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Erschienen in: Herz 4/2015

01.06.2015 | Original article

Association between left ventricular dysfunction, anemia, and chronic renal failure

Analysis of the Heart Failure Prevalence and Predictors in Turkey (HAPPY) cohort

verfasst von: A. Kepez, MD, B. Mutlu, M. Degertekin, C. Erol

Erschienen in: Herz | Ausgabe 4/2015

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Abstract

Background

Anemia and chronic renal failure (CRF) are frequent comorbidities in patients with heart failure (HF), and they have been reported to be associated with increased mortality and hospitalization rates. HF, anemia, and CRF have been reported to interact with each other forming a vicious cycle termed cardio-renal-anemia syndrome. The aim of the present study was to evaluate the association of HF, anemia, and CRF using data from the large-scale“Heart Failure Prevalence and Predictors in Turkey (HAPPY)” study.

Patients and methods

Among the HAPPY cohort, 3,369 subjects who had either left ventricular dysfunction (LVD) or normal left ventricular function on echocardiography or normal serum NT-proBNP levels were included in this analysis.

Results

The prevalence of anemia and CRF was significantly higher in patients with LVD compared with subjects with normal ventricular function (20.7 % vs. 4.0 % and 19.0 % vs. 3.7 %, respectively; p < 0.001 for each). Binary logistic regression analyses for the presence of LVD, anemia, and CRF demonstrated that each one was an independent predictor for the presence of the others.

Conclusion

These findings point to the presence of cardio-renal-anemia syndrome and the necessity of treating these comorbidities in patients with HF.
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Metadaten
Titel
Association between left ventricular dysfunction, anemia, and chronic renal failure
Analysis of the Heart Failure Prevalence and Predictors in Turkey (HAPPY) cohort
verfasst von
A. Kepez, MD
B. Mutlu
M. Degertekin
C. Erol
Publikationsdatum
01.06.2015
Verlag
Urban & Vogel
Erschienen in
Herz / Ausgabe 4/2015
Print ISSN: 0340-9937
Elektronische ISSN: 1615-6692
DOI
https://doi.org/10.1007/s00059-013-3967-z

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