and large-scale integration. Nat Rev Neurosci 2:229–239. doi:10.1038/35067550 CrossRefPubMed

Tognoli E, Kelso JAS (2014) The metastable brain. Neuron 81:35–48. doi:10.1016/j.neuron.2013.12.022 CrossRefPubMedPubMedCentral

Tan HRM, Lana L, Uhlhaas PJ (2013) High-frequency neural oscillations and visual processing deficits in schizophrenia. Front Psychol 4:1–19. doi:10.3389/fpsyg.2013.00621 CrossRef

Borsboom D, Cramer AOJ, Schmittmann VD et al (2011) The small world of psychopathology. PLoS One. doi:10.1371/journal.pone.0027407 PubMedPubMedCentral

Micheloyannis S (2012) World J Psychiatry. doi:10.5498/wjp.v2.i1.EDITORIAL PubMedPubMedCentral

Shim M, Kim DW, Lee SH, Im CH (2014) Disruptions in small-world cortical functional connectivity network during an auditory oddball paradigm task in patients with schizophrenia. Schizophr Res 156:197–203. doi:10.1016/j.schres.2014.04.012 CrossRefPubMed

Smit DJA, Stam CJ, Posthuma D et al (2008) Heritability of “small-world” networks in the brain: a graph theoretical analysis of resting-state EEG functional connectivity. Hum Brain Mapp 29:1368–1378. doi:10.1002/hbm.20468 CrossRefPubMed

Li M, Chen Z, Li T (2012) Small-world brain networks in schizophrenia. Shanghai Arch Psychiatry 24:322–327. doi:10.3969/j.issn.1002-0829.2012.06.003 PubMedPubMedCentral

Buzsáki G (2006) Diversity of cortical functions. Rythm. Brain. Oxford University Press, New York, pp 21–79CrossRef

10.

Wang Q, Su T-P, Zhou Y et al (2012) Anatomical insights into disrupted small-world networks in schizophrenia. Neuroimage 59:1085–1093. doi:10.1016/j.neuroimage.2011.09.035 CrossRefPubMed

11.

Bassett DS, Bullmore E, Verchinski BA et al (2008) Hierarchical organization of human cortical networks in health and schizophrenia. J Neurosci 28:9239–9248. doi:10.1523/JNEUROSCI.1929-08.2008 CrossRefPubMedPubMedCentral

12.

He H, Sui J, Yu Q et al (2012) Altered small-world brain networks in schizophrenia patients during working memory performance. PLoS One 7:e38195. doi:10.1371/journal.pone.0038195 CrossRefPubMedPubMedCentral

13.

Lichtenstein P, Yip BH, Björk C et al (2009) Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 373:234–239. doi:10.1016/S0140-6736(09)60072-6 CrossRefPubMed

14.

Fazzari P, Paternain AV, Valiente M et al (2010) Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature 464:1376–1380. doi:10.1038/nature08928 CrossRefPubMed

15.

Neddens J, Fish KN, Tricoire L et al (2011) Conserved interneuron-specific ErbB4 expression in frontal cortex of rodents, monkeys, and humans: implications for schizophrenia. Biol Psychiatry 70:636–645. doi:10.1016/j.biopsych.2011.04.016 CrossRefPubMedPubMedCentral

16.

Calaora V, Rogister B, Bismuth K et al (2001) Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro. J Neurosci 21:4740–4751PubMed

17.

Flames N, Long JE, Garratt AN et al (2004) Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1. Neuron 44:251–561. doi:10.1016/j.neuron.2004.09.028 CrossRefPubMed

18.

Harrison PJ, Law AJ (2006) Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biol Psychiatry 60:132–140. doi:10.1016/j.biopsych.2005.11.002 CrossRefPubMed

19.

Bin Kwon O, Paredes D, Gonzalez CM et al (2008) Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors. Proc Natl Acad Sci U S A 105:15587–15592. doi:10.1073/pnas.0805722105 CrossRef

20.

Banerjee A, MacDonald ML, Borgmann-Winter KE, Hahn CG (2010) Neuregulin 1–ErbB4 pathway in schizophrenia: from genes to an interactome. Brain Res Bull 83:132–139. doi:10.1016/j.brainresbull.2010.04.011 CrossRefPubMedPubMedCentral

21.

Stefansson H, Sigurdsson E, Steinthorsdottir V et al (2002) Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 71:877–892. doi:10.1086/342734 CrossRefPubMedPubMedCentral

22.

Keri S, Kiss I, Seres I, Kelemen O (2009) A polymorphism of the neuregulin 1 gene(SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia. Am J Med Genet Part B Neuropsychiatr Genet 150:418–420. doi:10.1002/ajmg.b.30812 CrossRef

23.

