nach oben

Erschienen in:

25.06.2018 | Original Article

¹⁸F-FDG PET/CT can predict chemosensitivity and proliferation of epithelial ovarian cancer via SUVmax value

verfasst von: Shuai Liu, Zheng Feng, Hao Wen, Zhaoxia Jiang, Herong Pan, Yu Deng, Lei Zhang, Xingzhu Ju, Xiaojun Chen, Xiaohua Wu

Erschienen in: Japanese Journal of Radiology | Ausgabe 9/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose

This study aimed to explore the clinical and prognostic significance of ¹⁸F-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) in epithelial ovarian cancer (EOC).

Methods

We retrospectively investigated 48 EOC patients who underwent preoperative ¹⁸F-FDG PET/CT and primary cytoreductive surgery at our hospital between January 2010 and June 2015. None of these patients received neoadjuvant chemotherapy. PET/CT parameters including the maximum and average standardized uptake value (SUVmax, SUVavg), the metabolic tumor volume (MTV) were measured. Tumor proliferation marker Ki67 was evaluated using immunohistochemistry. The relationships between the PET/CT parameters and chemosensitivity, tumor proliferation, and overall survival (OS) were analyzed, respectively.

Results

The median (range) SUVmax, SUVavg, and MTV values were 11.42 (3.14–20.20), 4.8 (2.55–9.47), and 150.11 (0.19–792.46), respectively. Overall, 93.8% (45/48) of patients had high-grade serous ovarian cancer. The SUVmax value had a positive correlation with the Ki67 index (P = 0.030, r = 0.314), and a higher SUVmax level was associated with chemosensitivity (P = 0.026). However, neither SUVavg nor MTV had associations with the patients’ clinicopathological parameters. None of these three PET/CT parameters were found to be potential predictors of OS.

Conclusions

Preoperative ¹⁸F-FDG PET/CT had a predictive value on chemosensitivity and proliferation after primary debulking surgery in EOC patients noninvasively.

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108.CrossRefPubMed

Berek JS, Crum C, Friedlander M. Cancer of the ovary, fallopian tube, and peritoneum. Int J Gynaecol Obstet. 2015;131(Suppl 2):S111–22.CrossRefPubMed

Risum S, Loft A, Hogdall C, Berthelsen AK, Hogdall E, Lundvall L, et al. Standardized FDG uptake as a prognostic variable and as a predictor of incomplete cytoreduction in primary advanced ovarian cancer. Acta Oncol (Stockholm, Sweden). 2011;50(3):415–9.CrossRef

Nakamura K, Hongo A, Kodama J, Hiramatsu Y. The pretreatment of maximum standardized uptake values (SUVmax) of the primary tumor is predictor for poor prognosis for patients with epithelial ovarian cancer. Acta Med Okayama. 2012;66(1):53–60.PubMed

Tanizaki Y, Kobayashi A, Shiro M, Ota N, Takano R, Mabuchi Y, et al. Diagnostic value of preoperative SUVmax on FDG-PET/CT for the detection of ovarian cancer. Int J Gynecol Cancer. 2014;24(3):454–60.CrossRefPubMed

Konishi H, Takehara K, Kojima A, Okame S, Yamamoto Y, Shiroyama Y, et al. Maximum standardized uptake value of fluorodeoxyglucose positron emission tomography/computed tomography is a prognostic factor in ovarian clear cell adenocarcinoma. Int J Gynecol Cancer. 2014;24(7):1190–4.CrossRefPubMed

Lee JW, Cho A, Lee JH, Yun M, Lee JD, Kim YT, et al. The role of metabolic tumor volume and total lesion glycolysis on ¹⁸F-FDG PET/CT in the prognosis of epithelial ovarian cancer. Eur J Nucl Med Mol Imaging. 2014;41(10):1898–906.CrossRefPubMed

Chung HH, Kwon HW, Kang KW, Park NH, Song YS, Chung JK, et al. Prognostic value of preoperative metabolic tumor volume and total lesion glycolysis in patients with epithelial ovarian cancer. Ann Surg Oncol. 2012;19(6):1966–72.CrossRefPubMed

Fanfani F, Monterossi G, Fagotti A, Gallotta V, Costantini B, Vizzielli G, et al. Positron emission tomography–laparoscopy based method in the prediction of complete cytoreduction in platinum-sensitive recurrent ovarian cancer. Ann Surg Oncol. 2015;22(2):649–54.CrossRefPubMed

10.

