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Erschienen in: CardioVascular and Interventional Radiology 9/2016

05.04.2016 | Technical Note

18F-FDOPA PET/CT-Guided Radiofrequency Ablation of Liver Metastases from Neuroendocrine Tumours: Technical Note on a Preliminary Experience

verfasst von: Roberto Luigi Cazzato, Julien Garnon, Nitin Ramamurthy, Georgia Tsoumakidou, Alessio Imperiale, Izzie Jacques Namer, Philippe Bachellier, Jean Caudrelier, Pramod Rao, Guillaume Koch, Afshin Gangi

Erschienen in: CardioVascular and Interventional Radiology | Ausgabe 9/2016

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Aim

To review our preliminary experience with 6-l-18F-fluorodihydroxyphenylalanine (18F-FDOPA) PET/CT-guided radiofrequency ablation (RFA) of liver metastases from neuroendocrine tumours (NETs).

Materials and Methods

Three patients (mean age 51.3 years; range 43–56) with gastro-entero pancreatic NET (GEP-NET) liver metastases underwent 18F-FDOPA PET/CT-guided RFA. Patients were referred with oligometastatic hepatic-confined disease (1–6 metastases; <3 cm) on 18F-FDOPA PET/CT; poor lesion visualisation on US, CT, and MR; and ongoing symptoms. Procedures were performed in an interventional PET/CT scanner under general anaesthesia using a split-dose protocol. Lesion characteristics, procedural duration and technical success (accurate probe placement and post-procedural ablation-zone photopaenia), complications, patient and operator dose, and clinical outcomes were evaluated.

Results

Thirteen liver metastases (mean size 11.4 mm, range 8–16) were treated in three patients (two presented with “carcinoid syndrome”). Technical success was 100 % with a mean procedural duration of 173.3 min (range 90–210) and no immediate complications. Mean patient dose was 2844 mGy·cm (range 2104–3686). Operator and radiographer doses were acceptable other than the operator’s right hand in the first case (149 µSv); this normalised in the second case. There was no local tumour or extra-hepatic disease progression at mid-term follow-up (mean 12.6 months; range 6–20); however, two cases progressed with new liver metastases at different sites. There was 100 % clinical success (n = 2) in resolving carcinoid syndrome symptoms.

Conclusion

18F-FDOPA PET/CT-guided RFA appears technically feasible, safe, and effective in patients with GEP-NETs and low-burden hepatic metastases. Further prospective studies are required to elucidate its precise role in tailored multimodality management of GEP-NET liver metastases.
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Metadaten
Titel
18F-FDOPA PET/CT-Guided Radiofrequency Ablation of Liver Metastases from Neuroendocrine Tumours: Technical Note on a Preliminary Experience
verfasst von
Roberto Luigi Cazzato
Julien Garnon
Nitin Ramamurthy
Georgia Tsoumakidou
Alessio Imperiale
Izzie Jacques Namer
Philippe Bachellier
Jean Caudrelier
Pramod Rao
Guillaume Koch
Afshin Gangi
Publikationsdatum
05.04.2016
Verlag
Springer US
Erschienen in
CardioVascular and Interventional Radiology / Ausgabe 9/2016
Print ISSN: 0174-1551
Elektronische ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-016-1334-1

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