nach oben

Erschienen in:

07.05.2018 | Brief Report

β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma)

verfasst von: Yuka Suzuki, Shu Ichihara, Tomonori Kawasaki, Hiroyuki Yanai, Satoshi Kitagawa, Yoshie Shimoyama, Shigeo Nakamura, Masato Nakaguro

Erschienen in: Virchows Archiv | Ausgabe 2/2018

Einloggen, um Zugang zu erhalten

Abstract

Sinonasal glomangiopericytoma (SN-GPC) is an uncommon mesenchymal tumor with myoid differentiation. Recently, mutations in exon 3 of the gene coding for β-catenin (CTNNB1) and its nuclear expression were discovered in SN-GPC. β-catenin protein is a key regulatory molecule of the canonical Wnt signaling pathway. The expression of β-catenin target proteins is not well characterized in SN-GPC. We examined three SN-GPCs by immunohistochemistry and CTNNB1 mutation analysis. All cases expressed nuclear β-catenin. We identified CTNNB1 exon 3 mutations in two analyzable cases. Lymphoid enhancer-binding factor 1 (LEF1), a protein downstream from β-catenin, was also expressed in all cases. Our results further characterized the activation of the Wnt signaling pathway caused by CTNNB1 exon 3 mutation and suggest the utility of LEF1 immunohistochemistry in the differential diagnosis of SN-GPC.

Compagno J, Hyams VJ (1976) Hemangiopericytoma-like intranasal tumors. A clinicopathologic study of 23 cases. Am J Clin Pathol 66:672–683CrossRefPubMed

Thompson LD, Miettinen M, Wenig BM (2003) Sinonasal-type hemangiopericytoma: a clinicopathologic and immunophenotypic analysis of 104 cases showing perivascular myoid differentiation. Am J Surg Pathol 27:737–749CrossRefPubMed

Granter SR, Badizadegan K, Fletcher CD (1998) Myofibromatosis in adults, glomangiopericytoma, and myopericytoma: a spectrum of tumors showing perivascular myoid differentiation. Am J Surg Pathol 22:513–525CrossRefPubMed

Agaimy A, Barthelmess S, Geddert H, Boltze C, Moskalev EA, Koch M, Wiemann S, Hartmann A, Haller F (2014) Phenotypical and molecular distinctness of sinonasal haemangiopericytoma compared to solitary fibrous tumour of the sinonasal tract. Histopathology 65:667–673. https://doi.org/10.1111/his.12452 CrossRefPubMed

Taketo MM (2004) Shutting down Wnt signal-activated cancer. Nat Genet 36:320–322. https://doi.org/10.1038/ng0404-320 CrossRefPubMed

Lasota J, Felisiak-Golabek A, Aly FZ, Wang ZF, Thompson LD, Miettinen M (2015) Nuclear expression and gain-of-function beta-catenin mutation in glomangiopericytoma (sinonasal-type hemangiopericytoma): insight into pathogenesis and a diagnostic marker. Mod Pathol 28:715–720. https://doi.org/10.1038/modpathol.2014.161 CrossRefPubMed

Haller F, Bieg M, Moskalev EA, Barthelmess S, Geddert H, Boltze C, Diessl N, Braumandl K, Brors B, Iro H, Hartmann A, Wiemann S, Agaimy A (2015) Recurrent mutations within the amino-terminal region of beta-catenin are probable key molecular driver events in sinonasal hemangiopericytoma. Am J Pathol 185:563–571. https://doi.org/10.1016/j.ajpath.2014.10.019 CrossRefPubMed

Zou Y, Zhang Y, Church J, Liu X (2016) Comparison of beta-catenin and LEF1 Immunohistochemical stains in desmoid-type fibromatosis and its selected mimickers, with unexpected finding of LEF1 positivity in scars. Appl Immunohistochem Mol Morphol. https://doi.org/10.1097/pai.0000000000000487

Bilodeau EA, Acquafondata M, Barnes EL, Seethala RR (2015) A comparative analysis of LEF-1 in odontogenic and salivary tumors. Hum Pathol 46:255–259. https://doi.org/10.1016/j.humpath.2014.10.018 CrossRefPubMed

10.

El-Naggar A, Chan JK, Grandis J, Takata T, Slootweg P (eds) (2017) World Health Organization classification of head and neck tumours. IARC Press, Lyon

11.

Huss S, Nehles J, Binot E, Wardelmann E, Mittler J, Kleine MA, Kunstlinger H, Hartmann W, Hohenberger P, Merkelbach-Bruse S, Buettner R, Schildhaus HU (2013) Beta-catenin (CTNNB1) mutations and clinicopathological features of mesenteric desmoid-type fibromatosis. Histopathology 62:294–304. https://doi.org/10.1111/j.1365-2559.2012.04355.x CrossRefPubMed

12.

