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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Women's Health 1/2015

β-hCG resolution times during expectant management of tubal ectopic pregnancies

Zeitschrift:
BMC Women's Health > Ausgabe 1/2015
Autoren:
D. Mavrelos, M. Memtsa, S. Helmy, G. Derdelis, E. Jauniaux, D. Jurkovic
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

DM collected the data, performed statistical analysis and drafted the manuscript. MM assisted in data collection and assisted in drafting the manuscript. HS assisted in drafting the manuscript. GD assisted in data collection and proofing. EJ contributed to the design of the analysis and drafting and redrafting the manuscript. DJ conceived the study and supervised the drafting and redrafting of the manuscript. All authors read and approved the final manuscript.

Abstract

Background

A subset of women with a tubal ectopic pregnancy can be safely managed expectantly. Expectant management involves a degree of disruption with hospital visits to determine serum β-hCG (β-human chorionic gonadotrophin) concentration until the pregnancy test becomes negative and expectant management is considered complete. The length of time required for the pregnancy test to become negative and the parameters that influence this interval have not been described. Information on the likely length of follow up would be useful for women considering expectant management of their tubal ectopic pregnancy.

Methods

This was a retrospective study at a tertiary referral center in an inner city London Hospital. We included women who were diagnosed with a tubal ectopic pregnancy by transvaginal ultrasound between March 2009 and March 2014. During the study period 474 women were diagnosed with a tubal ectopic pregnancy and 256 (54 %) of them fulfilled our management criteria for expectant management. A total of 158 (33 %) women had successful expectant management and in those cases we recorded the diameter of the ectopic pregnancy (mm), the maximum serum β-hCG (IU/L) and levels during follow up until resolution as well as the interval to resolution (days).

Results

The median interval from maximum serum β-hCG concentration to resolution was 18.0 days (IQR 11.0–28.0). The maximum serum β-hCG concentration and the rate of decline of β-hCG were independently associated with the length of follow up. Women’s age and size of ectopic pregnancy did not have significant effects on the length of follow up.

Conclusion

Women undergoing expectant management of ectopic pregnancy can be informed that the likely length of follow up is under 3 weeks and that it positively correlates with initial β-hCG level at the time of diagnosis.
Literatur
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