McBain CJ, Fisahn A (2001) Interneurons unbound. Nat Rev Neurosci 2:11–23. doi:10.1038/35049047 CrossRefPubMed

24.

McIntosh AM, Moorhead TWJ, Job D et al (2008) The effects of a neuregulin 1 variant on white matter density and integrity. Mol Psychiatry 13:1054–1059. doi:10.1038/sj.mp.4002103 CrossRefPubMed

25.

Buonanno A (2010) The neuregulin signaling pathway and schizophrenia: from genes to synapses and neural circuits. Brain Res Bull 83:122–131. doi:10.1016/j.brainresbull.2010.07.012 CrossRefPubMedPubMedCentral

26.

Cho Y, Ryu S, Huh I et al (2015) Effects of genetic variations in NRG1 on cognitive domains in patients with schizophrenia and healthy individuals. Psychiatr Genet. doi:10.1097/YPG.0000000000000087

27.

Hall J, Whalley HC, Job DE et al (2006) A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms. Nat Neurosci 9:1477–1478. doi:10.1038/nn1795 CrossRefPubMed

28.

Gutiérrez-Fernández A, Palomino A, González-Pinto A et al (2014) Novel association of neuregulin 1 gene with bipolar disorder but not with schizophrenia. Schizophr Res 159:552–553. doi:10.1016/j.schres.2014.09.001 CrossRefPubMed

29.

Goes FS, Willour VL, Zandi PP et al (2009) Family-based association study of neuregulin 1 with psychotic bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 150B:693–702. doi:10.1002/ajmg.b.30895 CrossRefPubMed

30.

Bledowski C, Prvulovic D, Hoechstetter K et al (2004) Localizing P300 generators in visual target and distractor processing: a combined event-related potential and functional magnetic resonance imaging study. J Neurosci 24:9353–9360. doi:10.1523/JNEUROSCI.1897-04.2004 CrossRefPubMed

31.

Bachiller A, Poza J, Gómez C et al (2015) A comparative study of event-related coupling patterns during an auditory oddball task in schizophrenia. J Neural Eng 12:016007. doi:10.1088/1741-2560/12/1/016007 CrossRefPubMed

32.

Mallat S (1999) A wavelet tour of signal processing. Academic Press, Waltham, MA, pp 20–41

33.

Torrence C, Compo GP (1998) A practical guide to wavelet analysis. Bull Am Meteorol Soc 79:61–78. doi:10.1175/1520-0477(1998)079<0061:APGTWA>2.0.CO;2 CrossRef

34.

Nunez PL, Srinivasan R, Westdorp AF et al (1997) EEG coherency. I: statistics, reference electrode, volume conduction, Laplacians, cortical imaging, and interpretation at multiple scales. Electroencephalogr Clin Neurophysiol 103:499–515CrossRefPubMed

35.

Boccaletti S, Latora V, Moreno Y et al (2006) Complex networks: structure and dynamics. Phys Rep 424:175–308. doi:10.1016/j.physrep.2005.10.009 CrossRef

36.

Stam CJ, de Haan W, Daffertshofer A et al (2009) Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer’s disease. Brain 132:213–224. doi:10.1093/brain/awn262 CrossRefPubMed

37.

Rubinov M, Sporns O (2010) Complex network measures of brain connectivity: uses and interpretations. Neuroimage 52:1059–1069. doi:10.1016/j.neuroimage.2009.10.003 CrossRefPubMed

38.

Bachiller A, Lubeiro A, Díez A et al (2014) Decreased entropy modulation of EEG response to novelty and relevance in schizophrenia during a P300 task. Eur Arch Psychiatry Clin Neurosci. doi:10.1007/s00406-014-0525-5

39.

Von Stein A, Sarnthein J (2000) Different frequencies for different scales of cortical integration: from local gamma to long range alpha/theta synchronization. Int J Psychophysiol 38:301–313CrossRef

40.

Siegel M, Donner TH, Engel AK (2012) Spectral fingerprints of large-scale neuronal interactions. Nat Rev Neurosci 13:121–134. doi:10.1038/nrn3137 PubMed

41.

Mothersill O, Kelly S, Rose EJ, Donohoe G (2012) The effects of psychosis risk variants on brain connectivity: a review. Front Psychiatry 3:18. doi:10.3389/fpsyt.2012.00018 CrossRefPubMedPubMedCentral

42.

Sprooten E, Lymer GKS, Muñoz Maniega S et al (2009) The relationship of anterior thalamic radiation integrity to psychosis risk associated neuregulin-1 variants. Mol Psychiatry 14(237–8):233. doi:10.1038/mp.2008.136 CrossRef

43.

