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01.07.2024 | ORIGINAL PAPER

Association between miR-202, miR-211, and miR-1238 gene polymorphisms and risk of vitiligo

verfasst von: Mahdieh Jafari Shahroudi, Mahnaz Rezaei, Mehdi Mirzaeipour, Mohsen Saravani, Hossein Shahraki-Ghadimi, Sara Arab

Erschienen in: Archives of Dermatological Research | Ausgabe 5/2024

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Abstract

Vitiligo, as a common pigment defect in the skin, hair, and mucous membranes, results from the destruction of melanocytes. Recent investigations have shown that miRNA dysregulation contributes in the pathogenesis of vitiligo. Therefore, in this research, our aim is to explore the relationship between miR-202 rs12355840, miR-211 rs8039189, and miR-1238 rs12973308 polymorphisms and susceptibility to vitiligo. A total number of 136 vitiligo patients and 129 healthy individuals as a control group were included in this research. The salting out approach was implemented to extraction genomic DNA. The genetic polymorphisms of miR-202 rs12355840, miR-211 rs8039189, and miR-1238 rs12973308 were determined using PCR–RFLP approach. The findings revealed that miR-202 rs12355840 polymorphism under codominant (CT and TT genotypes), dominant, recessive, overdominant, and also allelic models is correlated with increased risk of vitiligo. In addition, codominant, dominant, overdominant, as well as allelic models of miR-211 rs8039189 polymorphism decrease risk of vitiligo. No significant relationship was observed between the miR-1238 rs12973308 polymorphism and susceptibility to vitiligo. The miR-211 rs8039189 polymorphism may serve a protective effect on vitiligo development and miR-202 rs12355840 polymorphism may act as a risk factor for vitiligo susceptibility.

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Titel: Association between miR-202, miR-211, and miR-1238 gene polymorphisms and risk of vitiligo
verfasst von: Mahdieh Jafari Shahroudi
Mahnaz Rezaei
Mehdi Mirzaeipour
Mohsen Saravani
Hossein Shahraki-Ghadimi
Sara Arab
Publikationsdatum: 01.07.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Dermatological Research / Ausgabe 5/2024
Print ISSN: 0340-3696
Elektronische ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-024-02847-y

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