Background
Methods
Subjects
PET/CT imaging
PET/CT image analysis
Statistical analysis
Results
Characteristics of subjects
Age (y) | |
Mean ± SD | 58 ± 11 |
Range | 34 − 79 |
Gender | Number (%) |
Female | 38 (43.2) |
Male | 50 (56.8) |
H. Pylori infection | Number (%) |
Positive | 37 (42.0) |
Negative | 51 (58.0) |
Chronic atrophic gastritis | Number (%) |
Positive (H. Pylori positive) | 37 (40.9) |
(H. Pylori negative) | 24 (27.3) |
Negative | 27 (31.8) |
Neoplasms (finding on fiberscopy) | Number |
Early gastric cancer (H. Pylori positive) | 4 |
Gastric adenoma (H. Pylori positive) | 2 |
MALT lymphoma (H. Pylori positive) | 1 |
Other fiberscopic findings | 3 |
Superficial gastritis (H. Pylori positive) | 3 |
(H. Pylori negative) | 2 |
Erosive gastritis (H. Pylori positive) | 2 |
(H. Pylori negative) | 3 |
Gastric ulcer scar (H. Pylori positive) | 1 |
Duodenal ulcer scar (H. Pylori positive) | 1 |
Erosion of E-C Junction (H. Pylori negative) | 1 |
Reflux esophagitis (H. Pylori positive) | 1 |
(H. Pylori negative) | 1 |
PET/CT image analysis
H. pylori(+) N = 37 | H. pylori(-) N = 51 | |
---|---|---|
SUVmax (mean ± SD) | ||
Fornix | 4.01 ± 0.80 | 3.38 ± 0.97++ |
Corpus | 3.70 ± 0.95** | 2.71 ± 0.90*+ |
Antrum | 3.58 ± 1.12*** | 2.68 ± 0.99*+ |
Maximum | 4.36 ± 0.88 | 3.57 ± 1.01 |
Mean | 3.76 ± 0.78 | 2.93 ± 0.80+ |
SUVmean (mean ± SD) | ||
Fornix | 3.62 ± 0.71 | 3.06 ± 0.90++ |
Corpus | 3.31 ± 0.87*** | 2.39 ± 0.83*+ |
Antrum | 3.06 ± 0.96** | 2.30 ± 0.87*+ |
Maximum | 3.90 ± 0.74 | 3.19 ± 0.92+ |
Mean | 3.33 ± 0.67 | 2.58 ± 0.73+ |
Chr Gastritis(+) N = 60 | Chr Gastritis(-) N = 28 | |
---|---|---|
SUVmax (mean ± SD) | ||
Fornix | 3.86 ± 0.91 | 3.20 ± 0.92+ |
Corpus | 3.39 ± 1.00* | 2.57 ± 0.92*+ |
Antrum | 3.37 ± 1.19** | 2.39 ± 0.67*+ |
Maximum | 4.12 ± 0.97 | 3.42 ± 1.02++ |
Mean | 3.54 ± 0.89 | 2.72 ± 0.62+ |
SUVmean (mean ± SD) | ||
Fornix | 3.49 ± 0.85 | 2.88 ± 0.80+++ |
Corpus | 3.02 ± 0.94* | 2.25 ± 0.81*+ |
Antrum | 2.88 ± 1.01* | 2.06 ± 0.65*+ |
Maximum | 3.69 ± 0.88 | 3.06 ± 0.90++ |
Mean | 3.13 ± 0.79 | 2.40 ± 0.55+ |
Diagnostic performance by ROC analysis
Predictive Indicators | AUC | Cut-off | Sensitivity | Specificity | 95 % CI of AUC | P value |
---|---|---|---|---|---|---|
Maximun SUVmax | 0.738 | 3.66 | 81.1 % | 60.8 % | 0.635 – 0.841 | <0.001 |
Mean SUVmax | 0.793 | 3.11 | 81.1 % | 72.5 % | 0.699 – 0.887 | < 0.001 |
Maximun SUVmean | 0.739 | 3.30 | 81.1 % | 62.7 % | 0.636 – 0.841 | < 0.001 |
Mean SUVmean | 0.807 | 2.66 | 86.5 % | 70.6 % | 0.715 – 0.898 | < 0.001 |
Diagnostic performance of SUVs for chronic atrophic gastritis | ||||||
Maximun SUVmax | 0.708 | 3.42 | 76.7 % | 60.7 % | 0.585 – 0.831 | 0.02 |
Mean SUVmax | 0.773 | 2.86 | 76.7 % | 67.9 % | 0.671 – 0.875 | < 0.001 |
Maximun SUVmean | 0.709 | 3.15 | 75.0 % | 64.3 % | 0.585 – 0.833 | 0.02 |
Mean SUVmean | 0.784 | 2.57 | 75.0 % | 78.6 % | 0.684 – 0.884 | < 0.001 |
Predictive Indicators | AUC | Cut-off | Sensitivity | Specificity | 95 % CI of AUC | P value |
---|---|---|---|---|---|---|
Maximun SUVmax | 0.739 | 1.64 | 64.9 % | 72.5 % | 0.637 – 0.841 | <0.001 |
Mean SUVmax | 0.796 | 1.31 | 81.1 % | 74.5 % | 0.700 – 0.892 | <0.001 |
Maximum SUVmean | 0.738 | 1.37 | 83.8 % | 60.8 % | 0.635 – 0.841 | <0.001 |
Mean SUVmean | 0.791 | 1.15 | 81.1 % | 72.5 % | 0.695 – 0.887 | <0.001 |
Diagnostic performance of SUVs normalized by SUV in the liver for chronic atrophic gastritis | ||||||
Maximun SUVmax | 0.721 | 1.44 | 73.3 % | 60.7 % | 0.596 – 0.847 | 0.01 |
Mean SUVmax | 0.793 | 1.25 | 76.7 % | 78.6 % | 0.686 – 0.900 | <0.001 |
Maximum SUVmean | 0.711 | 1.25 | 83.3 % | 60.7 % | 0.583 – 0.838 | 0.02 |
Mean SUVmean | 0.790 | 1.09 | 78.3 % | 75.0 % | 0.682 – 0.897 | <0.001 |