Jo VY, Fletcher CDM (2017) Nuclear beta-catenin expression is frequent in sinonasal hemangiopericytoma and its mimics. Head Neck Pathol 11:119–123. https://doi.org/10.1007/s12105-016-0737-2 CrossRefPubMed

13.

Tse LL, Chan JK (2002) Sinonasal haemangiopericytoma-like tumour: a sinonasal glomus tumour or a haemangiopericytoma? Histopathology 40:510–517CrossRefPubMed

14.

Doyle LA, Vivero M, Fletcher CD, Mertens F, Hornick JL (2014) Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics. Mod Pathol 27:390–395. https://doi.org/10.1038/modpathol.2013.164 CrossRefPubMed

15.

Pauli J, Gundelach R, Vanelli-Rees A, Rees G, Campbell C, Dubey S, Perry C (2008) Juvenile nasopharyngeal angiofibroma: an immunohistochemical characterisation of the stromal cell. Pathology 40:396–400. https://doi.org/10.1080/00313020802035857 CrossRefPubMed

Titel: β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma)
verfasst von: Yuka Suzuki
Shu Ichihara
Tomonori Kawasaki
Hiroyuki Yanai
Satoshi Kitagawa
Yoshie Shimoyama
Shigeo Nakamura
Masato Nakaguro
Publikationsdatum: 07.05.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 2/2018
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-018-2370-9

Genetic zygosity of mature ovarian teratomas, struma ovarii, and ovarian carcinoids

Original Article

A case of multiple familial trichoepitheliomas responding to treatment with the Hedgehog signaling pathway inhibitor vismodegib

Brief Report

Reply to the letter “How to standardize the evaluation of tumor regression grading of gastrointestinal cancers after neoadjuvant therapy?” by Dr. Nasierowska-Guttmejer and Dr. Szawlowski, VIAR-D-18-00181

Letter to the Editor

Neuroendocrine tumor of the pancreas with rhabdoid feature

Open Access
Brief Report

How to standardize the evaluation of tumor regression grading of gastrointestinal cancers after neoadjuvant therapy?

Letter to the Editor

HOXB13 is not expressed in pleomorphic giant cell carcinoma of the bladder

Letter to the Editor

Neu im Fachgebiet Pathologie

Overview of a comparative analysis of microsatellite instability and standard mismatch repair protein-deficiency tests in a large cancer cohort

Hauptreferate: Hauptprogramm der DGP

A retrospective analysis was carried out based on a large cancer patient cohort of our institute ( n  = 1306; collected from 2018 to 2023). dMMR was tested by four IHC reactions (MLH1 and PMS2 or MSH2 and MSH 6). Further, parallel pentaplex …

Molekulare Testung bei mesenchymalen Neoplasien: Was, wann und wie testen?

Sarkome
Übersichtsartikel

Mit dem weit verbreiteten Einsatz diverser molekularer Methoden in der histopathologischen Routinediagnostik hat die Tumorklassifikation in den letzten beiden Jahrzehnten signifikante Fortschritte gemacht. Dabei wurden zum einen zahlreiche …

Reconstructing 3D histological structures using machine learning (artificial intelligence) algorithms

Hauptreferate: Hauptprogramm der DGP

Artificial intelligence (AI) has recently been applied to pathological and medical image analysis with high sensitivity and specificity [ 1 , 2 ], aiding in various dental diagnostic techniques. The use of AI in image annotation has enhanced the …

Key considerations when implementing new diagnostic technologies in routine practice

Hauptreferate: Arbeitsgemeinschaften der DGP

This review explores several key considerations that are critical for implementing new diagnostic technologies into routine practice. These elements will provide a comprehensive guide for navigating the complexities of integrating cutting-edge …

Springer Medizin

β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma)

Abstract

Weitere Artikel der Ausgabe 2/2018

Genetic zygosity of mature ovarian teratomas, struma ovarii, and ovarian carcinoids

A case of multiple familial trichoepitheliomas responding to treatment with the Hedgehog signaling pathway inhibitor vismodegib

Reply to the letter “How to standardize the evaluation of tumor regression grading of gastrointestinal cancers after neoadjuvant therapy?” by Dr. Nasierowska-Guttmejer and Dr. Szawlowski, VIAR-D-18-00181

Neuroendocrine tumor of the pancreas with rhabdoid feature

How to standardize the evaluation of tumor regression grading of gastrointestinal cancers after neoadjuvant therapy?

HOXB13 is not expressed in pleomorphic giant cell carcinoma of the bladder

Neu im Fachgebiet Pathologie

Overview of a comparative analysis of microsatellite instability and standard mismatch repair protein-deficiency tests in a large cancer cohort

Molekulare Testung bei mesenchymalen Neoplasien: Was, wann und wie testen?

Reconstructing 3D histological structures using machine learning (artificial intelligence) algorithms

Key considerations when implementing new diagnostic technologies in routine practice

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten