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Brain Structure and Function

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01.04.2012 | Original Article

α-Synuclein in the olfactory system of a mouse model of Parkinson’s disease: correlation with olfactory projections

verfasst von: Isabel Ubeda-Bañon, Daniel Saiz-Sanchez, Carlos de la Rosa-Prieto, Alino Martinez-Marcos

Erschienen in: Brain Structure and Function | Ausgabe 2/2012

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Abstract

Olfactory deficits are an early feature of Parkinson’s disease (PD). Neuropathologically, α-synucleinopathy (Lewy bodies and neurites) is observed earlier (stage 1) in the olfactory system than in the substantia nigra (stage 3), and this could underlies the early olfactory symptoms. In the present report, we analyzed the distribution of α-synuclein deposits in tertiary olfactory structures (anterior olfactory nucleus, olfactory tubercle, piriform cortex, posterolateral cortical amygdala and lateral entorhinal cortex) of homozygous transgenic mice (aged 2–8 months) overexpressing the human A53T variant of α-synuclein. To address the hypothesis of progressive α-synucleinopathy within the olfactory system, the distribution of α-synuclein was analyzed in conjunction with tracer injections into the main olfactory bulb. The time-course of α-synuclein expression revealed a significant increase in the piriform cortex at the age of 8 months compared to other brain structures. Tracing experiments revealed that olfactory projections are reduced in homozygous as compared to wild type animals. Double-labeling experiments show labeled axonal collaterals of mitral cells entering layer II of the piriform cortex in close proximity to α-synuclein-positive cells. To our knowledge, this is the first study addressing the progression of α-synuclein expression in a vulnerable neuronal pathway in PD.

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Titel: α-Synuclein in the olfactory system of a mouse model of Parkinson’s disease: correlation with olfactory projections
verfasst von: Isabel Ubeda-Bañon
Daniel Saiz-Sanchez
Carlos de la Rosa-Prieto
Alino Martinez-Marcos
Publikationsdatum: 01.04.2012
Verlag: Springer-Verlag
Erschienen in: Brain Structure and Function / Ausgabe 2/2012
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-011-0347-4

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α-Synuclein in the olfactory system of a mouse model of Parkinson’s disease: correlation with olfactory projections

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