Vargas HA, Burger IA, Goldman DA, Micco M, Sosa RE, Weber W, et al. Volume-based quantitative FDG PET/CT metrics and their association with optimal debulking and progression-free survival in patients with recurrent ovarian cancer undergoing secondary cytoreductive surgery. Eur Radiol. 2015;25(11):3348–53.CrossRefPubMedPubMedCentral

11.

Kitajima K, Suenaga Y, Ueno Y, Maeda T, Ebina Y, Yamada H, et al. Preoperative risk stratification using metabolic parameters of ¹⁸F-FDG PET/CT in patients with endometrial cancer. Eur J Nucl Med Mol Imaging. 2015;42(8):1268–75.CrossRefPubMed

12.

Yamamoto M, Tsujikawa T, Fujita Y, Chino Y, Kurokawa T, Kiyono Y, et al. Metabolic tumor burden predicts prognosis of ovarian cancer patients who receive platinum-based adjuvant chemotherapy. Cancer Sci. 2016;107(4):478–85.CrossRefPubMedPubMedCentral

13.

Kim CY, Jeong SY, Chong GO, Son SH, Jung JH, Kim DH, et al. Quantitative metabolic parameters measured on F-18 FDG PET/CT predict survival after relapse in patients with relapsed epithelial ovarian cancer. Gynecol Oncol. 2015;136(3):498–504.CrossRefPubMed

14.

Feng Z, Wen H, Bi R, Duan Y, Yang W, Wu X. Thrombocytosis and hyperfibrinogenemia are predictive factors of clinical outcomes in high-grade serous ovarian cancer patients. BMC Cancer. 2016;16:43.CrossRefPubMedPubMedCentral

15.

Feng Z, Wen H, Ju X, Bi R, Chen X, Yang W, et al. Expression of hypothalamic-pituitary-gonadal axis-related hormone receptors in low-grade serous ovarian cancer (LGSC). J Ovarian Res. 2017;10(1):7.CrossRefPubMedPubMedCentral

16.

Yang Z, Shi Q, Zhang Y, Pan H, Yao Z, Hu S, et al. Pretreatment ¹⁸F-FDG uptake heterogeneity can predict survival in patients with locally advanced nasopharyngeal carcinoma–a retrospective study. Radiat Oncol (London, England). 2015;10:4.CrossRef

17.

Kurtipek E, Cayci M, Duzgun N, Esme H, Terzi Y, Bakdik S, et al. ¹⁸F-FDG PET/CT mean SUV and metabolic tumor volume for mean survival time in non-small cell lung cancer. Clin Nucl Med. 2015;40(6):459–63.CrossRefPubMed

18.

Lee HJ, Lee JJ, Park JY, Kim JH, Kim YM, Kim YT, et al. Prognostic value of metabolic parameters determined by preoperative ¹⁸F-FDG PET/CT in patients with uterine carcinosarcoma. J Gynecol Oncol. 2017;28(4):e43.CrossRefPubMedPubMedCentral

19.

Czernin J, Weber WA, Herschman HR. Molecular imaging in the development of cancer therapeutics. Annu Rev Med. 2006;57:99–118.CrossRefPubMed

20.

Jager PL, de Korte MA, Lub-de Hooge MN, van Waarde A, Koopmans KP, Perik PJ, et al. Molecular imaging: what can be used today. Cancer Imaging. 2005;5 Spec No A:S27–32.CrossRefPubMed

21.

Bono Y, Mizumoto Y, Nakamura M, Iwadare J, Obata T, Fujiwara H. FDG-PET-positive ovarian thecoma with GLUT5 expression: five cases. J Obstet Gynaecol Res. 2017;43(3):599–603.CrossRefPubMed

22.

Del Gobbo A, Pellegrinelli A, Gaudioso G, Castellani M, Zito Marino F, Franco R, et al. Analysis of NSCLC tumour heterogeneity, proliferative and 18F-FDG PET indices reveals Ki67 prognostic role in adenocarcinomas. Histopathology. 2016;68(5):746–51.CrossRefPubMed

23.