Uhlhaas PJ, Singer W (2012) Neuronal dynamics and neuropsychiatric disorders: toward a translational paradigm for dysfunctional large-scale networks. Neuron 75:963–980. doi:10.1016/j.neuron.2012.09.004 CrossRefPubMed

44.

Uhlhaas PJ, Haenschel C, Nikolić D, Singer W (2008) The role of oscillations and synchrony in cortical networks and their putative relevance for the pathophysiology of schizophrenia. Schizophr Bull 34:927–943. doi:10.1093/schbul/sbn062 CrossRefPubMedPubMedCentral

45.

Law AJ, Lipska BK, Weickert CS et al (2006) Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5’ SNPs associated with the disease. Proc Natl Acad Sci U S A 103:6747–6752. doi:10.1073/pnas.0602002103 CrossRefPubMedPubMedCentral

46.

Hahn C-G, Wang H-Y, Cho D-S et al (2006) Altered neuregulin 1–ErbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nat Med 12:824–828. doi:10.1038/nm1418 CrossRefPubMed

47.

Gu Z, Jiang Q, Fu AKY et al (2005) Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex. J Neurosci 25:4974–4984. doi:10.1523/JNEUROSCI.1086-05.2005 CrossRefPubMed

48.

Pitcher GM, Kalia LV, Ng D et al (2011) Schizophrenia susceptibility pathway neuregulin 1–ErbB4 suppresses Src upregulation of NMDA receptors. Nat Med 17:470–478. doi:10.1038/nm.2315 CrossRefPubMedPubMedCentral

49.

Bjarnadottir M, Misner DL, Haverfield-Gross S et al (2007) Neuregulin1 (NRG1) signaling through Fyn modulates NMDA receptor phosphorylation: differential synaptic function in NRG1 ± knock-outs compared with wild-type mice. J Neurosci 27:4519–4529. doi:10.1523/JNEUROSCI.4314-06.2007 CrossRefPubMed

50.

Woo RS, Li XM, Tao Y et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54:599–610. doi:10.1016/j.neuron.2007.04.009 CrossRefPubMed

51.

Ting AK, Chen Y, Wen L et al (2011) Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. J Neurosci 31:15–25. doi:10.1523/JNEUROSCI.2538-10.2011 CrossRefPubMedPubMedCentral

52.

Lewis DA, Moghaddam B (2006) Cognitive dysfunction in schizophrenia: convergence of gamma-aminobutyric acid and glutamate alterations. Arch Neurol 63:1372–1376. doi:10.1001/archneur.63.10.1372 CrossRefPubMed

53.

Bramon E, Dempster E, Frangou S et al (2008) Neuregulin-1 and the P300 waveform-A preliminary association study using a psychosis endophenotype. Schizophr Res 103:178–185. doi:10.1016/j.schres.2008.03.025 CrossRefPubMed

54.

Uhlhaas PJ (2015) Neural dynamics in mental disorders. World Psychiatry 14:116–118. doi:10.1002/wps.20203 CrossRefPubMedPubMedCentral

Titel: Variation at NRG1 genotype related to modulation of small-world properties of the functional cortical network
verfasst von: Alba Lubeiro
Javier Gomez-Pilar
Oscar Martín
Aitor Palomino
Myriam Fernández
Ana González-Pinto
Jesús Poza
Roberto Hornero
Vicente Molina
Publikationsdatum: 09.12.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 1/2017
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-015-0659-0

Neu im Fachgebiet Psychiatrie

23.04.2024 | Demenz | Nachrichten

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Variation at NRG1 genotype related to modulation of small-world properties of the functional cortical network

Abstract

Neu im Fachgebiet Psychiatrie

Demenzkranke durch Antipsychotika vielfach gefährdet

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

„Psychotherapie ist auch bei sehr alten Menschen hochwirksam!“

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Update Psychiatrie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2017

Evidence for alterations of cortical folding in anorexia nervosa

Driving skills in unmedicated first- and recurrent-episode schizophrenic patients

Neural correlates of distraction in borderline personality disorder before and after dialectical behavior therapy

Candidate gene associations studies in psychiatry: time to move forward

Predictors of smoking reduction outcomes in a sample of 287 patients with schizophrenia spectrum disorders

Elevated methylation and decreased serum concentrations of BDNF in patients in levomethadone compared to diamorphine maintenance treatment

Neu im Fachgebiet Psychiatrie

Demenzkranke durch Antipsychotika vielfach gefährdet

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

„Psychotherapie ist auch bei sehr alten Menschen hochwirksam!“

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Update Psychiatrie