Hu SL, Yang ZY, Zhou ZR, Yu XJ, Ping B, Zhang YJ. Role of SUV(max) obtained by ¹⁸F-FDG PET/CT in patients with a solitary pancreatic lesion: predicting malignant potential and proliferation. Nucl Med Commun. 2013;34(6):533–9.CrossRefPubMed

24.

Abgral R, Leboulleux S, Deandreis D, Auperin A, Lumbroso J, Dromain C, et al. Performance of ¹⁸fluorodeoxyglucose-positron emission tomography and somatostatin receptor scintigraphy for high Ki67 (≧ 10%) well-differentiated endocrine carcinoma staging. J Clin Endocrinol Metab. 2011;96(3):665–71.CrossRefPubMed

25.

Ueda S, Tsuda H, Saeki T, Omata J, Osaki A, Shigekawa T, et al. Early metabolic response to neoadjuvant letrozole, measured by FDG PET/CT, is correlated with a decrease in the Ki67 labeling index in patients with hormone receptor-positive primary breast cancer: a pilot study. Breast Cancer (Tokyo, Japan). 2011;18(4):299–308.CrossRef

26.

Onishi R, Noguchi M, Kaida H, Moriya F, Chikui K, Kurata S, et al. Assessment of cell proliferation in renal cell carcinoma using dual-phase 18F-fluorodeoxyglucose PET/CT. Oncol Lett. 2015;10(2):822–8.CrossRefPubMedPubMedCentral

27.

Aloj L, Caraco C, Jagoda E, Eckelman WC, Neumann RD. Glut-1 and hexokinase expression: relationship with 2-fluoro-2-deoxy-d-glucose uptake in A431 and T47D cells in culture. Cancer Res. 1999;59(18):4709–14.PubMed

28.

Tanimoto K, Yoshikawa K, Obata T, Ikehira H, Shiraishi T, Watanabe K, et al. Role of glucose metabolism and cellularity for tumor malignancy evaluation using FDG-PET/CT and MRI. Nucl Med Commun. 2010;31(6):604–9.PubMed

29.

Vallius T, Peter A, Auranen A, Carpen O, Kemppainen J, Matomaki J, et al. 18F-FDG-PET/CT can identify histopathological non-responders to platinum-based neoadjuvant chemotherapy in advanced epithelial ovarian cancer. Gynecol Oncol. 2016;140(1):29–35.CrossRefPubMed

30.

Avril N, Sassen S, Schmalfeldt B, Naehrig J, Rutke S, Weber WA, et al. Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer. J Clin Oncol. 2005;23(30):7445–53.CrossRefPubMed

Titel: 18F-FDG PET/CT can predict chemosensitivity and proliferation of epithelial ovarian cancer via SUVmax value
verfasst von: Shuai Liu
Zheng Feng
Hao Wen
Zhaoxia Jiang
Herong Pan
Yu Deng
Lei Zhang
Xingzhu Ju
Xiaojun Chen
Xiaohua Wu
Publikationsdatum: 25.06.2018
Verlag: Springer Japan
Erschienen in: Japanese Journal of Radiology / Ausgabe 9/2018
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-018-0755-y

Neu im Fachgebiet Radiologie

18.04.2024 | Pädiatrische Notfallmedizin | Nachrichten

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

¹⁸F-FDG PET/CT can predict chemosensitivity and proliferation of epithelial ovarian cancer via SUVmax value

Abstract

Purpose

Methods

Results

Conclusions

Neu im Fachgebiet Radiologie

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Studie bestätigt Potenzial von KI in der Radiologie

Quantitative Angiografie könnte IVUS-Alternative darstellen

Update Radiologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 9/2018

Simple quantification of paracardial and epicardial fat dimensions at low-dose chest CT: correlation with metabolic risk factors and usefulness in predicting metabolic syndrome

99mTc-GSA SPECT/CT fusion imaging for hepatectomy candidates with extremely deteriorated ICG value

Denoising of 3D magnetic resonance images with multi-channel residual learning of convolutional neural network

Radiofrequency ablation versus cryoablation for T1b renal cell carcinoma: a multi-center study

Normal liver tissue change after proton beam therapy

Imaging findings in radiation therapy complications of the central nervous system

Neu im Fachgebiet Radiologie

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Studie bestätigt Potenzial von KI in der Radiologie

Quantitative Angiografie könnte IVUS-Alternative darstellen

Update Radiologie